Multispectral Imaging (MSI): Review of Current Applications
Multispectral Imaging (MSI) is a unique layer-by-layer imaging technique that allows the visualization of a wide array of retinal and choroidal pathologies including retinovascular disorders, retinal pigment epithelial changes, and choroidal lesions. Herein, we summarize the basic imaging principles and current applications of MSI together with recent technology advances in the field. MSI detects reflectance signal from both normal chorioretinal tissue and pathological lesions. Either hyperreflectance or hyporeflectance reveals the absorption activity of pigments such as haemoglobin and melanin and the reflection from inte...
Source: Survey of Ophthalmology - June 13, 2023 Category: Opthalmology Authors: Feiyan Ma, Mingzhen Yuan, Igor Kozak Tags: Review article Source Type: research
Clinical features and therapeutic management of choroidal osteoma: A Systematic Review
Choroidal osteoma (CO) is a benign ossifying tumor within the choroid. Complications associated with CO, including disruption of retinal pigment epithelium (RPE), atrophy of photoreceptor, subretinal fluid (SRF), and choroidal neovascularization (CNV), present challenges for clinicians, and management remain controversial. We performed a comprehensive search in the PubMed, EMBASE, and Ovid databases for published studies and case reports relating to the management of choroidal osteoma. Since it was first described in 1978, various case reports of ocular complications associated with CO have been documented, and various the...
Source: Survey of Ophthalmology - June 13, 2023 Category: Opthalmology Authors: Li Zhang, Qi-Bo Ran, Chun-Yan Lei, Mei-Xia Zhang Source Type: research
“Surgical and anesthetic influences of the oculocardiac reflex in adults and children during strabismus surgery”
Letter to the Editors: (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - June 13, 2023 Category: Opthalmology Authors: Robert W. Arnold Source Type: research
Surgical and anesthetic influences of the oculocardiac reflex in adults and children during strabismus surgery
Dear Editor, (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - June 13, 2023 Category: Opthalmology Authors: Shira L. Robbins, Mark Greenberg, Ilona Juan Source Type: research
Patient-reported outcomes in patients with vitreous floaters: a systematic literature review
Seeking treatment for bothersome vitreous floaters is patient driven. To measure the impact of floaters and treatment on an individual ’s quality of life, patient-reported outcome measurements (PROMs) are essential. We review all studies using a PROM for patients with floaters. We evaluated content coverage against quality-of-life domains previously identified in other ophthalmic disorders, and against a qualitative study investi gating quality-of-life issues in patients with floaters. We assessed measurement properties of PROMs using an extensive range of psychometric quality criteria. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - June 12, 2023 Category: Opthalmology Authors: Jarinne E. Woudstra-de Jong, Sonia S. Manning-Charalampidou, Hans Vingerling, Jan J. Busschbach, Konrad Pesudovs Tags: Review article Source Type: research
New developments in the management of persistent corneal epithelial defects
Persistent epithelial defect (PED) is a corneal epithelial defect that failed to heal after 2 weeks. It is a condition that carries much morbidity, and our understanding of PED remains poor, with current treatment methods often having unsatisfactory outcomes. With PED becoming more prevalent, more efforts are required to establish reliable treatment modalities.Our reviews describe the causes of PED and the different approaches developed to manage them, as well as their associated limitations. Emphasis is placed on understanding various advances in the development of new treatment modalities. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - June 8, 2023 Category: Opthalmology Authors: Thia Zhang Zhe, Ho Yik To, Kendrick Co Shih, Louis Tong Tags: Review article Source Type: research
Fundus fluorescein angiography imaging of retinopathy of prematurity in infants: A review
Fluorescein angiography in retinopathy of prematurity is increasingly utilized over the past decade. The development of ultra-wide-field imaging combined with fluorescein angiography has allowed improved visualization of the peripheral retinal vasculature. Patient cooperation in the pediatric population is particularly challenging, but hand-held digital retinal photography has shown promise and can visualize the infant retina without the need for anesthesia and intravenous access. Many features of retinopathy of prematurity and its response to laser and anti-VEGF treatment can be either exclusively or better visualized on ...
