In Vitro Laboratory Models of Proliferative Vitreoretinopathy

Proliferative vitreoretinopathy (PVR), the most common cause of recurrent retinal detachment, is characterized by the formation and contraction of fibrotic membranes on the surface of the retina. There are no FDA-approved drugs to prevent or treat PVR. Therefore, it is necessary to develop accurate in vitro models of the disease that will enable researchers to screen drug candidates and prioritize the most promising candidates for clinical studies. We provide a summary of recent in vitro PVR models, as well as avenues for model improvement.
Source: Survey of Ophthalmology - Category: Opthalmology Authors: Tags: Review article Source Type: research