Pharmacologically-induced uveitis
Treatments of numerous systemic and local diseases of different etiologies may be accompanied by an unwanted side effect in the form of uveitis. We inform readers about medications that have the potential to cause uveitis and analyze the strength of association of these medications with uveitis. Subsequently, cessation of medication or appropriate treatment can be individualized for each patient for the purpose of preventing further damage to tissue structure and function. Being aware of these associations, physicians may readily identify medications that may cause uveitis and avoid expensive and unnecessary clinical and l...
Source: Survey of Ophthalmology - January 10, 2021 Category: Opthalmology Authors: Maram E.A. Abdalla Elsayed, Igor Kozak Tags: Review article Source Type: research
The clinical and pathogenic spectrum of surgically-induced scleral necrosis: A review
The onset of scleral necrosis after ocular surgery may have catastrophic ocular and systemic consequences. The two most frequent surgeries causing surgically-induced scleral necrosis (SISN) are pterygium excision and cataract extraction. Several pathogenic mechanisms are involved in surgically induced scleral necrosis. All of them are poorly understood. Ocular trauma increasing lytic action of collagenases with subsequent collagen degradation, vascular disruption leading to local ischemia, and immune complex deposition activating the complement system represents some of the events that lead to scleral necrosis. (Source: Su...
Source: Survey of Ophthalmology - January 7, 2021 Category: Opthalmology Authors: Raul E. Ruiz-Lozano, Lucas A. Garza-Garza, Osvaldo Davila-Cavazos, C. Stephen Foster, Alejandro Rodriguez-Garcia Tags: Major review Source Type: research
The Clinical and Pathogenic Spectrum of Surgically-Induced Scleral Necrosis. A Review.
The onset of scleral necrosis after ocular surgery can have catastrophic ocular and systemic consequences. The two most frequent surgeries causing surgically-induced scleral necrosis (SISN) are pterygium excision and cataract extraction. Several pathogenic mechanisms are involved in SISN. All of them are poorly understood. Ocular trauma increasing lytic action of collagenases with subsequent collagen degradation, vascular disruption leading to local ischemia, and immune complex deposition activating the complement system represents some of the events that lead to scleral necrosis. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - January 7, 2021 Category: Opthalmology Authors: Raul E. Ruiz-Lozano, Lucas A. Garza-Garza, Osvaldo Cavazos-Davila, C. Stephen Foster, Alejandro Rodriguez-Garcia Source Type: research
Vascular Abnormalities in Uveitis
Inflammation can involve several ocular structures, including the sclera, retina, uvea, and cause vascular changes in these tissues. Although retinal vasculitis is the most common finding associated with uveitis involving the posterior segment, other vascular abnormalities may be seen in the retina. These include capillary non perfusion and ischemia, vascular occlusions, pre-retinal neovascularization, micro- and macro-aneurysms, and telangiectasia. Moreover, vasoproliferative tumors and subsequent Coat-like response can develop secondary to uveitis. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - January 4, 2021 Category: Opthalmology Authors: Nazanin Ebrahimiadib, Arash Maleki, Kaveh Fadakar, Ambika Manhapra, Fariba Ghassemi, C. Stephen Foster Source Type: research
Photodynamic Therapy for Choroidal Melanoma: What is the response rate?
To determine the response rate of choroidal melanoma following primary photodynamic therapy we conducted a meta-analysis of published studies. A total of 7 studies reporting photodynamic therapy (PDT) as primary treatment of choroidal melanoma in 162 patients with a mean tumor height of 2.8 mm (1.4 to 4.2) were identified. 46% of tumors were amelanotic, 48% were fully pigmented, and 6% had partial pigmentation. The PDT parameters in all studies included 10 minute intravenous infusion of verteporfin (6mg/m2), but varied in number of sessions (1 to 3), fluence (1x to 19x), and number of spots (single or multiple). (Source: S...
Source: Survey of Ophthalmology - January 1, 2021 Category: Opthalmology Authors: Sari Yordi, Hansell Soto, Randy C. Bowen, Arun D. Singh Source Type: research
