Accumulation of immune-suppressive CD4 + T cells in aging - tempering inflammaging at the expense of immunity
Semin Immunol. 2023 Aug 24;70:101836. doi: 10.1016/j.smim.2023.101836. Online ahead of print.ABSTRACTThe 'immune risk profile' has been shown to predict mortality in the elderly, highlighting the need to better understand age-related immune dysfunction. While aging leads to many defects affecting all arms of the immune system, this review is focused on the accrual of immuno-suppressive CD4 + T cell populations, including FoxP3 + regulatory T cells, and subsets of IL-10-producing T follicular helper cells. New data suggest that such accumulations constitute feedback mechanisms to temper the ongoing progressive low-grade inf...
Source: Seminars in Immunology - August 26, 2023 Category: Allergy & Immunology Authors: Alyssa L Thomas Alzbeta Godarova Joseph A Wayman Emily R Miraldi David A Hildeman Claire A Chougnet Source Type: research
Enteric neuro-immune interactions in intestinal health and disease
Semin Immunol. 2023 Aug 24;70:101819. doi: 10.1016/j.smim.2023.101819. Online ahead of print.ABSTRACTThe enteric nervous system is an autonomous neuronal circuit that regulates many processes far beyond the peristalsis in the gastro-intestinal tract. This circuit, consisting of enteric neurons and enteric glial cells, can engage in many intercellular interactions shaping the homeostatic microenvironment in the gut. Perhaps the most well documented interactions taking place, are the intestinal neuro-immune interactions which are essential for the fine-tuning of oral tolerance. In the context of intestinal disease, compellin...
Source: Seminars in Immunology - August 26, 2023 Category: Allergy & Immunology Authors: Lies van Baarle Michelle Stakenborg Gianluca Matteoli Source Type: research
Accumulation of immune-suppressive CD4 + T cells in aging - tempering inflammaging at the expense of immunity
Semin Immunol. 2023 Aug 24;70:101836. doi: 10.1016/j.smim.2023.101836. Online ahead of print.ABSTRACTThe 'immune risk profile' has been shown to predict mortality in the elderly, highlighting the need to better understand age-related immune dysfunction. While aging leads to many defects affecting all arms of the immune system, this review is focused on the accrual of immuno-suppressive CD4 + T cell populations, including FoxP3 + regulatory T cells, and subsets of IL-10-producing T follicular helper cells. New data suggest that such accumulations constitute feedback mechanisms to temper the ongoing progressive low-grade inf...
Source: Seminars in Immunology - August 26, 2023 Category: Allergy & Immunology Authors: Alyssa L Thomas Alzbeta Godarova Joseph A Wayman Emily R Miraldi David A Hildeman Claire A Chougnet Source Type: research
Enteric neuro-immune interactions in intestinal health and disease
Semin Immunol. 2023 Aug 24;70:101819. doi: 10.1016/j.smim.2023.101819. Online ahead of print.ABSTRACTThe enteric nervous system is an autonomous neuronal circuit that regulates many processes far beyond the peristalsis in the gastro-intestinal tract. This circuit, consisting of enteric neurons and enteric glial cells, can engage in many intercellular interactions shaping the homeostatic microenvironment in the gut. Perhaps the most well documented interactions taking place, are the intestinal neuro-immune interactions which are essential for the fine-tuning of oral tolerance. In the context of intestinal disease, compellin...
Source: Seminars in Immunology - August 26, 2023 Category: Allergy & Immunology Authors: Lies van Baarle Michelle Stakenborg Gianluca Matteoli Source Type: research
Accumulation of immune-suppressive CD4 + T cells in aging - tempering inflammaging at the expense of immunity
Semin Immunol. 2023 Aug 24;70:101836. doi: 10.1016/j.smim.2023.101836. Online ahead of print.ABSTRACTThe 'immune risk profile' has been shown to predict mortality in the elderly, highlighting the need to better understand age-related immune dysfunction. While aging leads to many defects affecting all arms of the immune system, this review is focused on the accrual of immuno-suppressive CD4 + T cell populations, including FoxP3 + regulatory T cells, and subsets of IL-10-producing T follicular helper cells. New data suggest that such accumulations constitute feedback mechanisms to temper the ongoing progressive low-grade inf...
