Exposure to topiramate and acetazolamide causes endocrine disrupting effects in female rats during estrus

CONCLUSION: These results demonstrate that both acetazolamide and topiramate have endocrine disrupting effects in rats. Topiramate primarily targeted the choroid plexus and the pituitary gland while acetazolamide had broader systemic effects. Furthermore, topiramate predominantly targeted sex hormones, whereas acetazolamide widely affected all classes of hormones. A similar effect in humans has not yet been documented but these concerning findings warrants further investigations.PMID:38580201 | DOI:10.1016/j.taap.2024.116919

Source: Toxicology and Applied Pharmacology - April 5, 2024 Category: Toxicology Authors: Christina Kamp-Jensen Louise Norgil Donslund Bjarne Styrishave Rigmor H øjland Jensen Connar Stanley James Westgate Source Type: research