Regulatory T cells in allergic inflammation
Semin Immunol. 2023 Oct 12;70:101847. doi: 10.1016/j.smim.2023.101847. Online ahead of print.ABSTRACTRegulatory T (Treg) cells maintain immune tolerance to allergens at the environmental interfaces in the airways, skin and gut, marshalling in the process distinct immune regulatory circuits operative in the respective tissues. Treg cells are coordinately mobilized with allergic effector mechanisms in the context of a tissue-protective allergic inflammatory response against parasites, toxins and potentially harmful allergens, serving to both limit the inflammation and promote local tissue repair. Allergic diseases are associ...
Source: Seminars in Immunology - October 14, 2023 Category: Allergy & Immunology Authors: Mehdi Benamar Qian Chen Monica Martinez-Blanco Talal A Chatila Source Type: research
Regulatory T cells in allergic inflammation
Semin Immunol. 2023 Oct 12;70:101847. doi: 10.1016/j.smim.2023.101847. Online ahead of print.ABSTRACTRegulatory T (Treg) cells maintain immune tolerance to allergens at the environmental interfaces in the airways, skin and gut, marshalling in the process distinct immune regulatory circuits operative in the respective tissues. Treg cells are coordinately mobilized with allergic effector mechanisms in the context of a tissue-protective allergic inflammatory response against parasites, toxins and potentially harmful allergens, serving to both limit the inflammation and promote local tissue repair. Allergic diseases are associ...
Source: Seminars in Immunology - October 14, 2023 Category: Allergy & Immunology Authors: Mehdi Benamar Qian Chen Monica Martinez-Blanco Talal A Chatila Source Type: research
Regulatory T cells in allergic inflammation
Semin Immunol. 2023 Oct 12;70:101847. doi: 10.1016/j.smim.2023.101847. Online ahead of print.ABSTRACTRegulatory T (Treg) cells maintain immune tolerance to allergens at the environmental interfaces in the airways, skin and gut, marshalling in the process distinct immune regulatory circuits operative in the respective tissues. Treg cells are coordinately mobilized with allergic effector mechanisms in the context of a tissue-protective allergic inflammatory response against parasites, toxins and potentially harmful allergens, serving to both limit the inflammation and promote local tissue repair. Allergic diseases are associ...
Source: Seminars in Immunology - October 14, 2023 Category: Allergy & Immunology Authors: Mehdi Benamar Qian Chen Monica Martinez-Blanco Talal A Chatila Source Type: research
Regulatory T cells in allergic inflammation
Semin Immunol. 2023 Oct 12;70:101847. doi: 10.1016/j.smim.2023.101847. Online ahead of print.ABSTRACTRegulatory T (Treg) cells maintain immune tolerance to allergens at the environmental interfaces in the airways, skin and gut, marshalling in the process distinct immune regulatory circuits operative in the respective tissues. Treg cells are coordinately mobilized with allergic effector mechanisms in the context of a tissue-protective allergic inflammatory response against parasites, toxins and potentially harmful allergens, serving to both limit the inflammation and promote local tissue repair. Allergic diseases are associ...
Source: Seminars in Immunology - October 14, 2023 Category: Allergy & Immunology Authors: Mehdi Benamar Qian Chen Monica Martinez-Blanco Talal A Chatila Source Type: research
Chemical modulation of gasdermin D activity: Therapeutic implications and consequences
Semin Immunol. 2023 Oct 6;70:101845. doi: 10.1016/j.smim.2023.101845. Online ahead of print.ABSTRACTThe gasdermin family of proteins are central effectors of the inflammatory, lytic cell death modality known as pyroptosis. Characterized in 2015, the most well-studied member gasdermin D can be proteolyzed, typically by caspases, to generate an active pore-forming N-terminal domain. At least well-studied three pharmacological inhibitors (necrosulfonamide, disulfiram, dimethyl fumarate) since 2018 have been shown to affect gasdermin D activity either through modulation of processing or interference with pore formation. A mult...
