Better safe than sorry: Naive T-cell dynamics in healthy ageing
Semin Immunol. 2023 Sep 14;70:101839. doi: 10.1016/j.smim.2023.101839. Online ahead of print.ABSTRACTIt is well-known that the functioning of the immune system gradually deteriorates with age, and we are increasingly confronted with its consequences as the life expectancy of the human population increases. Changes in the T-cell pool are among the most prominent features of the changing immune system during healthy ageing, and changes in the naive T-cell pool in particular are generally held responsible for its gradual deterioration. These changes in the naive T-cell pool are thought to be due to involution of the thymus. I...
Source: Seminars in Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Rob J de Boer Kiki Tesselaar Jos é A M Borghans Source Type: research
Proteostasis in T cell aging
Semin Immunol. 2023 Sep 12;70:101838. doi: 10.1016/j.smim.2023.101838. Online ahead of print.ABSTRACTAging leads to a decline in immune cell function, which leaves the organism vulnerable to infections and age-related multimorbidities. One major player of the adaptive immune response are T cells, and recent studies argue for a major role of disturbed proteostasis contributing to reduced function of these cells upon aging. Proteostasis refers to the state of a healthy, balanced proteome in the cell and is influenced by synthesis (translation), maintenance and quality control of proteins, as well as degradation of damaged or...
Source: Seminars in Immunology - September 14, 2023 Category: Allergy & Immunology Authors: A Elisabeth Gressler Houfu Leng Heidi Zinecker Anna Katharina Simon Source Type: research
Proteostasis in T cell aging
Semin Immunol. 2023 Sep 12;70:101838. doi: 10.1016/j.smim.2023.101838. Online ahead of print.ABSTRACTAging leads to a decline in immune cell function, which leaves the organism vulnerable to infections and age-related multimorbidities. One major player of the adaptive immune response are T cells, and recent studies argue for a major role of disturbed proteostasis contributing to reduced function of these cells upon aging. Proteostasis refers to the state of a healthy, balanced proteome in the cell and is influenced by synthesis (translation), maintenance and quality control of proteins, as well as degradation of damaged or...
Source: Seminars in Immunology - September 14, 2023 Category: Allergy & Immunology Authors: A Elisabeth Gressler Houfu Leng Heidi Zinecker Anna Katharina Simon Source Type: research
Epigenetic and transcriptional control of gasdermins
Semin Immunol. 2023 Sep 11;70:101841. doi: 10.1016/j.smim.2023.101841. Online ahead of print.ABSTRACTCells undergo an inflammatory programmed lytic cell death called 'pyroptosis' (with the Greek roots 'fiery'), often featuring morphological hallmarks such as large ballooning protrusions and subsequent bursting. Originally described as a caspase-1-dependent cell death in response to bacterial infection, pyroptosis has since been re-defined in 2018 as a cell death dependent on plasma membrane pores by a gasdermin (GSDM) family member [1,2]. GSDMs form pores in the plasma membrane as well as organelle membranes, thereby initi...
Source: Seminars in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Cristhian Cadena Opher S Kornfeld Bettina L Lee Nobuhiko Kayagaki Source Type: research
Epigenetic and transcriptional control of gasdermins
Semin Immunol. 2023 Sep 11;70:101841. doi: 10.1016/j.smim.2023.101841. Online ahead of print.ABSTRACTCells undergo an inflammatory programmed lytic cell death called 'pyroptosis' (with the Greek roots 'fiery'), often featuring morphological hallmarks such as large ballooning protrusions and subsequent bursting. Originally described as a caspase-1-dependent cell death in response to bacterial infection, pyroptosis has since been re-defined in 2018 as a cell death dependent on plasma membrane pores by a gasdermin (GSDM) family member [1,2]. GSDMs form pores in the plasma membrane as well as organelle membranes, thereby initi...
Source: Seminars in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Cristhian Cadena Opher S Kornfeld Bettina L Lee Nobuhiko Kayagaki Source Type: research
The paradox of aging: Aging-related shifts in T cell function and metabolism
Semin Immunol. 2023 Aug 31;70:101834. doi: 10.1016/j.smim.2023.101834. Online ahead of print.ABSTRACTT cell survival, differentiation after stimulation, and function are intrinsically linked to distinct cellular metabolic states. The ability of T cells to readily transition between metabolic states enables flexibility to meet the changing energy demands defined by distinct effector states or T cell lineages. Immune aging is characterized, in part, by the loss of naïve T cells, accumulation of senescent T cells, severe dysfunction in memory phenotype T cells in particular, and elevated levels of inflammatory cytokines, or ...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Kylie M Quinn Daniela M Vicencio Nicole L La Gruta Source Type: research
Thymus aging and immune reconstitution, progresses and challenges
Semin Immunol. 2023 Aug 31;70:101837. doi: 10.1016/j.smim.2023.101837. Online ahead of print.ABSTRACTThymus is a primary lymphoid organ essential for the development of T lymphocytes. Age-related thymic involution is a prominent feature of immune senescence. The thymus undergoes rapid growth during fetal and neonatal development, peaks in size before puberty and then begins to undergo a decrease in cellularity with age. Dramatic changes occur with age-associated thymic involution. The most prominent features of thymic involution include: (i) epithelial structure disruption, (ii) adipogenesis, and (iii) thymocyte developmen...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Yue Ru Li Juan Carlos Z úñiga-Pflücker Source Type: research
The paradox of aging: Aging-related shifts in T cell function and metabolism
