Contributions of the early-life microbiome to childhood atopy and asthma development
Semin Immunol. 2023 Jun 26;69:101795. doi: 10.1016/j.smim.2023.101795. Online ahead of print.ABSTRACTThe rapid rise in atopy and asthma in industrialized nations has led to the identification of early life environmental factors that promote these conditions and spurred research into how such exposures may mediate the trajectory to childhood disease development. Over the past decade, the human microbiome has emerged as a key determinant of human health. This is largely due to the increasing appreciation for the myriad of non-mutually exclusive mechanisms by which microbes tune and train host immunity. Microbiomes, particula...
Source: Seminars in Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Holly Steininger Jacqueline Moltzau-Anderson Susan V Lynch Source Type: research
Age-dependent changes in T follicular helper cells shape the humoral immune response to vaccination
Semin Immunol. 2023 Jun 26;69:101801. doi: 10.1016/j.smim.2023.101801. Online ahead of print.ABSTRACTVaccination is an excellent strategy to limit the morbidity and mortality associated with infectious disease. Vaccination creates protective, long-lived antibody-mediated immunity by inducing the germinal centre response, an intricate immune reaction that produces memory B cells and long-lived antibody-secreting plasma cells that provide protection against (re)infection. The magnitude and quality of the germinal centre response declines with age, contributing to poor vaccine-induced immunity in older individuals. T follicul...
Source: Seminars in Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Michelle A Linterman Source Type: research
Contributions of the early-life microbiome to childhood atopy and asthma development
Semin Immunol. 2023 Jun 26;69:101795. doi: 10.1016/j.smim.2023.101795. Online ahead of print.ABSTRACTThe rapid rise in atopy and asthma in industrialized nations has led to the identification of early life environmental factors that promote these conditions and spurred research into how such exposures may mediate the trajectory to childhood disease development. Over the past decade, the human microbiome has emerged as a key determinant of human health. This is largely due to the increasing appreciation for the myriad of non-mutually exclusive mechanisms by which microbes tune and train host immunity. Microbiomes, particula...
Source: Seminars in Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Holly Steininger Jacqueline Moltzau-Anderson Susan V Lynch Source Type: research
Harnessing the power of oncolytic virotherapy and tertiary lymphoid structures to amplify antitumor immune responses in cancer patients
Semin Immunol. 2023 Jun 23;69:101796. doi: 10.1016/j.smim.2023.101796. Online ahead of print.ABSTRACTTertiary lymphoid structures (TLS) are ectopic aggregates of immune cells that develop in non-lymphoid tissues under persistent inflammation. Since their presence has been associated with a better prognosis in cancer patients, modulating TLS formation is being part of new challenges in immunotherapy. Although mechanisms underlying TLS genesis are still not fully understood, different strategies have been developed in preclinical models to induce their formation and ultimately enhance antitumor responses. Herein, we will dis...
Source: Seminars in Immunology - June 25, 2023 Category: Allergy & Immunology Authors: Ana Houel Johann Foloppe Marie-Caroline Dieu-Nosjean Source Type: research
Harnessing the power of oncolytic virotherapy and tertiary lymphoid structures to amplify antitumor immune responses in cancer patients
Semin Immunol. 2023 Jun 23;69:101796. doi: 10.1016/j.smim.2023.101796. Online ahead of print.ABSTRACTTertiary lymphoid structures (TLS) are ectopic aggregates of immune cells that develop in non-lymphoid tissues under persistent inflammation. Since their presence has been associated with a better prognosis in cancer patients, modulating TLS formation is being part of new challenges in immunotherapy. Although mechanisms underlying TLS genesis are still not fully understood, different strategies have been developed in preclinical models to induce their formation and ultimately enhance antitumor responses. Herein, we will dis...
