Pharmaco-EEG analysis of ligands varying in selectivity for α1 subunit-containing GABAA receptors during the active phase in rats
ConclusionsOverall, these findings support the establishment of pharmaco-EEG “signatures” for identifying subtype-selective GABAA modulatorsin vivo. (Source: Psychopharmacology)
Source: Psychopharmacology - August 22, 2023 Category: Psychiatry Source Type: research
Psilocybin therapy for treatment resistant depression: prediction of clinical outcome by natural language processing
ConclusionsA machine learning algorithm using NLP and EBI accurately predicts long-term patient response, allowing rapid prognostication of personalized response to psilocybin treatment and insight into therapeutic model optimization. Further research is required to understand if language data from earlier stages in the therapeutic process hold similar predictive power. (Source: Psychopharmacology)
Source: Psychopharmacology - August 22, 2023 Category: Psychiatry Source Type: research
Sex and age differences in mice models of effort-based decision-making and anergia in depression: the role of dopamine, and cerebral-dopamine-neurotrophic-factor
AbstractMesolimbic dopamine (DA) regulates vigor in motivated behavior. While previous results have mainly been performed in male rodents, the present studies compared CD1 male and female mice in effort-based decision-making tests of motivation. These tests offered choices between several reinforcers that require different levels of effort (progressive ratio/choice task and 3-choice-T-maze task). Sweet reinforcers were used in both tasks. In the operant tasks, females worked harder as the task required more effort to access a 10% sucrose solution. Although males and females did not differ in preference for 10% vs 3% soluti...
Source: Psychopharmacology - August 18, 2023 Category: Psychiatry Source Type: research
Repeated chemogenetic activation of dopaminergic neurons induces reversible changes in baseline and amphetamine-induced behaviors
ConclusionsWe found that repeated DREADD activation of DA neurons evokes homeostatic changes that should be factored into the interpretation of chronic DREADD applications and their impact on circuit function and behavior. These effects are likely to also be seen in other neuronal systems and underscore the importance of studying neuroadaptive changes with chronic or repeated DREADD activation. (Source: Psychopharmacology)
Source: Psychopharmacology - August 18, 2023 Category: Psychiatry Source Type: research
Sex and age differences in mice models of effort-based decision-making and anergia in depression: the role of dopamine, and cerebral-dopamine-neurotrophic-factor
AbstractMesolimbic dopamine (DA) regulates vigor in motivated behavior. While previous results have mainly been performed in male rodents, the present studies compared CD1 male and female mice in effort-based decision-making tests of motivation. These tests offered choices between several reinforcers that require different levels of effort (progressive ratio/choice task and 3-choice-T-maze task). Sweet reinforcers were used in both tasks. In the operant tasks, females worked harder as the task required more effort to access a 10% sucrose solution. Although males and females did not differ in preference for 10% vs 3% soluti...
Source: Psychopharmacology - August 18, 2023 Category: Psychiatry Source Type: research
Repeated chemogenetic activation of dopaminergic neurons induces reversible changes in baseline and amphetamine-induced behaviors
ConclusionsWe found that repeated DREADD activation of DA neurons evokes homeostatic changes that should be factored into the interpretation of chronic DREADD applications and their impact on circuit function and behavior. These effects are likely to also be seen in other neuronal systems and underscore the importance of studying neuroadaptive changes with chronic or repeated DREADD activation. (Source: Psychopharmacology)
Source: Psychopharmacology - August 18, 2023 Category: Psychiatry Source Type: research
Continuous home cage monitoring of activity and sleep in mice during repeated paroxetine treatment and discontinuation
ConclusionsThis study provides the first example of how continuous non-invasive home cage monitoring can be used to detect objective behavioural changes in activity and sleep during and after drug treatment in mice. These data suggest that effects of paroxetine administration reversed soon after its discontinuation but identified an emergent change in sleep bout duration, which could be used as a biomarker in future preclinical studies to prevent or minimise SSRI discontinuation symptoms. (Source: Psychopharmacology)
Source: Psychopharmacology - August 16, 2023 Category: Psychiatry Source Type: research
Reproductive experience alters the effects of diazepam and fluoxetine on anxiety-like behaviour, fear extinction, and corticosterone levels in female rats
ConclusionsReproductive experience alters the dose responsivity and efficacy of common anti-anxiety medications in female rats. These findings highlight the importance of considering reproductive status in studies on anxiety and its treatment. (Source: Psychopharmacology)
Source: Psychopharmacology - August 15, 2023 Category: Psychiatry Source Type: research
Sprague Dawley rats from different vendors vary in the modulation of prepulse inhibition of startle (PPI) by dopamine, acetylcholine, and glutamate drugs
ConclusionsSD rats showed vendor differences in sensitivity to pharmacological modulation of PPI and startle. We encourage researchers to sample rats from separate vendors before experimentation to identify the most suited source of subjects for their specific endpoints. (Source: Psychopharmacology)
Source: Psychopharmacology - August 14, 2023 Category: Psychiatry Source Type: research
Characterization of behavioral changes in T-maze alternation from dopamine D1 agonists with different receptor coupling mechanisms
ConclusionsThese data suggest that D1 signaling bias in these two pathways (cAMP vs β-arrestin) has complex effects on cognitive processes as assessed by T-maze alternation. Understanding these mechanisms should allow the identification or discovery of D1 agonists that can provide superior cognitive enhancement. (Source: Psychopharmacology)
Source: Psychopharmacology - August 14, 2023 Category: Psychiatry Source Type: research
Sprague Dawley rats from different vendors vary in the modulation of prepulse inhibition of startle (PPI) by dopamine, acetylcholine, and glutamate drugs
ConclusionsSD rats showed vendor differences in sensitivity to pharmacological modulation of PPI and startle. We encourage researchers to sample rats from separate vendors before experimentation to identify the most suited source of subjects for their specific endpoints. (Source: Psychopharmacology)
Source: Psychopharmacology - August 14, 2023 Category: Psychiatry Source Type: research
Characterization of behavioral changes in T-maze alternation from dopamine D1 agonists with different receptor coupling mechanisms
ConclusionsThese data suggest that D1 signaling bias in these two pathways (cAMP vs β-arrestin) has complex effects on cognitive processes as assessed by T-maze alternation. Understanding these mechanisms should allow the identification or discovery of D1 agonists that can provide superior cognitive enhancement. (Source: Psychopharmacology)
Source: Psychopharmacology - August 14, 2023 Category: Psychiatry Source Type: research
