Insufficient autophagy enables the nuclear factor erythroid 2-related factor 2 (NRF2) to promote ferroptosis in morphine-treated SH-SY5Y cells
ConclusionMorphine-induced ferroptosis is regulated by the opioid receptor and GPX4 rather than the xCT antiporter. NRF2-mediated ferroptosis in morphine-exposed cells may stem from increased p62-related insufficient autophagy. (Source: Psychopharmacology)
Source: Psychopharmacology - December 5, 2023 Category: Psychiatry Source Type: research
Effects of cannabidiol on fear conditioning in anxiety disorders: decreased threat expectation during retention, but no enhanced fear re-extinction
ConclusionsThe current findings provide no evidence for enhanced fear re-extinction by CBD. However, CBD acutely decreased threat expectation at retention, without affecting other indices of fear. More studies are needed to elucidate possible interactions with AD use and sex, as well as potential effects of CBD on threat expectancies. (Source: Psychopharmacology)
Source: Psychopharmacology - December 4, 2023 Category: Psychiatry Source Type: research
Abelson Helper Integration Site 1 haplotypes and peripheral blood expression associates with lithium response and immunomodulation in bipolar patients
ConclusionsOur study suggests the involvement ofAHI1 in the lithium mode of action. Moreover, mood-stabilizing treatment associated with the innate immunity-related gene expression in BD patients and only the lithium-treated BD patients showed significantly elevated expression of anti-inflammatoryIL10, suggesting lithium ’s immunomodulatory potential. (Source: Psychopharmacology)
Source: Psychopharmacology - December 1, 2023 Category: Psychiatry Source Type: research
Effects of testosterone enanthate on aggression, risk-taking, competition, mood, and other cognitive domains during 28 days of severe energy deprivation
ConclusionsExogeneous testosterone enanthate (200 mg/week) during severe energy restriction did not reliably alter the measures of cognition. Study limitations include the relatively small sample size compared to many studies of acute testosterone administration. The findings are specific to healthy males experiencing severe energy deficit and sh ould not be generalized to effects of other doses, formulations, or acute administration of endogenous testosterone or studies conducted with larger samples using tests of cognitive function designed to detect specific effects of testosterone. (Source: Psychopharmacology)
Source: Psychopharmacology - December 1, 2023 Category: Psychiatry Source Type: research
Abelson Helper Integration Site 1 haplotypes and peripheral blood expression associates with lithium response and immunomodulation in bipolar patients
ConclusionsOur study suggests the involvement ofAHI1 in the lithium mode of action. Moreover, mood-stabilizing treatment associated with the innate immunity-related gene expression in BD patients and only the lithium-treated BD patients showed significantly elevated expression of anti-inflammatoryIL10, suggesting lithium ’s immunomodulatory potential. (Source: Psychopharmacology)
Source: Psychopharmacology - December 1, 2023 Category: Psychiatry Source Type: research
Effects of testosterone enanthate on aggression, risk-taking, competition, mood, and other cognitive domains during 28 days of severe energy deprivation
ConclusionsExogeneous testosterone enanthate (200 mg/week) during severe energy restriction did not reliably alter the measures of cognition. Study limitations include the relatively small sample size compared to many studies of acute testosterone administration. The findings are specific to healthy males experiencing severe energy deficit and sh ould not be generalized to effects of other doses, formulations, or acute administration of endogenous testosterone or studies conducted with larger samples using tests of cognitive function designed to detect specific effects of testosterone. (Source: Psychopharmacology)
Source: Psychopharmacology - December 1, 2023 Category: Psychiatry Source Type: research
Se-(Methyl)-selenocysteine ameliorates blood-brain barrier disruption of focal cerebral ischemia mice via ferroptosis inhibition and tight junction upregulation in an Akt/GSK3 β-dependent manner
ConclusionThese results suggested that SeMC exerted protection against ischemic stroke, which might be attributed to activating the Akt/GSK3 β signaling pathway and increasing the nuclear translocation of Nrf2 and β-catenin, subsequently maintaining the integrity of BBB.Graphical abstract (Source: Psychopharmacology)
Source: Psychopharmacology - November 29, 2023 Category: Psychiatry Source Type: research
A practice quit model to test early efficacy of medications for alcohol use disorder in a randomized clinical trial
ConclusionsThis study reports mostly null findings, which challenges us to decompose its nuanced design to consider model refinements. Possible changes to the model include considering the requirement for intrinsic motivation for change, including a longer practice quit period, encompassing the medication administration timeframe in the practice quit period, increasing the required sample size for signal detection, and examining a post COVID-19 pandemic cohort. (Source: Psychopharmacology)
Source: Psychopharmacology - November 28, 2023 Category: Psychiatry Source Type: research
The anterior insula and its projection to amygdala nuclei modulate the abstinence-exacerbated expression of conditioned place preference
ConclusionsThese results suggest that aIC and its glutamatergic output to amygdala nuclei constitute critical neurobiological substrates mediating enhanced motivational cue reactivity during the incubation of amphetamine craving rather than contextual memory recall. Moreover, cortical NMDA receptor signaling may become sensitized during abstinence, ultimately modulating disproportioned drug seeking. (Source: Psychopharmacology)
Source: Psychopharmacology - November 27, 2023 Category: Psychiatry Source Type: research
Noradrenergic regulation of cue-guided decision making and impulsivity is doubly dissociable across frontal brain regions
ConclusionsThese data highlight a double dissociation between the behavioural effects of noradrenergic signaling across frontal regions with respect to risky choice and impulsive action. Given that the influence of noradrenergic manipulations on motor impulsivity could depend on baseline risk preference, these data also suggest that the noradrenaline system may function differently in subjects that are susceptible to the risk-promoting lure of win-associated cues. (Source: Psychopharmacology)
Source: Psychopharmacology - November 25, 2023 Category: Psychiatry Source Type: research
