The Mineralocorticoid Receptor in the Vasculature: Friend or Foe?
Annu Rev Physiol. 2023 Oct 3. doi: 10.1146/annurev-physiol-042022-015223. Online ahead of print.ABSTRACTOriginally described as the renal aldosterone receptor that regulates sodium homeostasis, it is now clear that mineralocorticoid receptors (MRs) are widely expressed, including in vascular endothelial and smooth muscle cells. Ample data demonstrate that endothelial and smooth muscle cell MRs contribute to cardiovascular disease in response to risk factors (aging, obesity, hypertension, atherosclerosis) by inducing vasoconstriction, vascular remodeling, inflammation, and oxidative stress. Extrapolating from its role in di...
Source: Physiological Reviews - October 3, 2023 Category: Physiology Authors: Jaime Ibarrola Iris Z Jaffe Source Type: research
The Mineralocorticoid Receptor in the Vasculature: Friend or Foe?
Annu Rev Physiol. 2023 Oct 3. doi: 10.1146/annurev-physiol-042022-015223. Online ahead of print.ABSTRACTOriginally described as the renal aldosterone receptor that regulates sodium homeostasis, it is now clear that mineralocorticoid receptors (MRs) are widely expressed, including in vascular endothelial and smooth muscle cells. Ample data demonstrate that endothelial and smooth muscle cell MRs contribute to cardiovascular disease in response to risk factors (aging, obesity, hypertension, atherosclerosis) by inducing vasoconstriction, vascular remodeling, inflammation, and oxidative stress. Extrapolating from its role in di...
Source: Physiological Reviews - October 3, 2023 Category: Physiology Authors: Jaime Ibarrola Iris Z Jaffe Source Type: research
The Mineralocorticoid Receptor in the Vasculature: Friend or Foe?
Annu Rev Physiol. 2023 Oct 3. doi: 10.1146/annurev-physiol-042022-015223. Online ahead of print.ABSTRACTOriginally described as the renal aldosterone receptor that regulates sodium homeostasis, it is now clear that mineralocorticoid receptors (MRs) are widely expressed, including in vascular endothelial and smooth muscle cells. Ample data demonstrate that endothelial and smooth muscle cell MRs contribute to cardiovascular disease in response to risk factors (aging, obesity, hypertension, atherosclerosis) by inducing vasoconstriction, vascular remodeling, inflammation, and oxidative stress. Extrapolating from its role in di...
Source: Physiological Reviews - October 3, 2023 Category: Physiology Authors: Jaime Ibarrola Iris Z Jaffe Source Type: research
The Mineralocorticoid Receptor in the Vasculature: Friend or Foe?
Annu Rev Physiol. 2023 Oct 3. doi: 10.1146/annurev-physiol-042022-015223. Online ahead of print.ABSTRACTOriginally described as the renal aldosterone receptor that regulates sodium homeostasis, it is now clear that mineralocorticoid receptors (MRs) are widely expressed, including in vascular endothelial and smooth muscle cells. Ample data demonstrate that endothelial and smooth muscle cell MRs contribute to cardiovascular disease in response to risk factors (aging, obesity, hypertension, atherosclerosis) by inducing vasoconstriction, vascular remodeling, inflammation, and oxidative stress. Extrapolating from its role in di...
Source: Physiological Reviews - October 3, 2023 Category: Physiology Authors: Jaime Ibarrola Iris Z Jaffe Source Type: research
The Mineralocorticoid Receptor in the Vasculature: Friend or Foe?
Annu Rev Physiol. 2023 Oct 3. doi: 10.1146/annurev-physiol-042022-015223. Online ahead of print.ABSTRACTOriginally described as the renal aldosterone receptor that regulates sodium homeostasis, it is now clear that mineralocorticoid receptors (MRs) are widely expressed, including in vascular endothelial and smooth muscle cells. Ample data demonstrate that endothelial and smooth muscle cell MRs contribute to cardiovascular disease in response to risk factors (aging, obesity, hypertension, atherosclerosis) by inducing vasoconstriction, vascular remodeling, inflammation, and oxidative stress. Extrapolating from its role in di...
