New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
Physiol Rev. 2023 Aug 24. doi: 10.1152/physrev.00014.2022. Online ahead of print.ABSTRACTCell excitability and its modulation by hormones and neurotransmitters involve the concerted action of membrane proteins, especially ion channels. Unique complements of co-expressed ion channels are exquisitely balanced against each other in different excitable cell types, establishing distinct electrical properties that are tailored for diverse physiological contributions, and dysfunction of any component may induce a disease state. A crucial parameter controlling cell excitability is the resting membrane potential (RMP) set by extra-...
Source: Physiological Reviews - August 24, 2023 Category: Physiology Authors: Arnaud Monteil Adriano Senatore Antonio Gil-Nagel Paloma Parra-Diaz Philippe Lory Nathalie C Gu érineau Source Type: research
Community-Acquired Bacterial Co-infections and COVID-19
Physiol Rev. 2023 Aug 17. doi: 10.1152/physrev.00010.2023. Online ahead of print.NO ABSTRACTPMID:37589392 | DOI:10.1152/physrev.00010.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - August 17, 2023 Category: Physiology Authors: Michael John Patton Amit Gaggar Matthew Might Nathaniel Erdmann Carlos J Orihuela Kevin S Harrod Source Type: research
Mesenchymal stromal cells for improvement of cardiac function following acute myocardial infarction: a matter of timing
Physiol Rev. 2023 Aug 17. doi: 10.1152/physrev.00009.2023. Online ahead of print.ABSTRACTAcute myocardial infarction (AMI) is the leading cause of cardiovascular death and remains the most common cause of heart failure (HF). Re-opening of the occluded artery i.e., reperfusion, is the only way to save the myocardium. However, the expected benefits on infarct size are disappointing due to the reperfusion paradox, which also induces specific cell death. These ischemia-reperfusion (IR) lesions can account for up to 50% of final infarct size, a major determinant for both mortality and the risk of heart failure (morbidity). In t...
Source: Physiological Reviews - August 17, 2023 Category: Physiology Authors: St éphanie Barrère-Lemaire Anne Vincent Christian Jorgensen Christophe Piot Jo ël Nargeot Farida Djouad Source Type: research
Community-Acquired Bacterial Co-infections and COVID-19
Physiol Rev. 2023 Aug 17. doi: 10.1152/physrev.00010.2023. Online ahead of print.NO ABSTRACTPMID:37589392 | DOI:10.1152/physrev.00010.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - August 17, 2023 Category: Physiology Authors: Michael John Patton Amit Gaggar Matthew Might Nathaniel Erdmann Carlos J Orihuela Kevin S Harrod Source Type: research
Mesenchymal stromal cells for improvement of cardiac function following acute myocardial infarction: a matter of timing
Physiol Rev. 2023 Aug 17. doi: 10.1152/physrev.00009.2023. Online ahead of print.ABSTRACTAcute myocardial infarction (AMI) is the leading cause of cardiovascular death and remains the most common cause of heart failure (HF). Re-opening of the occluded artery i.e., reperfusion, is the only way to save the myocardium. However, the expected benefits on infarct size are disappointing due to the reperfusion paradox, which also induces specific cell death. These ischemia-reperfusion (IR) lesions can account for up to 50% of final infarct size, a major determinant for both mortality and the risk of heart failure (morbidity). In t...
Source: Physiological Reviews - August 17, 2023 Category: Physiology Authors: St éphanie Barrère-Lemaire Anne Vincent Christian Jorgensen Christophe Piot Jo ël Nargeot Farida Djouad Source Type: research
Community-Acquired Bacterial Co-infections and COVID-19
Physiol Rev. 2023 Aug 17. doi: 10.1152/physrev.00010.2023. Online ahead of print.NO ABSTRACTPMID:37589392 | DOI:10.1152/physrev.00010.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - August 17, 2023 Category: Physiology Authors: Michael John Patton Amit Gaggar Matthew Might Nathaniel Erdmann Carlos J Orihuela Kevin S Harrod Source Type: research
Mesenchymal stromal cells for improvement of cardiac function following acute myocardial infarction: a matter of timing
Physiol Rev. 2023 Aug 17. doi: 10.1152/physrev.00009.2023. Online ahead of print.ABSTRACTAcute myocardial infarction (AMI) is the leading cause of cardiovascular death and remains the most common cause of heart failure (HF). Re-opening of the occluded artery i.e., reperfusion, is the only way to save the myocardium. However, the expected benefits on infarct size are disappointing due to the reperfusion paradox, which also induces specific cell death. These ischemia-reperfusion (IR) lesions can account for up to 50% of final infarct size, a major determinant for both mortality and the risk of heart failure (morbidity). In t...
Source: Physiological Reviews - August 17, 2023 Category: Physiology Authors: St éphanie Barrère-Lemaire Anne Vincent Christian Jorgensen Christophe Piot Jo ël Nargeot Farida Djouad Source Type: research
Community-Acquired Bacterial Co-infections and COVID-19
Physiol Rev. 2023 Aug 17. doi: 10.1152/physrev.00010.2023. Online ahead of print.NO ABSTRACTPMID:37589392 | DOI:10.1152/physrev.00010.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - August 17, 2023 Category: Physiology Authors: Michael John Patton Amit Gaggar Matthew Might Nathaniel Erdmann Carlos J Orihuela Kevin S Harrod Source Type: research
Mesenchymal stromal cells for improvement of cardiac function following acute myocardial infarction: a matter of timing
Physiol Rev. 2023 Aug 17. doi: 10.1152/physrev.00009.2023. Online ahead of print.ABSTRACTAcute myocardial infarction (AMI) is the leading cause of cardiovascular death and remains the most common cause of heart failure (HF). Re-opening of the occluded artery i.e., reperfusion, is the only way to save the myocardium. However, the expected benefits on infarct size are disappointing due to the reperfusion paradox, which also induces specific cell death. These ischemia-reperfusion (IR) lesions can account for up to 50% of final infarct size, a major determinant for both mortality and the risk of heart failure (morbidity). In t...
