Subretinal hyperreflective material (SHRM) in retinal and chorioretinal disorders: A comprehensive review
Subretinal hyperreflective material (SHRM) is a common and remarkable optical coherence tomography (OCT) biomarker whose importance is emerging in several retinal and chorioretinal diseases, including age-related macular degeneration, central serous chorioretinopathy, polypoidal choroidal vasculopathy, pathologic myopia, posterior uveitis, vitelliform lesions and macular dystrophies, and more rare disorders.Multimodal imaging, also thanks to the introduction of OCT angiography, allowed a deeper characterisation of SHRM components and its morphological changes after treatment, suggesting its usefulness in clinical practice....
Source: Survey of Ophthalmology - December 29, 2023 Category: Opthalmology Authors: Alessandro Feo, Elisa Stradiotto, Riccardo Sacconi, Matteo Menean, Giuseppe Querques, Mario R Romano Source Type: research
Multicolor imaging: Current clinical applications
Multicolor (MC) imaging is an innovative pseudocolor fundus imaging modality based on confocal scanning laser ophthalmoscopy. It effectively scans the retina at different depths to create a composite image. The green reflectance image depicts the middle retinal while blue reflectance image provides images of the retinal surface. The infrared reflectance image depicts retinal structures at the level of outer retina and choroid. We systematically analyze published case reports, case series, and original articles on MC imaging where it has helped in discovering additional clinical features of retinal diseases not readily appa...
Source: Survey of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Rupak Roy, Surabhi Chattree, Urvashi Kala, Bristi Majumdar, Janhavi Desai, Sampurna Bhattacharya, Ahana Sen, Sugandha Goel, Nicey Roy Thomas, Maitreyi Chowdhury, Kalpita Das, Eesh Nigam, Debmalya Das, Kumar Saurabh Tags: Review article Source Type: research
Multicolour Imaging: Current Clinical Applications
Multicolor (MC) imaging is an innovative, pseudocolor fundus imaging modality based on confocal scanning laser ophthalmoscopy. It effectively scans the retina at different depths to create a composite image. The green reflectance image depicts the middle retinal while blue reflectance image provides images of the retinal surface. The infrared reflectance image depicts retinal structures at the level of outer retina and choroid. In the current review, we systematically analyze published case reports, case series, and original articles on MC imaging where it has helped in discovering additional clinical features of retinal d...
Source: Survey of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Rupak Roy, Surabhi Chattree, Urvashi Kala, Bristi Majumdar, Janhavi Desai, Sampurna Bhattacharya, Ahana Sen, Sugandha Goel, Nicey Roy Thomas, Maitreyi Chowdhury, Kalpita Das, Eesh Nigam, Debmalya Das, Kumar Saurabh Tags: Review article Source Type: research
Diagnostic accuracy of artificial intelligence in detecting retinitis pigmentosa: A systematic review and meta-analysis
Retinitis pigmentosa (RP) is often undetected in its early stages. Artificial intelligence (AI) has emerged as a promising tool in medical diagnostics. Therefore, we conducted a systematic review and meta-analysis to evaluate the diagnostic accuracy of AI in detecting RP using various ophthalmic images. We conducted a systematic search on PubMed, Scopus, and Web of Science databases on December 31, 2022. We included studies in the English language that used any ophthalmic imaging modality, such as OCT or fundus photography, used any AI technologies, had at least an expert in ophthalmology as a reference standard, and propo...
