BK Channelopathies and < em > KCNMA1 < /em > -Linked Disease Models
Annu Rev Physiol. 2023 Oct 31. doi: 10.1146/annurev-physiol-030323-042845. Online ahead of print.ABSTRACTNovel KCNMA1 variants, encoding the BK K+ channel, are associated with a debilitating dyskinesia and epilepsy syndrome. Neurodevelopmental delay, cognitive disability, and brain and structural malformations are also diagnosed at lower incidence. More than half of affected individuals present with a rare negative episodic motor disorder, paroxysmal nonkinesigenic dyskinesia (PNKD3). The mechanistic relationship of PNKD3 to epilepsy and the broader spectrum of KCNMA1-associated symptomology is unknown. This review summari...
Source: Physiological Reviews - October 31, 2023 Category: Physiology Authors: Andrea L Meredith Source Type: research
BK Channelopathies and < em > KCNMA1 < /em > -Linked Disease Models
Annu Rev Physiol. 2023 Oct 31. doi: 10.1146/annurev-physiol-030323-042845. Online ahead of print.ABSTRACTNovel KCNMA1 variants, encoding the BK K+ channel, are associated with a debilitating dyskinesia and epilepsy syndrome. Neurodevelopmental delay, cognitive disability, and brain and structural malformations are also diagnosed at lower incidence. More than half of affected individuals present with a rare negative episodic motor disorder, paroxysmal nonkinesigenic dyskinesia (PNKD3). The mechanistic relationship of PNKD3 to epilepsy and the broader spectrum of KCNMA1-associated symptomology is unknown. This review summari...
Source: Physiological Reviews - October 31, 2023 Category: Physiology Authors: Andrea L Meredith Source Type: research
BK Channelopathies and < em > KCNMA1 < /em > -Linked Disease Models
Annu Rev Physiol. 2023 Oct 31. doi: 10.1146/annurev-physiol-030323-042845. Online ahead of print.ABSTRACTNovel KCNMA1 variants, encoding the BK K+ channel, are associated with a debilitating dyskinesia and epilepsy syndrome. Neurodevelopmental delay, cognitive disability, and brain and structural malformations are also diagnosed at lower incidence. More than half of affected individuals present with a rare negative episodic motor disorder, paroxysmal nonkinesigenic dyskinesia (PNKD3). The mechanistic relationship of PNKD3 to epilepsy and the broader spectrum of KCNMA1-associated symptomology is unknown. This review summari...
Source: Physiological Reviews - October 31, 2023 Category: Physiology Authors: Andrea L Meredith Source Type: research
BK Channelopathies and < em > KCNMA1 < /em > -Linked Disease Models
Annu Rev Physiol. 2023 Oct 31. doi: 10.1146/annurev-physiol-030323-042845. Online ahead of print.ABSTRACTNovel KCNMA1 variants, encoding the BK K+ channel, are associated with a debilitating dyskinesia and epilepsy syndrome. Neurodevelopmental delay, cognitive disability, and brain and structural malformations are also diagnosed at lower incidence. More than half of affected individuals present with a rare negative episodic motor disorder, paroxysmal nonkinesigenic dyskinesia (PNKD3). The mechanistic relationship of PNKD3 to epilepsy and the broader spectrum of KCNMA1-associated symptomology is unknown. This review summari...
Source: Physiological Reviews - October 31, 2023 Category: Physiology Authors: Andrea L Meredith Source Type: research
Effects of 4 weeks of whole-body vibration training on energy expenditure during deep squats of male well-trained students
Front Physiol. 2023 Oct 11;14:1232045. doi: 10.3389/fphys.2023.1232045. eCollection 2023.ABSTRACTFrom the perspective of energy expenditure, this study investigated the effects of whole-body vibration training on the energy metabolism of deep squats with different weights. Twenty-two healthy male college students with sports experiences were selected and randomly assigned to perform resistance exercise vibration (REV) or resistance exercise (RE) with varying loads two times per week for 4 weeks. Oxygen uptake and heart rate were measured before, during, and after exercises using a gas analyzer, and energy expenditure was c...
Source: Physiological Reviews - October 27, 2023 Category: Physiology Authors: Xiaohan Huang Zhengyang Ye Xuelin Qin Source Type: research
Effects of 4 weeks of whole-body vibration training on energy expenditure during deep squats of male well-trained students
Front Physiol. 2023 Oct 11;14:1232045. doi: 10.3389/fphys.2023.1232045. eCollection 2023.ABSTRACTFrom the perspective of energy expenditure, this study investigated the effects of whole-body vibration training on the energy metabolism of deep squats with different weights. Twenty-two healthy male college students with sports experiences were selected and randomly assigned to perform resistance exercise vibration (REV) or resistance exercise (RE) with varying loads two times per week for 4 weeks. Oxygen uptake and heart rate were measured before, during, and after exercises using a gas analyzer, and energy expenditure was c...
Source: Physiological Reviews - October 27, 2023 Category: Physiology Authors: Xiaohan Huang Zhengyang Ye Xuelin Qin Source Type: research
Effects of 4 weeks of whole-body vibration training on energy expenditure during deep squats of male well-trained students
Front Physiol. 2023 Oct 11;14:1232045. doi: 10.3389/fphys.2023.1232045. eCollection 2023.ABSTRACTFrom the perspective of energy expenditure, this study investigated the effects of whole-body vibration training on the energy metabolism of deep squats with different weights. Twenty-two healthy male college students with sports experiences were selected and randomly assigned to perform resistance exercise vibration (REV) or resistance exercise (RE) with varying loads two times per week for 4 weeks. Oxygen uptake and heart rate were measured before, during, and after exercises using a gas analyzer, and energy expenditure was c...
