Cystic fibrosis modulator therapy can reverse cystic bronchiectasis
This report describes the reversal of cystic bronchiectasis following a year of CF modulator therapy, providing exciting new insights into the pathogenesis of bronchiectasis in CF. AbstractBronchiectasis is often considered progressive and irreversible, so cases of regression or reversal are an important step in understanding the underlying pathophysiological mechanisms. Cystic fibrosis, (CF) caused by pathogenic variants in thecystic fibrosis transmembrane conductance regulator (CFTR) gene has been a success story in personalized medicine. The recent development ofCFTR modulator therapies has revolutionized care. Dramatic...
Source: Respirology Case Reports - June 13, 2023 Category: Respiratory Medicine Authors: Peter G. Middleton,
Nicholas J. Simmonds Tags: CASE SERIES Source Type: research
Pulmonary hypertension secondary to interstitial fibrosis with pulmonary venous lesions masquerading pulmonary veno ‐occlusive disease
We present a 41-year-old man with idiopathic interstitial pneumonia and pulmonary hypertension (PH) in the setting of a non-autoimmune background whose clinical presentation masqueraded pulmonary veno-occlusive disease (PVOD). Because of no histological evidence of venous occlusion in his previous lung biopsy, phosphodiesterase type-5 inhibitor was given, resulting in sudden onset of pulmonary edema. At autopsy, there were histological features of interstitial fibrosis with occlusion of the lobular septal veins and venules. Clinical presentations of PH due to interstitial fibrosis with pulmonary venous lesions may simulate...
Source: Respirology Case Reports - June 11, 2023 Category: Respiratory Medicine Authors: Hiroki Nakayama,
Masayuki Ishida,
Hiroshi Nakaoka,
Yuki Nishimura,
Ryu ‐ichirou Imai,
Hiroki Sugane,
Hayato Hosoda,
Yoko Nakaoka,
Koji Nishida,
Shu‐ichi Seki,
Sho‐ichi Kubokawa,
Kazuya Kawai,
Naohisa Hamashige,
Yoshinori Doi Tags: CASE REPORT Source Type: research
One ‐stop‐shop: Lung cancer and pheochromocytoma diagnosed by robotic‐assisted bronchoscopy and EBUS scope on a single endoscopic event
We present a case of a lung squamous cell carcinoma diagnosed by shape-sensing robotic-assisted bronchoscopy (ssRAB), negative mediastinal and hilar staging with endobronchial ultrasound (EBUS) and transbronchial needle aspiration (TBNA), and a pheochromocytoma diagnosed through endoscopic ultrasound with bronchoscope (EUS-B) fine needle aspiration (FNA) all in the same endoscopic procedure. (Source: Respirology Case Reports)
Source: Respirology Case Reports - June 10, 2023 Category: Respiratory Medicine Authors: Anoop Koratala,
Nikitha C. Chandra,
Alejandra Yu Lee ‐Mateus,
David Abia‐Trujillo,
Britney N. Hazelett,
Janani Reisenauer,
Ryan Chadha,
Sebastian Fernandez‐Bussy Tags: CASE REPORT Source Type: research
Exploring bilateral pneumothorax leading to a rare diagnosis in a young lady
This case illustrates a young lady presented with bilateral pneumothorax, new identification of lung cysts and chylous pleural effusion leading to the diagnosis of lymphangioleiomyomatosis. Key messageBilateral pneumothorax is a rare occurrence and vigilant clinical examination is mandatory to suspect that during the presentation. This case illustrates a young lady presented with bilateral pneumothorax, new identification of lung cysts and chylous pleural effusion leading to diagnosis of lymphangioleiomyomatosis. (Source: Respirology Case Reports)
Source: Respirology Case Reports - June 9, 2023 Category: Respiratory Medicine Authors: Harshana Bandara,
Dushantha Madegedara Tags: CLINICAL IMAGE Source Type: research
Mediastinal hematoma following thrombolysis for acute pulmonary thromboembolism
We report a case of mediastinal hematoma with new onset hemodynamic compromise following thrombolysis for acute massive pulmonary embolism. Clinico-radiological features and Point of Care Ultrasound (POCUS) findings helped in the identification of the bleeding site in our case. Despite early diagnosis and timely intervention, the patient succumbed to secondary complications. (Source: Respirology Case Reports)
Source: Respirology Case Reports - June 9, 2023 Category: Respiratory Medicine Authors: Chitra Veluthat,
Uma Maheswari Krishnaswamy,
Kavitha Venkatnarayan,
Priya Ramachandran,
Uma Devaraj Tags: CASE REPORT Source Type: research
Mixed Mycobacterium kansasii and Mycobacterium smegmatis infection in an adult ‐onset immunodeficiency patient with anti‐interferon‐γ autoantibodies
In this case report, we present a newly diagnosed AIGA patient who initially presented with disseminated mycobacterial infection. PCR-based testing revealed a mixed pulmonary infection withMycobacterium kansasii andMycobacterium smegmatis, as well as disseminatedM. kansasii infection. After completing 12 months of antibiotics treatment, the infection resolved, and there was no evidence of reactivation, even in the absence of AIGA-specific treatment. AbstractAnti-interferon-gamma autoantibody (AIGA) is a rare adult-onset immunodeficiency disease that increases the risk of occult infection. Nontuberculous mycobacteria (NT...