Source: Survey of Ophthalmology - November 30, 2023 Category: Opthalmology Authors: Ayman Mohammed Musleh, Saif Aldeen AlRyalat, Mohammad Naim Abid, Yahia Salem, Haitham Mounir Hamila, Ahmed B. Sallam Tags: Review article Source Type: research
Table of Contents
(Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - November 28, 2023 Category: Opthalmology Source Type: research
Hypomorphic variants in inherited retinal and ocular diseases: A review of the literature with clinical cases
Hypomorphic variants decrease, but do not eliminate, gene function via a reduction in the amount of mRNA or protein product produced by a gene or by production of a gene product with reduced function. Many hypomorphic variants have been implicated in inherited retinal diseases (IRDs) and other genetic ocular conditions; however, there is heterogeneity in the use of the term “hypomorphic” in the scientific literature. We searched for all hypomorphic variants reported to cause IRDs and ocular disorders. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - November 28, 2023 Category: Opthalmology Authors: Tobin B.T. Thuma, Rebecca A. Procopio, Hiram J. Jimenez, Kammi B. Gunton, Jose S. Pulido Source Type: research
Peripapillary Fluid: Obvious and Not So Obvious!
Intraretinal or subretinal fluid in the peripapillary area can be clinically visualized in conditions such as peripapillary choroidal neovascularization, optic disc pit maculopathy, and optic nerve head tumors and granulomas. Optical coherence tomography (OCT) helps to visualize peripapillary fluid in many other chorioretinal conditions such as peripapillary pachychoroid syndrome, posterior uveitis, central retinal vein occlusion), malignant hypertension, hypotonic maculopathy as well as neuroophthalmological conditions such as glaucoma, microcystic macular edema (MME) and disc edema due papilledema, non-arteritic anterior...
Source: Survey of Ophthalmology - November 26, 2023 Category: Opthalmology Authors: Supriya Arora, Dinah Zur, Claudio Iovino, Jay Chhablani Source Type: research
The effect of complement C3 or C5 inhibition on geographic atrophy secondary to age-related macular degeneration: A living systematic review and meta-analysis
With the introduction of therapies to treat geographic atrophy (GA), GA management in clinical practice is now possible. A living systematic review can provide access to timely and robust evidence synthesis. This review found that complement factor 3 and 5 (C3 and C5) inhibition compared to sham likely reduces change in square root GA area at 12 months and untransformed GA area at 24 months. There is likely little to no difference in the rate of systemic treatment-emergent adverse events compared to sham. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - November 24, 2023 Category: Opthalmology Authors: Anubhav Garg, Keean Nanji, Felicia Tai, Mark Phillips, Dena Zeraatkar, Sunir J. Garg, SriniVas R. Sadda, Peter K. Kaiser, Robyn H. Guymer, Sobha Sivaprasad, Charles C. Wykoff, Varun Chaudhary Tags: Review article Source Type: research
Diagnostic methods for dysthyroid optic neuropathy: A systematic review and analysis
Diagnosis of dysthyroid optic neuropathy (DON) typically relies on a set of diagnostic clinical features, including decreased visual acuity, impaired color vision, presence of relative afferent pupillary defect, optic disc swelling and ancillary tests including visual field (VF), pattern visual evoked potential (pVEP), and apical crowding or optic nerve stretching on neuroimaging. We summarize various diagnostic methods to establish or rule out DON. A total of 95 studies (involving 4619 DON eyes) met the inclusion criteria. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - November 23, 2023 Category: Opthalmology Authors: Stella Weng Chi Sio, Benson Kang To Chan, Fatema Mohamed Ali Abdulla Aljufairi, Jake Uy Sebastian, Kenneth Ka Hei Lai, Clement Chee Yung Tham, Chi Pui Pang, Kelvin Kam Lung Chong Tags: Review article Source Type: research
Age-related macular degeneration and neurodegenerative disorders: Shared pathways in complex interactions
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the elderly, and neurodegenerative disorders such as Alzheimer' disease and Parkinson disease are debilitating conditions that affect millions worldwide. Despite the different clinical manifestations of these diseases, growing evidence suggests that they share common pathways in their pathogenesis including inflammation, oxidative stress, and impaired autophagy. In this review, we explore the complex interactions between AMD and neurodegenerative disorders, focusing on their shared mechanisms and potential therapeutic targets. (Source: S...
