Bilateral endobronchial metastases from hepatocellular carcinoma (HCC): A case report with literature review
We describe a case of a 62-year-old male who first presented with pulmonary symptoms secondary to bilateral endobronchial metastatic disease from newly diagnosed hepatocellular carcinoma. AbstractHepatocellular carcinoma presenting with endobronchial metastases is extremely rare, with less than 15 cases reported over the last 4 decades. We describe a case of a 62-year-old male who first presented with pulmonary symptoms secondary to bilateral endobronchial metastatic disease from newly diagnosed hepatocellular carcinoma. (Source: Respirology Case Reports)
Source: Respirology Case Reports - July 4, 2023 Category: Respiratory Medicine Authors: Leping Koay,
Hwei Yee Lee,
Huiying Xu,
Chee Kiang Phua Tags: CASE REPORT Source Type: research
Hypercalcemia in metastatic parathyroid carcinoma followed by hypocalcemia after resection: A case report
Parathyroid carcinoma is rare. This is a valuable case in which the serum calcium level was controlled by surgery. The patient also developed post-operative hypocalcaemia, which should be reported. AbstractA 72-year-old man was diagnosed with hypercalcaemia 13 years ago. He was diagnosed with hyperparathyroidism associated with a parathyroid tumour and surgery was performed. Postoperatively, his serum calcium levels, which had once normalized, rose again. Medical treatment for hypercalcaemia failed to control the condition. A chest computed tomography showed multiple pulmonary nodules which were diagnosed as pulmonary m...
Source: Respirology Case Reports - July 4, 2023 Category: Respiratory Medicine Authors: Takuya Ohashi,
Mitsumasa Kawago,
Yoshimitsu Hirai,
Yumi Yata,
Aya Fusamoto,
Hideto Iguchi,
Takahito Nakaya,
Megumi Kiyoi,
Miwako Miyasaka,
Mari Kawaji,
Yuki Furuta,
Yoshiharu Nishimura Tags: CASE REPORT Source Type: research
Telomere biology disorder presenting acutely with pulmonary fibrosis and hepatopulmonary syndrome in a young adult male
A 33-year-old man presented with acute dyspnoea and orthodeoxia. CT chest showed established pulmonary fibrosis in a usual interstitial pneumonia pattern and additional investigations revealed oesophageal varices and portal hypertensive gastropathy from liver cirrhosis. Telomere length testing demonstrated short telomeres (<1st percentile) with a gene panel identifying a pathogenic variant in TERT and a variant of uncertain significance in PARN. AbstractA 33-year-old man presented with acute dyspnoea and profound hypoxaemia, and had clubbing, greying of hair, orthodeoxia and fine inspiratory crackles. CT chest showed es...
Source: Respirology Case Reports - June 30, 2023 Category: Respiratory Medicine Authors: Samantha Chin ‐Yun Kung,
Olivia Dixon,
Sarah Kentwell,
Raja S. Vasireddy,
Jonathan Rodgers,
Yuming Ding,
Tony Rahman,
Caroline Tallis,
Ian A. Yang,
John A. Mackintosh Tags: CASE REPORT Source Type: research
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(Source: Respirology Case Reports)
Source: Respirology Case Reports - June 30, 2023 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research
A customized multimodality approach for prolonged air leaks (PAL) in mechanically ventilated patients
Persistent air leaks in mechanically ventilated patients can be challenging. Multimodality approach using various bronchoscopic techniques followed by pleurodesis can be game changer. AbstractARDS in general and severe COVID ARDS (CARDS) is particularly associated with high rates of barotrauma. Two cases with severe CARDS developed bilateral pneumothorax with persistent air leak (PAL). Conservative management with prolonged chest tube drainage did not help in PAL resolution and both patients continued to be on high-end ventilatory support. The course was further complicated by the presence of septic shock. The 1st patient ...
