SIRT7: the seventh key to unlocking the mystery of aging
Physiol Rev. 2023 Sep 7. doi: 10.1152/physrev.00044.2022. Online ahead of print.ABSTRACTAging is a chronic yet natural physiological decline of the body. Throughout the life, humans are continuously exposed to a variety of exogenous and endogenous stresses, to which they engender various counteractive responses at the cellular, tissue, organ, as well as organismal levels. The compromised cellular and tissue functions, which occur due to genetic factors or prolonged stress (or even the stress response), may accelerate aging. Over the last two decades, the sirtuin (SIRT) family of lysine deacylases has emerged as a key regul...
Source: Physiological Reviews - September 7, 2023 Category: Physiology Authors: Umar Raza Xiaolong Tang Zuojun Liu Baohua Liu Source Type: research
SIRT7: the seventh key to unlocking the mystery of aging
Physiol Rev. 2023 Sep 7. doi: 10.1152/physrev.00044.2022. Online ahead of print.ABSTRACTAging is a chronic yet natural physiological decline of the body. Throughout the life, humans are continuously exposed to a variety of exogenous and endogenous stresses, to which they engender various counteractive responses at the cellular, tissue, organ, as well as organismal levels. The compromised cellular and tissue functions, which occur due to genetic factors or prolonged stress (or even the stress response), may accelerate aging. Over the last two decades, the sirtuin (SIRT) family of lysine deacylases has emerged as a key regul...
Source: Physiological Reviews - September 7, 2023 Category: Physiology Authors: Umar Raza Xiaolong Tang Zuojun Liu Baohua Liu Source Type: research
SIRT7: the seventh key to unlocking the mystery of aging
Physiol Rev. 2023 Sep 7. doi: 10.1152/physrev.00044.2022. Online ahead of print.ABSTRACTAging is a chronic yet natural physiological decline of the body. Throughout the life, humans are continuously exposed to a variety of exogenous and endogenous stresses, to which they engender various counteractive responses at the cellular, tissue, organ, as well as organismal levels. The compromised cellular and tissue functions, which occur due to genetic factors or prolonged stress (or even the stress response), may accelerate aging. Over the last two decades, the sirtuin (SIRT) family of lysine deacylases has emerged as a key regul...
Source: Physiological Reviews - September 7, 2023 Category: Physiology Authors: Umar Raza Xiaolong Tang Zuojun Liu Baohua Liu Source Type: research
SIRT7: the seventh key to unlocking the mystery of aging
Physiol Rev. 2023 Sep 7. doi: 10.1152/physrev.00044.2022. Online ahead of print.ABSTRACTAging is a chronic yet natural physiological decline of the body. Throughout the life, humans are continuously exposed to a variety of exogenous and endogenous stresses, to which they engender various counteractive responses at the cellular, tissue, organ, as well as organismal levels. The compromised cellular and tissue functions, which occur due to genetic factors or prolonged stress (or even the stress response), may accelerate aging. Over the last two decades, the sirtuin (SIRT) family of lysine deacylases has emerged as a key regul...
Source: Physiological Reviews - September 7, 2023 Category: Physiology Authors: Umar Raza Xiaolong Tang Zuojun Liu Baohua Liu Source Type: research
SIRT7: the seventh key to unlocking the mystery of aging
Physiol Rev. 2023 Sep 7. doi: 10.1152/physrev.00044.2022. Online ahead of print.ABSTRACTAging is a chronic yet natural physiological decline of the body. Throughout the life, humans are continuously exposed to a variety of exogenous and endogenous stresses, to which they engender various counteractive responses at the cellular, tissue, organ, as well as organismal levels. The compromised cellular and tissue functions, which occur due to genetic factors or prolonged stress (or even the stress response), may accelerate aging. Over the last two decades, the sirtuin (SIRT) family of lysine deacylases has emerged as a key regul...
