Effects of arginine vasopressin on human anxiety and associations with sex, dose, and V1a-receptor genotype
ConclusionsExogenous AVP has modest sex- and dose-dependent effects on anxiety/affect in humans. Further, allelic variation in the V1a promoter appears associated with responsiveness to AVP ’s effects and, at least in women, to stable levels of anxiety/affect. (Source: Psychopharmacology)
Source: Psychopharmacology - February 15, 2024 Category: Psychiatry Source Type: research
Distinct roles of the left and right prelimbic cortices in the modulation of ethanol consumption in male mice under acute and chronic social defeat stress
ConclusionsThe results suggest that the LPrL may play a role in inhibiting ethanol consumption induced by chronic SDS, while the RPrL may be involved in the disinhibition of ethanol consumption. (Source: Psychopharmacology)
Source: Psychopharmacology - February 13, 2024 Category: Psychiatry Source Type: research
Individual differences in GHB consumption in a new voluntary GHB self-administration model in outbred rats
Conclusion and implicationsThe GHB self-administration model was able to reflect individual susceptibility for addiction-like behavior. The reduction in long-term memory performance upon GHB self-administration calls for further research into the cognitive effects of chronic GHB use in humans. (Source: Psychopharmacology)
Source: Psychopharmacology - February 9, 2024 Category: Psychiatry Source Type: research
The impact of doxycycline on human contextual fear memory
ConclusionOur results suggest that doxycycline does not substantially attenuate contextual fear memory. This might limit its potential for clinical application. (Source: Psychopharmacology)
Source: Psychopharmacology - February 9, 2024 Category: Psychiatry Source Type: research
Individual differences in GHB consumption in a new voluntary GHB self-administration model in outbred rats
Conclusion and implicationsThe GHB self-administration model was able to reflect individual susceptibility for addiction-like behavior. The reduction in long-term memory performance upon GHB self-administration calls for further research into the cognitive effects of chronic GHB use in humans. (Source: Psychopharmacology)
Source: Psychopharmacology - February 9, 2024 Category: Psychiatry Source Type: research
The impact of doxycycline on human contextual fear memory
ConclusionOur results suggest that doxycycline does not substantially attenuate contextual fear memory. This might limit its potential for clinical application. (Source: Psychopharmacology)
Source: Psychopharmacology - February 9, 2024 Category: Psychiatry Source Type: research
Relationship between opioid cross-tolerance during buprenorphine stabilization and return to opioid use during buprenorphine dose tapering
ConclusionsIn these buprenorphine-stabilized regular heroin users, IDU is associated with attenuated ‘liking’ response (more cross-tolerance) to buprenorphine and to high-dose hydromorphone challenge and, in turn, this cross-tolerance (but not IDU) predicts faster return to opioid use. Further research should examine mechanisms that link cross-tolerance to treatment response. (Source: Psychopharmacology)
Source: Psychopharmacology - February 8, 2024 Category: Psychiatry Source Type: research
Intermittent nicotine access is as effective as continuous access in promoting nicotine seeking and taking in rats
ConclusionsIntermittent nicotine use is just as effective as continuous use in producing addiction-relevant behaviours, despite significantly less nicotine exposure. This has implications for modeling nicotine self-administration patterns in human smokers and resulting effects on brain and behaviour. (Source: Psychopharmacology)
Source: Psychopharmacology - February 7, 2024 Category: Psychiatry Source Type: research
Rapamycin attenuates reconsolidation of a backwards-conditioned aversive stimuli in female mice
ConclusionsOur study provides novel evidence that indirect retrieval cues are sensitive to rapamycin in female mice. The capacity to indirectly reactivate memories and render them susceptible to disruption is critical in the translation of reconsolidation-based approaches to the clinic. (Source: Psychopharmacology)
Source: Psychopharmacology - February 5, 2024 Category: Psychiatry Source Type: research
Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae
ConclusionsOur data suggest that diosgenin reverses SDS + EtOH interaction-induced behavioral changes via normalization of hypothalamic–pituitary–adrenal axis, neurochemical neurotransmissions, and inhibition of oxidative and inflammatory mediators in mice brains. (Source: Psychopharmacology)
Source: Psychopharmacology - February 5, 2024 Category: Psychiatry Source Type: research
Rapamycin attenuates reconsolidation of a backwards-conditioned aversive stimuli in female mice
ConclusionsOur study provides novel evidence that indirect retrieval cues are sensitive to rapamycin in female mice. The capacity to indirectly reactivate memories and render them susceptible to disruption is critical in the translation of reconsolidation-based approaches to the clinic. (Source: Psychopharmacology)
Source: Psychopharmacology - February 5, 2024 Category: Psychiatry Source Type: research
Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae
ConclusionsOur data suggest that diosgenin reverses SDS + EtOH interaction-induced behavioral changes via normalization of hypothalamic–pituitary–adrenal axis, neurochemical neurotransmissions, and inhibition of oxidative and inflammatory mediators in mice brains. (Source: Psychopharmacology)
Source: Psychopharmacology - February 5, 2024 Category: Psychiatry Source Type: research
