B cell clonality in cancer
Semin Immunol. 2024 Mar;72:101874. doi: 10.1016/j.smim.2024.101874. Epub 2024 Mar 19.ABSTRACTCarcinogenesis in the process of long-term co-evolution of tumor cells and immune environment essentially becomes possible due to incorrect decisions made, remembered, and reproduced by the immune system at the level of clonal populations of antigen-specific T- and B-lymphocytes. Tumor-immunity interaction determines the nature of such errors and, consequently, delineates the possible ways of successful immunotherapeutic intervention. It is generally recognized that tumor-infiltrating B cells (TIL-B) can play both pro-tumor and ant...
Source: Seminars in Immunology - March 20, 2024 Category: Allergy & Immunology Authors: E A Bryushkova N V Mushenkova M A Turchaninova D K Lukyanov D M Chudakov E O Serebrovskaya Source Type: research
B cell clonality in cancer
Semin Immunol. 2024 Mar;72:101874. doi: 10.1016/j.smim.2024.101874. Epub 2024 Mar 19.ABSTRACTCarcinogenesis in the process of long-term co-evolution of tumor cells and immune environment essentially becomes possible due to incorrect decisions made, remembered, and reproduced by the immune system at the level of clonal populations of antigen-specific T- and B-lymphocytes. Tumor-immunity interaction determines the nature of such errors and, consequently, delineates the possible ways of successful immunotherapeutic intervention. It is generally recognized that tumor-infiltrating B cells (TIL-B) can play both pro-tumor and ant...
Source: Seminars in Immunology - March 20, 2024 Category: Allergy & Immunology Authors: E A Bryushkova N V Mushenkova M A Turchaninova D K Lukyanov D M Chudakov E O Serebrovskaya Source Type: research
B cell clonality in cancer
Semin Immunol. 2024 Mar;72:101874. doi: 10.1016/j.smim.2024.101874. Epub 2024 Mar 19.ABSTRACTCarcinogenesis in the process of long-term co-evolution of tumor cells and immune environment essentially becomes possible due to incorrect decisions made, remembered, and reproduced by the immune system at the level of clonal populations of antigen-specific T- and B-lymphocytes. Tumor-immunity interaction determines the nature of such errors and, consequently, delineates the possible ways of successful immunotherapeutic intervention. It is generally recognized that tumor-infiltrating B cells (TIL-B) can play both pro-tumor and ant...
Source: Seminars in Immunology - March 20, 2024 Category: Allergy & Immunology Authors: E A Bryushkova N V Mushenkova M A Turchaninova D K Lukyanov D M Chudakov E O Serebrovskaya Source Type: research
B cell clonality in cancer
Semin Immunol. 2024 Mar 18;72:101874. doi: 10.1016/j.smim.2024.101874. Online ahead of print.ABSTRACTCarcinogenesis in the process of long-term co-evolution of tumor cells and immune environment essentially becomes possible due to incorrect decisions made, remembered, and reproduced by the immune system at the level of clonal populations of antigen-specific T- and B-lymphocytes. Tumor-immunity interaction determines the nature of such errors and, consequently, delineates the possible ways of successful immunotherapeutic intervention. It is generally recognized that tumor-infiltrating B cells (TIL-B) can play both pro-tumor...
Source: Seminars in Immunology - March 20, 2024 Category: Allergy & Immunology Authors: E A Bryushkova N V Mushenkova M A Turchaninova D K Lukyanov D M Chudakov E O Serebrovskaya Source Type: research
B cell clonality in cancer
Semin Immunol. 2024 Mar 18;72:101874. doi: 10.1016/j.smim.2024.101874. Online ahead of print.ABSTRACTCarcinogenesis in the process of long-term co-evolution of tumor cells and immune environment essentially becomes possible due to incorrect decisions made, remembered, and reproduced by the immune system at the level of clonal populations of antigen-specific T- and B-lymphocytes. Tumor-immunity interaction determines the nature of such errors and, consequently, delineates the possible ways of successful immunotherapeutic intervention. It is generally recognized that tumor-infiltrating B cells (TIL-B) can play both pro-tumor...
