Not just any headache
A 40-year-old man with a history of traumatic retinal detachment in the left eye treated with scleral buckle and migraine with aura presented to clinic for persistent blurry vision of the right eye following an episode of migraine with aura. The patient had experienced migraines with visual auras starting as a teenager, which normally resolve within an hour except for the most recent episode. Humphrey visual field showed right superior homonymous quadrantanopia. Computed tomography of the head without contrast showed acute ischemia in the left occipital lobe. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - October 27, 2023 Category: Opthalmology Authors: Janet Fan, Pamela Davila, Noor Laylani, Andrew G. Lee, Benjamin Frishberg Source Type: research
Management of vernal keratoconjunctivitis: Navigating a changing treatment landscape
Vernal keratoconjunctivitis (VKC) is a chronic, progressive, and potentially sight-threatening form of ocular inflammatory disease that primarily affects children and young adults. Prevalence varies by region, ranging from (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - October 25, 2023 Category: Opthalmology Authors: Asim Ali, Leonard Bielory, Stephanie Dotchin, Patrick Hamel, Yi Ning J. Strube, Euna B. Koo Source Type: research
Systematic review of prognostic factors associated with progression to late age-related macular degeneration: Pinnacle study report 2
There is a need to identify accurately prognostic factors that determine the progression of intermediate to late-stage age-related macular degeneration (AMD). Currently, clinicians cannot provide individualized prognoses of disease progression. Moreover, enriching clinical trials with rapid progressors may facilitate delivery of shorter intervention trials aimed at delaying or preventing progression to late AMD. Thus, we performed a systematic review to outline and assess the accuracy of reporting prognostic factors for the progression of intermediate to late AMD. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - October 25, 2023 Category: Opthalmology Authors: Ahmed M. Hagag, Rebecca Kaye, Vy Hoang, Sophie Riedl, Philipp Anders, Beth Stuart, Ghislaine Traber, Christian Appenzeller-Herzog, Ursula Schmidt-Erfurth, Hrvoje Bogunovic, Hendrik P. Scholl, Toby Prevost, Lars Fritsche, Daniel Rueckert, Sobha Sivaprasad, Source Type: research
Unusual Conjunctival Melanocytic Proliferations. Report of Five Cases and Review of the Literature
Indeterminate melanocytic proliferations of the conjunctiva have both benign and malignant features that previously made these lesions nearly impossible to categorize in existing classification schemes. With the evolution of immunohistochemistry and molecular genetics, however, subclassifications have emerged that allow for a more tailored diagnosis and management. These conjunctival melanocytic proliferations include deep penetrating nevus, granular cell nevus, and nevoid melanoma. There remains a small subset of conjunctival melanocytic proliferations that defy precise characterization as nevi, primary acquired melanosis...
Source: Survey of Ophthalmology - October 25, 2023 Category: Opthalmology Authors: Adrianna Eder, Tatyana Milman, Hardeep Singh Mudhar, Sara E Lally, Carol L Shields, Khanh Bui, Jill R Wells, Hans E. Grossniklaus Source Type: research
Observations on the association between obstructive sleep apnea and floppy eyelid syndrome: A systematic review and meta-analysis
Dear Editor: (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - October 7, 2023 Category: Opthalmology Authors: Jian S. Chan, Matthew K. Lee, Peter J. Tweedie, Claudia J. Tiong, Amy T. Tsoi, Aadhavi Vasanthan, Jed Maegraith, Grace A. Borchert, James R. Gunasegaram, Anna M. Waldie, Geoff Wilcsek Franzco, Ian C. Francis Source Type: research
Response to “Observations on the association between Obstructive Sleep Apnea and Floppy Eyelid Syndrome: A systematic review and meta-analysis”
Dear Editor: (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - October 7, 2023 Category: Opthalmology Authors: Alex Jia Yang Cheong, Owen Tsung Wen Ho, Sean Kang Xuan Wang, Chang Yi Woon, Anna See, Adele Chin Wei Ng, Shaun Ray Han Loh, Soon-Phaik Chee, Song Tar Toh Source Type: research
Review of smartphone funduscopy for diabetic retinopathy screening
I detail advances in fundoucopy diagnosis systems integrating smartphones. Smartphone funduscopy devices are comprised of lens devices connecting with smartphones and software applications to be used for mobile retinal image capturing and diagnosis of diabetic retinopathy. This is particularly beneficial to automate and mobilize retinopathy screening techniques and methods in remote and rural areas as those diabetes patients are often not meeting the required regular screening for diabetic retinopathy. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - October 6, 2023 Category: Opthalmology Authors: Neil Vaughan Tags: Review article Source Type: research
The role of intravitreal anti-vascular endothelial growth factor injection in peripheral exudative hemorrhagic chorioretinopathy: A systematic review
Anti-vascular endothelial growth factor (anti-VEGF) injections have revolutionised the field of ophthalmology, and their use in a variety of retinal diseases is growing. One target disease is peripheral exudative haemorrhagic chorioretinopathy (PEHCR), a disease that is uncommon and poorly understood. Despite this, there are numerous studies and case reports outlining the potential role of intravitreal injection of anti-VEGF medicines to treat it. As such, an evidence-based understanding of its risk-benefit profile is vital. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - October 6, 2023 Category: Opthalmology Authors: Akash Gowda, Bobak Bahrami, Wilson Wong Jun Jie, Robert Casson, Weng Onn Chan Source Type: research
Ocular surface toxicities associated with modern anticancer therapies
