Aging of lymphoid stromal architecture impacts immune responses
Semin Immunol. 2023 Aug 10;70:101817. doi: 10.1016/j.smim.2023.101817. Online ahead of print.ABSTRACTThe secondary lymphoid organs (SLOs) undergo structural changes with age, which correlates with diminishing immune responses against infectious disease. A growing body of research suggests that the aged tissue microenvironment can contribute to decreased immune function, independent of intrinsic changes to hematopoietic cells with age. Stromal cells impart structural integrity, facilitate fluid transport, and provide chemokine and cytokine signals that are essential for immune homeostasis. Mechanisms that drive SLO developm...
Source: Seminars in Immunology - August 12, 2023 Category: Allergy & Immunology Authors: Jessica N Lancaster Source Type: research
Aging of lymphoid stromal architecture impacts immune responses
Semin Immunol. 2023 Aug 10;70:101817. doi: 10.1016/j.smim.2023.101817. Online ahead of print.ABSTRACTThe secondary lymphoid organs (SLOs) undergo structural changes with age, which correlates with diminishing immune responses against infectious disease. A growing body of research suggests that the aged tissue microenvironment can contribute to decreased immune function, independent of intrinsic changes to hematopoietic cells with age. Stromal cells impart structural integrity, facilitate fluid transport, and provide chemokine and cytokine signals that are essential for immune homeostasis. Mechanisms that drive SLO developm...
Source: Seminars in Immunology - August 12, 2023 Category: Allergy & Immunology Authors: Jessica N Lancaster Source Type: research
Aging of lymphoid stromal architecture impacts immune responses
Semin Immunol. 2023 Aug 10;70:101817. doi: 10.1016/j.smim.2023.101817. Online ahead of print.ABSTRACTThe secondary lymphoid organs (SLOs) undergo structural changes with age, which correlates with diminishing immune responses against infectious disease. A growing body of research suggests that the aged tissue microenvironment can contribute to decreased immune function, independent of intrinsic changes to hematopoietic cells with age. Stromal cells impart structural integrity, facilitate fluid transport, and provide chemokine and cytokine signals that are essential for immune homeostasis. Mechanisms that drive SLO developm...
Source: Seminars in Immunology - August 12, 2023 Category: Allergy & Immunology Authors: Jessica N Lancaster Source Type: research
Epithelial inflammasomes, gasdermins, and mucosal inflammation - Lessons from Salmonella and Shigella infected mice
Semin Immunol. 2023 Aug 8;70:101812. doi: 10.1016/j.smim.2023.101812. Online ahead of print.ABSTRACTBesides its crucial function in nutrient absorbance and as barrier against the microbiota, the gut epithelium is essential for sensing pathogenic insults and mounting of an appropriate early immune response. In mice, the activation of the canonical NAIP/NLRC4 inflammasome is critical for the defense against enterobacterial infections. Activation of the NAIP/NLRC4 inflammasome triggers the extrusion of infected intestinal epithelial cells (IEC) into the gut lumen, concomitant with inflammasome-mediated lytic cell death. The m...
Source: Seminars in Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Ersin G ül Stefan A Fattinger Mikael E Sellin Wolf-Dietrich Hardt Source Type: research
Epithelial inflammasomes, gasdermins, and mucosal inflammation - Lessons from Salmonella and Shigella infected mice
Semin Immunol. 2023 Aug 8;70:101812. doi: 10.1016/j.smim.2023.101812. Online ahead of print.ABSTRACTBesides its crucial function in nutrient absorbance and as barrier against the microbiota, the gut epithelium is essential for sensing pathogenic insults and mounting of an appropriate early immune response. In mice, the activation of the canonical NAIP/NLRC4 inflammasome is critical for the defense against enterobacterial infections. Activation of the NAIP/NLRC4 inflammasome triggers the extrusion of infected intestinal epithelial cells (IEC) into the gut lumen, concomitant with inflammasome-mediated lytic cell death. The m...
