The neutral CB1 antagonist AM6527 reduces ethanol seeking, binge-like consumption, reinforcing, and withdrawal effects in male and female mice
ConclusionsCurrent findings support previous studies with CB1R neutral antagonist in reducing voluntary ethanol intake and seeking behavior. Based on results shown in this work, AM6527 can be developed as a first in class CB1R neutral antagonist to treat AUD in both males and females. (Source: Psychopharmacology)
Source: Psychopharmacology - November 25, 2023 Category: Psychiatry Source Type: research
Acute effects of outdoor and indoor walking on cigarette cravings, withdrawal symptoms and affective response during temporary smoking abstinence
ConclusionThe study adds to existing evidence that short bouts of indoor or outdoor exercise can help reduce cigarette cravings and increase well-being in abstinent smokers. Further studies are needed to address the potential additional effect of outdoor exercise on craving, affective states and smoking cessation. (Source: Psychopharmacology)
Source: Psychopharmacology - November 25, 2023 Category: Psychiatry Source Type: research
Noradrenergic regulation of cue-guided decision making and impulsivity is doubly dissociable across frontal brain regions
ConclusionsThese data highlight a double dissociation between the behavioural effects of noradrenergic signaling across frontal regions with respect to risky choice and impulsive action. Given that the influence of noradrenergic manipulations on motor impulsivity could depend on baseline risk preference, these data also suggest that the noradrenaline system may function differently in subjects that are susceptible to the risk-promoting lure of win-associated cues. (Source: Psychopharmacology)
Source: Psychopharmacology - November 25, 2023 Category: Psychiatry Source Type: research
The neutral CB1 antagonist AM6527 reduces ethanol seeking, binge-like consumption, reinforcing, and withdrawal effects in male and female mice
ConclusionsCurrent findings support previous studies with CB1R neutral antagonist in reducing voluntary ethanol intake and seeking behavior. Based on results shown in this work, AM6527 can be developed as a first in class CB1R neutral antagonist to treat AUD in both males and females. (Source: Psychopharmacology)
Source: Psychopharmacology - November 25, 2023 Category: Psychiatry Source Type: research
Acute effects of outdoor and indoor walking on cigarette cravings, withdrawal symptoms and affective response during temporary smoking abstinence
ConclusionThe study adds to existing evidence that short bouts of indoor or outdoor exercise can help reduce cigarette cravings and increase well-being in abstinent smokers. Further studies are needed to address the potential additional effect of outdoor exercise on craving, affective states and smoking cessation. (Source: Psychopharmacology)
Source: Psychopharmacology - November 25, 2023 Category: Psychiatry Source Type: research
Electroconvulsive therapy improves hematological inflammatory markers in bipolar disorder
ConclusionECT seems to improve the CBC-derived inflammatory markers (RDW and PDW) subsequently, improving the underlying inflammatory process in BD without disturbing PLT homeostasis which support its anti-inflammatory role in BD.Graphical Abstract (Source: Psychopharmacology)
Source: Psychopharmacology - November 24, 2023 Category: Psychiatry Source Type: research
Neurobehavioral protective effects of Japanese sake yeast supplement against chronic stress-induced anxiety and depression-like symptoms in mice: Possible role of central adenosine receptors
ConclusionsWe conclude that oral sake yeast supplement exerts a neurobehavioral protective effect predominantly by activating central A1Rs. (Source: Psychopharmacology)
Source: Psychopharmacology - November 23, 2023 Category: Psychiatry Source Type: research
Sex-specific effects of neuromodulatory drugs on normal and stress-induced social dominance and aggression in rats
ConclusionThese results showed that Risperidone has stronger effects on male social behavior whereas Paroxetine and Donepezil differentially affect social abilities in both sexes during normal and stressed situations. (Source: Psychopharmacology)
Source: Psychopharmacology - November 23, 2023 Category: Psychiatry Source Type: research
Supraphysiological testosterone levels from anabolic steroid use and reduced sensitivity to negative facial expressions in men
ConclusionsOur findings demonstrate impaired facial emotion recognition among men currently using AAS compared to controls. While further studies are needed to investigate potential mechanisms, our analysis did not support a simple mediation effect of serum FTI. (Source: Psychopharmacology)
Source: Psychopharmacology - November 22, 2023 Category: Psychiatry Source Type: research
Neural underpinnings of response inhibition in substance use disorders: weak meta-analytic evidence for a widely used construct
ConclusionWe discuss that the role of task-based response inhibition may require some refinement as an overarching marker for SUD pathology. Finally, we give a few prospects for future research that should be further explored in this context. (Source: Psychopharmacology)
Source: Psychopharmacology - November 21, 2023 Category: Psychiatry Source Type: research
Removal of the ovaries suppresses ethanol drinking and promotes aversion-resistance in C57BL/6J female mice
ConclusionsThese results indicate that circulating ovarian hormones may be protective against the development of aversion-resistant EtOH drinking and call for further investigation of the role of ovarian hormones in models of addictive behavior. (Source: Psychopharmacology)
Source: Psychopharmacology - November 17, 2023 Category: Psychiatry Source Type: research
Alkoxy chain length governs the potency of 2-benzylbenzimidazole ‘nitazene’ opioids associated with human overdose
ConclusionsOverall, our data show that certain nitazene NSOs are more potent than fentanyl as MOR agonists in mice, highlighting concerns regarding the high potential for overdose in humans who are exposed to these compounds. (Source: Psychopharmacology)
Source: Psychopharmacology - November 17, 2023 Category: Psychiatry Source Type: research
Norepinephrine depletion in the brain sex-dependently modulates aspects of spatial learning and memory in female and male rats
ConclusionsDespite significantly reducing levels of norepinephrine, DSP-4 had only a modest impact on spatial learning and behavioral flexibility. Memory retrieval and early reversal learning were most affected and in a sex-specific manner. These data suggest that norepinephrine has sex-specific neuromodulatory effects on memory retrieval with a lesser effect on cognitive flexibility and no impact on acquisition of learned behavior. (Source: Psychopharmacology)
Source: Psychopharmacology - November 17, 2023 Category: Psychiatry Source Type: research
