Expectancy for Adderall influences subjective mood and drug effects regardless of concurrent caffeine ingestion: A randomized controlled trial
ConclusionsExpectation for prescription stimulant effects influenced subjective outcomes in a sample of high-risk college students. These findings may inform expectancy challenge interventions to reduce NPS.Trial registrationClinicalTrials.gov Identifier: NCT03648684. (Source: Psychopharmacology)
Source: Psychopharmacology - September 23, 2023 Category: Psychiatry Source Type: research

Voluntary wheel running during adolescence prevents the increase in ethanol intake induced by social defeat in male mice
ConclusionsThe pre-exposure of VWR prevented the increase in consumption and motivation for ethanol induced by SD in susceptible mice. On the other hand, it appears that VWR did not exhibit any significant long-term effects on BDNF signaling, which is mainly affected in susceptible mice after ethanol intake. (Source: Psychopharmacology)
Source: Psychopharmacology - September 22, 2023 Category: Psychiatry Source Type: research

Frontostriatal circuitry and the tryptophan kynurenine pathway in major psychiatric disorders
ConclusionsThe findings suggest that KP may influence cognitive performance across psychiatric conditions via frontostriatal dysfunction. (Source: Psychopharmacology)
Source: Psychopharmacology - September 22, 2023 Category: Psychiatry Source Type: research

Voluntary wheel running during adolescence prevents the increase in ethanol intake induced by social defeat in male mice
ConclusionsThe pre-exposure of VWR prevented the increase in consumption and motivation for ethanol induced by SD in susceptible mice. On the other hand, it appears that VWR did not exhibit any significant long-term effects on BDNF signaling, which is mainly affected in susceptible mice after ethanol intake. (Source: Psychopharmacology)
Source: Psychopharmacology - September 22, 2023 Category: Psychiatry Source Type: research

Frontostriatal circuitry and the tryptophan kynurenine pathway in major psychiatric disorders
ConclusionsThe findings suggest that KP may influence cognitive performance across psychiatric conditions via frontostriatal dysfunction. (Source: Psychopharmacology)
Source: Psychopharmacology - September 22, 2023 Category: Psychiatry Source Type: research

Effect of the mGlu4 positive allosteric modulator ADX-88178 on parkinsonism, psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset
ConclusionsWhereas these results provide additional evidence of the anti-parkinsonian and anti-dyskinetic effects of mGlu4 positive allosteric modulation as an adjunct to L-DOPA, they also suggest that ADX-88178 may exacerbate dopaminergic psychosis. Further studies are needed to evaluate this possible adverse effect of mGlu4 PAMs on PD psychosis. (Source: Psychopharmacology)
Source: Psychopharmacology - September 21, 2023 Category: Psychiatry Source Type: research

MK-801 and cognitive functions: Investigating the behavioral effects of a non-competitive NMDA receptor antagonist
ConclusionDizocilpine continues to be of significant importance in preclinical research, facilitating the exploration of various procognitive therapeutic agents. However, given its potential undesirable effects, it is imperative to meticulously determine the appropriate dosages and conduct supplementary evaluations for any undesirable outcomes, which could complicate the interpretation of the findings. (Source: Psychopharmacology)
Source: Psychopharmacology - September 19, 2023 Category: Psychiatry Source Type: research

Simvastatin ameliorates synaptic plasticity impairment in chronic mild stress-induced depressed mice by modulating hippocampal NMDA receptor
ConclusionsThese findings suggest that simvastatin can improve the dysfunction of NMDAR and ameliorate hippocampal synaptic plasticity impairment in depressed mice. (Source: Psychopharmacology)
Source: Psychopharmacology - September 16, 2023 Category: Psychiatry Source Type: research

Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid
ConclusionsOur findings demonstrate that the expression of group I and group II mGlu receptors is upregulated at synapses of infant VPA rats and suggest that mGlu2/3 receptor modulation may have a therapeutic potential in ASD. (Source: Psychopharmacology)
Source: Psychopharmacology - September 14, 2023 Category: Psychiatry Source Type: research

L-Theanine adjunct to risperidone in the treatment of chronic schizophrenia inpatients: a randomized, double-blind, placebo-controlled clinical trial
ConclusionsL-Theanine adjunct to risperidone safely and tolerably outperformed adjunctive placebo for schizophrenia, and promising evidence indicated its effects on primary negative symptoms, which need to be scrutinized in further studies.Trial registrationThe study protocol was registered and published prospectively in the Iranian Registry of Clinical Trials (http://www.irct.ir; registration number: IRCT20090117001556N133) on 2020 –12-12. (Source: Psychopharmacology)
Source: Psychopharmacology - September 12, 2023 Category: Psychiatry Source Type: research

Pharmacological inhibition of plasminogen activator inhibitor-1 prevents memory deficits and reduces neuropathology in APP/PS1 mice
ConclusionOur results suggest that PAI-1 inhibition could improve memory function and reduce the accumulation of amyloid levels in APP/PS1 mice. Such effects are more prominent when TM5A15 is administered before advanced AD pathology and memory deficits occur. (Source: Psychopharmacology)
Source: Psychopharmacology - September 12, 2023 Category: Psychiatry Source Type: research