Source: Seminars in Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Ersin G ül Stefan A Fattinger Mikael E Sellin Wolf-Dietrich Hardt Source Type: research
Epithelial inflammasomes, gasdermins, and mucosal inflammation - Lessons from Salmonella and Shigella infected mice
Semin Immunol. 2023 Aug 8;70:101812. doi: 10.1016/j.smim.2023.101812. Online ahead of print.ABSTRACTBesides its crucial function in nutrient absorbance and as barrier against the microbiota, the gut epithelium is essential for sensing pathogenic insults and mounting of an appropriate early immune response. In mice, the activation of the canonical NAIP/NLRC4 inflammasome is critical for the defense against enterobacterial infections. Activation of the NAIP/NLRC4 inflammasome triggers the extrusion of infected intestinal epithelial cells (IEC) into the gut lumen, concomitant with inflammasome-mediated lytic cell death. The m...
Source: Seminars in Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Ersin G ül Stefan A Fattinger Mikael E Sellin Wolf-Dietrich Hardt Source Type: research
Immune aging - A mechanism in autoimmune disease
Semin Immunol. 2023 Aug 3;69:101814. doi: 10.1016/j.smim.2023.101814. Online ahead of print.ABSTRACTEvidence is emerging that the process of immune aging is a mechanism leading to autoimmunity. Over lifetime, the immune system adapts to profound changes in hematopoiesis and lymphogenesis, and progressively restructures in face of an ever-expanding exposome. Older adults fail to generate adequate immune responses against microbial infections and tumors, but accumulate aged T cells, B cells and myeloid cells. Age-associated B cells are highly efficient in autoantibody production. T-cell aging promotes the accrual of end-diff...
Source: Seminars in Immunology - August 5, 2023 Category: Allergy & Immunology Authors: Yanyan Zheng Qingxiang Liu Jorg J Goronzy Cornelia M Weyand Source Type: research
Immune aging - A mechanism in autoimmune disease
Semin Immunol. 2023 Aug 3;69:101814. doi: 10.1016/j.smim.2023.101814. Online ahead of print.ABSTRACTEvidence is emerging that the process of immune aging is a mechanism leading to autoimmunity. Over lifetime, the immune system adapts to profound changes in hematopoiesis and lymphogenesis, and progressively restructures in face of an ever-expanding exposome. Older adults fail to generate adequate immune responses against microbial infections and tumors, but accumulate aged T cells, B cells and myeloid cells. Age-associated B cells are highly efficient in autoantibody production. T-cell aging promotes the accrual of end-diff...
Source: Seminars in Immunology - August 5, 2023 Category: Allergy & Immunology Authors: Yanyan Zheng Qingxiang Liu Jorg J Goronzy Cornelia M Weyand Source Type: research
Immune aging - A mechanism in autoimmune disease
Semin Immunol. 2023 Aug 3;69:101814. doi: 10.1016/j.smim.2023.101814. Online ahead of print.ABSTRACTEvidence is emerging that the process of immune aging is a mechanism leading to autoimmunity. Over lifetime, the immune system adapts to profound changes in hematopoiesis and lymphogenesis, and progressively restructures in face of an ever-expanding exposome. Older adults fail to generate adequate immune responses against microbial infections and tumors, but accumulate aged T cells, B cells and myeloid cells. Age-associated B cells are highly efficient in autoantibody production. T-cell aging promotes the accrual of end-diff...
Source: Seminars in Immunology - August 5, 2023 Category: Allergy & Immunology Authors: Yanyan Zheng Qingxiang Liu Jorg J Goronzy Cornelia M Weyand Source Type: research
Immune aging - A mechanism in autoimmune disease
Semin Immunol. 2023 Aug 3;69:101814. doi: 10.1016/j.smim.2023.101814. Online ahead of print.ABSTRACTEvidence is emerging that the process of immune aging is a mechanism leading to autoimmunity. Over lifetime, the immune system adapts to profound changes in hematopoiesis and lymphogenesis, and progressively restructures in face of an ever-expanding exposome. Older adults fail to generate adequate immune responses against microbial infections and tumors, but accumulate aged T cells, B cells and myeloid cells. Age-associated B cells are highly efficient in autoantibody production. T-cell aging promotes the accrual of end-diff...