Source: Seminars in Immunology - March 20, 2024 Category: Allergy & Immunology Authors: E A Bryushkova N V Mushenkova M A Turchaninova D K Lukyanov D M Chudakov E O Serebrovskaya Source Type: research
B cell clonality in cancer
Semin Immunol. 2024 Mar 18;72:101874. doi: 10.1016/j.smim.2024.101874. Online ahead of print.ABSTRACTCarcinogenesis in the process of long-term co-evolution of tumor cells and immune environment essentially becomes possible due to incorrect decisions made, remembered, and reproduced by the immune system at the level of clonal populations of antigen-specific T- and B-lymphocytes. Tumor-immunity interaction determines the nature of such errors and, consequently, delineates the possible ways of successful immunotherapeutic intervention. It is generally recognized that tumor-infiltrating B cells (TIL-B) can play both pro-tumor...
Source: Seminars in Immunology - March 20, 2024 Category: Allergy & Immunology Authors: E A Bryushkova N V Mushenkova M A Turchaninova D K Lukyanov D M Chudakov E O Serebrovskaya Source Type: research
B cell clonality in cancer
Semin Immunol. 2024 Mar 18;72:101874. doi: 10.1016/j.smim.2024.101874. Online ahead of print.ABSTRACTCarcinogenesis in the process of long-term co-evolution of tumor cells and immune environment essentially becomes possible due to incorrect decisions made, remembered, and reproduced by the immune system at the level of clonal populations of antigen-specific T- and B-lymphocytes. Tumor-immunity interaction determines the nature of such errors and, consequently, delineates the possible ways of successful immunotherapeutic intervention. It is generally recognized that tumor-infiltrating B cells (TIL-B) can play both pro-tumor...
Source: Seminars in Immunology - March 20, 2024 Category: Allergy & Immunology Authors: E A Bryushkova N V Mushenkova M A Turchaninova D K Lukyanov D M Chudakov E O Serebrovskaya Source Type: research
B cell clonality in cancer
Semin Immunol. 2024 Mar 18;72:101874. doi: 10.1016/j.smim.2024.101874. Online ahead of print.ABSTRACTCarcinogenesis in the process of long-term co-evolution of tumor cells and immune environment essentially becomes possible due to incorrect decisions made, remembered, and reproduced by the immune system at the level of clonal populations of antigen-specific T- and B-lymphocytes. Tumor-immunity interaction determines the nature of such errors and, consequently, delineates the possible ways of successful immunotherapeutic intervention. It is generally recognized that tumor-infiltrating B cells (TIL-B) can play both pro-tumor...
Source: Seminars in Immunology - March 20, 2024 Category: Allergy & Immunology Authors: E A Bryushkova N V Mushenkova M A Turchaninova D K Lukyanov D M Chudakov E O Serebrovskaya Source Type: research
B cell clonality in cancer
Semin Immunol. 2024 Mar 18;72:101874. doi: 10.1016/j.smim.2024.101874. Online ahead of print.ABSTRACTCarcinogenesis in the process of long-term co-evolution of tumor cells and immune environment essentially becomes possible due to incorrect decisions made, remembered, and reproduced by the immune system at the level of clonal populations of antigen-specific T- and B-lymphocytes. Tumor-immunity interaction determines the nature of such errors and, consequently, delineates the possible ways of successful immunotherapeutic intervention. It is generally recognized that tumor-infiltrating B cells (TIL-B) can play both pro-tumor...
Source: Seminars in Immunology - March 20, 2024 Category: Allergy & Immunology Authors: E A Bryushkova N V Mushenkova M A Turchaninova D K Lukyanov D M Chudakov E O Serebrovskaya Source Type: research
Systems biology of B cells in COVID-19
Semin Immunol. 2024 Mar 13;72:101875. doi: 10.1016/j.smim.2024.101875. Online ahead of print.ABSTRACTThe integration of multi-'omic datasets into complex systems-wide assessments has become a mainstay in immunologic investigation. This focus on high-dimensional data collection and analysis was on full display in the investigation of COVID-19, the respiratory illness resulting from infection by the novel coronavirus SARS-CoV-2. Particularly in the area of B cell biology, tremendous efforts in both cellular and serologic investigation have resulted in an increasingly detailed mapping of the coordinated effector, memory, and ...
