The Ion Channels of Endomembranes
Physiol Rev. 2024 Mar 7. doi: 10.1152/physrev.00025.2023. Online ahead of print.ABSTRACTThe endomembrane system consists of organellar membranes in the biosynthetic pathway: endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles, as well as those in the degradative pathway: early endosomes, macropinosomes, phagosomes, autophagosomes, late endosomes, and lysosomes. These endomembrane organelles/vesicles work together to synthesize, modify, package, transport, and degrade proteins, carbohydrates, and lipids, regulating the balance between cellular anabolism and catabolism. Large ion concentration gradients exist...
Source: Physiological Reviews - March 7, 2024 Category: Physiology Authors: Meiqin Hu Xinghua Feng Qiang Liu Siyu Liu Fangqian Huang Haoxing Xu Source Type: research
Mechanisms of myosin II force generation. Insights from novel experimental techniques and approaches
Physiol Rev. 2024 Mar 7. doi: 10.1152/physrev.00014.2023. Online ahead of print.ABSTRACTMyosin II is a molecular motor that converts chemical energy derived from ATP hydrolysis into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range of cell functions relying on the development of force and motion. When the motor attaches to actin, ATP is hydrolyzed, and inorganic phosphate (Pi) and ADP are released from its active site. These reactions are coordinated with changes in the structure of myosin, promoting the so called "power-stroke" that causes sliding of actin filaments. The general featur...
Source: Physiological Reviews - March 7, 2024 Category: Physiology Authors: Dilson E Rassier Alf M ånsson Source Type: research
Best Practices for Data Management and Sharing in Experimental Biomedical Research
Physiol Rev. 2024 Mar 7. doi: 10.1152/physrev.00043.2023. Online ahead of print.ABSTRACTEffective data management is crucial for scientific integrity and reproducibility, a cornerstone of scientific progress. Well-organized and well-documented data enable validation and building upon results. Data management encompasses activities including organization, documentation, storage, sharing, and preservation. Robust data management establishes credibility, fostering trust within the scientific community and benefiting researchers' careers. In experimental biomedicine, comprehensive data management is vital due to the typically ...
Source: Physiological Reviews - March 7, 2024 Category: Physiology Authors: Teresa Cunha-Oliveira John P A Ioannidis Paulo J Oliveira Source Type: research
The Ion Channels of Endomembranes
Physiol Rev. 2024 Mar 7. doi: 10.1152/physrev.00025.2023. Online ahead of print.ABSTRACTThe endomembrane system consists of organellar membranes in the biosynthetic pathway: endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles, as well as those in the degradative pathway: early endosomes, macropinosomes, phagosomes, autophagosomes, late endosomes, and lysosomes. These endomembrane organelles/vesicles work together to synthesize, modify, package, transport, and degrade proteins, carbohydrates, and lipids, regulating the balance between cellular anabolism and catabolism. Large ion concentration gradients exist...
Source: Physiological Reviews - March 7, 2024 Category: Physiology Authors: Meiqin Hu Xinghua Feng Qiang Liu Siyu Liu Fangqian Huang Haoxing Xu Source Type: research
Mechanisms of myosin II force generation. Insights from novel experimental techniques and approaches
Physiol Rev. 2024 Mar 7. doi: 10.1152/physrev.00014.2023. Online ahead of print.ABSTRACTMyosin II is a molecular motor that converts chemical energy derived from ATP hydrolysis into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range of cell functions relying on the development of force and motion. When the motor attaches to actin, ATP is hydrolyzed, and inorganic phosphate (Pi) and ADP are released from its active site. These reactions are coordinated with changes in the structure of myosin, promoting the so called "power-stroke" that causes sliding of actin filaments. The general featur...