Source: Physiological Reviews - August 17, 2023 Category: Physiology Authors: St éphanie Barrère-Lemaire Anne Vincent Christian Jorgensen Christophe Piot Jo ël Nargeot Farida Djouad Source Type: research
Community-Acquired Bacterial Co-infections and COVID-19
Physiol Rev. 2023 Aug 17. doi: 10.1152/physrev.00010.2023. Online ahead of print.NO ABSTRACTPMID:37589392 | DOI:10.1152/physrev.00010.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - August 17, 2023 Category: Physiology Authors: Michael John Patton Amit Gaggar Matthew Might Nathaniel Erdmann Carlos J Orihuela Kevin S Harrod Source Type: research
Mesenchymal stromal cells for improvement of cardiac function following acute myocardial infarction: a matter of timing
Physiol Rev. 2023 Aug 17. doi: 10.1152/physrev.00009.2023. Online ahead of print.ABSTRACTAcute myocardial infarction (AMI) is the leading cause of cardiovascular death and remains the most common cause of heart failure (HF). Re-opening of the occluded artery i.e., reperfusion, is the only way to save the myocardium. However, the expected benefits on infarct size are disappointing due to the reperfusion paradox, which also induces specific cell death. These ischemia-reperfusion (IR) lesions can account for up to 50% of final infarct size, a major determinant for both mortality and the risk of heart failure (morbidity). In t...
Source: Physiological Reviews - August 17, 2023 Category: Physiology Authors: St éphanie Barrère-Lemaire Anne Vincent Christian Jorgensen Christophe Piot Jo ël Nargeot Farida Djouad Source Type: research
Community-Acquired Bacterial Co-infections and COVID-19
Physiol Rev. 2023 Aug 17. doi: 10.1152/physrev.00010.2023. Online ahead of print.NO ABSTRACTPMID:37589392 | DOI:10.1152/physrev.00010.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - August 17, 2023 Category: Physiology Authors: Michael John Patton Amit Gaggar Matthew Might Nathaniel Erdmann Carlos J Orihuela Kevin S Harrod Source Type: research
Mesenchymal stromal cells for improvement of cardiac function following acute myocardial infarction: a matter of timing
Physiol Rev. 2023 Aug 17. doi: 10.1152/physrev.00009.2023. Online ahead of print.ABSTRACTAcute myocardial infarction (AMI) is the leading cause of cardiovascular death and remains the most common cause of heart failure (HF). Re-opening of the occluded artery i.e., reperfusion, is the only way to save the myocardium. However, the expected benefits on infarct size are disappointing due to the reperfusion paradox, which also induces specific cell death. These ischemia-reperfusion (IR) lesions can account for up to 50% of final infarct size, a major determinant for both mortality and the risk of heart failure (morbidity). In t...
Source: Physiological Reviews - August 17, 2023 Category: Physiology Authors: St éphanie Barrère-Lemaire Anne Vincent Christian Jorgensen Christophe Piot Jo ël Nargeot Farida Djouad Source Type: research
Inflammation o'clock: interactions of circadian rhythms with inflammation-induced skeletal muscle atrophy
J Physiol. 2023 Aug 10. doi: 10.1113/JP284808. Online ahead of print.ABSTRACTCircadian rhythms are ∼24 h cycles evident in behaviour, physiology and metabolism. The molecular mechanism directing circadian rhythms is the circadian clock, which is composed of an interactive network of transcription-translation feedback loops. The core clock genes include Bmal1, Clock, Rev-erbα/β, Per and Cry. In addition to keeping time, the core clock regulates a daily programme of gene expression that is important for overall cell homeostasis. The circadian clock mechanism is present in all cells, including skeletal muscle fibres, and ...
Source: Physiological Reviews - August 11, 2023 Category: Physiology Authors: Francielly Morena da Silva Karyn A Esser Kevin A Murach Nicholas P Greene Source Type: research
Inflammation o'clock: interactions of circadian rhythms with inflammation-induced skeletal muscle atrophy
J Physiol. 2023 Aug 10. doi: 10.1113/JP284808. Online ahead of print.ABSTRACTCircadian rhythms are ∼24 h cycles evident in behaviour, physiology and metabolism. The molecular mechanism directing circadian rhythms is the circadian clock, which is composed of an interactive network of transcription-translation feedback loops. The core clock genes include Bmal1, Clock, Rev-erbα/β, Per and Cry. In addition to keeping time, the core clock regulates a daily programme of gene expression that is important for overall cell homeostasis. The circadian clock mechanism is present in all cells, including skeletal muscle fibres, and ...
Source: Physiological Reviews - August 11, 2023 Category: Physiology Authors: Francielly Morena da Silva Karyn A Esser Kevin A Murach Nicholas P Greene Source Type: research
