Computational modeling of cardiac electrophysiology and arrhythmogenesis
Physiol Rev. 2023 Dec 28. doi: 10.1152/physrev.00017.2023. Online ahead of print.ABSTRACTThe complexity of cardiac electrophysiology, involving dynamic changes in numerous components across multiple spatial (from ion channel to organ) and temporal (from milliseconds to days) scales makes an intuitive or empirical analysis of cardiac arrhythmogenesis challenging. Multiscale mechanistic computational models of cardiac electrophysiology provide precise control over individual parameters, and their reproducibility enables a thorough assessment of arrhythmia mechanisms. This review provides a comprehensive analysis of models of...
Source: Physiological Reviews - December 28, 2023 Category: Physiology Authors: Natalia A Trayanova Aurore Lyon Julie Shade Jordi Heijman Source Type: research
INNOVATIVE TECHNIQUES AND NEW INSIGHTS: Studying cardiac ionic currents and action potentials in physiologically relevant conditions
Physiol Mini Rev. 2023 May-Jun;16(3):22-34.ABSTRACTCardiac arrhythmias are associated with various forms of heart diseases. Ventricular arrhythmias present a significant risk for sudden cardiac death. Atrial fibrillations predispose to blood clots leading to stroke and heart attack. Scientists have been developing patch-clamp technology to study ion channels and action potentials (APs) underlying cardiac excitation and arrhythmias. Beyond the traditional patch-clamp techniques, innovative new techniques were developed for studying complex arrhythmia mechanisms. Here we review the recent development of methods including AP-...
Source: Physiological Reviews - December 18, 2023 Category: Physiology Authors: Ye Chen-Izu Bence Hegyi Zhong Jian Balazs Horvath John A Shaw Tamas Banyasz Leighton T Izu Source Type: research
INNOVATIVE TECHNIQUES AND NEW INSIGHTS: Studying cardiac ionic currents and action potentials in physiologically relevant conditions
Physiol Mini Rev. 2023 May-Jun;16(3):22-34.ABSTRACTCardiac arrhythmias are associated with various forms of heart diseases. Ventricular arrhythmias present a significant risk for sudden cardiac death. Atrial fibrillations predispose to blood clots leading to stroke and heart attack. Scientists have been developing patch-clamp technology to study ion channels and action potentials (APs) underlying cardiac excitation and arrhythmias. Beyond the traditional patch-clamp techniques, innovative new techniques were developed for studying complex arrhythmia mechanisms. Here we review the recent development of methods including AP-...
Source: Physiological Reviews - December 18, 2023 Category: Physiology Authors: Ye Chen-Izu Bence Hegyi Zhong Jian Balazs Horvath John A Shaw Tamas Banyasz Leighton T Izu Source Type: research
INNOVATIVE TECHNIQUES AND NEW INSIGHTS: Studying cardiac ionic currents and action potentials in physiologically relevant conditions
Physiol Mini Rev. 2023 May-Jun;16(3):22-34.ABSTRACTCardiac arrhythmias are associated with various forms of heart diseases. Ventricular arrhythmias present a significant risk for sudden cardiac death. Atrial fibrillations predispose to blood clots leading to stroke and heart attack. Scientists have been developing patch-clamp technology to study ion channels and action potentials (APs) underlying cardiac excitation and arrhythmias. Beyond the traditional patch-clamp techniques, innovative new techniques were developed for studying complex arrhythmia mechanisms. Here we review the recent development of methods including AP-...
Source: Physiological Reviews - December 18, 2023 Category: Physiology Authors: Ye Chen-Izu Bence Hegyi Zhong Jian Balazs Horvath John A Shaw Tamas Banyasz Leighton T Izu Source Type: research
INNOVATIVE TECHNIQUES AND NEW INSIGHTS: Studying cardiac ionic currents and action potentials in physiologically relevant conditions
Physiol Mini Rev. 2023 May-Jun;16(3):22-34.ABSTRACTCardiac arrhythmias are associated with various forms of heart diseases. Ventricular arrhythmias present a significant risk for sudden cardiac death. Atrial fibrillations predispose to blood clots leading to stroke and heart attack. Scientists have been developing patch-clamp technology to study ion channels and action potentials (APs) underlying cardiac excitation and arrhythmias. Beyond the traditional patch-clamp techniques, innovative new techniques were developed for studying complex arrhythmia mechanisms. Here we review the recent development of methods including AP-...