Source: Respirology Case Reports - June 8, 2023 Category: Respiratory Medicine Authors: Yun ‐Tse Chou,
Wei‐An Liao,
Chin‐Wei Kuo Tags: CASE REPORT Source Type: research
Primary pulmonary lymphoma diagnosed by ultrasound ‐guided transthoracic needle biopsy
Ultrasound-guided transthoracic needle biopsy is a relatively safe procedure diagnosing subpleural pulmonary mass and has high sensitivity in the diagnosis of lung cancer. However, the usefulness in other rare malignancies is unknown. This case shows the effectiveness in diagnosing not only lung cancer but also rare malignancies including primary pulmonary lymphoma. Key messageUltrasound-guided transthoracic needle biopsy is a relatively safe procedure diagnosing subpleural pulmonary mass and has high sensitivity in the diagnosis of lung cancer. However, the usefulness in other rare malignancies is unknown. This case shows...
Source: Respirology Case Reports - June 7, 2023 Category: Respiratory Medicine Authors: Yasuhito Sekimoto,
Mitsuaki Sekiya,
Makiko Kohmaru,
Tomoko Okuma,
Manabu Tajima,
Hideaki Sato,
Kazuhisa Takahashi Tags: CLINICAL IMAGE Source Type: research
Rare T263P epidermal growth factor receptor extracellular domain mutation of advanced non ‐small cell lung cancer in a Vietnamese male patient
In this study, we first report a patient with advanced lung adenocarcinoma harbouring only a rare T263P EGFR mutation who benefited from first-line afatinib therapy in Vietnam. The patient achieved a partial response with a time-to-treatment failure of 5 months. The patient subsequently received several chemotherapy regimens as the disease progressed, with overall survival of 17 months. Non-small cell lung cancer with a rare T263P EGFR mutation responds to afatinib but has a poor prognosis. AbstractT263P mutation is one of the rareEGFR mutations located on chromosome 7p11.2, which is a change in amino acid residue at ...
Source: Respirology Case Reports - June 2, 2023 Category: Respiratory Medicine Authors: Kien Hung Do,
Tai Van Nguyen,
Tu Anh Do,
Duc Thanh Le,
Phuong Thi Bich Nguyen,
Chu Van Nguyen Tags: CASE REPORT Source Type: research
Simultaneous regression of non ‐small cell lung cancer and orbital extranodal marginal zone lymphoma with chemoradiotherapy for lung cancer
This report describes the case of a 79-year-old Japanese man diagnosed with orbital extranodal marginal zone lymphoma (EMZL) and stage IIIA lung cancer. The patient received concurrent chemoradiation for lung cancer with carboplatin/paclitaxel treatment, resulting in regression of both the lymphoma and lung cancer. AbstractThis report describes the case of a 79-year-old Japanese man diagnosed with orbital extranodal marginal zone lymphoma (EMZL) and stage IIIA lung cancer. The patient received concurrent chemoradiation for lung cancer with carboplatin/paclitaxel treatment, resulting in regression of both the lymphoma and l...
Source: Respirology Case Reports - May 31, 2023 Category: Respiratory Medicine Authors: Issei Oi,
Zentaro Saito,
Takanori Ito,
Takuma Imakita,
Osamu Kanai,
Kohei Fujita,
Hiromasa Tachibana,
Minako Mori,
Koki Morioshi,
Tadashi Mio Tags: CASE REPORT Source Type: research
Issue Information
(Source: Respirology Case Reports)
Source: Respirology Case Reports - May 31, 2023 Category: Respiratory Medicine Tags: ISSUE INFORMATION Source Type: research
Variable radiographic and histologic presentations of amiodarone ‐related interstitial lung disease and the importance of avoiding re‐exposure
Amiodarone-related interstitial lung disease may exhibit variable clinical, radiographic, and histologic presentations. Prompt discontinuation and avoiding re-exposure of the agent is important to prevent the progression and recurrence of the interstitial lung disease. AbstractAmiodarone is a commonly used antiarrhythmic agent but exhibits potential pulmonary toxicity. In this case series, we describe the clinical, radiographic, and histologic manifestations of three patients who developed interstitial lung disease (ILD) following amiodarone treatment for variable lengths of time with different dosages. The presentations o...