Source: Seminars in Immunology - October 8, 2023 Category: Allergy & Immunology Authors: Bowen Zhou Derek W Abbott Source Type: research
Chemical modulation of gasdermin D activity: Therapeutic implications and consequences
Semin Immunol. 2023 Oct 6;70:101845. doi: 10.1016/j.smim.2023.101845. Online ahead of print.ABSTRACTThe gasdermin family of proteins are central effectors of the inflammatory, lytic cell death modality known as pyroptosis. Characterized in 2015, the most well-studied member gasdermin D can be proteolyzed, typically by caspases, to generate an active pore-forming N-terminal domain. At least well-studied three pharmacological inhibitors (necrosulfonamide, disulfiram, dimethyl fumarate) since 2018 have been shown to affect gasdermin D activity either through modulation of processing or interference with pore formation. A mult...
Source: Seminars in Immunology - October 8, 2023 Category: Allergy & Immunology Authors: Bowen Zhou Derek W Abbott Source Type: research
Chemical modulation of gasdermin D activity: Therapeutic implications and consequences
Semin Immunol. 2023 Oct 6;70:101845. doi: 10.1016/j.smim.2023.101845. Online ahead of print.ABSTRACTThe gasdermin family of proteins are central effectors of the inflammatory, lytic cell death modality known as pyroptosis. Characterized in 2015, the most well-studied member gasdermin D can be proteolyzed, typically by caspases, to generate an active pore-forming N-terminal domain. At least well-studied three pharmacological inhibitors (necrosulfonamide, disulfiram, dimethyl fumarate) since 2018 have been shown to affect gasdermin D activity either through modulation of processing or interference with pore formation. A mult...
Source: Seminars in Immunology - October 8, 2023 Category: Allergy & Immunology Authors: Bowen Zhou Derek W Abbott Source Type: research
Chemical modulation of gasdermin D activity: Therapeutic implications and consequences
Semin Immunol. 2023 Oct 6;70:101845. doi: 10.1016/j.smim.2023.101845. Online ahead of print.ABSTRACTThe gasdermin family of proteins are central effectors of the inflammatory, lytic cell death modality known as pyroptosis. Characterized in 2015, the most well-studied member gasdermin D can be proteolyzed, typically by caspases, to generate an active pore-forming N-terminal domain. At least well-studied three pharmacological inhibitors (necrosulfonamide, disulfiram, dimethyl fumarate) since 2018 have been shown to affect gasdermin D activity either through modulation of processing or interference with pore formation. A mult...
Source: Seminars in Immunology - October 8, 2023 Category: Allergy & Immunology Authors: Bowen Zhou Derek W Abbott Source Type: research
Chemical modulation of gasdermin D activity: Therapeutic implications and consequences
Semin Immunol. 2023 Oct 6;70:101845. doi: 10.1016/j.smim.2023.101845. Online ahead of print.ABSTRACTThe gasdermin family of proteins are central effectors of the inflammatory, lytic cell death modality known as pyroptosis. Characterized in 2015, the most well-studied member gasdermin D can be proteolyzed, typically by caspases, to generate an active pore-forming N-terminal domain. At least well-studied three pharmacological inhibitors (necrosulfonamide, disulfiram, dimethyl fumarate) since 2018 have been shown to affect gasdermin D activity either through modulation of processing or interference with pore formation. A mult...