Source: Respirology Case Reports - June 28, 2023 Category: Respiratory Medicine Authors: Sameer Bansal,
Arul Furtado,
Hariprasad Kalpakam,
Chakravarthi Loknath,
Ravindra M. Mehta Tags: CASE SERIES Source Type: research
Diffuse pulmonary meningotheliomatosis
(DPM) is a rare pulmonary disease of unknown aetiology. These imaging findings are characteristic of DPM, adding to the limited number of literature reports on the rare disease. Key messageDiffuse pulmonary meningotheliomatosis (DPM) is an ultra-rare pulmonary disease characterized by innumerable bilateral minute meningothelial-like nodules, sometimes presenting a characteristic ‘cheerio-sign’ on imaging. Most patients with DPM are asymptomatic and experience no disease progression. Although little is known about its nature, DPM may be associated with pulmonary malignancies, mostly lung adenocarcinoma. (Source: Respirology Case Reports)
Source: Respirology Case Reports - June 22, 2023 Category: Respiratory Medicine Authors: Anthony Nadrous,
Sushilkumar Sonavane,
Andras Khoor,
Alejandra Yu ‐Lee Mateus,
Augustine Lee Tags: CLINICAL IMAGE Source Type: research
Pathological complete response in an advance stage IIIB non ‐small cell lung cancer secondary to neoadjuvant osimertinib targeted therapy: A case report and review of literature
The use of osimertinib as a safe and effective neoadjuvant targeted therapy for potentially resectable advance non-small cell lung carcinoma. AbstractNeoadjuvant chemotherapy is a therapeutic option for potentially resectable non-small cell lung cancer (NSCLC). The role of neoadjuvant targeted therapy (NTT) remains less explored. This case highlights the use of neoadjuvant osimertinib in a case of advanced NSCLC. A 67-year-old woman had a left lower lobe lung mass measuring 5.0 × 5.1 × 7.0 cm with an enlarged subcarinal lymph node (LN) on her positron emission tomography scan. Following biopsy, a diagnosis of ...
Source: Respirology Case Reports - June 21, 2023 Category: Respiratory Medicine Authors: Chun Ian Soo,
Diana Bee ‐Lan Ong,
Ka Kiat Chin,
Leng Cheng Sia,
Vijayan Munusamy,
Nur Husna Ibrahim,
Thian Chee Loh,
Jiunn Liang Tan,
Mau Ern Poh,
Chee Kuan Wong,
Yong Kek Pang,
Chong Kin Liam Tags: CASE REPORT Source Type: research
Paediatric foreign body aspiration and endobronchial granuloma
Paediatric foreign body aspiration may result in pulmonary complications. Both surgical and bronchoscopic intervention have been described in managing larger endobronchial lesions. In this case, complete resolution of the granulomatous lesions was achieved with conservative management. Key messagePaediatric foreign body aspiration can result in pulmonary complications including the formation of endobronchial granuloma, which can be managed conservatively or via surgical or bronchoscopic intervention. This case highlights the importance of having a high index of suspicion for foreign body aspiration in patients with persist...
Source: Respirology Case Reports - June 21, 2023 Category: Respiratory Medicine Authors: Adeline Y. L. Lim,
Sadasivam Suresh Tags: CLINICAL IMAGE Source Type: research
Endobronchial indocyanine green instillation to identify the intersegmental plane for successful segmentectomy
We describe three cases of anatomical segmentectomy (AS) using the combination of endobronchial infiltration of indocyanine green (ICG) to identify the intersegmental plane (critical for the performance of AS), and Computed Tomography (CT) guided methylene blue injection for lesion localisation. The operations were completed successfully demonstrating satisfactory post-operative outcomes including lesion resection with clear surgical margins and acceptable length of stay. We believe that endobronchial instillation of ICG and CT-guided methylene blue injection for lesion localisation show promise as a technique to complemen...
Source: Respirology Case Reports - June 20, 2023 Category: Respiratory Medicine Authors: Paul Lilburn,
Jonathan Kwan,
Jonathan Williamson,
Kevin Ho ‐Shon,
Mohammad Azari,
Michael Wilson,
Alvin Ing,
Tajalli Saghaie Tags: CASE SERIES Source Type: research
Cystic fibrosis modulator therapy can reverse cystic bronchiectasis
This report describes the reversal of cystic bronchiectasis following a year of CF modulator therapy, providing exciting new insights into the pathogenesis of bronchiectasis in CF. AbstractBronchiectasis is often considered progressive and irreversible, so cases of regression or reversal are an important step in understanding the underlying pathophysiological mechanisms. Cystic fibrosis, (CF) caused by pathogenic variants in thecystic fibrosis transmembrane conductance regulator (CFTR) gene has been a success story in personalized medicine. The recent development ofCFTR modulator therapies has revolutionized care. Dramatic...
