The noncanonical inflammasome-induced pyroptosis and septic shock
Semin Immunol. 2023 Sep 29;70:101844. doi: 10.1016/j.smim.2023.101844. Online ahead of print.ABSTRACTSepsis remains one of the most common and lethal conditions globally. Currently, no proposed target specific to sepsis improves survival in clinical trials. Thus, an in-depth understanding of the pathogenesis of sepsis is needed to propel the discovery of effective treatment. Recently attention to sepsis has intensified because of a growing recognition of a non-canonical inflammasome-triggered lytic mode of cell death termed pyroptosis upon sensing cytosolic lipopolysaccharide (LPS). Although the consequences of activation ...
Source: Seminars in Immunology - October 1, 2023 Category: Allergy & Immunology Authors: Junru Wu Jingjing Cai Yiting Tang Ben Lu Source Type: research
The immunology and cell biology of T cell aging
Semin Immunol. 2023 Sep 28;70:101843. doi: 10.1016/j.smim.2023.101843. Online ahead of print.NO ABSTRACTPMID:37776667 | DOI:10.1016/j.smim.2023.101843 (Source: Seminars in Immunology)
Source: Seminars in Immunology - September 30, 2023 Category: Allergy & Immunology Authors: J örg J Goronzy Nan-Ping Weng Source Type: research
The immunology and cell biology of T cell aging
Semin Immunol. 2023 Sep 28;70:101843. doi: 10.1016/j.smim.2023.101843. Online ahead of print.NO ABSTRACTPMID:37776667 | DOI:10.1016/j.smim.2023.101843 (Source: Seminars in Immunology)
Source: Seminars in Immunology - September 30, 2023 Category: Allergy & Immunology Authors: J örg J Goronzy Nan-Ping Weng Source Type: research
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging
Semin Immunol. 2023 Sep 18;70:101840. doi: 10.1016/j.smim.2023.101840. Online ahead of print.ABSTRACTPopulation aging, a pervasive global demographic trend, is anticipated to challenge health and social systems worldwide. This phenomenon is due to medical advancements enabling longer lifespans, with 20% of the US population soon to be over 65 years old. Consequently, there will be a surge in age-related diseases. Senescence, characterized by the loss of biological maintenance and homeostasis at molecular and cellular levels, either correlates with or directly causes age-related phenotypic changes. Decline of the immune sys...
Source: Seminars in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Julia Han Noll Bruce L Levine Carl H June Joseph A Fraietta Source Type: research
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging
Semin Immunol. 2023 Sep 18;70:101840. doi: 10.1016/j.smim.2023.101840. Online ahead of print.ABSTRACTPopulation aging, a pervasive global demographic trend, is anticipated to challenge health and social systems worldwide. This phenomenon is due to medical advancements enabling longer lifespans, with 20% of the US population soon to be over 65 years old. Consequently, there will be a surge in age-related diseases. Senescence, characterized by the loss of biological maintenance and homeostasis at molecular and cellular levels, either correlates with or directly causes age-related phenotypic changes. Decline of the immune sys...
Source: Seminars in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Julia Han Noll Bruce L Levine Carl H June Joseph A Fraietta Source Type: research
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging
Semin Immunol. 2023 Sep 18;70:101840. doi: 10.1016/j.smim.2023.101840. Online ahead of print.ABSTRACTPopulation aging, a pervasive global demographic trend, is anticipated to challenge health and social systems worldwide. This phenomenon is due to medical advancements enabling longer lifespans, with 20% of the US population soon to be over 65 years old. Consequently, there will be a surge in age-related diseases. Senescence, characterized by the loss of biological maintenance and homeostasis at molecular and cellular levels, either correlates with or directly causes age-related phenotypic changes. Decline of the immune sys...
