The paradox of aging: Aging-related shifts in T cell function and metabolism
Semin Immunol. 2023 Aug 31;70:101834. doi: 10.1016/j.smim.2023.101834. Online ahead of print.ABSTRACTT cell survival, differentiation after stimulation, and function are intrinsically linked to distinct cellular metabolic states. The ability of T cells to readily transition between metabolic states enables flexibility to meet the changing energy demands defined by distinct effector states or T cell lineages. Immune aging is characterized, in part, by the loss of naïve T cells, accumulation of senescent T cells, severe dysfunction in memory phenotype T cells in particular, and elevated levels of inflammatory cytokines, or ...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Kylie M Quinn Daniela M Vicencio Nicole L La Gruta Source Type: research
Thymus aging and immune reconstitution, progresses and challenges
Semin Immunol. 2023 Aug 31;70:101837. doi: 10.1016/j.smim.2023.101837. Online ahead of print.ABSTRACTThymus is a primary lymphoid organ essential for the development of T lymphocytes. Age-related thymic involution is a prominent feature of immune senescence. The thymus undergoes rapid growth during fetal and neonatal development, peaks in size before puberty and then begins to undergo a decrease in cellularity with age. Dramatic changes occur with age-associated thymic involution. The most prominent features of thymic involution include: (i) epithelial structure disruption, (ii) adipogenesis, and (iii) thymocyte developmen...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Yue Ru Li Juan Carlos Z úñiga-Pflücker Source Type: research
The paradox of aging: Aging-related shifts in T cell function and metabolism
Semin Immunol. 2023 Aug 31;70:101834. doi: 10.1016/j.smim.2023.101834. Online ahead of print.ABSTRACTT cell survival, differentiation after stimulation, and function are intrinsically linked to distinct cellular metabolic states. The ability of T cells to readily transition between metabolic states enables flexibility to meet the changing energy demands defined by distinct effector states or T cell lineages. Immune aging is characterized, in part, by the loss of naïve T cells, accumulation of senescent T cells, severe dysfunction in memory phenotype T cells in particular, and elevated levels of inflammatory cytokines, or ...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Kylie M Quinn Daniela M Vicencio Nicole L La Gruta Source Type: research
Thymus aging and immune reconstitution, progresses and challenges
Semin Immunol. 2023 Aug 31;70:101837. doi: 10.1016/j.smim.2023.101837. Online ahead of print.ABSTRACTThymus is a primary lymphoid organ essential for the development of T lymphocytes. Age-related thymic involution is a prominent feature of immune senescence. The thymus undergoes rapid growth during fetal and neonatal development, peaks in size before puberty and then begins to undergo a decrease in cellularity with age. Dramatic changes occur with age-associated thymic involution. The most prominent features of thymic involution include: (i) epithelial structure disruption, (ii) adipogenesis, and (iii) thymocyte developmen...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Yue Ru Li Juan Carlos Z úñiga-Pflücker Source Type: research
The paradox of aging: Aging-related shifts in T cell function and metabolism
Semin Immunol. 2023 Aug 31;70:101834. doi: 10.1016/j.smim.2023.101834. Online ahead of print.ABSTRACTT cell survival, differentiation after stimulation, and function are intrinsically linked to distinct cellular metabolic states. The ability of T cells to readily transition between metabolic states enables flexibility to meet the changing energy demands defined by distinct effector states or T cell lineages. Immune aging is characterized, in part, by the loss of naïve T cells, accumulation of senescent T cells, severe dysfunction in memory phenotype T cells in particular, and elevated levels of inflammatory cytokines, or ...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Kylie M Quinn Daniela M Vicencio Nicole L La Gruta Source Type: research
Thymus aging and immune reconstitution, progresses and challenges
Semin Immunol. 2023 Aug 31;70:101837. doi: 10.1016/j.smim.2023.101837. Online ahead of print.ABSTRACTThymus is a primary lymphoid organ essential for the development of T lymphocytes. Age-related thymic involution is a prominent feature of immune senescence. The thymus undergoes rapid growth during fetal and neonatal development, peaks in size before puberty and then begins to undergo a decrease in cellularity with age. Dramatic changes occur with age-associated thymic involution. The most prominent features of thymic involution include: (i) epithelial structure disruption, (ii) adipogenesis, and (iii) thymocyte developmen...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Yue Ru Li Juan Carlos Z úñiga-Pflücker Source Type: research
Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging
Semin Immunol. 2023 Aug 29;70:101835. doi: 10.1016/j.smim.2023.101835. Online ahead of print.ABSTRACTAging is characterized by progressive loss of organ and tissue function, and the immune system is no exception to that inevitable principle. Of all the age-related changes in the body, reduction of the size of, and naïve T (Tn) cell output from, the thymus occurs earliest, being prominent already before or by the time of puberty. Therefore, to preserve immunity against new infections, over much of their lives, vertebrates dominantly rely on peripheral maintenance of the Tn cell pool in the secondary lymphoid organs (SLO). ...
Source: Seminars in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Sandip Ashok Sonar Makiko Watanabe Janko Ž Nikolich Source Type: research
T cell control of SARS-CoV-2: When, which, and where?
Semin Immunol. 2023 Aug 29;70:101828. doi: 10.1016/j.smim.2023.101828. Online ahead of print.ABSTRACTEfficient immune protection against viruses such as SARS-CoV-2 requires the coordinated activity of innate immunity, B and T cells. Accumulating data point to a critical role for T cells not only in the clearance of established infection, but also for aborting viral replication independently of humoral immunity. Here we review the evidence supporting the contribution of antiviral T cells and consider which of their qualitative features favour efficient control of infection. We highlight how studies of SARS-CoV-2 and other c...
