Toolkit for mapping the clonal landscape of tumor-infiltrating B cells
Semin Immunol. 2024 Jan 31;72:101864. doi: 10.1016/j.smim.2024.101864. Online ahead of print.ABSTRACTOur current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor - in distinct cancers, subcohorts and individual patients - is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute to the antitumor response, while others steer the immune response away from the desired mechanics. To step up to a new level of understanding and managing B cell behaviors in the tumor microenvironment, we need to rationally discern thes...
Source: Seminars in Immunology - February 1, 2024 Category: Allergy & Immunology Authors: E O Serebrovskaya E A Bryushkova D K Lukyanov N V Mushenkova D M Chudakov M A Turchaninova Source Type: research
Toolkit for mapping the clonal landscape of tumor-infiltrating B cells
Semin Immunol. 2024 Jan 31;72:101864. doi: 10.1016/j.smim.2024.101864. Online ahead of print.ABSTRACTOur current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor - in distinct cancers, subcohorts and individual patients - is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute to the antitumor response, while others steer the immune response away from the desired mechanics. To step up to a new level of understanding and managing B cell behaviors in the tumor microenvironment, we need to rationally discern thes...
Source: Seminars in Immunology - February 1, 2024 Category: Allergy & Immunology Authors: E O Serebrovskaya E A Bryushkova D K Lukyanov N V Mushenkova D M Chudakov M A Turchaninova Source Type: research
Toolkit for mapping the clonal landscape of tumor-infiltrating B cells
Semin Immunol. 2024 Jan 31;72:101864. doi: 10.1016/j.smim.2024.101864. Online ahead of print.ABSTRACTOur current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor - in distinct cancers, subcohorts and individual patients - is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute to the antitumor response, while others steer the immune response away from the desired mechanics. To step up to a new level of understanding and managing B cell behaviors in the tumor microenvironment, we need to rationally discern thes...
Source: Seminars in Immunology - February 1, 2024 Category: Allergy & Immunology Authors: E O Serebrovskaya E A Bryushkova D K Lukyanov N V Mushenkova D M Chudakov M A Turchaninova Source Type: research
Toolkit for mapping the clonal landscape of tumor-infiltrating B cells
Semin Immunol. 2024 Jan 31;72:101864. doi: 10.1016/j.smim.2024.101864. Online ahead of print.ABSTRACTOur current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor - in distinct cancers, subcohorts and individual patients - is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute to the antitumor response, while others steer the immune response away from the desired mechanics. To step up to a new level of understanding and managing B cell behaviors in the tumor microenvironment, we need to rationally discern thes...
Source: Seminars in Immunology - February 1, 2024 Category: Allergy & Immunology Authors: E O Serebrovskaya E A Bryushkova D K Lukyanov N V Mushenkova D M Chudakov M A Turchaninova Source Type: research
Toolkit for mapping the clonal landscape of tumor-infiltrating B cells
Semin Immunol. 2024 Jan 31;72:101864. doi: 10.1016/j.smim.2024.101864. Online ahead of print.ABSTRACTOur current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor - in distinct cancers, subcohorts and individual patients - is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute to the antitumor response, while others steer the immune response away from the desired mechanics. To step up to a new level of understanding and managing B cell behaviors in the tumor microenvironment, we need to rationally discern thes...
Source: Seminars in Immunology - February 1, 2024 Category: Allergy & Immunology Authors: E O Serebrovskaya E A Bryushkova D K Lukyanov N V Mushenkova D M Chudakov M A Turchaninova Source Type: research
Toolkit for mapping the clonal landscape of tumor-infiltrating B cells
Semin Immunol. 2024 Jan 31;72:101864. doi: 10.1016/j.smim.2024.101864. Online ahead of print.ABSTRACTOur current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor - in distinct cancers, subcohorts and individual patients - is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute to the antitumor response, while others steer the immune response away from the desired mechanics. To step up to a new level of understanding and managing B cell behaviors in the tumor microenvironment, we need to rationally discern thes...
Source: Seminars in Immunology - February 1, 2024 Category: Allergy & Immunology Authors: E O Serebrovskaya E A Bryushkova D K Lukyanov N V Mushenkova D M Chudakov M A Turchaninova Source Type: research
Toolkit for mapping the clonal landscape of tumor-infiltrating B cells
Semin Immunol. 2024 Jan 31;72:101864. doi: 10.1016/j.smim.2024.101864. Online ahead of print.ABSTRACTOur current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor - in distinct cancers, subcohorts and individual patients - is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute to the antitumor response, while others steer the immune response away from the desired mechanics. To step up to a new level of understanding and managing B cell behaviors in the tumor microenvironment, we need to rationally discern thes...
