Biobehavioral and affective stress responses during nicotine withdrawal: Influence of regular cannabis co-use
ConclusionsThis study partially replicated earlier findings on the effects of chronic nicotine use and provided novel results regarding the influence of cannabis co-use on physiological and affective responses to stress in nicotine users during nicotine withdrawal. (Source: Psychopharmacology)
Source: Psychopharmacology - October 28, 2023 Category: Psychiatry Source Type: research
Improving behavioral deficits induced by perinatal ethanol and stress exposure in adolescent male rat progeny via maternal melatonin treatment
ConclusionIt was concluded that MT could prevent stress response and memory impairments arising from dual exposure to ethanol and stress by inhibiting OS. (Source: Psychopharmacology)
Source: Psychopharmacology - October 27, 2023 Category: Psychiatry Source Type: research
Protective effects of alpha-lipoic acid on anxiety-like behavior, memory and prevention of hippocampal oxidative stress in methamphetamine-treated rats
In this study, preventive effect of the alpha-lipoic acid on memory impairment in methamphetamine-induced neurotoxicity was investigated.MethodsWistar male rats (200 –220 g) were allocated to five groups (seven rats in each group): (1) saline + saline, (2) saline + vehicle (sunflower oil as alpha-lipoic acid solvent), (3) methamphetamine + vehicle, (4) methamphetamine + alpha-lipoic acid 10 mg/kg, and (5) methamphetamine + alpha-lipoic ac id 40 mg/kg. Rats received intraperitoneal methamphetamine repeatedly (2 × 20 mg/kg, 2 h interval). Alpha-lipoic acid was injected 30 min, 24 h, and 48 ...
Source: Psychopharmacology - October 26, 2023 Category: Psychiatry Source Type: research
Acquisition of cocaine reinforcement using fixed-ratio and concurrent choice schedules in socially housed female and male monkeys
ConclusionsThe behavioral data in females suggests that duration of social enrichment and stress can differentially impact vulnerability to cocaine reinforcement. The findings in socially housed male monkeys, using concurrent food vs. cocaine choice schedules of reinforcement, confirmed earlier social-rank differences using an FR schedule and showed that vulnerability could be modified by exposure to cocaine. (Source: Psychopharmacology)
Source: Psychopharmacology - October 26, 2023 Category: Psychiatry Source Type: research
Oral ketamine may offer a solution to the ketamine conundrum
AbstractKetamine has received considerable attention for its rapid and robust antidepressant response over the past decade. Current evidence, in clinical populations, predominantly relates to parenterally administered ketamine, which is reported to produce significant undesirable side effects, with additional concerns regarding long-term safety and abuse potential. Attempts to produce a similar drug to ketamine, without the psychotomimetic side effects, have proved elusive. Orally administered ketamine has a different pharmacological profile to parentally administered ketamine, suggesting it may be a viable alternative. Em...
Source: Psychopharmacology - October 26, 2023 Category: Psychiatry Source Type: research
Serotonin 2C receptors are also important in head-twitch responses in male mice
ConclusionThese findings showed that while 5-HT2AR is the main initiator of HTR, the 5-HT2CR also has a distinct property that renders it effective in inducing HTR in male mice. (Source: Psychopharmacology)
Source: Psychopharmacology - October 26, 2023 Category: Psychiatry Source Type: research
Protective effects of alpha-lipoic acid on anxiety-like behavior, memory and prevention of hippocampal oxidative stress in methamphetamine-treated rats
In this study, preventive effect of the alpha-lipoic acid on memory impairment in methamphetamine-induced neurotoxicity was investigated.MethodsWistar male rats (200 –220 g) were allocated to five groups (seven rats in each group): (1) saline + saline, (2) saline + vehicle (sunflower oil as alpha-lipoic acid solvent), (3) methamphetamine + vehicle, (4) methamphetamine + alpha-lipoic acid 10 mg/kg, and (5) methamphetamine + alpha-lipoic ac id 40 mg/kg. Rats received intraperitoneal methamphetamine repeatedly (2 × 20 mg/kg, 2 h interval). Alpha-lipoic acid was injected 30 min, 24 h, and 48 ...
Source: Psychopharmacology - October 26, 2023 Category: Psychiatry Source Type: research
Acquisition of cocaine reinforcement using fixed-ratio and concurrent choice schedules in socially housed female and male monkeys
ConclusionsThe behavioral data in females suggests that duration of social enrichment and stress can differentially impact vulnerability to cocaine reinforcement. The findings in socially housed male monkeys, using concurrent food vs. cocaine choice schedules of reinforcement, confirmed earlier social-rank differences using an FR schedule and showed that vulnerability could be modified by exposure to cocaine. (Source: Psychopharmacology)
Source: Psychopharmacology - October 26, 2023 Category: Psychiatry Source Type: research
Oral ketamine may offer a solution to the ketamine conundrum
AbstractKetamine has received considerable attention for its rapid and robust antidepressant response over the past decade. Current evidence, in clinical populations, predominantly relates to parenterally administered ketamine, which is reported to produce significant undesirable side effects, with additional concerns regarding long-term safety and abuse potential. Attempts to produce a similar drug to ketamine, without the psychotomimetic side effects, have proved elusive. Orally administered ketamine has a different pharmacological profile to parentally administered ketamine, suggesting it may be a viable alternative. Em...
Source: Psychopharmacology - October 26, 2023 Category: Psychiatry Source Type: research
Serotonin 2C receptors are also important in head-twitch responses in male mice
ConclusionThese findings showed that while 5-HT2AR is the main initiator of HTR, the 5-HT2CR also has a distinct property that renders it effective in inducing HTR in male mice. (Source: Psychopharmacology)
Source: Psychopharmacology - October 26, 2023 Category: Psychiatry Source Type: research
The effect of SSRIs on fear learning: a systematic review and meta-analysis
ConclusionsThis review suggests that the efficacy of SSRIs may be related to their effects on contextual fear expression and extinction to cue, rather than fear acquisition. However, these effects of SSRIs may be due to a more general inhibition of fear-related emotions. Therefore, additional meta-analyses on the effects of SSRIs on unconditioned fear responses may provide further insight into the actions of SSRIs. (Source: Psychopharmacology)
Source: Psychopharmacology - October 24, 2023 Category: Psychiatry Source Type: research
Paternal deprivation induces vigilance-avoidant behavior and accompanies sex-specific alterations in stress reactivity and central proinflammatory cytokine response in California mice (Peromyscus californicus)
ConclusionGreater social vigilance behavior was demonstrated in paternally deprived mice while they avoided social interaction with a novel same-sex conspecific; however, in response to a familiar same-sex conspecific, paternal deprivation increased social vigilance behavior but only in females. It is possible that different neurobiological mechanisms underlie these observed behavioral outcomes as sex-specific central proinflammatory cytokine and stress responsivity were observed in paternally deprived offspring. (Source: Psychopharmacology)
Source: Psychopharmacology - October 24, 2023 Category: Psychiatry Source Type: research