Source: Seminars in Immunology - August 26, 2023 Category: Allergy & Immunology Authors: Alyssa L Thomas Alzbeta Godarova Joseph A Wayman Emily R Miraldi David A Hildeman Claire A Chougnet Source Type: research
The role of caspase-8 in inflammatory signalling and pyroptotic cell death
Semin Immunol. 2023 Aug 23;70:101832. doi: 10.1016/j.smim.2023.101832. Online ahead of print.ABSTRACTThe programmed cell death machinery exhibits surprising flexibility, capable of crosstalk and non-apoptotic roles. Much of this complexity arises from the diverse functions of caspase-8, a cysteine-aspartic acid protease typically associated with activating caspase-3 and - 7 to induce apoptosis. However, recent research has revealed that caspase-8 also plays a role in regulating the lytic gasdermin cell death machinery, contributing to pyroptosis and immune responses in contexts such as infection, autoinflammation, and T-ce...
Source: Seminars in Immunology - August 25, 2023 Category: Allergy & Immunology Authors: Jiyi Pang James E Vince Source Type: research
The role of caspase-8 in inflammatory signalling and pyroptotic cell death
Semin Immunol. 2023 Aug 23;70:101832. doi: 10.1016/j.smim.2023.101832. Online ahead of print.ABSTRACTThe programmed cell death machinery exhibits surprising flexibility, capable of crosstalk and non-apoptotic roles. Much of this complexity arises from the diverse functions of caspase-8, a cysteine-aspartic acid protease typically associated with activating caspase-3 and - 7 to induce apoptosis. However, recent research has revealed that caspase-8 also plays a role in regulating the lytic gasdermin cell death machinery, contributing to pyroptosis and immune responses in contexts such as infection, autoinflammation, and T-ce...
Source: Seminars in Immunology - August 25, 2023 Category: Allergy & Immunology Authors: Jiyi Pang James E Vince Source Type: research
T cell control of inflammaging
Semin Immunol. 2023 Aug 21;70:101818. doi: 10.1016/j.smim.2023.101818. Online ahead of print.ABSTRACTT cells are a critical component of the immune system, found in abundance in blood, secondary lymphoid organs, and peripheral tissues. As individuals age, T cells are particularly susceptible to changes, making them one of the most affected immune subsets. These changes can have significant implications for age-related dysregulations, including the development of low-grade inflammation - a hallmark of aging known as inflammaging. In this review, we first present age-related changes in the functionality of the T cell compart...
Source: Seminars in Immunology - August 23, 2023 Category: Allergy & Immunology Authors: Irina Shchukina Pavla Bohacova Maxim N Artyomov Source Type: research
T cell control of inflammaging
Semin Immunol. 2023 Aug 21;70:101818. doi: 10.1016/j.smim.2023.101818. Online ahead of print.ABSTRACTT cells are a critical component of the immune system, found in abundance in blood, secondary lymphoid organs, and peripheral tissues. As individuals age, T cells are particularly susceptible to changes, making them one of the most affected immune subsets. These changes can have significant implications for age-related dysregulations, including the development of low-grade inflammation - a hallmark of aging known as inflammaging. In this review, we first present age-related changes in the functionality of the T cell compart...
Source: Seminars in Immunology - August 23, 2023 Category: Allergy & Immunology Authors: Irina Shchukina Pavla Bohacova Maxim N Artyomov Source Type: research
T cell control of inflammaging
Semin Immunol. 2023 Aug 21;70:101818. doi: 10.1016/j.smim.2023.101818. Online ahead of print.ABSTRACTT cells are a critical component of the immune system, found in abundance in blood, secondary lymphoid organs, and peripheral tissues. As individuals age, T cells are particularly susceptible to changes, making them one of the most affected immune subsets. These changes can have significant implications for age-related dysregulations, including the development of low-grade inflammation - a hallmark of aging known as inflammaging. In this review, we first present age-related changes in the functionality of the T cell compart...