Source: Seminars in Immunology - February 1, 2024 Category: Allergy & Immunology Authors: E O Serebrovskaya E A Bryushkova D K Lukyanov N V Mushenkova D M Chudakov M A Turchaninova Source Type: research
Type I and type III interferons: From basic biology and genetics to clinical development for COVID-19 and beyond
Semin Immunol. 2024 Jan 24;72:101863. doi: 10.1016/j.smim.2024.101863. Online ahead of print.ABSTRACTType I and type III interferons (IFNs) constitute a key antiviral defense systems of the body, inducing viral resistance to cells and mediating diverse innate and adaptive immune functions. Defective type I and type III IFN responses have recently emerged as the 'Achilles heel' in COVID-19, with such patients developing severe disease and exhibiting a high risk for critical pneumonia and death. Here, we review the biology of type I and type III IFNs, their similarities and important functional differences, and their roles i...
Source: Seminars in Immunology - January 25, 2024 Category: Allergy & Immunology Authors: Evangelos Andreakos COVID Human Genetic Effort Source Type: research
To die or not to die: Gasdermins in intestinal health and disease
Semin Immunol. 2024 Feb;71:101865. doi: 10.1016/j.smim.2024.101865. Epub 2024 Jan 16.ABSTRACTIntestinal homeostasis is achieved by the balance among intestinal epithelium, immune cells, and gut microbiota. Gasdermins (GSDMs), a family of membrane pore forming proteins, can trigger rapid inflammatory cell death in the gut, mainly pyroptosis and NETosis. Importantly, there is increasing literature on the non-cell lytic roles of GSDMs in intestinal homeostasis and disease. While GSDMA is low and PJVK is not expressed in the gut, high GSDMB and GSDMC expression is found almost restrictively in intestinal epithelial cells. Conv...
Source: Seminars in Immunology - January 17, 2024 Category: Allergy & Immunology Authors: Zhaoyu Lin Qianyue Chen Hai-Bin Ruan Source Type: research
Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases
Semin Immunol. 2024 Feb;71:101859. doi: 10.1016/j.smim.2023.101859. Epub 2024 Jan 13.NO ABSTRACTPMID:38219459 | DOI:10.1016/j.smim.2023.101859 (Source: Seminars in Immunology)
Source: Seminars in Immunology - January 14, 2024 Category: Allergy & Immunology Authors: Susana G Rodrigues Schalk van der Merwe Aleksander Krag Reiner Wiest Source Type: research
Inactivated whole virion vaccine protects K18-hACE2 Tg mice against the Omicron SARS-CoV-2 variant via cross-reactive T cells and nonneutralizing antibody responses
Eur J Immunol. 2023 Dec 13:e2350664. doi: 10.1002/eji.202350664. Online ahead of print.ABSTRACTCOVID-19 is a systemic inflammatory disease initiated by SARS-CoV-2 virus infection. Multiple vaccines against the Wuhan variant of SARS-CoV-2 have been developed including a whole virion beta-propiolactone-inactivated vaccine based on the B.1.1 strain (CoviVac). Since most of the population has been vaccinated by targeting the original or early variants of SARS-CoV-2, the emergence of novel mutant variants raises concern over possible evasion of vaccine-induced immune responses. Here, we report on the mechanism of protection by ...
Source: Seminars in Immunology - December 13, 2023 Category: Allergy & Immunology Authors: Andrey A Kruglov Marina A Bondareva Violetta S Gogoleva Iaroslav K Semin Irina V Astrakhantseva Ruslan Zvartsev Aleksandr S Lunin Vasiliy D Apolokhov Elena Yu Shustova Viktor P Volok Aleksey A Ustyugov Aydar A Ishmukhametov Sergei A Nedospasov Liubov I Ko Source Type: research
Inactivated whole virion vaccine protects K18-hACE2 Tg mice against the Omicron SARS-CoV-2 variant via cross-reactive T cells and nonneutralizing antibody responses
Eur J Immunol. 2023 Dec 13:e2350664. doi: 10.1002/eji.202350664. Online ahead of print.ABSTRACTCOVID-19 is a systemic inflammatory disease initiated by SARS-CoV-2 virus infection. Multiple vaccines against the Wuhan variant of SARS-CoV-2 have been developed including a whole virion beta-propiolactone-inactivated vaccine based on the B.1.1 strain (CoviVac). Since most of the population has been vaccinated by targeting the original or early variants of SARS-CoV-2, the emergence of novel mutant variants raises concern over possible evasion of vaccine-induced immune responses. Here, we report on the mechanism of protection by ...
