Cross state-dependent memory retrieval between tramadol and ethanol: involvement of dorsal hippocampal GABAA receptors
ConclusionThe findings strongly confirmed cross-SDM between tramadol and ethanol and the critical role of dorsal hippocampal GABAA receptors in the cross-SDM between tramadol and ethanol. (Source: Psychopharmacology)
Source: Psychopharmacology - September 27, 2023 Category: Psychiatry Source Type: research
Inhibition of fatty acid binding protein-5 in the basolateral amygdala induces anxiolytic effects and accelerates fear memory extinction
ConclusionsThese findings demonstrate a novel intra-BLA FABP5 signaling mechanism regulating anxiety and fear memory behaviours, neuronal activity states, local anxiety-related molecular pathways, and functional AEA modulation. (Source: Psychopharmacology)
Source: Psychopharmacology - September 25, 2023 Category: Psychiatry Source Type: research
Expectancy for Adderall influences subjective mood and drug effects regardless of concurrent caffeine ingestion: A randomized controlled trial
ConclusionsExpectation for prescription stimulant effects influenced subjective outcomes in a sample of high-risk college students. These findings may inform expectancy challenge interventions to reduce NPS.Trial registrationClinicalTrials.gov Identifier: NCT03648684. (Source: Psychopharmacology)
Source: Psychopharmacology - September 23, 2023 Category: Psychiatry Source Type: research
Voluntary wheel running during adolescence prevents the increase in ethanol intake induced by social defeat in male mice
ConclusionsThe pre-exposure of VWR prevented the increase in consumption and motivation for ethanol induced by SD in susceptible mice. On the other hand, it appears that VWR did not exhibit any significant long-term effects on BDNF signaling, which is mainly affected in susceptible mice after ethanol intake. (Source: Psychopharmacology)
Source: Psychopharmacology - September 22, 2023 Category: Psychiatry Source Type: research
Frontostriatal circuitry and the tryptophan kynurenine pathway in major psychiatric disorders
ConclusionsThe findings suggest that KP may influence cognitive performance across psychiatric conditions via frontostriatal dysfunction. (Source: Psychopharmacology)
Source: Psychopharmacology - September 22, 2023 Category: Psychiatry Source Type: research
Voluntary wheel running during adolescence prevents the increase in ethanol intake induced by social defeat in male mice
ConclusionsThe pre-exposure of VWR prevented the increase in consumption and motivation for ethanol induced by SD in susceptible mice. On the other hand, it appears that VWR did not exhibit any significant long-term effects on BDNF signaling, which is mainly affected in susceptible mice after ethanol intake. (Source: Psychopharmacology)
Source: Psychopharmacology - September 22, 2023 Category: Psychiatry Source Type: research
Frontostriatal circuitry and the tryptophan kynurenine pathway in major psychiatric disorders
ConclusionsThe findings suggest that KP may influence cognitive performance across psychiatric conditions via frontostriatal dysfunction. (Source: Psychopharmacology)
Source: Psychopharmacology - September 22, 2023 Category: Psychiatry Source Type: research
Effect of the mGlu4 positive allosteric modulator ADX-88178 on parkinsonism, psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset
ConclusionsWhereas these results provide additional evidence of the anti-parkinsonian and anti-dyskinetic effects of mGlu4 positive allosteric modulation as an adjunct to L-DOPA, they also suggest that ADX-88178 may exacerbate dopaminergic psychosis. Further studies are needed to evaluate this possible adverse effect of mGlu4 PAMs on PD psychosis. (Source: Psychopharmacology)
Source: Psychopharmacology - September 21, 2023 Category: Psychiatry Source Type: research
MK-801 and cognitive functions: Investigating the behavioral effects of a non-competitive NMDA receptor antagonist
ConclusionDizocilpine continues to be of significant importance in preclinical research, facilitating the exploration of various procognitive therapeutic agents. However, given its potential undesirable effects, it is imperative to meticulously determine the appropriate dosages and conduct supplementary evaluations for any undesirable outcomes, which could complicate the interpretation of the findings. (Source: Psychopharmacology)
Source: Psychopharmacology - September 19, 2023 Category: Psychiatry Source Type: research
Simvastatin ameliorates synaptic plasticity impairment in chronic mild stress-induced depressed mice by modulating hippocampal NMDA receptor
ConclusionsThese findings suggest that simvastatin can improve the dysfunction of NMDAR and ameliorate hippocampal synaptic plasticity impairment in depressed mice. (Source: Psychopharmacology)
Source: Psychopharmacology - September 16, 2023 Category: Psychiatry Source Type: research
