Effects of fentanyl self-administration on risk-taking behavior in male rats
ConclusionsResults from the current study reveal that the synthetic opioid fentanyl leads to long-lasting increases in risk taking in male rats. Future experiments will extend this work to females and identify neural mechanisms that underlie these drug-induced changes in risk taking. (Source: Psychopharmacology)
Source: Psychopharmacology - August 23, 2023 Category: Psychiatry Source Type: research
Potential antidepressant-like effects of N-3 polyunsaturated fatty acids through inhibition of endoplasmic reticulum stress
ConclusionCUMS-induced depressive-like behaviors are related to the disturbance of ERS. Furthermore, supplementary N-3 PUFAs might be an effective way to alleviate ERS. (Source: Psychopharmacology)
Source: Psychopharmacology - August 23, 2023 Category: Psychiatry Source Type: research
Effects of fentanyl self-administration on risk-taking behavior in male rats
ConclusionsResults from the current study reveal that the synthetic opioid fentanyl leads to long-lasting increases in risk taking in male rats. Future experiments will extend this work to females and identify neural mechanisms that underlie these drug-induced changes in risk taking. (Source: Psychopharmacology)
Source: Psychopharmacology - August 23, 2023 Category: Psychiatry Source Type: research
The efficacy and tolerability of inhaled nitrous oxide in major depressive disorder: a systematic review and meta-analysis
ConclusionOur study suggested that N2O has a rapid and long-lasting antidepressant effect in patients with MDD. However, the efficacy of lower or titrated concentration of N2O should be further investigated. (Source: Psychopharmacology)
Source: Psychopharmacology - August 23, 2023 Category: Psychiatry Source Type: research
Potential antidepressant-like effects of N-3 polyunsaturated fatty acids through inhibition of endoplasmic reticulum stress
ConclusionCUMS-induced depressive-like behaviors are related to the disturbance of ERS. Furthermore, supplementary N-3 PUFAs might be an effective way to alleviate ERS. (Source: Psychopharmacology)
Source: Psychopharmacology - August 23, 2023 Category: Psychiatry Source Type: research
The efficacy and tolerability of inhaled nitrous oxide in major depressive disorder: a systematic review and meta-analysis
ConclusionOur study suggested that N2O has a rapid and long-lasting antidepressant effect in patients with MDD. However, the efficacy of lower or titrated concentration of N2O should be further investigated. (Source: Psychopharmacology)
Source: Psychopharmacology - August 23, 2023 Category: Psychiatry Source Type: research
Psilocybin therapy for treatment resistant depression: prediction of clinical outcome by natural language processing
ConclusionsA machine learning algorithm using NLP and EBI accurately predicts long-term patient response, allowing rapid prognostication of personalized response to psilocybin treatment and insight into therapeutic model optimization. Further research is required to understand if language data from earlier stages in the therapeutic process hold similar predictive power. (Source: Psychopharmacology)
Source: Psychopharmacology - August 22, 2023 Category: Psychiatry Source Type: research
Pharmaco-EEG analysis of ligands varying in selectivity for α1 subunit-containing GABAA receptors during the active phase in rats
ConclusionsOverall, these findings support the establishment of pharmaco-EEG “signatures” for identifying subtype-selective GABAA modulatorsin vivo. (Source: Psychopharmacology)
Source: Psychopharmacology - August 22, 2023 Category: Psychiatry Source Type: research
Psilocybin therapy for treatment resistant depression: prediction of clinical outcome by natural language processing
ConclusionsA machine learning algorithm using NLP and EBI accurately predicts long-term patient response, allowing rapid prognostication of personalized response to psilocybin treatment and insight into therapeutic model optimization. Further research is required to understand if language data from earlier stages in the therapeutic process hold similar predictive power. (Source: Psychopharmacology)
Source: Psychopharmacology - August 22, 2023 Category: Psychiatry Source Type: research
Sex and age differences in mice models of effort-based decision-making and anergia in depression: the role of dopamine, and cerebral-dopamine-neurotrophic-factor
AbstractMesolimbic dopamine (DA) regulates vigor in motivated behavior. While previous results have mainly been performed in male rodents, the present studies compared CD1 male and female mice in effort-based decision-making tests of motivation. These tests offered choices between several reinforcers that require different levels of effort (progressive ratio/choice task and 3-choice-T-maze task). Sweet reinforcers were used in both tasks. In the operant tasks, females worked harder as the task required more effort to access a 10% sucrose solution. Although males and females did not differ in preference for 10% vs 3% soluti...
Source: Psychopharmacology - August 18, 2023 Category: Psychiatry Source Type: research
Repeated chemogenetic activation of dopaminergic neurons induces reversible changes in baseline and amphetamine-induced behaviors
ConclusionsWe found that repeated DREADD activation of DA neurons evokes homeostatic changes that should be factored into the interpretation of chronic DREADD applications and their impact on circuit function and behavior. These effects are likely to also be seen in other neuronal systems and underscore the importance of studying neuroadaptive changes with chronic or repeated DREADD activation. (Source: Psychopharmacology)
Source: Psychopharmacology - August 18, 2023 Category: Psychiatry Source Type: research
Sex and age differences in mice models of effort-based decision-making and anergia in depression: the role of dopamine, and cerebral-dopamine-neurotrophic-factor
AbstractMesolimbic dopamine (DA) regulates vigor in motivated behavior. While previous results have mainly been performed in male rodents, the present studies compared CD1 male and female mice in effort-based decision-making tests of motivation. These tests offered choices between several reinforcers that require different levels of effort (progressive ratio/choice task and 3-choice-T-maze task). Sweet reinforcers were used in both tasks. In the operant tasks, females worked harder as the task required more effort to access a 10% sucrose solution. Although males and females did not differ in preference for 10% vs 3% soluti...
Source: Psychopharmacology - August 18, 2023 Category: Psychiatry Source Type: research
Repeated chemogenetic activation of dopaminergic neurons induces reversible changes in baseline and amphetamine-induced behaviors
ConclusionsWe found that repeated DREADD activation of DA neurons evokes homeostatic changes that should be factored into the interpretation of chronic DREADD applications and their impact on circuit function and behavior. These effects are likely to also be seen in other neuronal systems and underscore the importance of studying neuroadaptive changes with chronic or repeated DREADD activation. (Source: Psychopharmacology)
Source: Psychopharmacology - August 18, 2023 Category: Psychiatry Source Type: research
