The gut-brain vascular axis in neuroinflammation
Semin Immunol. 2023 Jul 7;69:101802. doi: 10.1016/j.smim.2023.101802. Online ahead of print.ABSTRACTThe multifaceted microbiota characterizing our gut plays a crucial role in maintaining immune, metabolic and tissue homeostasis of the intestine as well as of distal organs, including the central nervous system. Microbial dysbiosis is reported in several inflammatory intestinal diseases characterized by the impairment of the gut epithelial and vascular barriers, defined as leaky gut, and it is reported as a potential danger condition associated with the development of metabolic, inflammatory and neurodegenerative diseases. R...
Source: Seminars in Immunology - July 9, 2023 Category: Allergy & Immunology Authors: Sara Carloni Maria Rescigno Source Type: research
Siglecs as potential targets of therapy in human mast cell- and/or eosinophil-associated diseases
Semin Immunol. 2023 Jul 4;69:101799. doi: 10.1016/j.smim.2023.101799. Online ahead of print.ABSTRACTSiglecs (sialic acid-binding immunoglobulin-like lectins) are a family of vertebrate glycan-binding cell-surface proteins. The majority mediate cellular inhibitory activity once engaged by specific ligands or ligand-mimicking molecules. As a result, Siglec engagement is now of interest as a strategy to therapeutically dampen unwanted cellular responses. When considering allergic inflammation, human eosinophils and mast cells express overlapping but distinct patterns of Siglecs. For example, Siglec-6 is selectively and promin...
Source: Seminars in Immunology - July 6, 2023 Category: Allergy & Immunology Authors: Jeremy A O'Sullivan Bradford A Youngblood Robert P Schleimer Bruce S Bochner Source Type: research
Siglecs as potential targets of therapy in human mast cell- and/or eosinophil-associated diseases
Semin Immunol. 2023 Jul 4;69:101799. doi: 10.1016/j.smim.2023.101799. Online ahead of print.ABSTRACTSiglecs (sialic acid-binding immunoglobulin-like lectins) are a family of vertebrate glycan-binding cell-surface proteins. The majority mediate cellular inhibitory activity once engaged by specific ligands or ligand-mimicking molecules. As a result, Siglec engagement is now of interest as a strategy to therapeutically dampen unwanted cellular responses. When considering allergic inflammation, human eosinophils and mast cells express overlapping but distinct patterns of Siglecs. For example, Siglec-6 is selectively and promin...
Source: Seminars in Immunology - July 6, 2023 Category: Allergy & Immunology Authors: Jeremy A O'Sullivan Bradford A Youngblood Robert P Schleimer Bruce S Bochner Source Type: research
Siglecs as potential targets of therapy in human mast cell- and/or eosinophil-associated diseases
Semin Immunol. 2023 Jul 4;69:101799. doi: 10.1016/j.smim.2023.101799. Online ahead of print.ABSTRACTSiglecs (sialic acid-binding immunoglobulin-like lectins) are a family of vertebrate glycan-binding cell-surface proteins. The majority mediate cellular inhibitory activity once engaged by specific ligands or ligand-mimicking molecules. As a result, Siglec engagement is now of interest as a strategy to therapeutically dampen unwanted cellular responses. When considering allergic inflammation, human eosinophils and mast cells express overlapping but distinct patterns of Siglecs. For example, Siglec-6 is selectively and promin...
Source: Seminars in Immunology - July 6, 2023 Category: Allergy & Immunology Authors: Jeremy A O'Sullivan Bradford A Youngblood Robert P Schleimer Bruce S Bochner Source Type: research
Pyroptosis modulation by bacterial effector proteins
Semin Immunol. 2023 Jul 3;69:101804. doi: 10.1016/j.smim.2023.101804. Online ahead of print.ABSTRACTPyroptosis is a proinflammatory form of programmed cell death featured with membrane pore formation that causes cellular swelling and allows the release of intracellular inflammatory mediators. This cell death process is elicited by the activation of the pore-forming proteins named gasdermins, and is intricately orchestrated by diverse regulatory factors in mammalian hosts to exert a prompt immune response against infections. However, growing evidence suggests that bacterial pathogens have evolved to regulate host pyroptosis...
Source: Seminars in Immunology - July 5, 2023 Category: Allergy & Immunology Authors: Qiyao Chai Zehui Lei Cui Hua Liu Source Type: research
Pyroptosis modulation by bacterial effector proteins
Semin Immunol. 2023 Jul 3;69:101804. doi: 10.1016/j.smim.2023.101804. Online ahead of print.ABSTRACTPyroptosis is a proinflammatory form of programmed cell death featured with membrane pore formation that causes cellular swelling and allows the release of intracellular inflammatory mediators. This cell death process is elicited by the activation of the pore-forming proteins named gasdermins, and is intricately orchestrated by diverse regulatory factors in mammalian hosts to exert a prompt immune response against infections. However, growing evidence suggests that bacterial pathogens have evolved to regulate host pyroptosis...
Source: Seminars in Immunology - July 5, 2023 Category: Allergy & Immunology Authors: Qiyao Chai Zehui Lei Cui Hua Liu Source Type: research
Age-dependent changes in T follicular helper cells shape the humoral immune response to vaccination
Semin Immunol. 2023 Jun 26;69:101801. doi: 10.1016/j.smim.2023.101801. Online ahead of print.ABSTRACTVaccination is an excellent strategy to limit the morbidity and mortality associated with infectious disease. Vaccination creates protective, long-lived antibody-mediated immunity by inducing the germinal centre response, an intricate immune reaction that produces memory B cells and long-lived antibody-secreting plasma cells that provide protection against (re)infection. The magnitude and quality of the germinal centre response declines with age, contributing to poor vaccine-induced immunity in older individuals. T follicul...