Source: Respirology Case Reports - June 13, 2023 Category: Respiratory Medicine Authors: Peter G. Middleton,
Nicholas J. Simmonds Tags: CASE SERIES Source Type: research
Pulmonary hypertension secondary to interstitial fibrosis with pulmonary venous lesions masquerading pulmonary veno ‐occlusive disease
We present a 41-year-old man with idiopathic interstitial pneumonia and pulmonary hypertension (PH) in the setting of a non-autoimmune background whose clinical presentation masqueraded pulmonary veno-occlusive disease (PVOD). Because of no histological evidence of venous occlusion in his previous lung biopsy, phosphodiesterase type-5 inhibitor was given, resulting in sudden onset of pulmonary edema. At autopsy, there were histological features of interstitial fibrosis with occlusion of the lobular septal veins and venules. Clinical presentations of PH due to interstitial fibrosis with pulmonary venous lesions may simulate...
Source: Respirology Case Reports - June 11, 2023 Category: Respiratory Medicine Authors: Hiroki Nakayama,
Masayuki Ishida,
Hiroshi Nakaoka,
Yuki Nishimura,
Ryu ‐ichirou Imai,
Hiroki Sugane,
Hayato Hosoda,
Yoko Nakaoka,
Koji Nishida,
Shu‐ichi Seki,
Sho‐ichi Kubokawa,
Kazuya Kawai,
Naohisa Hamashige,
Yoshinori Doi Tags: CASE REPORT Source Type: research
One ‐stop‐shop: Lung cancer and pheochromocytoma diagnosed by robotic‐assisted bronchoscopy and EBUS scope on a single endoscopic event
We present a case of a lung squamous cell carcinoma diagnosed by shape-sensing robotic-assisted bronchoscopy (ssRAB), negative mediastinal and hilar staging with endobronchial ultrasound (EBUS) and transbronchial needle aspiration (TBNA), and a pheochromocytoma diagnosed through endoscopic ultrasound with bronchoscope (EUS-B) fine needle aspiration (FNA) all in the same endoscopic procedure. (Source: Respirology Case Reports)
Source: Respirology Case Reports - June 10, 2023 Category: Respiratory Medicine Authors: Anoop Koratala,
Nikitha C. Chandra,
Alejandra Yu Lee ‐Mateus,
David Abia‐Trujillo,
Britney N. Hazelett,
Janani Reisenauer,
Ryan Chadha,
Sebastian Fernandez‐Bussy Tags: CASE REPORT Source Type: research
Exploring bilateral pneumothorax leading to a rare diagnosis in a young lady
This case illustrates a young lady presented with bilateral pneumothorax, new identification of lung cysts and chylous pleural effusion leading to the diagnosis of lymphangioleiomyomatosis. Key messageBilateral pneumothorax is a rare occurrence and vigilant clinical examination is mandatory to suspect that during the presentation. This case illustrates a young lady presented with bilateral pneumothorax, new identification of lung cysts and chylous pleural effusion leading to diagnosis of lymphangioleiomyomatosis. (Source: Respirology Case Reports)
Source: Respirology Case Reports - June 9, 2023 Category: Respiratory Medicine Authors: Harshana Bandara,
Dushantha Madegedara Tags: CLINICAL IMAGE Source Type: research
Mediastinal hematoma following thrombolysis for acute pulmonary thromboembolism
We report a case of mediastinal hematoma with new onset hemodynamic compromise following thrombolysis for acute massive pulmonary embolism. Clinico-radiological features and Point of Care Ultrasound (POCUS) findings helped in the identification of the bleeding site in our case. Despite early diagnosis and timely intervention, the patient succumbed to secondary complications. (Source: Respirology Case Reports)
Source: Respirology Case Reports - June 9, 2023 Category: Respiratory Medicine Authors: Chitra Veluthat,
Uma Maheswari Krishnaswamy,
Kavitha Venkatnarayan,
Priya Ramachandran,
Uma Devaraj Tags: CASE REPORT Source Type: research
Mixed Mycobacterium kansasii and Mycobacterium smegmatis infection in an adult ‐onset immunodeficiency patient with anti‐interferon‐γ autoantibodies
In this case report, we present a newly diagnosed AIGA patient who initially presented with disseminated mycobacterial infection. PCR-based testing revealed a mixed pulmonary infection withMycobacterium kansasii andMycobacterium smegmatis, as well as disseminatedM. kansasii infection. After completing 12 months of antibiotics treatment, the infection resolved, and there was no evidence of reactivation, even in the absence of AIGA-specific treatment. AbstractAnti-interferon-gamma autoantibody (AIGA) is a rare adult-onset immunodeficiency disease that increases the risk of occult infection. Nontuberculous mycobacteria (NT...
Source: Respirology Case Reports - June 8, 2023 Category: Respiratory Medicine Authors: Yun ‐Tse Chou,
Wei‐An Liao,
Chin‐Wei Kuo Tags: CASE REPORT Source Type: research