Source: Physiological Reviews - September 7, 2023 Category: Physiology Authors: Umar Raza Xiaolong Tang Zuojun Liu Baohua Liu Source Type: research
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
Physiol Rev. 2023 Aug 24. doi: 10.1152/physrev.00014.2022. Online ahead of print.ABSTRACTCell excitability and its modulation by hormones and neurotransmitters involve the concerted action of membrane proteins, especially ion channels. Unique complements of co-expressed ion channels are exquisitely balanced against each other in different excitable cell types, establishing distinct electrical properties that are tailored for diverse physiological contributions, and dysfunction of any component may induce a disease state. A crucial parameter controlling cell excitability is the resting membrane potential (RMP) set by extra-...
Source: Physiological Reviews - August 24, 2023 Category: Physiology Authors: Arnaud Monteil Nathalie C Gu érineau Antonio Gil-Nagel Paloma Parra-Diaz Philippe Lory Adriano Senatore Source Type: research
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
Physiol Rev. 2023 Aug 24. doi: 10.1152/physrev.00014.2022. Online ahead of print.ABSTRACTCell excitability and its modulation by hormones and neurotransmitters involve the concerted action of membrane proteins, especially ion channels. Unique complements of co-expressed ion channels are exquisitely balanced against each other in different excitable cell types, establishing distinct electrical properties that are tailored for diverse physiological contributions, and dysfunction of any component may induce a disease state. A crucial parameter controlling cell excitability is the resting membrane potential (RMP) set by extra-...
Source: Physiological Reviews - August 24, 2023 Category: Physiology Authors: Arnaud Monteil Nathalie C Gu érineau Antonio Gil-Nagel Paloma Parra-Diaz Philippe Lory Adriano Senatore Source Type: research
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
Physiol Rev. 2023 Aug 24. doi: 10.1152/physrev.00014.2022. Online ahead of print.ABSTRACTCell excitability and its modulation by hormones and neurotransmitters involve the concerted action of membrane proteins, especially ion channels. Unique complements of co-expressed ion channels are exquisitely balanced against each other in different excitable cell types, establishing distinct electrical properties that are tailored for diverse physiological contributions, and dysfunction of any component may induce a disease state. A crucial parameter controlling cell excitability is the resting membrane potential (RMP) set by extra-...
Source: Physiological Reviews - August 24, 2023 Category: Physiology Authors: Arnaud Monteil Nathalie C Gu érineau Antonio Gil-Nagel Paloma Parra-Diaz Philippe Lory Adriano Senatore Source Type: research
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
Physiol Rev. 2023 Aug 24. doi: 10.1152/physrev.00014.2022. Online ahead of print.ABSTRACTCell excitability and its modulation by hormones and neurotransmitters involve the concerted action of membrane proteins, especially ion channels. Unique complements of co-expressed ion channels are exquisitely balanced against each other in different excitable cell types, establishing distinct electrical properties that are tailored for diverse physiological contributions, and dysfunction of any component may induce a disease state. A crucial parameter controlling cell excitability is the resting membrane potential (RMP) set by extra-...
Source: Physiological Reviews - August 24, 2023 Category: Physiology Authors: Arnaud Monteil Nathalie C Gu érineau Antonio Gil-Nagel Paloma Parra-Diaz Philippe Lory Adriano Senatore Source Type: research
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
Physiol Rev. 2023 Aug 24. doi: 10.1152/physrev.00014.2022. Online ahead of print.ABSTRACTCell excitability and its modulation by hormones and neurotransmitters involve the concerted action of membrane proteins, especially ion channels. Unique complements of co-expressed ion channels are exquisitely balanced against each other in different excitable cell types, establishing distinct electrical properties that are tailored for diverse physiological contributions, and dysfunction of any component may induce a disease state. A crucial parameter controlling cell excitability is the resting membrane potential (RMP) set by extra-...