Source: Seminars in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Mariana O Diniz Mala K Maini Leo Swadling Source Type: research
Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging
Semin Immunol. 2023 Aug 29;70:101835. doi: 10.1016/j.smim.2023.101835. Online ahead of print.ABSTRACTAging is characterized by progressive loss of organ and tissue function, and the immune system is no exception to that inevitable principle. Of all the age-related changes in the body, reduction of the size of, and naïve T (Tn) cell output from, the thymus occurs earliest, being prominent already before or by the time of puberty. Therefore, to preserve immunity against new infections, over much of their lives, vertebrates dominantly rely on peripheral maintenance of the Tn cell pool in the secondary lymphoid organs (SLO). ...
Source: Seminars in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Sandip Ashok Sonar Makiko Watanabe Janko Ž Nikolich Source Type: research
T cell control of SARS-CoV-2: When, which, and where?
Semin Immunol. 2023 Aug 29;70:101828. doi: 10.1016/j.smim.2023.101828. Online ahead of print.ABSTRACTEfficient immune protection against viruses such as SARS-CoV-2 requires the coordinated activity of innate immunity, B and T cells. Accumulating data point to a critical role for T cells not only in the clearance of established infection, but also for aborting viral replication independently of humoral immunity. Here we review the evidence supporting the contribution of antiviral T cells and consider which of their qualitative features favour efficient control of infection. We highlight how studies of SARS-CoV-2 and other c...
Source: Seminars in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Mariana O Diniz Mala K Maini Leo Swadling Source Type: research
Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging
Semin Immunol. 2023 Aug 29;70:101835. doi: 10.1016/j.smim.2023.101835. Online ahead of print.ABSTRACTAging is characterized by progressive loss of organ and tissue function, and the immune system is no exception to that inevitable principle. Of all the age-related changes in the body, reduction of the size of, and naïve T (Tn) cell output from, the thymus occurs earliest, being prominent already before or by the time of puberty. Therefore, to preserve immunity against new infections, over much of their lives, vertebrates dominantly rely on peripheral maintenance of the Tn cell pool in the secondary lymphoid organs (SLO). ...
Source: Seminars in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Sandip Ashok Sonar Makiko Watanabe Janko Ž Nikolich Source Type: research
T cell control of SARS-CoV-2: When, which, and where?
Semin Immunol. 2023 Aug 29;70:101828. doi: 10.1016/j.smim.2023.101828. Online ahead of print.ABSTRACTEfficient immune protection against viruses such as SARS-CoV-2 requires the coordinated activity of innate immunity, B and T cells. Accumulating data point to a critical role for T cells not only in the clearance of established infection, but also for aborting viral replication independently of humoral immunity. Here we review the evidence supporting the contribution of antiviral T cells and consider which of their qualitative features favour efficient control of infection. We highlight how studies of SARS-CoV-2 and other c...
Source: Seminars in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Mariana O Diniz Mala K Maini Leo Swadling Source Type: research
Gasdermins and cancers
Semin Immunol. 2023 Aug 28;70:101833. doi: 10.1016/j.smim.2023.101833. Online ahead of print.ABSTRACTThe identification of gasdermin as the executor of pyroptosis has opened new avenues for the study of this process. Although pyroptosis research has mainly focused on immune cells since it was discovered three decades ago, accumulating evidence suggests that pyroptosis plays crucial roles in many biological processes. One example is the discovery of gasdermin-mediated cancer cell pyroptosis (CCP) which has become an important and frontier field in oncology. Recent studies have shown that CCP induction can heat tumor microen...
Source: Seminars in Immunology - August 30, 2023 Category: Allergy & Immunology Authors: Junwei Hou Tiansheng Li Jung-Mao Hsu Xin Zhang Mien-Chie Hung Source Type: research
Gasdermins and cancers
Semin Immunol. 2023 Aug 28;70:101833. doi: 10.1016/j.smim.2023.101833. Online ahead of print.ABSTRACTThe identification of gasdermin as the executor of pyroptosis has opened new avenues for the study of this process. Although pyroptosis research has mainly focused on immune cells since it was discovered three decades ago, accumulating evidence suggests that pyroptosis plays crucial roles in many biological processes. One example is the discovery of gasdermin-mediated cancer cell pyroptosis (CCP) which has become an important and frontier field in oncology. Recent studies have shown that CCP induction can heat tumor microen...
Source: Seminars in Immunology - August 30, 2023 Category: Allergy & Immunology Authors: Junwei Hou Tiansheng Li Jung-Mao Hsu Xin Zhang Mien-Chie Hung Source Type: research
Enteric neuro-immune interactions in intestinal health and disease
Semin Immunol. 2023 Aug 24;70:101819. doi: 10.1016/j.smim.2023.101819. Online ahead of print.ABSTRACTThe enteric nervous system is an autonomous neuronal circuit that regulates many processes far beyond the peristalsis in the gastro-intestinal tract. This circuit, consisting of enteric neurons and enteric glial cells, can engage in many intercellular interactions shaping the homeostatic microenvironment in the gut. Perhaps the most well documented interactions taking place, are the intestinal neuro-immune interactions which are essential for the fine-tuning of oral tolerance. In the context of intestinal disease, compellin...
Source: Seminars in Immunology - August 26, 2023 Category: Allergy & Immunology Authors: Lies van Baarle Michelle Stakenborg Gianluca Matteoli Source Type: research