Source: Seminars in Immunology - December 13, 2023 Category: Allergy & Immunology Authors: Andrey A Kruglov Marina A Bondareva Violetta S Gogoleva Iaroslav K Semin Irina V Astrakhantseva Ruslan Zvartsev Aleksandr S Lunin Vasiliy D Apolokhov Elena Yu Shustova Viktor P Volok Aleksey A Ustyugov Aydar A Ishmukhametov Sergei A Nedospasov Liubov I Ko Source Type: research
Inactivated whole virion vaccine protects K18-hACE2 Tg mice against the Omicron SARS-CoV-2 variant via cross-reactive T cells and nonneutralizing antibody responses
Eur J Immunol. 2023 Dec 13:e2350664. doi: 10.1002/eji.202350664. Online ahead of print.ABSTRACTCOVID-19 is a systemic inflammatory disease initiated by SARS-CoV-2 virus infection. Multiple vaccines against the Wuhan variant of SARS-CoV-2 have been developed including a whole virion beta-propiolactone-inactivated vaccine based on the B.1.1 strain (CoviVac). Since most of the population has been vaccinated by targeting the original or early variants of SARS-CoV-2, the emergence of novel mutant variants raises concern over possible evasion of vaccine-induced immune responses. Here, we report on the mechanism of protection by ...
Source: Seminars in Immunology - December 13, 2023 Category: Allergy & Immunology Authors: Andrey A Kruglov Marina A Bondareva Violetta S Gogoleva Iaroslav K Semin Irina V Astrakhantseva Ruslan Zvartsev Aleksandr S Lunin Vasiliy D Apolokhov Elena Yu Shustova Viktor P Volok Aleksey A Ustyugov Aydar A Ishmukhametov Sergei A Nedospasov Liubov I Ko Source Type: research
Inactivated whole virion vaccine protects K18-hACE2 Tg mice against the Omicron SARS-CoV-2 variant via cross-reactive T cells and nonneutralizing antibody responses
Eur J Immunol. 2023 Dec 13:e2350664. doi: 10.1002/eji.202350664. Online ahead of print.ABSTRACTCOVID-19 is a systemic inflammatory disease initiated by SARS-CoV-2 virus infection. Multiple vaccines against the Wuhan variant of SARS-CoV-2 have been developed including a whole virion beta-propiolactone-inactivated vaccine based on the B.1.1 strain (CoviVac). Since most of the population has been vaccinated by targeting the original or early variants of SARS-CoV-2, the emergence of novel mutant variants raises concern over possible evasion of vaccine-induced immune responses. Here, we report on the mechanism of protection by ...
Source: Seminars in Immunology - December 13, 2023 Category: Allergy & Immunology Authors: Andrey A Kruglov Marina A Bondareva Violetta S Gogoleva Iaroslav K Semin Irina V Astrakhantseva Ruslan Zvartsev Aleksandr S Lunin Vasiliy D Apolokhov Elena Yu Shustova Viktor P Volok Aleksey A Ustyugov Aydar A Ishmukhametov Sergei A Nedospasov Liubov I Ko Source Type: research
Inactivated whole virion vaccine protects K18-hACE2 Tg mice against the Omicron SARS-CoV-2 variant via cross-reactive T cells and nonneutralizing antibody responses
Eur J Immunol. 2023 Dec 13:e2350664. doi: 10.1002/eji.202350664. Online ahead of print.ABSTRACTCOVID-19 is a systemic inflammatory disease initiated by SARS-CoV-2 virus infection. Multiple vaccines against the Wuhan variant of SARS-CoV-2 have been developed including a whole virion beta-propiolactone-inactivated vaccine based on the B.1.1 strain (CoviVac). Since most of the population has been vaccinated by targeting the original or early variants of SARS-CoV-2, the emergence of novel mutant variants raises concern over possible evasion of vaccine-induced immune responses. Here, we report on the mechanism of protection by ...
Source: Seminars in Immunology - December 13, 2023 Category: Allergy & Immunology Authors: Andrey A Kruglov Marina A Bondareva Violetta S Gogoleva Iaroslav K Semin Irina V Astrakhantseva Ruslan Zvartsev Aleksandr S Lunin Vasiliy D Apolokhov Elena Yu Shustova Viktor P Volok Aleksey A Ustyugov Aydar A Ishmukhametov Sergei A Nedospasov Liubov I Ko Source Type: research