Source: Seminars in Immunology - October 8, 2023 Category: Allergy & Immunology Authors: Bowen Zhou Derek W Abbott Source Type: research
The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions
The objective of this review is to highlight and evaluate recent studies on epithelial physiology and its role in the pathogenesis of chronic diseases in light of the epithelial barrier theory.PMID:37801907 | DOI:10.1016/j.smim.2023.101846 (Source: Seminars in Immunology)
Source: Seminars in Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Duygu Yazici Ismail Ogulur Yagiz Pat Huseyn Babayev Elena Barletta Sena Ardicli Manal Bel Imam Mengting Huang Jana Koch Manru Li Debbie Maurer Urszula Radzikowska Pattraporn Satitsuksanoa Stephan R Schneider Na Sun Stephan Traidl Alexandra Wallimann Sebas Source Type: research
The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions
The objective of this review is to highlight and evaluate recent studies on epithelial physiology and its role in the pathogenesis of chronic diseases in light of the epithelial barrier theory.PMID:37801907 | DOI:10.1016/j.smim.2023.101846 (Source: Seminars in Immunology)
Source: Seminars in Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Duygu Yazici Ismail Ogulur Yagiz Pat Huseyn Babayev Elena Barletta Sena Ardicli Manal Bel Imam Mengting Huang Jana Koch Manru Li Debbie Maurer Urszula Radzikowska Pattraporn Satitsuksanoa Stephan R Schneider Na Sun Stephan Traidl Alexandra Wallimann Sebas Source Type: research
The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions
The objective of this review is to highlight and evaluate recent studies on epithelial physiology and its role in the pathogenesis of chronic diseases in light of the epithelial barrier theory.PMID:37801907 | DOI:10.1016/j.smim.2023.101846 (Source: Seminars in Immunology)
Source: Seminars in Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Duygu Yazici Ismail Ogulur Yagiz Pat Huseyn Babayev Elena Barletta Sena Ardicli Manal Bel Imam Mengting Huang Jana Koch Manru Li Debbie Maurer Urszula Radzikowska Pattraporn Satitsuksanoa Stephan R Schneider Na Sun Stephan Traidl Alexandra Wallimann Sebas Source Type: research
The noncanonical inflammasome-induced pyroptosis and septic shock
Semin Immunol. 2023 Sep 29;70:101844. doi: 10.1016/j.smim.2023.101844. Online ahead of print.ABSTRACTSepsis remains one of the most common and lethal conditions globally. Currently, no proposed target specific to sepsis improves survival in clinical trials. Thus, an in-depth understanding of the pathogenesis of sepsis is needed to propel the discovery of effective treatment. Recently attention to sepsis has intensified because of a growing recognition of a non-canonical inflammasome-triggered lytic mode of cell death termed pyroptosis upon sensing cytosolic lipopolysaccharide (LPS). Although the consequences of activation ...
Source: Seminars in Immunology - October 1, 2023 Category: Allergy & Immunology Authors: Junru Wu Jingjing Cai Yiting Tang Ben Lu Source Type: research
The noncanonical inflammasome-induced pyroptosis and septic shock
Semin Immunol. 2023 Sep 29;70:101844. doi: 10.1016/j.smim.2023.101844. Online ahead of print.ABSTRACTSepsis remains one of the most common and lethal conditions globally. Currently, no proposed target specific to sepsis improves survival in clinical trials. Thus, an in-depth understanding of the pathogenesis of sepsis is needed to propel the discovery of effective treatment. Recently attention to sepsis has intensified because of a growing recognition of a non-canonical inflammasome-triggered lytic mode of cell death termed pyroptosis upon sensing cytosolic lipopolysaccharide (LPS). Although the consequences of activation ...
Source: Seminars in Immunology - October 1, 2023 Category: Allergy & Immunology Authors: Junru Wu Jingjing Cai Yiting Tang Ben Lu Source Type: research
The noncanonical inflammasome-induced pyroptosis and septic shock
Semin Immunol. 2023 Sep 29;70:101844. doi: 10.1016/j.smim.2023.101844. Online ahead of print.ABSTRACTSepsis remains one of the most common and lethal conditions globally. Currently, no proposed target specific to sepsis improves survival in clinical trials. Thus, an in-depth understanding of the pathogenesis of sepsis is needed to propel the discovery of effective treatment. Recently attention to sepsis has intensified because of a growing recognition of a non-canonical inflammasome-triggered lytic mode of cell death termed pyroptosis upon sensing cytosolic lipopolysaccharide (LPS). Although the consequences of activation ...
Source: Seminars in Immunology - October 1, 2023 Category: Allergy & Immunology Authors: Junru Wu Jingjing Cai Yiting Tang Ben Lu Source Type: research