Cancer treatments have recently shifted from broad-spectrum cytotoxic therapies to more focused treatments, maximizing anti-cancerous activity while reducing toxicity to healthy cells. These modern anticancer therapies (MATs) encompass a wide range of innovative molecules that mainly include immune checkpoint inhibitors (ICIs) and targeted anticancer therapies (TATs), comprising antibody drug conjugates (ADCs) and inhibitors of signal transduction (IST). Some MATs are associated with ocular surface (OS) adverse events (AEs) that can cause severe discomfort and even lead to loss of vision. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - October 6, 2023 Category: Opthalmology Authors: Rafael Boucher, Oscar Haigh, Emmanuel Barreau, St éphane Champiat, Olivier Lambotte, Clovis Adam, Marc Labetoulle, Antoine Rousseau Tags: Review article Source Type: research
Anterior chamber inflammation grading methods: A critical review
Assessing anterior chamber (AC) inflammation is highly subjective and challenging. Although various grading systems attempt to offer objectivity and standardization, the clinical assessment has high interobserver variability. Traditional techniques, such as laser flare meter and fluorophotometry, are not widely used since they are time-consuming. With the development of optical coherence tomography with high sensitivity, direct imaging offers an excellent alternative to objectively assess inflammation with the potential for automated analysis. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - October 5, 2023 Category: Opthalmology Authors: Hnin Hnin Oo, Madhuvanthi Mohan, Wenjun Song, William Rojas-Carabali, Edmund Tsui, Alejandra de-la-Torre, Carlos Cifuentes-Gonz ález, Andres Rousselot, Sangly P. Srinivas, Tariq Aslam, Vishali Gupta, Rupesh Agrawal Source Type: research
Early diabetic eye damage: Comparing detection methods using diagnostic power
It is now clear that retinal neuropathy precedes classical microvascular retinopathy in diabetes. Therefore, tests that underpin useful new endpoints must provide high diagnostic power well before the onset of moderate diabetic retinopathy (DR). Hence, we compare detection methods of early diabetic eye damage. We reviewed data from a range of functional and structural studies of early diabetic eye disease and computed Standardised Effect Size as a measure of diagnostic power, allowing the studies to be compared quantitatively. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - October 3, 2023 Category: Opthalmology Authors: Bhim B Rai, Joshua P van Kleef, Faran Sabeti, Robin Vlieger, Hanna Suominen, Ted Maddess Tags: Review article Source Type: research
Retinal organoids in disease modeling and drug discovery: Opportunities and challenges
Diseases leading to retinal cell loss can cause severe visual impairment and blindness. The lack of effective therapies to address retinal cell loss and the absence of intrinsic regeneration in the human retina leads to an irreversible pathological condition. Progress in recent years in the generation of human three-dimensional retinal organoids from pluripotent stem cells makes it possible to recreate the cytoarchitecture and associated cell-cell interactions of the human retina in remarkable detail. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - September 29, 2023 Category: Opthalmology Authors: Koushik Chakrabarty, Divyani Nayak, Jayasree Debnath, Debashish Das, Rohit Shetty, Arkasubhra Ghosh Tags: Review article Source Type: research
Retinal organoids in disease modelling and drug discovery: Opportunities and challenges
Diseases leading to retinal cell loss can cause severe visual impairment and blindness. The lack of effective therapies to address retinal cell loss and the absence of intrinsic regeneration in the human retina leads to an irreversible pathological condition. Progress in recent years in the generation of human three-dimensional (3D) retinal organoids (RO) from pluripotent stem cells makes it possible to recreate the cytoarchitecture and associated cell-cell interactions of the human retina in remarkable detail. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - September 29, 2023 Category: Opthalmology Authors: Koushik Chakrabarty, Divyani Nayak, Jayasree Debnath, Debashish Das, Rohit Shetty, Arkasubhra Ghosh Source Type: research
Adaptive optics imaging in inherited retinal diseases: A scoping review of the clinical literature
Adaptive optics (AO) imaging enables direct, objective assessments of retinal cells. Applications of AO show great promise in advancing our understanding of the etiology of inherited retinal disease (IRDs) and discovering new imaging biomarkers. This scoping review systematically identified and summarized clinical studies evaluating AO imaging in IRDs. Ovid MEDLINE and EMBASE were searched on 6 February 2023. Studies describing AO imaging in monogenic IRDs were included. Study screening and data extraction were performed by 2 reviewers independently. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - September 28, 2023 Category: Opthalmology Authors: Alexis Ceecee Britten-Jones, Lawrence Thai, Jeremy P.M. Flanagan, Phillip A. Bedggood, Thomas L. Edwards, Andrew B. Metha, Lauren N. Ayton Source Type: research
Ocular toxicities of fibroblast growth factor receptor Inhibitors: A review
Fibroblast growth factor receptor (FGFR) inhibitors are an emerging class of small molecule targeted cancer drugs with promising therapeutic possibilities for a wide variety of malignancies. While ocular adverse events from FGFR inhibitors are reported in clinical trials, subsequent case studies continue to reveal new toxicities. Disease pathology affecting multiple parts of the eye have been reported, but the ocular surface and the retina are the most commonly encountered areas affected by FGFR inhibitors, manifesting as dry eye and FGFR inhibitor-associated retinopathy, respectively. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - September 27, 2023 Category: Opthalmology Authors: Jerry Hsu, Jasmine H Francis, Sumayya Ahmad Source Type: research
