Anti-VEGF Crunch Syndrome in Proliferative Diabetic Retinopathy: A Review
Anti-vascular endothelial growth factor (anti-VEGF) crunch syndrome describes the progression to tractional retinal detachment following intravitreal anti-VEGF therapy in an eye with proliferative diabetic retinopathy (PDR). We reviewed the literature on the anti-VEGF crunch using the PubMed and Cochrane databases. Anti-VEGF crunch typically manifests as sudden vision loss in the affected eye between 1 and 6 weeks following intravitreal anti-VEGF injection, with a mean onset of 13 days. Risk factors for crunch development include the use of a higher anti-VEGF dose and increased severity of diabetic retinopathy with fibrosi...
Source: Survey of Ophthalmology - March 7, 2021 Category: Opthalmology Authors: Yiran Tan, Akira Fukutomi, Michelle Sun, Shane Durkin, Jagjit Gilhotra, Weng Chan Tags: Review Article Source Type: research
Congenital aniridia – A comprehensive review of clinical features and therapeutic approaches
Congenital aniridia is a panocular disease primarily characterized by various degrees of iris and foveal hypoplasia. In most cases, the genetic origin is a mutation in the paired-box gene 6 (PAX6), which leads to fundamental disturbances in eye development. Severe, secondary complications are common, including keratopathy, glaucoma, cataract, and dry eye disease. These tend to appear from childhood or adolescence and often lead to considerable visual impairment. Nonocular findings of the disease are also being reported, and the term “aniridia syndrome” is now being used more frequently. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - March 3, 2021 Category: Opthalmology Authors: Erlend C.S. Landsend, Neil Lagali, Tor P. Utheim Tags: Review article Source Type: research
Congenital Aniridia – A Comprehensive Review of Clinical Features and Therapeutic Approach
Congenital aniridia is a rare genetic eye disorder with total or partial absence of the iris from birth. In most cases the genetic origin of aniridia is a mutation in the PAX6 gene, leading to involvement of most eye structures. Hypoplasia of the fovea is usually present and is associated with reduced visual acuity and nystagmus. Aniridia-associated keratopathy, glaucoma, and cataract are serious and progressive complications that can further reduce visual function. Treatment of the ocular complications of aniridia is challenging and has a high risk of side effects. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - March 3, 2021 Category: Opthalmology Authors: Erlend C.S. Landsend, Neil Lagali, Tor P. Utheim Source Type: research
Neurodevelopmental Outcomes in Preterm Infants with Retinopathy of Prematurity
Over the past decade there has been a paradigm shift in the treatment of retinopathy of prematurity (ROP) with the introduction of anti-vascular endothelial growth factor (anti-VEGF) treatments. Anti-VEGF agents have the advantages of being easier to administer, requiring less anesthesia, having the potential for improved peripheral vision, and producing less refractive error than laser treatment. On the other hand, it is known that intravitreal administration of anti-VEGF agents lowers VEGF levels in the blood and raises the theoretical concerns of intraocular anti-VEGF causing deleterious effects in other organ systems, ...
Source: Survey of Ophthalmology - March 1, 2021 Category: Opthalmology Authors: Hao Tan, Patricia Blasco, Tamorah Lewis, Susan Ostmo, Michael F Chiang, J. Peter Campbell Source Type: research
Peripheral Ulcerative Keratitis
Peripheral ulcerative keratitis (PUK) is a destructive inflammatory disease of the juxtalimbal cornea associated with crescent-shaped corneal stromal thinning, an epithelial defect, and inflammatory cells in the corneal stroma.109,166 The predilection of the peripheral cornea for PUK is explained by its anatomical and physiological characteristics. PUK could be a presenting manifestation of an underlying ocular or systemic disease, which may be potentially lethal. Vasculitides and collagen vascular diseases of auto-immune etiology, such as rheumatoid arthritis (RA), granulomatosis with polyangiitis (GPA, formerly known as ...
