Norepinephrine depletion in the brain sex-dependently modulates aspects of spatial learning and memory in female and male rats

ConclusionsDespite significantly reducing levels of norepinephrine, DSP-4 had only a modest impact on spatial learning and behavioral flexibility. Memory retrieval and early reversal learning were most affected and in a sex-specific manner. These data suggest that norepinephrine has sex-specific neuromodulatory effects on memory retrieval with a lesser effect on cognitive flexibility and no impact on acquisition of learned behavior.

Source: Psychopharmacology - November 17, 2023 Category: Psychiatry Source Type: research