Source: Seminars in Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Matthew C Woodruff Caterina E Faliti Ignacio Sanz Source Type: research
Systems biology of B cells in COVID-19
Semin Immunol. 2024 Mar 13;72:101875. doi: 10.1016/j.smim.2024.101875. Online ahead of print.ABSTRACTThe integration of multi-'omic datasets into complex systems-wide assessments has become a mainstay in immunologic investigation. This focus on high-dimensional data collection and analysis was on full display in the investigation of COVID-19, the respiratory illness resulting from infection by the novel coronavirus SARS-CoV-2. Particularly in the area of B cell biology, tremendous efforts in both cellular and serologic investigation have resulted in an increasingly detailed mapping of the coordinated effector, memory, and ...
Source: Seminars in Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Matthew C Woodruff Caterina E Faliti Ignacio Sanz Source Type: research
Systems biology of B cells in COVID-19
Semin Immunol. 2024 Mar 13;72:101875. doi: 10.1016/j.smim.2024.101875. Online ahead of print.ABSTRACTThe integration of multi-'omic datasets into complex systems-wide assessments has become a mainstay in immunologic investigation. This focus on high-dimensional data collection and analysis was on full display in the investigation of COVID-19, the respiratory illness resulting from infection by the novel coronavirus SARS-CoV-2. Particularly in the area of B cell biology, tremendous efforts in both cellular and serologic investigation have resulted in an increasingly detailed mapping of the coordinated effector, memory, and ...
Source: Seminars in Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Matthew C Woodruff Caterina E Faliti Ignacio Sanz Source Type: research
Systems biology of B cells in COVID-19
Semin Immunol. 2024 Mar 13;72:101875. doi: 10.1016/j.smim.2024.101875. Online ahead of print.ABSTRACTThe integration of multi-'omic datasets into complex systems-wide assessments has become a mainstay in immunologic investigation. This focus on high-dimensional data collection and analysis was on full display in the investigation of COVID-19, the respiratory illness resulting from infection by the novel coronavirus SARS-CoV-2. Particularly in the area of B cell biology, tremendous efforts in both cellular and serologic investigation have resulted in an increasingly detailed mapping of the coordinated effector, memory, and ...
Source: Seminars in Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Matthew C Woodruff Caterina E Faliti Ignacio Sanz Source Type: research
Systems biology of B cells in COVID-19
Semin Immunol. 2024 Mar 13;72:101875. doi: 10.1016/j.smim.2024.101875. Online ahead of print.ABSTRACTThe integration of multi-'omic datasets into complex systems-wide assessments has become a mainstay in immunologic investigation. This focus on high-dimensional data collection and analysis was on full display in the investigation of COVID-19, the respiratory illness resulting from infection by the novel coronavirus SARS-CoV-2. Particularly in the area of B cell biology, tremendous efforts in both cellular and serologic investigation have resulted in an increasingly detailed mapping of the coordinated effector, memory, and ...
Source: Seminars in Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Matthew C Woodruff Caterina E Faliti Ignacio Sanz Source Type: research
Systems analysis of innate and adaptive immunity in Long COVID
Semin Immunol. 2024 Mar 8;72:101873. doi: 10.1016/j.smim.2024.101873. Online ahead of print.ABSTRACTSince the onset of the COVID-19 pandemic, significant progress has been made in developing effective preventive and therapeutic strategies against severe acute SARS-CoV-2 infection. However, the management of Long COVID (LC), an infection-associated chronic condition that has been estimated to affect 5-20% of individuals following SARS-CoV-2 infection, remains challenging due to our limited understanding of its mechanisms. Although LC is a heterogeneous disease that is likely to have several subtypes, immune system disturban...
Source: Seminars in Immunology - March 9, 2024 Category: Allergy & Immunology Authors: Michael J Peluso Mohamed Abdel-Mohsen Timothy J Henrich Nadia R Roan Source Type: research