Source: Physiological Reviews - March 7, 2024 Category: Physiology Authors: Dilson E Rassier Alf M ånsson Source Type: research
Best Practices for Data Management and Sharing in Experimental Biomedical Research
Physiol Rev. 2024 Mar 7. doi: 10.1152/physrev.00043.2023. Online ahead of print.ABSTRACTEffective data management is crucial for scientific integrity and reproducibility, a cornerstone of scientific progress. Well-organized and well-documented data enable validation and building upon results. Data management encompasses activities including organization, documentation, storage, sharing, and preservation. Robust data management establishes credibility, fostering trust within the scientific community and benefiting researchers' careers. In experimental biomedicine, comprehensive data management is vital due to the typically ...
Source: Physiological Reviews - March 7, 2024 Category: Physiology Authors: Teresa Cunha-Oliveira John P A Ioannidis Paulo J Oliveira Source Type: research
The Ion Channels of Endomembranes
Physiol Rev. 2024 Mar 7. doi: 10.1152/physrev.00025.2023. Online ahead of print.ABSTRACTThe endomembrane system consists of organellar membranes in the biosynthetic pathway: endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles, as well as those in the degradative pathway: early endosomes, macropinosomes, phagosomes, autophagosomes, late endosomes, and lysosomes. These endomembrane organelles/vesicles work together to synthesize, modify, package, transport, and degrade proteins, carbohydrates, and lipids, regulating the balance between cellular anabolism and catabolism. Large ion concentration gradients exist...
Source: Physiological Reviews - March 7, 2024 Category: Physiology Authors: Meiqin Hu Xinghua Feng Qiang Liu Siyu Liu Fangqian Huang Haoxing Xu Source Type: research
Mechanisms of myosin II force generation. Insights from novel experimental techniques and approaches
Physiol Rev. 2024 Mar 7. doi: 10.1152/physrev.00014.2023. Online ahead of print.ABSTRACTMyosin II is a molecular motor that converts chemical energy derived from ATP hydrolysis into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range of cell functions relying on the development of force and motion. When the motor attaches to actin, ATP is hydrolyzed, and inorganic phosphate (Pi) and ADP are released from its active site. These reactions are coordinated with changes in the structure of myosin, promoting the so called "power-stroke" that causes sliding of actin filaments. The general featur...
Source: Physiological Reviews - March 7, 2024 Category: Physiology Authors: Dilson E Rassier Alf M ånsson Source Type: research
Best Practices for Data Management and Sharing in Experimental Biomedical Research
Physiol Rev. 2024 Mar 7. doi: 10.1152/physrev.00043.2023. Online ahead of print.ABSTRACTEffective data management is crucial for scientific integrity and reproducibility, a cornerstone of scientific progress. Well-organized and well-documented data enable validation and building upon results. Data management encompasses activities including organization, documentation, storage, sharing, and preservation. Robust data management establishes credibility, fostering trust within the scientific community and benefiting researchers' careers. In experimental biomedicine, comprehensive data management is vital due to the typically ...
Source: Physiological Reviews - March 7, 2024 Category: Physiology Authors: Teresa Cunha-Oliveira John P A Ioannidis Paulo J Oliveira Source Type: research
The Ion Channels of Endomembranes
Physiol Rev. 2024 Mar 7. doi: 10.1152/physrev.00025.2023. Online ahead of print.ABSTRACTThe endomembrane system consists of organellar membranes in the biosynthetic pathway: endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles, as well as those in the degradative pathway: early endosomes, macropinosomes, phagosomes, autophagosomes, late endosomes, and lysosomes. These endomembrane organelles/vesicles work together to synthesize, modify, package, transport, and degrade proteins, carbohydrates, and lipids, regulating the balance between cellular anabolism and catabolism. Large ion concentration gradients exist...
Source: Physiological Reviews - March 7, 2024 Category: Physiology Authors: Meiqin Hu Xinghua Feng Qiang Liu Siyu Liu Fangqian Huang Haoxing Xu Source Type: research
Mechanisms of myosin II force generation. Insights from novel experimental techniques and approaches
Physiol Rev. 2024 Mar 7. doi: 10.1152/physrev.00014.2023. Online ahead of print.ABSTRACTMyosin II is a molecular motor that converts chemical energy derived from ATP hydrolysis into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range of cell functions relying on the development of force and motion. When the motor attaches to actin, ATP is hydrolyzed, and inorganic phosphate (Pi) and ADP are released from its active site. These reactions are coordinated with changes in the structure of myosin, promoting the so called "power-stroke" that causes sliding of actin filaments. The general featur...
