Electrical Devices for Visual Restoration
Given the rising number of patients with blindness from macular, optic nerve, and visual pathway disease, there is considerable interest in the potential of electrical stimulation devices to restore vision. Electrical devices for restoration of visual function can be grouped into three categories: 1) visual prostheses whose goal is to bypass damaged areas and directly activate downstream, intact portions of the visual pathway; 2) electric field stimulation whose goal is to activate endogenous transcriptional and molecular signaling pathways to promote neuroprotection and neuro-regeneration; and 3) neuromodulation whose sti...
Source: Survey of Ophthalmology - September 3, 2021 Category: Opthalmology Authors: Tamara Sharf, Tej Kalakuntla, Darrin J Lee, Kimberly K Gokoffski Source Type: research
Thinking inside the box: Current insights into targeting orbital tissue remodeling and inflammation in thyroid eye disease
Thyroid eye disease (TED) is an autoimmune disorder that manifests in the orbit. In TED, the connective tissue behind the eye becomes inflamed and remodels with increased fat accumulation and/or increased muscle and scar tissue. As orbital tissue expands, patients develop edema, exophthalmos, diplopia, and optic neuropathy. In severe cases, vision loss may occur secondary to corneal scarring from exposure or optic nerve compression. Currently there is no cure for TED, and treatments are limited. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - September 3, 2021 Category: Opthalmology Authors: Vardaan Gupta, Christine L. Hammond, Elisa Roztocil, Mithra O. Gonzalez, Steven E. Feldon, Collynn F. Woeller Tags: Review article Source Type: research
Ocriplasmin for treatment of vitreomacular traction and macular hole: A systematic literature review and individual participant data meta-analysis of randomized, controlled, double-masked trials
Ocriplasmin is used to treat vitreomacular traction (VMT), with or without full-thickness macular hole (MH). We systematically reviewed the evidence on ocriplasmin's effect on vitreomacular adhesion resolution (VMAR), MH closure, vitrectomy, and best-corrected visual acuity (BCVA) and investigated the effect of baseline covariates on outcome. We applied individual participant data meta-analyses to the entire population and to subgroups defined by MH or epiretinal membrane (ERM) presence. Safety data were pooled and tabulated. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - September 1, 2021 Category: Opthalmology Authors: Timothy L. Jackson, Julia Haller, Koenraad H. Blot, Luc Duchateau, Benedicte Lescrauwaet Tags: Review Article Source Type: research
Ocriplasmin for Treatment of Vitreomacular Traction and Macular Hole A Systematic Literature Review and Individual Participant Data Meta-Analysis of Randomized, Controlled, Double-Masked Trials
Ocriplasmin is used to treat vitreomacular traction (VMT), with or without full-thickness macular hole (MH). We systematically reviewed the evidence on ocriplasmin's effect on vitreomacular adhesion resolution (VMAR), MH closure, vitrectomy, and best-corrected visual acuity (BCVA) and investigated the effect of baseline covariates on outcome. We applied individual participant data meta-analyses to the entire population and to subgroups defined by MH or epiretinal membrane (ERM) presence. Safety data were pooled and tabulated. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - September 1, 2021 Category: Opthalmology Authors: Timothy L. Jackson, Julia Haller, Koenraad H. Blot, Luc Duchateau, Benedicte Lescrauwaet Source Type: research
Conjunctival myxoma: A systematic review of a rare tumor
Conjunctival myxoma is an uncommon benign tumor that may develop as a localized disease or as part of the Carney complex, in which case it can cause significant morbidity and mortality. Conjunctival myxomas can mimic other pure or mixed tumors and are often overlooked in clinical practice. Histopathological studies are essential for diagnosis; however, controversy regarding their pathological and immunohistochemical features makes the diagnostic process more difficult. Due to the importance of correctly classifying these conjunctival tumors, as well as recognizing when a systematic screening is required due to the possible...
Source: Survey of Ophthalmology - August 27, 2021 Category: Opthalmology Authors: Rosa Alvarado-Villacorta, Neyda Milagros Torres Zavala, Lelia Marroqu ín Loayza, Abelardo A. Rodríguez-Reyes Source Type: research