Source: Survey of Ophthalmology - May 19, 2023 Category: Opthalmology Authors: Michael Kvopka, WengOnn Chan, Stewart R Lake, Shane Durkin, Deepa Taranath Tags: Review article Source Type: research
Take the Lead
A 23-year-old previously healthy woman presented with headache, generalized seizures, ataxia, encephalopathy, abdominal pain, nausea and vomiting culminating in a 40- pound weight loss. A contrasted magnetic resonance imaging (MRI) scan of the brain showed T2/FLAIR hyperintensities in the sulci of the occipital and parietal lobes, a punctate focus of restricted diffusion along the inferior aspect of the left caudate head and an empty sella. A lumbar puncture showed an opening pressure of 55 cm H2O, and kidney, ureter, and bladder X-ray showed a radiopaque particle in the colon. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - May 18, 2023 Category: Opthalmology Authors: Michael S. Vaphiades, Andrew R. Carey Tags: Clinical challenges Source Type: research
In Vitro Laboratory Models of Proliferative Vitreoretinopathy
Proliferative vitreoretinopathy (PVR), the most common cause of recurrent retinal detachment, is characterized by the formation and contraction of fibrotic membranes on the surface of the retina. There are no FDA-approved drugs to prevent or treat PVR. Therefore, it is necessary to develop accurate in vitro models of the disease that will enable researchers to screen drug candidates and prioritize the most promising candidates for clinical studies. We provide a summary of recent in vitro PVR models, as well as avenues for model improvement. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - May 18, 2023 Category: Opthalmology Authors: Ashley Y. Gao, Andrew J. Haak, Sophie J. Bakri Tags: Review article Source Type: research
Iris melanoma: Prognostication for metastasis
In this study, we report prognostic status and survival outcomes in a series of 35 patients with biopsy-proven iris melanoma. Fluorescence in situ hybridization was performed in 10 (29%) cases and 2 (5%) underwent multiplex ligation-dependent probe amplification. In total, 9 cases demonstrated disomy 3, 2 cases with monosomy 3 (fluorescence in situ hybridization), and 1 had a technical failure. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - May 17, 2023 Category: Opthalmology Authors: Alexander Melendez-Moreno, Ya ğmur Seda Yeşiltaş, Jacquelyn Wrenn, Arun D. Singh Tags: Review article Source Type: research
Pole to pole
An otherwise asymptomatic 67-year-old man presented to his ophthalmologist complaining of acute painless “dark area on the right”. Visual acuity was preserved and a single cotton-wool spot was noted in each retina. An inferior right quadrantanopia was evident on automated visual field and computerized tomography of the brain confirmed a left occipital stroke. Acute phase markers were elevated and t emporal artery biopsy was consistent with a diagnosis of giant cell arteritis. Isolated retinal cotton wool spots, even in the absence of systemic signs and symptoms, may be suggestive of giant cell arteritis. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - May 17, 2023 Category: Opthalmology Authors: Francesco Pellegrini, Maria Basciu, Julie Falardeau Source Type: research
ris Melanoma: Prognostication for Metastasis
In this study we report prognostic status and survival outcomes in a series of 35 patients with biopsy-proven iris melanoma. Fluorescence in situ hybridization (FISH) was performed in 10 (29%) cases and 2 (5%) underwent MLPA. In total, 9 cases demonstrated disomy 3, 2 cases with monosomy 3 (FISH), and 1 had technical failure. On gene expression profile (GEP) testing, 20 of the 23 cases (90%) were GEP class 1A, and the remaining 3 (10%) were class 1B. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - May 17, 2023 Category: Opthalmology Authors: Alexander Melendez-Moreno, Ya ğmur Seda Yeşiltaş, Jacquelyn Wrenn, Arun D. Singh Tags: Review article Source Type: research
Dynamic eyelid reconstruction in facial nerve palsy
The consequences of facial nerve palsy and secondary inability of eyelid closure and blink may lead to devastating complications for the patient, including blindness. Reconstruction techniques to improve eyelid position and function can be broadly classified into ‘static’ and ‘dynamic’ techniques. Generally, ophthalmologists have been familiar with static procedures such as upper eyelid loading, tarsorrhaphy, canthoplasty and lower eyelid suspension. Recently, dynamic techniques are being increasingly described for patients who require definitive str ategies to improve eyelid function, once the initial critical goa...
Source: Survey of Ophthalmology - May 16, 2023 Category: Opthalmology Authors: Ahsen Hussain Tags: Review article Source Type: research
Recommendations for risk stratification of periocular squamous cell carcinoma
Periocular squamous cell carcinoma (SCC) is a common cutaneous malignancy with generally favorable outcomes; however, the periocular region is intrinsically a high-risk location, and there exists a subset of lesions with a propensity for poor outcomes. Orbital invasion, intracranial perineural spread, nodal and distant metastasis are feared complications. There are several staging systems for eyelid carcinoma and cutaneous SCC, but the definition of high-risk lesions remains heterogeneous. It is unclear exactly which lesions can be safely deescalated, and which require nodal evaluation and adjuvant multimodal therapy. (Sou...
Source: Survey of Ophthalmology - May 10, 2023 Category: Opthalmology Authors: Jessica Y. Tong, Shyamala C. Huilgol, Craig James, Dinesh Selva Tags: Review article Source Type: research
Future directions in managing aniridia-associated keratopathy
Congenital aniridia is a panocular disorder that is typically characterized by iris hypoplasia and aniridia-associated keratopathy (AAK). AAK results in the progressive loss of corneal transparency and thereby loss of vision. Currently, there is no approved therapy to delay or prevent its progression, and clinical management is challenging because of phenotypic variability and high risk of complications after interventions; however, new insights into the molecular pathogenesis of AAK may help improve its management. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - May 3, 2023 Category: Opthalmology Authors: Arianne J.H. van Velthoven, Tor P. Utheim, Maria Notara, Dominique Bremond-Gignac, Francisco C. Figueiredo, Heli Skottman, Daniel Aberdam, Julie T Daniels, Giulio Ferrari, Christina Grupcheva, Carina Koppen, Mohit Parekh, Thomas Ritter, Vito Romano, Stefa Tags: Dochead Source Type: research
