Future directions in managing aniridia-associated keratopathy

Congenital aniridia is a panocular disorder that is typically characterized by iris hypoplasia and aniridia-associated keratopathy (AAK). AAK results in the progressive loss of corneal transparency and thereby loss of vision. Currently, there is no approved therapy to delay or prevent its progression, and clinical management is challenging because of phenotypic variability and high risk of complications after interventions; however, new insights into the molecular pathogenesis of AAK may help improve its management.

Source: Survey of Ophthalmology - May 3, 2023 Category: Opthalmology Authors: Arianne J.H. van Velthoven, Tor P. Utheim, Maria Notara, Dominique Bremond-Gignac, Francisco C. Figueiredo, Heli Skottman, Daniel Aberdam, Julie T Daniels, Giulio Ferrari, Christina Grupcheva, Carina Koppen, Mohit Parekh, Thomas Ritter, Vito Romano, Stefa Tags: Dochead Source Type: research