Source: Physiological Reviews - October 3, 2023 Category: Physiology Authors: Jaime Ibarrola Iris Z Jaffe Source Type: research
Multiscale Structure and Function of the Aortic Valve Apparatus
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00038.2022. Online ahead of print.ABSTRACTWhile studying the aortic valve in isolation has facilitated the development of life-saving procedures and technologies, the dynamic interplay of the aortic valve and its surrounding structures is vital to preserving their function across the wide range of conditions encountered in an active lifestyle. Our view is that these structures should be viewed as an integrated functional unit, herein referred to as the aortic valve apparatus (AVA). The coupling of the aortic valve and root, left ventricular outflow tract, and blood circulation...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Hussam El-Nashar Malak Sabry Yuan-Tsan Tseng Nadine Francis Najma Latif Kim H Parker James E Moore Magdi H Yacoub Source Type: research
< em > Glucocorticoids, Their Uses, Sexual Dimorphisms, and Diseases: New Concepts, Mechanisms, and Discoveries < /em >
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00021.2023. Online ahead of print.ABSTRACTThe normal stress response in humans is governed by the hypothalamic-pituitary-adrenal (HPA) axis through heightened mechanisms during stress, raising blood levels of the glucocorticoid hormone cortisol. Glucocorticoids are quintessential compounds that balance the proper functioning of numerous systems in the mammalian body. They are also generated synthetically and are the preeminent therapy for inflammatory diseases. They act by binding to the nuclear receptor transcription factor, the glucocorticoid receptor (GR), which has two mai...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Genesee J Martinez Malik Appleton Zachary A Kipp Analia S Loria Booki Min Terry D Hinds Source Type: research
Multiscale Structure and Function of the Aortic Valve Apparatus
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00038.2022. Online ahead of print.ABSTRACTWhile studying the aortic valve in isolation has facilitated the development of life-saving procedures and technologies, the dynamic interplay of the aortic valve and its surrounding structures is vital to preserving their function across the wide range of conditions encountered in an active lifestyle. Our view is that these structures should be viewed as an integrated functional unit, herein referred to as the aortic valve apparatus (AVA). The coupling of the aortic valve and root, left ventricular outflow tract, and blood circulation...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Hussam El-Nashar Malak Sabry Yuan-Tsan Tseng Nadine Francis Najma Latif Kim H Parker James E Moore Magdi H Yacoub Source Type: research
< em > Glucocorticoids, Their Uses, Sexual Dimorphisms, and Diseases: New Concepts, Mechanisms, and Discoveries < /em >
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00021.2023. Online ahead of print.ABSTRACTThe normal stress response in humans is governed by the hypothalamic-pituitary-adrenal (HPA) axis through heightened mechanisms during stress, raising blood levels of the glucocorticoid hormone cortisol. Glucocorticoids are quintessential compounds that balance the proper functioning of numerous systems in the mammalian body. They are also generated synthetically and are the preeminent therapy for inflammatory diseases. They act by binding to the nuclear receptor transcription factor, the glucocorticoid receptor (GR), which has two mai...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Genesee J Martinez Malik Appleton Zachary A Kipp Analia S Loria Booki Min Terry D Hinds Source Type: research
Multiscale Structure and Function of the Aortic Valve Apparatus
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00038.2022. Online ahead of print.ABSTRACTWhile studying the aortic valve in isolation has facilitated the development of life-saving procedures and technologies, the dynamic interplay of the aortic valve and its surrounding structures is vital to preserving their function across the wide range of conditions encountered in an active lifestyle. Our view is that these structures should be viewed as an integrated functional unit, herein referred to as the aortic valve apparatus (AVA). The coupling of the aortic valve and root, left ventricular outflow tract, and blood circulation...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Hussam El-Nashar Malak Sabry Yuan-Tsan Tseng Nadine Francis Najma Latif Kim H Parker James E Moore Magdi H Yacoub Source Type: research