Source: Physiological Reviews - March 7, 2024 Category: Physiology Authors: Dilson E Rassier Alf M ånsson Source Type: research
Best Practices for Data Management and Sharing in Experimental Biomedical Research
Physiol Rev. 2024 Mar 7. doi: 10.1152/physrev.00043.2023. Online ahead of print.ABSTRACTEffective data management is crucial for scientific integrity and reproducibility, a cornerstone of scientific progress. Well-organized and well-documented data enable validation and building upon results. Data management encompasses activities including organization, documentation, storage, sharing, and preservation. Robust data management establishes credibility, fostering trust within the scientific community and benefiting researchers' careers. In experimental biomedicine, comprehensive data management is vital due to the typically ...
Source: Physiological Reviews - March 7, 2024 Category: Physiology Authors: Teresa Cunha-Oliveira John P A Ioannidis Paulo J Oliveira Source Type: research
The Ion Channels of Endomembranes
Physiol Rev. 2024 Mar 7. doi: 10.1152/physrev.00025.2023. Online ahead of print.ABSTRACTThe endomembrane system consists of organellar membranes in the biosynthetic pathway: endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles, as well as those in the degradative pathway: early endosomes, macropinosomes, phagosomes, autophagosomes, late endosomes, and lysosomes. These endomembrane organelles/vesicles work together to synthesize, modify, package, transport, and degrade proteins, carbohydrates, and lipids, regulating the balance between cellular anabolism and catabolism. Large ion concentration gradients exist...
Source: Physiological Reviews - March 7, 2024 Category: Physiology Authors: Meiqin Hu Xinghua Feng Qiang Liu Siyu Liu Fangqian Huang Haoxing Xu Source Type: research
Neuroprotective effects of dipeptidyl peptidase 4 inhibitor on Alzheimer's disease: a narrative review
Front Pharmacol. 2024 Feb 9;15:1361651. doi: 10.3389/fphar.2024.1361651. eCollection 2024.ABSTRACTInsulin resistance in brain and amyloidogenesis are principal pathological features of diabetes-related cognitive decline and development of Alzheimer's disease (AD). A growing body of evidence suggests that maintaining glucose under control in diabetic patients is beneficial for preventing AD development. Dipeptidyl peptidase 4 inhibitors (DDP4is) are a class of novel glucose-lowering medications through increasing insulin excretion and decreasing glucagon levels that have shown neuroprotective potential in recent studies. Th...
Source: Physiological Reviews - February 26, 2024 Category: Physiology Authors: Xin Jiang Ji Li Xiaohui Yao Hao Ding Aihong Gu Zhen Zhou Source Type: research
Neuroprotective effects of dipeptidyl peptidase 4 inhibitor on Alzheimer's disease: a narrative review
Front Pharmacol. 2024 Feb 9;15:1361651. doi: 10.3389/fphar.2024.1361651. eCollection 2024.ABSTRACTInsulin resistance in brain and amyloidogenesis are principal pathological features of diabetes-related cognitive decline and development of Alzheimer's disease (AD). A growing body of evidence suggests that maintaining glucose under control in diabetic patients is beneficial for preventing AD development. Dipeptidyl peptidase 4 inhibitors (DDP4is) are a class of novel glucose-lowering medications through increasing insulin excretion and decreasing glucagon levels that have shown neuroprotective potential in recent studies. Th...
Source: Physiological Reviews - February 26, 2024 Category: Physiology Authors: Xin Jiang Ji Li Xiaohui Yao Hao Ding Aihong Gu Zhen Zhou Source Type: research