Source: Seminars in Immunology - August 23, 2023 Category: Allergy & Immunology Authors: Irina Shchukina Pavla Bohacova Maxim N Artyomov Source Type: research
Aging of lymphoid stromal architecture impacts immune responses
Semin Immunol. 2023 Aug 10;70:101817. doi: 10.1016/j.smim.2023.101817. Online ahead of print.ABSTRACTThe secondary lymphoid organs (SLOs) undergo structural changes with age, which correlates with diminishing immune responses against infectious disease. A growing body of research suggests that the aged tissue microenvironment can contribute to decreased immune function, independent of intrinsic changes to hematopoietic cells with age. Stromal cells impart structural integrity, facilitate fluid transport, and provide chemokine and cytokine signals that are essential for immune homeostasis. Mechanisms that drive SLO developm...
Source: Seminars in Immunology - August 12, 2023 Category: Allergy & Immunology Authors: Jessica N Lancaster Source Type: research
Aging of lymphoid stromal architecture impacts immune responses
Semin Immunol. 2023 Aug 10;70:101817. doi: 10.1016/j.smim.2023.101817. Online ahead of print.ABSTRACTThe secondary lymphoid organs (SLOs) undergo structural changes with age, which correlates with diminishing immune responses against infectious disease. A growing body of research suggests that the aged tissue microenvironment can contribute to decreased immune function, independent of intrinsic changes to hematopoietic cells with age. Stromal cells impart structural integrity, facilitate fluid transport, and provide chemokine and cytokine signals that are essential for immune homeostasis. Mechanisms that drive SLO developm...
Source: Seminars in Immunology - August 12, 2023 Category: Allergy & Immunology Authors: Jessica N Lancaster Source Type: research
Aging of lymphoid stromal architecture impacts immune responses
Semin Immunol. 2023 Aug 10;70:101817. doi: 10.1016/j.smim.2023.101817. Online ahead of print.ABSTRACTThe secondary lymphoid organs (SLOs) undergo structural changes with age, which correlates with diminishing immune responses against infectious disease. A growing body of research suggests that the aged tissue microenvironment can contribute to decreased immune function, independent of intrinsic changes to hematopoietic cells with age. Stromal cells impart structural integrity, facilitate fluid transport, and provide chemokine and cytokine signals that are essential for immune homeostasis. Mechanisms that drive SLO developm...
Source: Seminars in Immunology - August 12, 2023 Category: Allergy & Immunology Authors: Jessica N Lancaster Source Type: research
Aging of lymphoid stromal architecture impacts immune responses
Semin Immunol. 2023 Aug 10;70:101817. doi: 10.1016/j.smim.2023.101817. Online ahead of print.ABSTRACTThe secondary lymphoid organs (SLOs) undergo structural changes with age, which correlates with diminishing immune responses against infectious disease. A growing body of research suggests that the aged tissue microenvironment can contribute to decreased immune function, independent of intrinsic changes to hematopoietic cells with age. Stromal cells impart structural integrity, facilitate fluid transport, and provide chemokine and cytokine signals that are essential for immune homeostasis. Mechanisms that drive SLO developm...
Source: Seminars in Immunology - August 12, 2023 Category: Allergy & Immunology Authors: Jessica N Lancaster Source Type: research
Aging of lymphoid stromal architecture impacts immune responses
Semin Immunol. 2023 Aug 10;70:101817. doi: 10.1016/j.smim.2023.101817. Online ahead of print.ABSTRACTThe secondary lymphoid organs (SLOs) undergo structural changes with age, which correlates with diminishing immune responses against infectious disease. A growing body of research suggests that the aged tissue microenvironment can contribute to decreased immune function, independent of intrinsic changes to hematopoietic cells with age. Stromal cells impart structural integrity, facilitate fluid transport, and provide chemokine and cytokine signals that are essential for immune homeostasis. Mechanisms that drive SLO developm...
Source: Seminars in Immunology - August 12, 2023 Category: Allergy & Immunology Authors: Jessica N Lancaster Source Type: research