Source: Seminars in Immunology - August 5, 2023 Category: Allergy & Immunology Authors: Yanyan Zheng Qingxiang Liu Jorg J Goronzy Cornelia M Weyand Source Type: research
Immune responses to SARS-CoV-2 infection and vaccination in children
Semin Immunol. 2023 Jun 20;69:101794. doi: 10.1016/j.smim.2023.101794. Online ahead of print.ABSTRACTDuring the three years since SARS-CoV-2 infections were first described a wealth of information has been gathered about viral variants and their changing properties, the disease presentations they elicit and how the many vaccines developed in record time protect from COVID-19 severe disease in different populations. A general theme throughout the pandemic has been the observation that children and young people in general fare well, with mild symptoms during acute infection and full recovery thereafter. It has also become cl...
Source: Seminars in Immunology - August 3, 2023 Category: Allergy & Immunology Authors: Petter Brodin Source Type: research
Aging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging
Semin Immunol. 2023 Aug 1;69:101816. doi: 10.1016/j.smim.2023.101816. Online ahead of print.ABSTRACTUnconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T cells by their recognition of non-peptide ligands presented by non-polymorphic antigen presenting molecules and rapid effector functions that are pre-programmed during their development. Here we review current knowledge of the effect of age on unconventional T cells, from early life to old age, in both mice and humans. We then discuss the role ...
Source: Seminars in Immunology - August 3, 2023 Category: Allergy & Immunology Authors: Ayako Kurioka Paul Klenerman Source Type: research
Immune responses to SARS-CoV-2 infection and vaccination in children
Semin Immunol. 2023 Jun 20;69:101794. doi: 10.1016/j.smim.2023.101794. Online ahead of print.ABSTRACTDuring the three years since SARS-CoV-2 infections were first described a wealth of information has been gathered about viral variants and their changing properties, the disease presentations they elicit and how the many vaccines developed in record time protect from COVID-19 severe disease in different populations. A general theme throughout the pandemic has been the observation that children and young people in general fare well, with mild symptoms during acute infection and full recovery thereafter. It has also become cl...
Source: Seminars in Immunology - August 3, 2023 Category: Allergy & Immunology Authors: Petter Brodin Source Type: research
Aging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging
Semin Immunol. 2023 Aug 1;69:101816. doi: 10.1016/j.smim.2023.101816. Online ahead of print.ABSTRACTUnconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T cells by their recognition of non-peptide ligands presented by non-polymorphic antigen presenting molecules and rapid effector functions that are pre-programmed during their development. Here we review current knowledge of the effect of age on unconventional T cells, from early life to old age, in both mice and humans. We then discuss the role ...
Source: Seminars in Immunology - August 3, 2023 Category: Allergy & Immunology Authors: Ayako Kurioka Paul Klenerman Source Type: research
Numbers and odds: TCR repertoire size and its age changes impacting on T cell functions
Semin Immunol. 2023 Jul 27;69:101810. doi: 10.1016/j.smim.2023.101810. Online ahead of print.ABSTRACTA vast array of αβ T cell receptors (TCRs) is generated during T cell development in the thymus through V(D)J recombination, which involves the rearrangement of multiple V, D, and J genes and the pairing of α and β chains. These diverse TCRs provide protection to the human body against a multitude of foreign pathogens and internal cancer cells. The entirety of TCRs present in an individual's T cells is referred to as the TCR repertoire. Despite an estimated 4 × 1011 T cells in the adult human body, the lower bound esti...
Source: Seminars in Immunology - July 29, 2023 Category: Allergy & Immunology Authors: Nan-Ping Weng Source Type: research