Source: Seminars in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Julia Han Noll Bruce L Levine Carl H June Joseph A Fraietta Source Type: research
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging
Semin Immunol. 2023 Sep 18;70:101840. doi: 10.1016/j.smim.2023.101840. Online ahead of print.ABSTRACTPopulation aging, a pervasive global demographic trend, is anticipated to challenge health and social systems worldwide. This phenomenon is due to medical advancements enabling longer lifespans, with 20% of the US population soon to be over 65 years old. Consequently, there will be a surge in age-related diseases. Senescence, characterized by the loss of biological maintenance and homeostasis at molecular and cellular levels, either correlates with or directly causes age-related phenotypic changes. Decline of the immune sys...
Source: Seminars in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Julia Han Noll Bruce L Levine Carl H June Joseph A Fraietta Source Type: research
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging
Semin Immunol. 2023 Sep 18;70:101840. doi: 10.1016/j.smim.2023.101840. Online ahead of print.ABSTRACTPopulation aging, a pervasive global demographic trend, is anticipated to challenge health and social systems worldwide. This phenomenon is due to medical advancements enabling longer lifespans, with 20% of the US population soon to be over 65 years old. Consequently, there will be a surge in age-related diseases. Senescence, characterized by the loss of biological maintenance and homeostasis at molecular and cellular levels, either correlates with or directly causes age-related phenotypic changes. Decline of the immune sys...
Source: Seminars in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Julia Han Noll Bruce L Levine Carl H June Joseph A Fraietta Source Type: research
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging
Semin Immunol. 2023 Sep 18;70:101840. doi: 10.1016/j.smim.2023.101840. Online ahead of print.ABSTRACTPopulation aging, a pervasive global demographic trend, is anticipated to challenge health and social systems worldwide. This phenomenon is due to medical advancements enabling longer lifespans, with 20% of the US population soon to be over 65 years old. Consequently, there will be a surge in age-related diseases. Senescence, characterized by the loss of biological maintenance and homeostasis at molecular and cellular levels, either correlates with or directly causes age-related phenotypic changes. Decline of the immune sys...
Source: Seminars in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Julia Han Noll Bruce L Levine Carl H June Joseph A Fraietta Source Type: research
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging
Semin Immunol. 2023 Sep 18;70:101840. doi: 10.1016/j.smim.2023.101840. Online ahead of print.ABSTRACTPopulation aging, a pervasive global demographic trend, is anticipated to challenge health and social systems worldwide. This phenomenon is due to medical advancements enabling longer lifespans, with 20% of the US population soon to be over 65 years old. Consequently, there will be a surge in age-related diseases. Senescence, characterized by the loss of biological maintenance and homeostasis at molecular and cellular levels, either correlates with or directly causes age-related phenotypic changes. Decline of the immune sys...
Source: Seminars in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Julia Han Noll Bruce L Levine Carl H June Joseph A Fraietta Source Type: research
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging
Semin Immunol. 2023 Sep 18;70:101840. doi: 10.1016/j.smim.2023.101840. Online ahead of print.ABSTRACTPopulation aging, a pervasive global demographic trend, is anticipated to challenge health and social systems worldwide. This phenomenon is due to medical advancements enabling longer lifespans, with 20% of the US population soon to be over 65 years old. Consequently, there will be a surge in age-related diseases. Senescence, characterized by the loss of biological maintenance and homeostasis at molecular and cellular levels, either correlates with or directly causes age-related phenotypic changes. Decline of the immune sys...
Source: Seminars in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Julia Han Noll Bruce L Levine Carl H June Joseph A Fraietta Source Type: research
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
Better safe than sorry: Naive T-cell dynamics in healthy ageing
Semin Immunol. 2023 Sep 14;70:101839. doi: 10.1016/j.smim.2023.101839. Online ahead of print.ABSTRACTIt is well-known that the functioning of the immune system gradually deteriorates with age, and we are increasingly confronted with its consequences as the life expectancy of the human population increases. Changes in the T-cell pool are among the most prominent features of the changing immune system during healthy ageing, and changes in the naive T-cell pool in particular are generally held responsible for its gradual deterioration. These changes in the naive T-cell pool are thought to be due to involution of the thymus. I...
Source: Seminars in Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Rob J de Boer Kiki Tesselaar Jos é A M Borghans Source Type: research