Source: Survey of Ophthalmology - February 28, 2021 Category: Opthalmology Authors: Dr. Yogita Gupta, Dr. Alisha Kishore, Dr. Pooja Kumari, Dr. Neelima Balakrishnan, Dr. Neiwete Lomi, Dr. Noopur Gupta, Dr. M. Vanathi, Dr. Radhika Tandon Source Type: research
Inverted internal limiting membrane flap technique for myopic macular hole: A meta-analysis
Macular hole (MH) can be a significant complication in patients with high myopia. The recently reported inverted internal limiting membrane (ILM) flap technique is a promising alternative to treat myopic MHs. We performed a meta-analysis of the published anatomical and functional results of the “inverted ILM flap” technique for the treatment of myopic MH with or without retinal detachment (RD). Our results showed that the inverted ILM flap technique, either covering or insertion, is an effective method for treating myopic MH with or without RD and provides high MH closure ranging from 91.8% to 97.1%. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - February 27, 2021 Category: Opthalmology Authors: Irini Chatziralli, Genovefa Machairoudia, Dimitrios Kazantzis, George Theodossiadis, Panagiotis Theodossiadis Tags: Review article Source Type: research
Table of Contents
(Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - February 26, 2021 Category: Opthalmology Source Type: research
Author's Response
We thank Norooznezhad et al1 for sharing their medical hypothesis regarding the potential role of cannabinoids as a possible treatment for choroidal neovascular membranes (CNVM). They present an intriguing mechanism via suppression of pro-inflammatory and pro-angiogenic factors. As outlined in our review, the therapeutic potential of cannabinoids have not been comprehensively evaluated. We look forward to further elucidation of the potential role of cannabinoids as anti-angiogenic agents.2 (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Helen Danesh-Meyer Tags: Letter Source Type: research
Authors ’ Response to Letter to the Editor
We thank Drs. Gonul and Eker for their interest in our manuscript1 and for the information they have added. Several of their assertions deserve detailed comments. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Andrzej Grzybowski, Piotr Brona, Luis Zeman, Michael W. Stewart Tags: Letter Source Type: research
Response to Letter to the Editor
We thank Drs. Gonul and Eker for their interest in our manuscript1 and for the information they have added. Several of their assertions deserve detailed comments. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Andrzej Grzybowski, Piotr Brona, Luis Zeman, Michael W. Stewart Tags: Letter Source Type: research
Authors' Response
Thank you for bringing this to my attention. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Morten S. Magno Tags: Letter Source Type: research
Response to Maskin
Thank you for bringing this to my attention. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Morten S. Magn ø Tags: Letter Source Type: research
Response to Survey
We thank Norooznezhad et al. for sharing their medical hypothesis regarding the potential role of cannabinoids as a possible treatment for choroidal neovascular membranes (CNVM). They present an intriguing mechanism via suppression of pro-inflammatory and pro-angiogenic factors. As outlined in our review, the therapeutic potential of cannabinoids have not been comprehensively evaluated. We look forward to further elucidation of the potential role of cannabinoids as anti-angiogenic agents. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Helen Danesh-Meyer Source Type: research
LTE 2 response Stewart
We thank Drs. Gonul and Eker for their interest in our manuscript 1 and for the information they have added. Several of their assertions deserve detailed comments. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Andrzej Grzybowski, Piotr Brona, Luis Zeman, Michael W. Stewart Source Type: research
Comments On: Grzybowski et al: Commonly used intracameral antibiotics for endophthalmitis prophylaxis: A literature review
We have read with considerable interest the article entitled “Commonly used intracameral antibiotics for endophthalmitis prophylaxis: A literature review,” by Grzybowski et al.6 The article describes the risks and adverse events related to the use of the three most common intracameral (IC) antibiotics: moxifloxacin, cefuroxime, and vancomycin. We are gra teful to the authors for their excellent work and would like to contribute further in terms of the adverse events associated with the IC moxifloxacin, including bilateral acute iris transillumination (BAIT), bilateral acute depigmentation of the iris (BADI), and toxic...
Source: Survey of Ophthalmology - February 18, 2021 Category: Opthalmology Authors: Saban Gonul, Serhat Eker Tags: Letter Source Type: research
