A systematic review of the role of clozapine for severe borderline personality disorder
ConclusionThere may be a role for clozapine in treating severe treatment refractory BPD, especially for those patients at high risk of suicide and frequent hospitalisations. (Source: Psychopharmacology)
Source: Psychopharmacology - August 12, 2023 Category: Psychiatry Source Type: research
Importance of additional behavioral observation in psychopharmacology: a case study on agomelatine ’s effects on feedback sensitivity in probabilistic reversal learning in rats
In this study, we evaluated the effects of single injections of 3 different doses of agomelatine (5, 10, and 40 mg/kg) on feedback sensitivity in rats. To this end, we tested 40 animals in the instrumental probabilistic reversal learning task in a Latin square design. The highest applied dose of agomelatine, prima facie, reduced the sensitivity of rats to negative feedback — an effect that can be considered antidepressant. However, additional behavioral observation dramatically changed the interpretation of the results and revealed that the perceived effect of agomelatine on sensitivity to negative feedback can actually ...
Source: Psychopharmacology - August 12, 2023 Category: Psychiatry Source Type: research
A systematic review of the role of clozapine for severe borderline personality disorder
ConclusionThere may be a role for clozapine in treating severe treatment refractory BPD, especially for those patients at high risk of suicide and frequent hospitalisations. (Source: Psychopharmacology)
Source: Psychopharmacology - August 12, 2023 Category: Psychiatry Source Type: research
Importance of additional behavioral observation in psychopharmacology: a case study on agomelatine ’s effects on feedback sensitivity in probabilistic reversal learning in rats
In this study, we evaluated the effects of single injections of 3 different doses of agomelatine (5, 10, and 40 mg/kg) on feedback sensitivity in rats. To this end, we tested 40 animals in the instrumental probabilistic reversal learning task in a Latin square design. The highest applied dose of agomelatine, prima facie, reduced the sensitivity of rats to negative feedback — an effect that can be considered antidepressant. However, additional behavioral observation dramatically changed the interpretation of the results and revealed that the perceived effect of agomelatine on sensitivity to negative feedback can actually ...
Source: Psychopharmacology - August 12, 2023 Category: Psychiatry Source Type: research
Preclinical and clinical pharmacology of brexanolone (allopregnanolone) for postpartum depression: a landmark journey from concept to clinic in neurosteroid replacement therapy
This article describes the critical role of neurosteroids in postpartum depression (PPD) and outlines the landmark pharmacological journey of brexanolone as a first-in-class neurosteroid antidepressant with significant advantages over traditional antidepressants. PPD is a neuroendocrine disorder that affects about 20% of mothers after childbirth and is characterized by symptoms including persistent sadness, fatigue, dysphoria, as well as disturbances in cognition, emotion, appetite, and sleep. The main pathology behind PPD is the postpartum reduction of neurosteroids, referred to as neurosteroid withdrawal, a concept pione...
Source: Psychopharmacology - August 11, 2023 Category: Psychiatry Source Type: research
