T cell control of SARS-CoV-2: When, which, and where?

Semin Immunol. 2023 Aug 29;70:101828. doi: 10.1016/j.smim.2023.101828. Online ahead of print.ABSTRACTEfficient immune protection against viruses such as SARS-CoV-2 requires the coordinated activity of innate immunity, B and T cells. Accumulating data point to a critical role for T cells not only in the clearance of established infection, but also for aborting viral replication independently of humoral immunity. Here we review the evidence supporting the contribution of antiviral T cells and consider which of their qualitative features favour efficient control of infection. We highlight how studies of SARS-CoV-2 and other coronaviridae in animals and humans have provided important lessons on the optimal timing (When), functionality and specificity (Which), and location (Where) of antiviral T cells. We discuss the clinical implications, particularly for the development of next-generation vaccines, and emphasise areas requiring further study.PMID:37651850 | DOI:10.1016/j.smim.2023.101828
Source: Seminars in Immunology - Category: Allergy & Immunology Authors: Source Type: research