Source: Survey of Ophthalmology - November 22, 2023 Category: Opthalmology Authors: Sayena Jabbehdari, Anthony C. Oganov, Fateme Rezagholi, Soheil Mohammadi, Hamid Harandi, Ghasem Yazdanpanah, J. Fernando Arevalo Tags: Review article Source Type: research
Planet of the Apex
A 63-year-old man with diabetes presented with unilateral ptosis and an exotropia. A diagnosis of isolated diabetic III nerve palsy was made. Subsequent neuro-ophthalmologic evaluation showed multiple cranial nerves involvement consistent with a diagnosis of orbital apex syndrome. Review of past medical history was significant for a previous nasopharyngeal carcinoma and biopsy of the involved site was consistent with tumor recurrence. This case highlights the importance of correct medical history taking and anatomo-clinical correlation in neuro-ophthalmology. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - November 22, 2023 Category: Opthalmology Authors: Francesco Pellegrini, Maria Basciu, Rod Foroozan Source Type: research
International incidence and temporal trends for rhegmatogenous retinal detachment: A systematic review and meta-analysis
We set out to estimate the international incidence of rhegmatogenous retinal detachment (RRD), and to evaluate its temporal trend over time. There is a lack of robust estimates on the worldwide incidence and trend for RRD, a major cause of acute vision loss. We conducted a systematic review of RRD incidence. The electronic databases PubMed, Scopus, and Thomson Reuters ’ Web of Science were searched from inception through 2nd June 2022. Random-effects meta-analysis model with logit transformation was performed to obtain pooled annual incidence estimates of RRD. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - November 22, 2023 Category: Opthalmology Authors: Jasmine Yaowei Ge, Zhen Ling Teo, Miao Li Chee, Yih-Chung Tham, Tyler Hyungtaek Rim, Ching-Yu Cheng, Tien Yin Wong, SNEC Surgical Retina Research Group, Edmund Yick Mun Wong, Shu Yen Lee, Ning Cheung Tags: Major review Source Type: research
In praise of povidone-iodine application in ophthalmology
Polyvinyl pyrrolidone or povidone-iodine (PVP-I) is a water-soluble complex formed by the combination of iodine and a water-soluble polymer, polyvinyl pyrrolidone. This complex exerts bactericidal, fungicidal, and virucidal action by gradually releasing free iodine at the site of application to react with pathogens. In ophthalmology, PVP-I is used as a disinfectant and antiseptic agent for preoperative preparation of the skin and mucous membranes and for treating contaminated wounds. PVP-I has been shown to reduce effectively the risk of endophthalmitis in various ocular procedures, including cataract surgery and intravitr...
Source: Survey of Ophthalmology - November 7, 2023 Category: Opthalmology Authors: Mohammad Soleimani, Ali A. Haydar, Kasra Cheraqpour, Haniyeh Zeidabadinejad, Amirreza Esfandiari, Niloofarsadaat Eshaghhosseiny, Alireza Shahmohammadi, Soraya Banz, Ali R. Djalilian Source Type: research
Cataractogenesis and molecular pathways, with reactive free oxygen species as a common pathway
Slowing down or stopping the natural process of cataractogenesis is certainly a challenge for those who today propose an option other than surgery. Addressing the same problem in different ways constitutes a new approach to solving what is today the number one cause of reversible blindness worldwide. The technological revolution, as well as the advances in the biological sciences, allows us to conceive mechanisms never thought of before to stop the process that, as a common pathway, constitutes opacification of the crystalline lens. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - November 6, 2023 Category: Opthalmology Authors: Arturo Iv án Pérez Pacheco Source Type: research
Cataractogenesis and molecular pathways with reactive free oxygen species as a common pathway
Slowing down or stopping the natural process of cataractogenesis is certainly a challenge for those who today propose a different option than surgery. Addressing the same problem in different ways constitutes a new approach to solving what is today the number one cause of reversible blindness worldwide. The technological revolution, as well as the advances in the different sciences, allows us to conceive mechanisms never thought of before to stop the process that, as a common pathway, constitutes opacification of the crystalline lens. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - November 6, 2023 Category: Opthalmology Authors: Arturo Iv án Pérez Pacheco Source Type: research
