Pyroptosis: A road to next-generation cancer immunotherapy
Semin Immunol. 2023 Jul;68:101782. doi: 10.1016/j.smim.2023.101782. Epub 2023 Jun 9.ABSTRACTThe goal of cancer immunotherapy is to clear tumor cells by activating antitumor immunity, especially by mobilizing tumor-reactive CD8+T cells. Pyroptosis, programmed lytic cell death mediated by gasdermin (GSDM), results in the release of cellular antigens, damage-associated molecular patterns (DAMPs) and cytokines. Therefore, pyroptotic tumor cell-derived tumor antigens and DAMPs not only reverse immunosuppression of the tumor microenvironment (TME) but also enhance tumor antigen presentation by dendritic cells, leading to robust ...
Source: Seminars in Immunology - June 11, 2023 Category: Allergy & Immunology Authors: Yiliang Fang Yaxing Tang Bo Huang Source Type: research
Pyroptosis: A road to next-generation cancer immunotherapy
Semin Immunol. 2023 Jun 9;68:101782. doi: 10.1016/j.smim.2023.101782. Online ahead of print.ABSTRACTThe goal of cancer immunotherapy is to clear tumor cells by activating antitumor immunity, especially by mobilizing tumor-reactive CD8+T cells. Pyroptosis, programmed lytic cell death mediated by gasdermin (GSDM), results in the release of cellular antigens, damage-associated molecular patterns (DAMPs) and cytokines. Therefore, pyroptotic tumor cell-derived tumor antigens and DAMPs not only reverse immunosuppression of the tumor microenvironment (TME) but also enhance tumor antigen presentation by dendritic cells, leading to...
Source: Seminars in Immunology - June 11, 2023 Category: Allergy & Immunology Authors: Yiliang Fang Yaxing Tang Bo Huang Source Type: research
Pyroptosis: A road to next-generation cancer immunotherapy
Semin Immunol. 2023 Jun 9;68:101782. doi: 10.1016/j.smim.2023.101782. Online ahead of print.ABSTRACTThe goal of cancer immunotherapy is to clear tumor cells by activating antitumor immunity, especially by mobilizing tumor-reactive CD8+T cells. Pyroptosis, programmed lytic cell death mediated by gasdermin (GSDM), results in the release of cellular antigens, damage-associated molecular patterns (DAMPs) and cytokines. Therefore, pyroptotic tumor cell-derived tumor antigens and DAMPs not only reverse immunosuppression of the tumor microenvironment (TME) but also enhance tumor antigen presentation by dendritic cells, leading to...
Source: Seminars in Immunology - June 11, 2023 Category: Allergy & Immunology Authors: Yiliang Fang Yaxing Tang Bo Huang Source Type: research
How mass spectrometric interrogation of MHC class I ligandomes has advanced our understanding of immune responses to viruses
Semin Immunol. 2023 Jun 3;68:101780. doi: 10.1016/j.smim.2023.101780. Online ahead of print.NO ABSTRACTPMID:37276649 | DOI:10.1016/j.smim.2023.101780 (Source: Seminars in Immunology)
Source: Seminars in Immunology - June 5, 2023 Category: Allergy & Immunology Authors: Nicola Ternette Eleni Adamopoulou Anthony W Purcell Source Type: research
How mass spectrometric interrogation of MHC class I ligandomes has advanced our understanding of immune responses to viruses
Semin Immunol. 2023 Jun 3;68:101780. doi: 10.1016/j.smim.2023.101780. Online ahead of print.NO ABSTRACTPMID:37276649 | DOI:10.1016/j.smim.2023.101780 (Source: Seminars in Immunology)
Source: Seminars in Immunology - June 5, 2023 Category: Allergy & Immunology Authors: Nicola Ternette Eleni Adamopoulou Anthony W Purcell Source Type: research
How mass spectrometric interrogation of MHC class I ligandomes has advanced our understanding of immune responses to viruses
Semin Immunol. 2023 Jun 3;68:101780. doi: 10.1016/j.smim.2023.101780. Online ahead of print.NO ABSTRACTPMID:37276649 | DOI:10.1016/j.smim.2023.101780 (Source: Seminars in Immunology)
Source: Seminars in Immunology - June 5, 2023 Category: Allergy & Immunology Authors: Nicola Ternette Eleni Adamopoulou Anthony W Purcell Source Type: research
How mass spectrometric interrogation of MHC class I ligandomes has advanced our understanding of immune responses to viruses
Semin Immunol. 2023 Jun 3;68:101780. doi: 10.1016/j.smim.2023.101780. Online ahead of print.NO ABSTRACTPMID:37276649 | DOI:10.1016/j.smim.2023.101780 (Source: Seminars in Immunology)
Source: Seminars in Immunology - June 5, 2023 Category: Allergy & Immunology Authors: Nicola Ternette Eleni Adamopoulou Anthony W Purcell Source Type: research
How mass spectrometric interrogation of MHC class I ligandomes has advanced our understanding of immune responses to viruses
Semin Immunol. 2023 Jun 3;68:101780. doi: 10.1016/j.smim.2023.101780. Online ahead of print.NO ABSTRACTPMID:37276649 | DOI:10.1016/j.smim.2023.101780 (Source: Seminars in Immunology)
Source: Seminars in Immunology - June 5, 2023 Category: Allergy & Immunology Authors: Nicola Ternette Eleni Adamopoulou Anthony W Purcell Source Type: research
Systems analysis of human innate immunity in COVID-19
Semin Immunol. 2023 May 22;68:101778. doi: 10.1016/j.smim.2023.101778. Online ahead of print.ABSTRACTRecent developments in sequencing technologies, the computer and data sciences, as well as increasingly high-throughput immunological measurements have made it possible to derive holistic views on pathophysiological processes of disease and treatment effects directly in humans. We and others have illustrated that incredibly predictive data for immune cell function can be generated by single cell multi-omics (SCMO) technologies and that these technologies are perfectly suited to dissect pathophysiological processes in a new ...