Semin Immunol. 2023 Aug 31;70:101834. doi: 10.1016/j.smim.2023.101834. Online ahead of print.ABSTRACTT cell survival, differentiation after stimulation, and function are intrinsically linked to distinct cellular metabolic states. The ability of T cells to readily transition between metabolic states enables flexibility to meet the changing energy demands defined by distinct effector states or T cell lineages. Immune aging is characterized, in part, by the loss of naïve T cells, accumulation of senescent T cells, severe dysfunction in memory phenotype T cells in particular, and elevated levels of inflammatory cytokines, or ...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Kylie M Quinn Daniela M Vicencio Nicole L La Gruta Source Type: research
Thymus aging and immune reconstitution, progresses and challenges
Semin Immunol. 2023 Aug 31;70:101837. doi: 10.1016/j.smim.2023.101837. Online ahead of print.ABSTRACTThymus is a primary lymphoid organ essential for the development of T lymphocytes. Age-related thymic involution is a prominent feature of immune senescence. The thymus undergoes rapid growth during fetal and neonatal development, peaks in size before puberty and then begins to undergo a decrease in cellularity with age. Dramatic changes occur with age-associated thymic involution. The most prominent features of thymic involution include: (i) epithelial structure disruption, (ii) adipogenesis, and (iii) thymocyte developmen...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Yue Ru Li Juan Carlos Z úñiga-Pflücker Source Type: research
The paradox of aging: Aging-related shifts in T cell function and metabolism
Semin Immunol. 2023 Aug 31;70:101834. doi: 10.1016/j.smim.2023.101834. Online ahead of print.ABSTRACTT cell survival, differentiation after stimulation, and function are intrinsically linked to distinct cellular metabolic states. The ability of T cells to readily transition between metabolic states enables flexibility to meet the changing energy demands defined by distinct effector states or T cell lineages. Immune aging is characterized, in part, by the loss of naïve T cells, accumulation of senescent T cells, severe dysfunction in memory phenotype T cells in particular, and elevated levels of inflammatory cytokines, or ...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Kylie M Quinn Daniela M Vicencio Nicole L La Gruta Source Type: research
Thymus aging and immune reconstitution, progresses and challenges
Semin Immunol. 2023 Aug 31;70:101837. doi: 10.1016/j.smim.2023.101837. Online ahead of print.ABSTRACTThymus is a primary lymphoid organ essential for the development of T lymphocytes. Age-related thymic involution is a prominent feature of immune senescence. The thymus undergoes rapid growth during fetal and neonatal development, peaks in size before puberty and then begins to undergo a decrease in cellularity with age. Dramatic changes occur with age-associated thymic involution. The most prominent features of thymic involution include: (i) epithelial structure disruption, (ii) adipogenesis, and (iii) thymocyte developmen...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Yue Ru Li Juan Carlos Z úñiga-Pflücker Source Type: research
The paradox of aging: Aging-related shifts in T cell function and metabolism
Semin Immunol. 2023 Aug 31;70:101834. doi: 10.1016/j.smim.2023.101834. Online ahead of print.ABSTRACTT cell survival, differentiation after stimulation, and function are intrinsically linked to distinct cellular metabolic states. The ability of T cells to readily transition between metabolic states enables flexibility to meet the changing energy demands defined by distinct effector states or T cell lineages. Immune aging is characterized, in part, by the loss of naïve T cells, accumulation of senescent T cells, severe dysfunction in memory phenotype T cells in particular, and elevated levels of inflammatory cytokines, or ...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Kylie M Quinn Daniela M Vicencio Nicole L La Gruta Source Type: research
Thymus aging and immune reconstitution, progresses and challenges
Semin Immunol. 2023 Aug 31;70:101837. doi: 10.1016/j.smim.2023.101837. Online ahead of print.ABSTRACTThymus is a primary lymphoid organ essential for the development of T lymphocytes. Age-related thymic involution is a prominent feature of immune senescence. The thymus undergoes rapid growth during fetal and neonatal development, peaks in size before puberty and then begins to undergo a decrease in cellularity with age. Dramatic changes occur with age-associated thymic involution. The most prominent features of thymic involution include: (i) epithelial structure disruption, (ii) adipogenesis, and (iii) thymocyte developmen...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Yue Ru Li Juan Carlos Z úñiga-Pflücker Source Type: research
The paradox of aging: Aging-related shifts in T cell function and metabolism
Semin Immunol. 2023 Aug 31;70:101834. doi: 10.1016/j.smim.2023.101834. Online ahead of print.ABSTRACTT cell survival, differentiation after stimulation, and function are intrinsically linked to distinct cellular metabolic states. The ability of T cells to readily transition between metabolic states enables flexibility to meet the changing energy demands defined by distinct effector states or T cell lineages. Immune aging is characterized, in part, by the loss of naïve T cells, accumulation of senescent T cells, severe dysfunction in memory phenotype T cells in particular, and elevated levels of inflammatory cytokines, or ...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Kylie M Quinn Daniela M Vicencio Nicole L La Gruta Source Type: research
Thymus aging and immune reconstitution, progresses and challenges
Semin Immunol. 2023 Aug 31;70:101837. doi: 10.1016/j.smim.2023.101837. Online ahead of print.ABSTRACTThymus is a primary lymphoid organ essential for the development of T lymphocytes. Age-related thymic involution is a prominent feature of immune senescence. The thymus undergoes rapid growth during fetal and neonatal development, peaks in size before puberty and then begins to undergo a decrease in cellularity with age. Dramatic changes occur with age-associated thymic involution. The most prominent features of thymic involution include: (i) epithelial structure disruption, (ii) adipogenesis, and (iii) thymocyte developmen...
Source: Seminars in Immunology - September 2, 2023 Category: Allergy & Immunology Authors: Yue Ru Li Juan Carlos Z úñiga-Pflücker Source Type: research