Source: Respirology Case Reports - May 26, 2023 Category: Respiratory Medicine Authors: I ‐Lin Tsai,
Li‐Ting Huang,
Yu‐Ting Yu,
Chung‐Ta Lee,
Tang‐Hsiu Huang Tags: CASE SERIES Source Type: research
Intrapleural findings of pulmonary light ‐chain deposition disease
Light-chain deposition disease is accompanied not only by characteristic CT findings but also by characteristic gross findings of the visceral pleura. Medical thoracoscopy could diagnose LCDD by the findings of the thoracic cavity. Key messageLight-chain deposition disease is accompanied not only by characteristic CT findings but also by characteristic gross findings of the visceral pleura. Medical thoracoscopy could diagnose LCDD by the findings of the thoracic cavity. (Source: Respirology Case Reports)
Source: Respirology Case Reports - May 25, 2023 Category: Respiratory Medicine Authors: Takashi Yamashita,
Kensuke Takei,
Yuta Matsubayashi,
Kiyomichi Mizuno,
Katsuyuki Asai Tags: CLINICAL IMAGE Source Type: research
A case of eosinophilic pneumonia induced by lettuce
We report a first case of eosinophilic pneumonia induced by lettuce in a lettuce farmer. AbstractA 56-year-old female lettuce farmer was admitted to the hospital with a low-grade fever, worsening cough, and dyspnoea. A blood test revealed eosinophilia and a high serum IgE concentration. The 3-year follow-up showed that her total IgE level increased in December, peaked in May, and suddenly decreased in August. This result was consistent with the lettuce harvest season. A chest x-ray taken on admission showed an infiltrative shadow in the upper lung field. Chest CT revealed patchy ground glass opacity on the upper lung field...
Source: Respirology Case Reports - May 25, 2023 Category: Respiratory Medicine Authors: Reina Sekiya,
Tatsuya Nagano,
Tatsuya Moriyama,
Aki Kawaguchi,
Takafumi Fukui,
Chihiro Mimura,
Yohei Kimura,
Hisashi Ohnishi,
Yoshikazu Kotani,
Yoshihiro Nishimura Tags: CASE REPORT Source Type: research
Resection of tracheal mucosa ‐associated lymphoid tissue (MALT) lymphoma by bronchoscopic high‐frequency electrosurgical snare: Case report
We herein report a case of mucosa-associated lymphoid tissue (MALT) lymphoma with tracheal metastasis from the left lower jaw that was resected with a bronchoscopic high-frequency electrosurgical snare. AbstractThere is no standard method of bronchoscopic local therapy for tracheal tumours. We herein present a case involving a 61-year-old woman who was diagnosed with tracheal mucosa-associated lymphoid tissue lymphoma and underwent resection by a bronchoscopic high-frequency electrosurgical snare. Few reports to date have described such use of high-frequency electrosurgical snares; however, they are effective for the treat...
Source: Respirology Case Reports - May 25, 2023 Category: Respiratory Medicine Authors: Satoshi Nakamura,
Yasuyuki Kishikawa,
Ai Koike,
Yuriko Takahata,
Yuki Okamatsu,
Akitaka Fujita,
Masako Arimura ‐Omori,
Taishi Harada Tags: CASE REPORT Source Type: research
Rapid onset of effect of benralizumab in a severe eosinophilic and allergic asthma patient with allergic bronchopulmonary aspergillosis
We report the case of a 65-year-old woman with combined severe eosinophilic and allergic asthma, who presented with refractory respiratory symptoms, hypereosinophilia and high immunoglobulin E (IgE) level. The patient had consistently poor Asthma Control Test (ACT) scores, despite a maximum dose of inhalation therapy. Upon further investigations, she was diagnosed with concomitant ABPA. The patient was started on oral prednisolone and itraconazole, but her symptoms persisted. She was then started on subcutaneous omalizumab, but switched to benralizumab after developing a severe allergic reaction. The patient experienced ra...
Source: Respirology Case Reports - May 25, 2023 Category: Respiratory Medicine Authors: Arvindran Alaga,
Khairil Ashraff,
Nurul Hana Din Khan Tags: CASE REPORT Source Type: research