Source: Physiological Reviews - December 18, 2023 Category: Physiology Authors: Ye Chen-Izu Bence Hegyi Zhong Jian Balazs Horvath John A Shaw Tamas Banyasz Leighton T Izu Source Type: research
INNOVATIVE TECHNIQUES AND NEW INSIGHTS: Studying cardiac ionic currents and action potentials in physiologically relevant conditions
Physiol Mini Rev. 2023 May-Jun;16(3):22-34.ABSTRACTCardiac arrhythmias are associated with various forms of heart diseases. Ventricular arrhythmias present a significant risk for sudden cardiac death. Atrial fibrillations predispose to blood clots leading to stroke and heart attack. Scientists have been developing patch-clamp technology to study ion channels and action potentials (APs) underlying cardiac excitation and arrhythmias. Beyond the traditional patch-clamp techniques, innovative new techniques were developed for studying complex arrhythmia mechanisms. Here we review the recent development of methods including AP-...
Source: Physiological Reviews - December 18, 2023 Category: Physiology Authors: Ye Chen-Izu Bence Hegyi Zhong Jian Balazs Horvath John A Shaw Tamas Banyasz Leighton T Izu Source Type: research
INNOVATIVE TECHNIQUES AND NEW INSIGHTS: Studying cardiac ionic currents and action potentials in physiologically relevant conditions
Physiol Mini Rev. 2023 May-Jun;16(3):22-34.ABSTRACTCardiac arrhythmias are associated with various forms of heart diseases. Ventricular arrhythmias present a significant risk for sudden cardiac death. Atrial fibrillations predispose to blood clots leading to stroke and heart attack. Scientists have been developing patch-clamp technology to study ion channels and action potentials (APs) underlying cardiac excitation and arrhythmias. Beyond the traditional patch-clamp techniques, innovative new techniques were developed for studying complex arrhythmia mechanisms. Here we review the recent development of methods including AP-...
Source: Physiological Reviews - December 18, 2023 Category: Physiology Authors: Ye Chen-Izu Bence Hegyi Zhong Jian Balazs Horvath John A Shaw Tamas Banyasz Leighton T Izu Source Type: research
INNOVATIVE TECHNIQUES AND NEW INSIGHTS: Studying cardiac ionic currents and action potentials in physiologically relevant conditions
Physiol Mini Rev. 2023 May-Jun;16(3):22-34.ABSTRACTCardiac arrhythmias are associated with various forms of heart diseases. Ventricular arrhythmias present a significant risk for sudden cardiac death. Atrial fibrillations predispose to blood clots leading to stroke and heart attack. Scientists have been developing patch-clamp technology to study ion channels and action potentials (APs) underlying cardiac excitation and arrhythmias. Beyond the traditional patch-clamp techniques, innovative new techniques were developed for studying complex arrhythmia mechanisms. Here we review the recent development of methods including AP-...
Source: Physiological Reviews - December 18, 2023 Category: Physiology Authors: Ye Chen-Izu Bence Hegyi Zhong Jian Balazs Horvath John A Shaw Tamas Banyasz Leighton T Izu Source Type: research
INNOVATIVE TECHNIQUES AND NEW INSIGHTS: Studying cardiac ionic currents and action potentials in physiologically relevant conditions
Physiol Mini Rev. 2023 May-Jun;16(3):22-34.ABSTRACTCardiac arrhythmias are associated with various forms of heart diseases. Ventricular arrhythmias present a significant risk for sudden cardiac death. Atrial fibrillations predispose to blood clots leading to stroke and heart attack. Scientists have been developing patch-clamp technology to study ion channels and action potentials (APs) underlying cardiac excitation and arrhythmias. Beyond the traditional patch-clamp techniques, innovative new techniques were developed for studying complex arrhythmia mechanisms. Here we review the recent development of methods including AP-...
Source: Physiological Reviews - December 18, 2023 Category: Physiology Authors: Ye Chen-Izu Bence Hegyi Zhong Jian Balazs Horvath John A Shaw Tamas Banyasz Leighton T Izu Source Type: research
INNOVATIVE TECHNIQUES AND NEW INSIGHTS: Studying cardiac ionic currents and action potentials in physiologically relevant conditions
Physiol Mini Rev. 2023 May-Jun;16(3):22-34.ABSTRACTCardiac arrhythmias are associated with various forms of heart diseases. Ventricular arrhythmias present a significant risk for sudden cardiac death. Atrial fibrillations predispose to blood clots leading to stroke and heart attack. Scientists have been developing patch-clamp technology to study ion channels and action potentials (APs) underlying cardiac excitation and arrhythmias. Beyond the traditional patch-clamp techniques, innovative new techniques were developed for studying complex arrhythmia mechanisms. Here we review the recent development of methods including AP-...