Source: Seminars in Immunology - June 2, 2023 Category: Allergy & Immunology Authors: Sophie M üller Joachim L Schultze Source Type: research
Systems analysis of human innate immunity in COVID-19
Semin Immunol. 2023 May 22;68:101778. doi: 10.1016/j.smim.2023.101778. Online ahead of print.ABSTRACTRecent developments in sequencing technologies, the computer and data sciences, as well as increasingly high-throughput immunological measurements have made it possible to derive holistic views on pathophysiological processes of disease and treatment effects directly in humans. We and others have illustrated that incredibly predictive data for immune cell function can be generated by single cell multi-omics (SCMO) technologies and that these technologies are perfectly suited to dissect pathophysiological processes in a new ...
Source: Seminars in Immunology - June 2, 2023 Category: Allergy & Immunology Authors: Sophie M üller Joachim L Schultze Source Type: research
Systems analysis of human innate immunity in COVID-19
Semin Immunol. 2023 May 22;68:101778. doi: 10.1016/j.smim.2023.101778. Online ahead of print.ABSTRACTRecent developments in sequencing technologies, the computer and data sciences, as well as increasingly high-throughput immunological measurements have made it possible to derive holistic views on pathophysiological processes of disease and treatment effects directly in humans. We and others have illustrated that incredibly predictive data for immune cell function can be generated by single cell multi-omics (SCMO) technologies and that these technologies are perfectly suited to dissect pathophysiological processes in a new ...
Source: Seminars in Immunology - June 2, 2023 Category: Allergy & Immunology Authors: Sophie M üller Joachim L Schultze Source Type: research
From Amish farm dust to bacterial lysates: The long and winding road to protection from allergic disease
Semin Immunol. 2023 May 19;68:101779. doi: 10.1016/j.smim.2023.101779. Online ahead of print.ABSTRACTAllergic diseases typically begin in early life and can impose a heavy burden on children and their families. Effective preventive measures are currently unavailable but may be ushered in by studies on the "farm effect", the strong protection from asthma and allergy found in children born and raised on traditional farms. Two decades of epidemiologic and immunologic research have demonstrated that this protection is provided by early and intense exposure to farm-associated microbes that target primarily innate immune pathway...
Source: Seminars in Immunology - May 21, 2023 Category: Allergy & Immunology Authors: Donata Vercelli Source Type: research
From Amish farm dust to bacterial lysates: The long and winding road to protection from allergic disease
Semin Immunol. 2023 May 19;68:101779. doi: 10.1016/j.smim.2023.101779. Online ahead of print.ABSTRACTAllergic diseases typically begin in early life and can impose a heavy burden on children and their families. Effective preventive measures are currently unavailable but may be ushered in by studies on the "farm effect", the strong protection from asthma and allergy found in children born and raised on traditional farms. Two decades of epidemiologic and immunologic research have demonstrated that this protection is provided by early and intense exposure to farm-associated microbes that target primarily innate immune pathway...
Source: Seminars in Immunology - May 21, 2023 Category: Allergy & Immunology Authors: Donata Vercelli Source Type: research
From Amish farm dust to bacterial lysates: The long and winding road to protection from allergic disease
Semin Immunol. 2023 May 19;68:101779. doi: 10.1016/j.smim.2023.101779. Online ahead of print.ABSTRACTAllergic diseases typically begin in early life and can impose a heavy burden on children and their families. Effective preventive measures are currently unavailable but may be ushered in by studies on the "farm effect", the strong protection from asthma and allergy found in children born and raised on traditional farms. Two decades of epidemiologic and immunologic research have demonstrated that this protection is provided by early and intense exposure to farm-associated microbes that target primarily innate immune pathway...
Source: Seminars in Immunology - May 21, 2023 Category: Allergy & Immunology Authors: Donata Vercelli Source Type: research
From Amish farm dust to bacterial lysates: The long and winding road to protection from allergic disease
Semin Immunol. 2023 May 19;68:101779. doi: 10.1016/j.smim.2023.101779. Online ahead of print.ABSTRACTAllergic diseases typically begin in early life and can impose a heavy burden on children and their families. Effective preventive measures are currently unavailable but may be ushered in by studies on the "farm effect", the strong protection from asthma and allergy found in children born and raised on traditional farms. Two decades of epidemiologic and immunologic research have demonstrated that this protection is provided by early and intense exposure to farm-associated microbes that target primarily innate immune pathway...
Source: Seminars in Immunology - May 21, 2023 Category: Allergy & Immunology Authors: Donata Vercelli Source Type: research