Source: Physiological Reviews - August 24, 2023 Category: Physiology Authors: Arnaud Monteil Nathalie C Gu érineau Antonio Gil-Nagel Paloma Parra-Diaz Philippe Lory Adriano Senatore Source Type: research
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
Physiol Rev. 2023 Aug 24. doi: 10.1152/physrev.00014.2022. Online ahead of print.ABSTRACTCell excitability and its modulation by hormones and neurotransmitters involve the concerted action of membrane proteins, especially ion channels. Unique complements of co-expressed ion channels are exquisitely balanced against each other in different excitable cell types, establishing distinct electrical properties that are tailored for diverse physiological contributions, and dysfunction of any component may induce a disease state. A crucial parameter controlling cell excitability is the resting membrane potential (RMP) set by extra-...
Source: Physiological Reviews - August 24, 2023 Category: Physiology Authors: Arnaud Monteil Nathalie C Gu érineau Antonio Gil-Nagel Paloma Parra-Diaz Philippe Lory Adriano Senatore Source Type: research
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
Physiol Rev. 2023 Aug 24. doi: 10.1152/physrev.00014.2022. Online ahead of print.ABSTRACTCell excitability and its modulation by hormones and neurotransmitters involve the concerted action of membrane proteins, especially ion channels. Unique complements of co-expressed ion channels are exquisitely balanced against each other in different excitable cell types, establishing distinct electrical properties that are tailored for diverse physiological contributions, and dysfunction of any component may induce a disease state. A crucial parameter controlling cell excitability is the resting membrane potential (RMP) set by extra-...
Source: Physiological Reviews - August 24, 2023 Category: Physiology Authors: Arnaud Monteil Nathalie C Gu érineau Antonio Gil-Nagel Paloma Parra-Diaz Philippe Lory Adriano Senatore Source Type: research
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
Physiol Rev. 2023 Aug 24. doi: 10.1152/physrev.00014.2022. Online ahead of print.ABSTRACTCell excitability and its modulation by hormones and neurotransmitters involve the concerted action of membrane proteins, especially ion channels. Unique complements of co-expressed ion channels are exquisitely balanced against each other in different excitable cell types, establishing distinct electrical properties that are tailored for diverse physiological contributions, and dysfunction of any component may induce a disease state. A crucial parameter controlling cell excitability is the resting membrane potential (RMP) set by extra-...
Source: Physiological Reviews - August 24, 2023 Category: Physiology Authors: Arnaud Monteil Nathalie C Gu érineau Antonio Gil-Nagel Paloma Parra-Diaz Philippe Lory Adriano Senatore Source Type: research
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
Physiol Rev. 2023 Aug 24. doi: 10.1152/physrev.00014.2022. Online ahead of print.ABSTRACTCell excitability and its modulation by hormones and neurotransmitters involve the concerted action of membrane proteins, especially ion channels. Unique complements of co-expressed ion channels are exquisitely balanced against each other in different excitable cell types, establishing distinct electrical properties that are tailored for diverse physiological contributions, and dysfunction of any component may induce a disease state. A crucial parameter controlling cell excitability is the resting membrane potential (RMP) set by extra-...
Source: Physiological Reviews - August 24, 2023 Category: Physiology Authors: Arnaud Monteil Nathalie C Gu érineau Antonio Gil-Nagel Paloma Parra-Diaz Philippe Lory Adriano Senatore Source Type: research
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
Physiol Rev. 2023 Aug 24. doi: 10.1152/physrev.00014.2022. Online ahead of print.ABSTRACTCell excitability and its modulation by hormones and neurotransmitters involve the concerted action of membrane proteins, especially ion channels. Unique complements of co-expressed ion channels are exquisitely balanced against each other in different excitable cell types, establishing distinct electrical properties that are tailored for diverse physiological contributions, and dysfunction of any component may induce a disease state. A crucial parameter controlling cell excitability is the resting membrane potential (RMP) set by extra-...
Source: Physiological Reviews - August 24, 2023 Category: Physiology Authors: Arnaud Monteil Nathalie C Gu érineau Antonio Gil-Nagel Paloma Parra-Diaz Philippe Lory Adriano Senatore Source Type: research