Source: Seminars in Immunology - June 25, 2023 Category: Allergy & Immunology Authors: Ana Houel Johann Foloppe Marie-Caroline Dieu-Nosjean Source Type: research
Harnessing the power of oncolytic virotherapy and tertiary lymphoid structures to amplify antitumor immune responses in cancer patients
Semin Immunol. 2023 Jun 23;69:101796. doi: 10.1016/j.smim.2023.101796. Online ahead of print.ABSTRACTTertiary lymphoid structures (TLS) are ectopic aggregates of immune cells that develop in non-lymphoid tissues under persistent inflammation. Since their presence has been associated with a better prognosis in cancer patients, modulating TLS formation is being part of new challenges in immunotherapy. Although mechanisms underlying TLS genesis are still not fully understood, different strategies have been developed in preclinical models to induce their formation and ultimately enhance antitumor responses. Herein, we will dis...
Source: Seminars in Immunology - June 25, 2023 Category: Allergy & Immunology Authors: Ana Houel Johann Foloppe Marie-Caroline Dieu-Nosjean Source Type: research
Pyroptosis-induced inflammation and tissue damage
Semin Immunol. 2023 Jun 21;69:101781. doi: 10.1016/j.smim.2023.101781. Online ahead of print.ABSTRACTPyroptosis is a programmed necrotic cell death executed by gasdermins, a family of pore-forming proteins. The cleavage of gasdermins by specific proteases enables their pore-forming activity. The activation of the prototype member of the gasdermin family, gasdermin D (GSDMD), is linked to innate immune monitoring by inflammasomes. Additional gasdermins such as GSDMA, GSDMB, GSDMC, and GSDME are activated by inflammasome-independent mechanisms. Pyroptosis is emerging as a key host defense strategy against pathogens. However,...
Source: Seminars in Immunology - June 23, 2023 Category: Allergy & Immunology Authors: Swathy O Vasudevan Bharat Behl Vijay A Rathinam Source Type: research
Introduction to the Special Issue: The Immunopeptidome
Semin Immunol. 2023 Jun 19;69:101798. doi: 10.1016/j.smim.2023.101798. Online ahead of print.NO ABSTRACTPMID:37348326 | DOI:10.1016/j.smim.2023.101798 (Source: Seminars in Immunology)
Source: Seminars in Immunology - June 22, 2023 Category: Allergy & Immunology Authors: Étienne Caron Claude Perreault Source Type: research
Introduction to the Special Issue: The Immunopeptidome
Semin Immunol. 2023 Jun 19;69:101798. doi: 10.1016/j.smim.2023.101798. Online ahead of print.NO ABSTRACTPMID:37348326 | DOI:10.1016/j.smim.2023.101798 (Source: Seminars in Immunology)
Source: Seminars in Immunology - June 22, 2023 Category: Allergy & Immunology Authors: Étienne Caron Claude Perreault Source Type: research
T follicular helper cells in cancer, tertiary lymphoid structures, and beyond
Semin Immunol. 2023 Jun 19;69:101797. doi: 10.1016/j.smim.2023.101797. Online ahead of print.ABSTRACTWith the emergence and success of checkpoint blockade immunotherapy, immuno-oncology has primarily focused on CD8 T cells, whose cytotoxic programs directly target tumor cells. However, the limited response rate of current immunotherapy regimens has prompted investigation into other types of tumor-infiltrating immune cells, such as CD4 T cells and B cells, and how they interact with CD8 T cells in a coordinated network. Recent studies have demonstrated the potential therapeutic benefits of CD4 T follicular helper (TFH) cell...
Source: Seminars in Immunology - June 21, 2023 Category: Allergy & Immunology Authors: Can Cui Joseph Craft Nikhil S Joshi Source Type: research
T follicular helper cells in cancer, tertiary lymphoid structures, and beyond
Semin Immunol. 2023 Jun 19;69:101797. doi: 10.1016/j.smim.2023.101797. Online ahead of print.ABSTRACTWith the emergence and success of checkpoint blockade immunotherapy, immuno-oncology has primarily focused on CD8 T cells, whose cytotoxic programs directly target tumor cells. However, the limited response rate of current immunotherapy regimens has prompted investigation into other types of tumor-infiltrating immune cells, such as CD4 T cells and B cells, and how they interact with CD8 T cells in a coordinated network. Recent studies have demonstrated the potential therapeutic benefits of CD4 T follicular helper (TFH) cell...
