Impact of aripiprazole discontinuation in remitted major depressive disorder: a randomized placebo-controlled trial
ConclusionsDefinitive conclusions could not be drawn owing to the small sample size. This study represents a starting point for investigating the safety of aripiprazole discontinuation on recurrence in patients with MDD who have achieved remission with AATA. Future studies with appropriate sample sizes calculated based on this study are needed. (Source: Psychopharmacology)
Source: Psychopharmacology - March 28, 2024 Category: Psychiatry Source Type: research
Light Cannabis Use and the Adolescent Brain: An 8-years Longitudinal Assessment of Mental Health, Cognition, and Reward Processing
ConclusionsImpairments in reward-related brain activity and cognitive functioning do not appear to precede or succeed cannabis use (i.e., weekly, or monthly use). Cannabis-na ïve adolescents with conduct problems and more socially engaged with their peers may be at a greater risk for lighter yet persistent cannabis use in the future. (Source: Psychopharmacology)
Source: Psychopharmacology - March 26, 2024 Category: Psychiatry Source Type: research
Stimulus mediation, specificity and impact of menthol in rats trained to discriminate puffs of nicotine e-cigarette aerosol from nicotine-free aerosol
ConclusionsNicotine aerosol puffs can function as a training stimulus in rats. The stimulus effects were CNS-mediated and receptor specific. Menthol appears to enhance the stimulus effects of nicotine aerosol through a pharmacodynamic rather than pharmacokinetic mechanism. (Source: Psychopharmacology)
Source: Psychopharmacology - March 23, 2024 Category: Psychiatry Source Type: research
Efficacy of probiotic supplements in improving the symptoms of psychosis, anxiety, insomnia, and anorexia due to amphetamine and methamphetamine use: a randomized clinical trial
ConclusionsThe use of probiotics was associated with improved sleep quality, increased appetite, and increased body mass index in patients with chronic methamphetamine use. Conducting more definitive clinical trials with larger sample sizes and longer-term follow-up of cases is recommended. (Source: Psychopharmacology)
Source: Psychopharmacology - March 21, 2024 Category: Psychiatry Source Type: research
Preconception opioids interact with mouse strain to alter morphine withdrawal in the next generation
AbstractRationaleTransgenerational effects of preconception morphine exposure in female rats have been reported which suggest that epigenetic modifications triggered by female opioid exposure, even when that exposure ends several weeks prior to pregnancy, has significant ramifications for their future offspring.ObjectiveThe current study compares two mouse strains with well-established genetic variation in their response to mu opioid receptor agonists, C57BL/6J (BL6) and 129S1/svlmJ (129) to determine whether genetic background modifies the impact of preconception opioid exposure.MethodsAdolescentfemales from both strains ...
Source: Psychopharmacology - March 19, 2024 Category: Psychiatry Source Type: research
Preeclampsia as a possible risk factor for memory impairment, anxiety- and depressive-like behavior in offspring
ConclusionsThese results suggest that preeclampsia predisposes early adolescent young male offspring to develop anxiety- and depressive-like behavior as well as memory impairment in early adolescent young female offspring. (Source: Psychopharmacology)
Source: Psychopharmacology - March 19, 2024 Category: Psychiatry Source Type: research
The effects of pramipexole on motivational vigour during a saccade task: a placebo-controlled study in healthy adults
AbstractMotivation allows us to energise actions when we expect reward and is reduced in depression. This effect, termed motivational vigour, has been proposed to rely on central dopamine, with dopaminergic agents showing promise in the treatment of depression. This suggests that dopaminergic agents might act to reduce depression by increasing the effects of reward or by helping energise actions. The aim of the current study was to investigate whether the dopamine agonist pramipexole enhanced motivational vigour during a rewarded saccade task. In addition, we asked whether the effects of pramipexole on vigour differ betwee...
Source: Psychopharmacology - March 18, 2024 Category: Psychiatry Source Type: research
Long-term disruption of tissue levels of glutamate and glutamatergic neurotransmission neuromodulators, taurine and kynurenic acid induced by amphetamine
ConclusionsThe most significant changes in the tissue levels of glutamate, taurine, and kynurenic acid were seen in the CPu-L 28 days after the last dose of AMPH. The emergence of these changes exclusively after 28 days suggests that the processes initiated by AMPH use and subsequent abstinence take time to become apparent and may be enduring. This could contribute to the incubation of craving and the risk of relapse. Developing pharmacological strategies to counteract the reduction in kynurenic acid induced by psychostimulants may provide new avenues for therapy development. (Source: Psychopharmacology)
Source: Psychopharmacology - March 14, 2024 Category: Psychiatry Source Type: research
Synergistic use of deep TMS therapy with IV ketamine infusions for major depressive disorder: a pilot study
ConclusionThese results support the notion that TMS treatments yield high response rates in treatment-resistant cases; however, in this investigation there was no added benefit for including 6 sessions of IV ketamine in conjunction with TMS. Future investigations using randomized-control designs and robust outcome measures are warranted. (Source: Psychopharmacology)
Source: Psychopharmacology - March 12, 2024 Category: Psychiatry Source Type: research
Noribogaine acute administration in rats promotes wakefulness and suppresses REM sleep
AbstractIbogaine is a potent atypical psychedelic that has gained considerable attention due to its antiaddictive and antidepressant properties in preclinical and clinical studies. Previous research from our group showed that ibogaine suppresses sleep and produces an altered wakefulness state, which resembles natural REM sleep. However, after systemic administration, ibogaine is rapidly metabolized to noribogaine, which also shows antiaddictive effects but with a distinct pharmacological profile, making this drug a promising therapeutic candidate. Therefore, we still ignore whether the sleep/wake alterations depend on ibog...
Source: Psychopharmacology - March 12, 2024 Category: Psychiatry Source Type: research
The role of mGluR5 on the therapeutic effects of ketamine in Wistar rats
ConclusionsThese findings suggest that suppressed mGluR5 activity is required for the antidepressant effects of ketamine. Consequently, the antagonism of mGluR5 enhances the antidepressant effectiveness of low dose ketamine, but eliminates its anxiolytic effects. (Source: Psychopharmacology)
Source: Psychopharmacology - March 9, 2024 Category: Psychiatry Source Type: research