Source: Seminars in Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Michelle A Linterman Source Type: research
Contributions of the early-life microbiome to childhood atopy and asthma development
Semin Immunol. 2023 Jun 26;69:101795. doi: 10.1016/j.smim.2023.101795. Online ahead of print.ABSTRACTThe rapid rise in atopy and asthma in industrialized nations has led to the identification of early life environmental factors that promote these conditions and spurred research into how such exposures may mediate the trajectory to childhood disease development. Over the past decade, the human microbiome has emerged as a key determinant of human health. This is largely due to the increasing appreciation for the myriad of non-mutually exclusive mechanisms by which microbes tune and train host immunity. Microbiomes, particula...
Source: Seminars in Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Holly Steininger Jacqueline Moltzau-Anderson Susan V Lynch Source Type: research
Age-dependent changes in T follicular helper cells shape the humoral immune response to vaccination
Semin Immunol. 2023 Jun 26;69:101801. doi: 10.1016/j.smim.2023.101801. Online ahead of print.ABSTRACTVaccination is an excellent strategy to limit the morbidity and mortality associated with infectious disease. Vaccination creates protective, long-lived antibody-mediated immunity by inducing the germinal centre response, an intricate immune reaction that produces memory B cells and long-lived antibody-secreting plasma cells that provide protection against (re)infection. The magnitude and quality of the germinal centre response declines with age, contributing to poor vaccine-induced immunity in older individuals. T follicul...
Source: Seminars in Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Michelle A Linterman Source Type: research
Contributions of the early-life microbiome to childhood atopy and asthma development
Semin Immunol. 2023 Jun 26;69:101795. doi: 10.1016/j.smim.2023.101795. Online ahead of print.ABSTRACTThe rapid rise in atopy and asthma in industrialized nations has led to the identification of early life environmental factors that promote these conditions and spurred research into how such exposures may mediate the trajectory to childhood disease development. Over the past decade, the human microbiome has emerged as a key determinant of human health. This is largely due to the increasing appreciation for the myriad of non-mutually exclusive mechanisms by which microbes tune and train host immunity. Microbiomes, particula...
Source: Seminars in Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Holly Steininger Jacqueline Moltzau-Anderson Susan V Lynch Source Type: research
Age-dependent changes in T follicular helper cells shape the humoral immune response to vaccination
Semin Immunol. 2023 Jun 26;69:101801. doi: 10.1016/j.smim.2023.101801. Online ahead of print.ABSTRACTVaccination is an excellent strategy to limit the morbidity and mortality associated with infectious disease. Vaccination creates protective, long-lived antibody-mediated immunity by inducing the germinal centre response, an intricate immune reaction that produces memory B cells and long-lived antibody-secreting plasma cells that provide protection against (re)infection. The magnitude and quality of the germinal centre response declines with age, contributing to poor vaccine-induced immunity in older individuals. T follicul...
Source: Seminars in Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Michelle A Linterman Source Type: research
Contributions of the early-life microbiome to childhood atopy and asthma development
Semin Immunol. 2023 Jun 26;69:101795. doi: 10.1016/j.smim.2023.101795. Online ahead of print.ABSTRACTThe rapid rise in atopy and asthma in industrialized nations has led to the identification of early life environmental factors that promote these conditions and spurred research into how such exposures may mediate the trajectory to childhood disease development. Over the past decade, the human microbiome has emerged as a key determinant of human health. This is largely due to the increasing appreciation for the myriad of non-mutually exclusive mechanisms by which microbes tune and train host immunity. Microbiomes, particula...
Source: Seminars in Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Holly Steininger Jacqueline Moltzau-Anderson Susan V Lynch Source Type: research
Age-dependent changes in T follicular helper cells shape the humoral immune response to vaccination
Semin Immunol. 2023 Jun 26;69:101801. doi: 10.1016/j.smim.2023.101801. Online ahead of print.ABSTRACTVaccination is an excellent strategy to limit the morbidity and mortality associated with infectious disease. Vaccination creates protective, long-lived antibody-mediated immunity by inducing the germinal centre response, an intricate immune reaction that produces memory B cells and long-lived antibody-secreting plasma cells that provide protection against (re)infection. The magnitude and quality of the germinal centre response declines with age, contributing to poor vaccine-induced immunity in older individuals. T follicul...
Source: Seminars in Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Michelle A Linterman Source Type: research
Contributions of the early-life microbiome to childhood atopy and asthma development
Semin Immunol. 2023 Jun 26;69:101795. doi: 10.1016/j.smim.2023.101795. Online ahead of print.ABSTRACTThe rapid rise in atopy and asthma in industrialized nations has led to the identification of early life environmental factors that promote these conditions and spurred research into how such exposures may mediate the trajectory to childhood disease development. Over the past decade, the human microbiome has emerged as a key determinant of human health. This is largely due to the increasing appreciation for the myriad of non-mutually exclusive mechanisms by which microbes tune and train host immunity. Microbiomes, particula...
Source: Seminars in Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Holly Steininger Jacqueline Moltzau-Anderson Susan V Lynch Source Type: research
Age-dependent changes in T follicular helper cells shape the humoral immune response to vaccination
Semin Immunol. 2023 Jun 26;69:101801. doi: 10.1016/j.smim.2023.101801. Online ahead of print.ABSTRACTVaccination is an excellent strategy to limit the morbidity and mortality associated with infectious disease. Vaccination creates protective, long-lived antibody-mediated immunity by inducing the germinal centre response, an intricate immune reaction that produces memory B cells and long-lived antibody-secreting plasma cells that provide protection against (re)infection. The magnitude and quality of the germinal centre response declines with age, contributing to poor vaccine-induced immunity in older individuals. T follicul...
Source: Seminars in Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Michelle A Linterman Source Type: research