Source: Seminars in Immunology - June 21, 2023 Category: Allergy & Immunology Authors: Can Cui Joseph Craft Nikhil S Joshi Source Type: research
Pyroptosis: A road to next-generation cancer immunotherapy
Semin Immunol. 2023 Jul;68:101782. doi: 10.1016/j.smim.2023.101782. Epub 2023 Jun 9.ABSTRACTThe goal of cancer immunotherapy is to clear tumor cells by activating antitumor immunity, especially by mobilizing tumor-reactive CD8+T cells. Pyroptosis, programmed lytic cell death mediated by gasdermin (GSDM), results in the release of cellular antigens, damage-associated molecular patterns (DAMPs) and cytokines. Therefore, pyroptotic tumor cell-derived tumor antigens and DAMPs not only reverse immunosuppression of the tumor microenvironment (TME) but also enhance tumor antigen presentation by dendritic cells, leading to robust ...
Source: Seminars in Immunology - June 11, 2023 Category: Allergy & Immunology Authors: Yiliang Fang Yaxing Tang Bo Huang Source Type: research
Pyroptosis: A road to next-generation cancer immunotherapy
Semin Immunol. 2023 Jul;68:101782. doi: 10.1016/j.smim.2023.101782. Epub 2023 Jun 9.ABSTRACTThe goal of cancer immunotherapy is to clear tumor cells by activating antitumor immunity, especially by mobilizing tumor-reactive CD8+T cells. Pyroptosis, programmed lytic cell death mediated by gasdermin (GSDM), results in the release of cellular antigens, damage-associated molecular patterns (DAMPs) and cytokines. Therefore, pyroptotic tumor cell-derived tumor antigens and DAMPs not only reverse immunosuppression of the tumor microenvironment (TME) but also enhance tumor antigen presentation by dendritic cells, leading to robust ...
Source: Seminars in Immunology - June 11, 2023 Category: Allergy & Immunology Authors: Yiliang Fang Yaxing Tang Bo Huang Source Type: research
Pyroptosis: A road to next-generation cancer immunotherapy
Semin Immunol. 2023 Jul;68:101782. doi: 10.1016/j.smim.2023.101782. Epub 2023 Jun 9.ABSTRACTThe goal of cancer immunotherapy is to clear tumor cells by activating antitumor immunity, especially by mobilizing tumor-reactive CD8+T cells. Pyroptosis, programmed lytic cell death mediated by gasdermin (GSDM), results in the release of cellular antigens, damage-associated molecular patterns (DAMPs) and cytokines. Therefore, pyroptotic tumor cell-derived tumor antigens and DAMPs not only reverse immunosuppression of the tumor microenvironment (TME) but also enhance tumor antigen presentation by dendritic cells, leading to robust ...
Source: Seminars in Immunology - June 11, 2023 Category: Allergy & Immunology Authors: Yiliang Fang Yaxing Tang Bo Huang Source Type: research
Pyroptosis: A road to next-generation cancer immunotherapy
Semin Immunol. 2023 Jul;68:101782. doi: 10.1016/j.smim.2023.101782. Epub 2023 Jun 9.ABSTRACTThe goal of cancer immunotherapy is to clear tumor cells by activating antitumor immunity, especially by mobilizing tumor-reactive CD8+T cells. Pyroptosis, programmed lytic cell death mediated by gasdermin (GSDM), results in the release of cellular antigens, damage-associated molecular patterns (DAMPs) and cytokines. Therefore, pyroptotic tumor cell-derived tumor antigens and DAMPs not only reverse immunosuppression of the tumor microenvironment (TME) but also enhance tumor antigen presentation by dendritic cells, leading to robust ...
Source: Seminars in Immunology - June 11, 2023 Category: Allergy & Immunology Authors: Yiliang Fang Yaxing Tang Bo Huang Source Type: research
