Intermittent nicotine access is as effective as continuous access in promoting nicotine seeking and taking in rats
ConclusionsIntermittent nicotine use is just as effective as continuous use in producing addiction-relevant behaviours, despite significantly less nicotine exposure. This has implications for modeling nicotine self-administration patterns in human smokers and resulting effects on brain and behaviour. (Source: Psychopharmacology)
Source: Psychopharmacology - February 7, 2024 Category: Psychiatry Source Type: research
Rapamycin attenuates reconsolidation of a backwards-conditioned aversive stimuli in female mice
ConclusionsOur study provides novel evidence that indirect retrieval cues are sensitive to rapamycin in female mice. The capacity to indirectly reactivate memories and render them susceptible to disruption is critical in the translation of reconsolidation-based approaches to the clinic. (Source: Psychopharmacology)
Source: Psychopharmacology - February 5, 2024 Category: Psychiatry Source Type: research
Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae
ConclusionsOur data suggest that diosgenin reverses SDS + EtOH interaction-induced behavioral changes via normalization of hypothalamic–pituitary–adrenal axis, neurochemical neurotransmissions, and inhibition of oxidative and inflammatory mediators in mice brains. (Source: Psychopharmacology)
Source: Psychopharmacology - February 5, 2024 Category: Psychiatry Source Type: research
Rapamycin attenuates reconsolidation of a backwards-conditioned aversive stimuli in female mice
ConclusionsOur study provides novel evidence that indirect retrieval cues are sensitive to rapamycin in female mice. The capacity to indirectly reactivate memories and render them susceptible to disruption is critical in the translation of reconsolidation-based approaches to the clinic. (Source: Psychopharmacology)
Source: Psychopharmacology - February 5, 2024 Category: Psychiatry Source Type: research
Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae
ConclusionsOur data suggest that diosgenin reverses SDS + EtOH interaction-induced behavioral changes via normalization of hypothalamic–pituitary–adrenal axis, neurochemical neurotransmissions, and inhibition of oxidative and inflammatory mediators in mice brains. (Source: Psychopharmacology)
Source: Psychopharmacology - February 5, 2024 Category: Psychiatry Source Type: research
Subthalamic high-frequency deep brain stimulation reduces addiction-like alcohol use and the possible negative influence of a peer presence
ConclusionsThese results highlight the influence of a peer ’s presence on escalated alcohol intake, and confirm the role of STN in addiction-like alcohol intake and in the social influence on drug consumption. (Source: Psychopharmacology)
Source: Psychopharmacology - February 3, 2024 Category: Psychiatry Source Type: research
Corydaline alleviates Parkinson ’s disease by regulating autophagy and GSK-3β phosphorylation
ConclusionCory enhanced autophagy, attenuated MPTP-induced cytotoxicity, and alleviated PD partly through the regulation of GSK-3 β phosphorylation. (Source: Psychopharmacology)
Source: Psychopharmacology - January 30, 2024 Category: Psychiatry Source Type: research
Serum indoleamine 2, 3-dioxygenase and tryptophan-2, 3-dioxygenase: potential biomarkers for the diagnosis of major depressive disorder
ConclusionThe study suggests that serum IDO and TDO may serve as novel biomarkers for diagnosing MDD. These findings may lead to a better understanding of the pathogenesis of MDD and the development of new therapeutic targets. (Source: Psychopharmacology)
Source: Psychopharmacology - January 30, 2024 Category: Psychiatry Source Type: research
Correction to: An automated group ‑housed oral fentanyl self‑administration method in mice
(Source: Psychopharmacology)
Source: Psychopharmacology - January 30, 2024 Category: Psychiatry Source Type: research
Corydaline alleviates Parkinson ’s disease by regulating autophagy and GSK-3β phosphorylation
ConclusionCory enhanced autophagy, attenuated MPTP-induced cytotoxicity, and alleviated PD partly through the regulation of GSK-3 β phosphorylation. (Source: Psychopharmacology)
Source: Psychopharmacology - January 30, 2024 Category: Psychiatry Source Type: research
Serum indoleamine 2, 3-dioxygenase and tryptophan-2, 3-dioxygenase: potential biomarkers for the diagnosis of major depressive disorder
ConclusionThe study suggests that serum IDO and TDO may serve as novel biomarkers for diagnosing MDD. These findings may lead to a better understanding of the pathogenesis of MDD and the development of new therapeutic targets. (Source: Psychopharmacology)
Source: Psychopharmacology - January 30, 2024 Category: Psychiatry Source Type: research
Correction to: An automated group ‑housed oral fentanyl self‑administration method in mice
(Source: Psychopharmacology)
Source: Psychopharmacology - January 30, 2024 Category: Psychiatry Source Type: research