Source: Physiological Reviews - October 27, 2023 Category: Physiology Authors: Xiaohan Huang Zhengyang Ye Xuelin Qin Source Type: research
Effects of 4 weeks of whole-body vibration training on energy expenditure during deep squats of male well-trained students
Front Physiol. 2023 Oct 11;14:1232045. doi: 10.3389/fphys.2023.1232045. eCollection 2023.ABSTRACTFrom the perspective of energy expenditure, this study investigated the effects of whole-body vibration training on the energy metabolism of deep squats with different weights. Twenty-two healthy male college students with sports experiences were selected and randomly assigned to perform resistance exercise vibration (REV) or resistance exercise (RE) with varying loads two times per week for 4 weeks. Oxygen uptake and heart rate were measured before, during, and after exercises using a gas analyzer, and energy expenditure was c...
Source: Physiological Reviews - October 27, 2023 Category: Physiology Authors: Xiaohan Huang Zhengyang Ye Xuelin Qin Source Type: research
Cannabinoid treatments in epilepsy and seizure disorders
Physiol Rev. 2023 Oct 26. doi: 10.1152/physrev.00049.2021. Online ahead of print.ABSTRACTCannabis was used to treat convulsions and other disorders since ancient times. In the last few decades, preclinical animal studies and clinical investigations have established the role of cannabidiol (CBD) in treating epilepsy and seizures and support potential therapeutic benefits for cannabinoids in other neurological and psychiatric disorders. Here, we comprehensively review the role of cannabinoids in epilepsy. We briefly review the diverse physiological processes mediating the central nervous system response to cannabinoids, incl...
Source: Physiological Reviews - October 26, 2023 Category: Physiology Authors: Orrin Devinsky Nicholas A Jones Mark O Cunningham B Ashan P Jayaskera Sasha Devore Benjamin J Whalley Source Type: research
CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease
In conclusion, subcellular CD36 localization is the major adaptive regulator of cellular uptake and metabolism of long-chain fatty acids, and appears a suitable target for metabolic modulation therapy to mend failing hearts.PMID:37882731 | DOI:10.1152/physrev.00011.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - October 26, 2023 Category: Physiology Authors: Jan F C Glatz Lisa C Heather Joost J F P Luiken Source Type: research
Cannabinoid treatments in epilepsy and seizure disorders
Physiol Rev. 2023 Oct 26. doi: 10.1152/physrev.00049.2021. Online ahead of print.ABSTRACTCannabis was used to treat convulsions and other disorders since ancient times. In the last few decades, preclinical animal studies and clinical investigations have established the role of cannabidiol (CBD) in treating epilepsy and seizures and support potential therapeutic benefits for cannabinoids in other neurological and psychiatric disorders. Here, we comprehensively review the role of cannabinoids in epilepsy. We briefly review the diverse physiological processes mediating the central nervous system response to cannabinoids, incl...
Source: Physiological Reviews - October 26, 2023 Category: Physiology Authors: Orrin Devinsky Nicholas A Jones Mark O Cunningham B Ashan P Jayaskera Sasha Devore Benjamin J Whalley Source Type: research
CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease
In conclusion, subcellular CD36 localization is the major adaptive regulator of cellular uptake and metabolism of long-chain fatty acids, and appears a suitable target for metabolic modulation therapy to mend failing hearts.PMID:37882731 | DOI:10.1152/physrev.00011.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - October 26, 2023 Category: Physiology Authors: Jan F C Glatz Lisa C Heather Joost J F P Luiken Source Type: research
Phosphoinositide Regulation of TRP Channels: A Functional Overview in the Structural Era
Annu Rev Physiol. 2023 Oct 23. doi: 10.1146/annurev-physiol-042022-013956. Online ahead of print.ABSTRACTTransient receptor potential (TRP) ion channels have diverse activation mechanisms including physical stimuli, such as high or low temperatures, and a variety of intracellular signaling molecules. Regulation by phosphoinositides and their derivatives is their only known common regulatory feature. For most TRP channels, phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] serves as a cofactor required for activity. Such dependence on PI(4,5)P2 has been demonstrated for members of the TRPM subfamily and for the epithelial TR...
Source: Physiological Reviews - October 23, 2023 Category: Physiology Authors: Tibor Rohacs Source Type: research
Phosphoinositide Regulation of TRP Channels: A Functional Overview in the Structural Era
Annu Rev Physiol. 2023 Oct 23. doi: 10.1146/annurev-physiol-042022-013956. Online ahead of print.ABSTRACTTransient receptor potential (TRP) ion channels have diverse activation mechanisms including physical stimuli, such as high or low temperatures, and a variety of intracellular signaling molecules. Regulation by phosphoinositides and their derivatives is their only known common regulatory feature. For most TRP channels, phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] serves as a cofactor required for activity. Such dependence on PI(4,5)P2 has been demonstrated for members of the TRPM subfamily and for the epithelial TR...
Source: Physiological Reviews - October 23, 2023 Category: Physiology Authors: Tibor Rohacs Source Type: research
Phosphoinositide Regulation of TRP Channels: A Functional Overview in the Structural Era
Annu Rev Physiol. 2023 Oct 23. doi: 10.1146/annurev-physiol-042022-013956. Online ahead of print.ABSTRACTTransient receptor potential (TRP) ion channels have diverse activation mechanisms including physical stimuli, such as high or low temperatures, and a variety of intracellular signaling molecules. Regulation by phosphoinositides and their derivatives is their only known common regulatory feature. For most TRP channels, phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] serves as a cofactor required for activity. Such dependence on PI(4,5)P2 has been demonstrated for members of the TRPM subfamily and for the epithelial TR...
Source: Physiological Reviews - October 23, 2023 Category: Physiology Authors: Tibor Rohacs Source Type: research