< em > Glucocorticoids, Their Uses, Sexual Dimorphisms, and Diseases: New Concepts, Mechanisms, and Discoveries < /em >
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00021.2023. Online ahead of print.ABSTRACTThe normal stress response in humans is governed by the hypothalamic-pituitary-adrenal (HPA) axis through heightened mechanisms during stress, raising blood levels of the glucocorticoid hormone cortisol. Glucocorticoids are quintessential compounds that balance the proper functioning of numerous systems in the mammalian body. They are also generated synthetically and are the preeminent therapy for inflammatory diseases. They act by binding to the nuclear receptor transcription factor, the glucocorticoid receptor (GR), which has two mai...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Genesee J Martinez Malik Appleton Zachary A Kipp Analia S Loria Booki Min Terry D Hinds Source Type: research
Multiscale Structure and Function of the Aortic Valve Apparatus
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00038.2022. Online ahead of print.ABSTRACTWhile studying the aortic valve in isolation has facilitated the development of life-saving procedures and technologies, the dynamic interplay of the aortic valve and its surrounding structures is vital to preserving their function across the wide range of conditions encountered in an active lifestyle. Our view is that these structures should be viewed as an integrated functional unit, herein referred to as the aortic valve apparatus (AVA). The coupling of the aortic valve and root, left ventricular outflow tract, and blood circulation...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Hussam El-Nashar Malak Sabry Yuan-Tsan Tseng Nadine Francis Najma Latif Kim H Parker James E Moore Magdi H Yacoub Source Type: research
< em > Glucocorticoids, Their Uses, Sexual Dimorphisms, and Diseases: New Concepts, Mechanisms, and Discoveries < /em >
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00021.2023. Online ahead of print.ABSTRACTThe normal stress response in humans is governed by the hypothalamic-pituitary-adrenal (HPA) axis through heightened mechanisms during stress, raising blood levels of the glucocorticoid hormone cortisol. Glucocorticoids are quintessential compounds that balance the proper functioning of numerous systems in the mammalian body. They are also generated synthetically and are the preeminent therapy for inflammatory diseases. They act by binding to the nuclear receptor transcription factor, the glucocorticoid receptor (GR), which has two mai...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Genesee J Martinez Malik Appleton Zachary A Kipp Analia S Loria Booki Min Terry D Hinds Source Type: research
Multiscale Structure and Function of the Aortic Valve Apparatus
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00038.2022. Online ahead of print.ABSTRACTWhile studying the aortic valve in isolation has facilitated the development of life-saving procedures and technologies, the dynamic interplay of the aortic valve and its surrounding structures is vital to preserving their function across the wide range of conditions encountered in an active lifestyle. Our view is that these structures should be viewed as an integrated functional unit, herein referred to as the aortic valve apparatus (AVA). The coupling of the aortic valve and root, left ventricular outflow tract, and blood circulation...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Hussam El-Nashar Malak Sabry Yuan-Tsan Tseng Nadine Francis Najma Latif Kim H Parker James E Moore Magdi H Yacoub Source Type: research
< em > Glucocorticoids, Their Uses, Sexual Dimorphisms, and Diseases: New Concepts, Mechanisms, and Discoveries < /em >
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00021.2023. Online ahead of print.ABSTRACTThe normal stress response in humans is governed by the hypothalamic-pituitary-adrenal (HPA) axis through heightened mechanisms during stress, raising blood levels of the glucocorticoid hormone cortisol. Glucocorticoids are quintessential compounds that balance the proper functioning of numerous systems in the mammalian body. They are also generated synthetically and are the preeminent therapy for inflammatory diseases. They act by binding to the nuclear receptor transcription factor, the glucocorticoid receptor (GR), which has two mai...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Genesee J Martinez Malik Appleton Zachary A Kipp Analia S Loria Booki Min Terry D Hinds Source Type: research
