Meta-analysis and systematic review of vesicular monoamine transporter (VMAT-2) inhibitors in schizophrenia and psychosis
ConclusionsVMAT-2 inhibitors may have antipsychotic activity and may offer promise for treatment of psychosis with the potential for a reduced risk of TD. (Source: Psychopharmacology)
Source: Psychopharmacology - January 19, 2024 Category: Psychiatry Source Type: research
Aripiprazole and its adverse effects in the form of impulsive-compulsive behaviors: A systematic review of case reports
AbstractAripiprazole is an efficacious treatment for both the positive and negative symptoms of schizophrenia and is also commonly used as a mood stabilizer. It is associated with better tolerability compared with other antipsychotics. However, there are reports of patients who experience problem gambling, hypersexuality, obsessive –compulsive symptoms, and other impulsive and/or compulsive behaviors as a result of aripiprazole administration and/or dosage increase. We aimed to do a systematic review of case reports published in this regard. After screening more than 6000 titles and abstracts in ten scientific search eng...
Source: Psychopharmacology - January 16, 2024 Category: Psychiatry Source Type: research
Pharmaco-toxicological effects of the novel tryptamine hallucinogen 5-MeO-MiPT on motor, sensorimotor, physiological, and cardiorespiratory parameters in mice —from a human poisoning case to the preclinical evidence
ConclusionsConsumption of 5-MeO-MiPT can affect the ability to perform activities and pose a risk to human health status, as the correspondence between the effects induced in mice and the symptoms occurred in the intoxication case suggests. However, our findings suggest that 5-MeO-MiPT should not be excluded from research in the psychiatric therapy field. (Source: Psychopharmacology)
Source: Psychopharmacology - January 12, 2024 Category: Psychiatry Source Type: research
Effects of social housing conditions on ethanol-induced behavioral sensitization in Swiss mice
ConclusionsThese results are consistent with the idea that higher levels of acute and sensitized ethanol stimulant effects are observed in mice housed in stressful housing conditions, such as social isolation. (Source: Psychopharmacology)
Source: Psychopharmacology - January 11, 2024 Category: Psychiatry Source Type: research
Combination strategy employing BACE1 inhibitor and memantine to boost cognitive benefits in Alzheimer ’s disease therapy
ConclusionsA combination strategy with BACE1 inhibitors and memantine may be able to increase the effectiveness of individual drugs within their safe dose range in AD therapy. (Source: Psychopharmacology)
Source: Psychopharmacology - January 10, 2024 Category: Psychiatry Source Type: research
Levels of neuronal pentraxin 2 in plasma is associated with cognitive function in patients with schizophrenia
ConclusionsThese findings indicate that NPTX2 may reveal novel aspects of disease etiology and act as a promising target for new drug development. (Source: Psychopharmacology)
Source: Psychopharmacology - January 8, 2024 Category: Psychiatry Source Type: research
Nucleus accumbens core dopamine D2 receptors are required for performance of the odor span task in male rats
ConclusionsThese findings suggest that D2 receptors in the NAc core are required for OST performance. (Source: Psychopharmacology)
Source: Psychopharmacology - January 6, 2024 Category: Psychiatry Source Type: research
Pharmacological diacylglycerol lipase inhibition impairs contextual fear extinction in mice
AbstractAcquisition and extinction of associative fear memories are critical for guiding adaptive behavioral responses to environmental threats, and dysregulation of these processes is thought to represent important neurobehavioral substrates of trauma and stress-related disorders including posttraumatic stress disorder (PTSD). Endogenous cannabinoid (eCB) signaling has been heavily implicated in the extinction of aversive fear memories and we have recently shown that pharmacological inhibition of 2-arachidonoylglycerol (2-AG) synthesis, a major eCB regulating synaptic suppression, impairs fear extinction in an auditory cu...
Source: Psychopharmacology - January 6, 2024 Category: Psychiatry Source Type: research
Nucleus accumbens core dopamine D2 receptors are required for performance of the odor span task in male rats
ConclusionsThese findings suggest that D2 receptors in the NAc core are required for OST performance. (Source: Psychopharmacology)
Source: Psychopharmacology - January 6, 2024 Category: Psychiatry Source Type: research
Pharmacological diacylglycerol lipase inhibition impairs contextual fear extinction in mice
AbstractAcquisition and extinction of associative fear memories are critical for guiding adaptive behavioral responses to environmental threats, and dysregulation of these processes is thought to represent important neurobehavioral substrates of trauma and stress-related disorders including posttraumatic stress disorder (PTSD). Endogenous cannabinoid (eCB) signaling has been heavily implicated in the extinction of aversive fear memories and we have recently shown that pharmacological inhibition of 2-arachidonoylglycerol (2-AG) synthesis, a major eCB regulating synaptic suppression, impairs fear extinction in an auditory cu...
Source: Psychopharmacology - January 6, 2024 Category: Psychiatry Source Type: research
Insight into differing decision-making strategies that underlie cognitively effort-based decision making using computational modeling in rats
ConclusionsModeling revealed the decision-making processes that are associated with cognitive effort costs, and how these differ across individuals. Reanalysis of drug data provided insight into the mechanisms through which different neurotransmitter systems impact cognitively effortful attention and decision-making processes, with relevance to multiple psychiatric disorders. (Source: Psychopharmacology)
Source: Psychopharmacology - January 3, 2024 Category: Psychiatry Source Type: research