Source: Physiological Reviews - December 18, 2023 Category: Physiology Authors: Ye Chen-Izu Bence Hegyi Zhong Jian Balazs Horvath John A Shaw Tamas Banyasz Leighton T Izu Source Type: research
Body mass and V'O < sub > 2 < /sub > at rest affect gross efficiency during moderate-intensity cycling in untrained young healthy men: correlations with V'O < sub > 2MAX < /sub >
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.03. Epub 2023 Dec 6.ABSTRACTSeventeen young healthy physically active males (age 23 ±3 years; body mass (BM) 72.5 ±7.9 kg; height 178 ±4 cm, (mean ±SD)), not specifically trained in cycling, participated in this study. The subjects performed two cycling incremental tests at the pedalling rate of 60 rev x min-1. The first test, with the power output (PO) increases of 30 W every 3 min, was to determine the maximal oxygen uptake (V'O2max) and the power output (PO) at V'O2max, while the second test (series of 6 minutes bouts of increasing intensity) was to deter...
Source: Physiological Reviews - December 12, 2023 Category: Physiology Authors: J A Zoladz J Zapart-Bukowska M Grandys Z Szkutnik B Grassi J Majerczak Source Type: research
Body mass and V'O < sub > 2 < /sub > at rest affect gross efficiency during moderate-intensity cycling in untrained young healthy men: correlations with V'O < sub > 2MAX < /sub >
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.03. Epub 2023 Dec 6.ABSTRACTSeventeen young healthy physically active males (age 23 ±3 years; body mass (BM) 72.5 ±7.9 kg; height 178 ±4 cm, (mean ±SD)), not specifically trained in cycling, participated in this study. The subjects performed two cycling incremental tests at the pedalling rate of 60 rev x min-1. The first test, with the power output (PO) increases of 30 W every 3 min, was to determine the maximal oxygen uptake (V'O2max) and the power output (PO) at V'O2max, while the second test (series of 6 minutes bouts of increasing intensity) was to deter...
Source: Physiological Reviews - December 12, 2023 Category: Physiology Authors: J A Zoladz J Zapart-Bukowska M Grandys Z Szkutnik B Grassi J Majerczak Source Type: research
Body mass and V'O < sub > 2 < /sub > at rest affect gross efficiency during moderate-intensity cycling in untrained young healthy men: correlations with V'O < sub > 2MAX < /sub >
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.03. Epub 2023 Dec 6.ABSTRACTSeventeen young healthy physically active males (age 23 ±3 years; body mass (BM) 72.5 ±7.9 kg; height 178 ±4 cm, (mean ±SD)), not specifically trained in cycling, participated in this study. The subjects performed two cycling incremental tests at the pedalling rate of 60 rev x min-1. The first test, with the power output (PO) increases of 30 W every 3 min, was to determine the maximal oxygen uptake (V'O2max) and the power output (PO) at V'O2max, while the second test (series of 6 minutes bouts of increasing intensity) was to deter...
Source: Physiological Reviews - December 12, 2023 Category: Physiology Authors: J A Zoladz J Zapart-Bukowska M Grandys Z Szkutnik B Grassi J Majerczak Source Type: research
Body mass and V'O < sub > 2 < /sub > at rest affect gross efficiency during moderate-intensity cycling in untrained young healthy men: correlations with V'O < sub > 2MAX < /sub >
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.03. Epub 2023 Dec 6.ABSTRACTSeventeen young healthy physically active males (age 23 ±3 years; body mass (BM) 72.5 ±7.9 kg; height 178 ±4 cm, (mean ±SD)), not specifically trained in cycling, participated in this study. The subjects performed two cycling incremental tests at the pedalling rate of 60 rev x min-1. The first test, with the power output (PO) increases of 30 W every 3 min, was to determine the maximal oxygen uptake (V'O2max) and the power output (PO) at V'O2max, while the second test (series of 6 minutes bouts of increasing intensity) was to deter...
Source: Physiological Reviews - December 12, 2023 Category: Physiology Authors: J A Zoladz J Zapart-Bukowska M Grandys Z Szkutnik B Grassi J Majerczak Source Type: research
Body mass and V'O < sub > 2 < /sub > at rest affect gross efficiency during moderate-intensity cycling in untrained young healthy men: correlations with V'O < sub > 2MAX < /sub >
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.03. Epub 2023 Dec 6.ABSTRACTSeventeen young healthy physically active males (age 23 ±3 years; body mass (BM) 72.5 ±7.9 kg; height 178 ±4 cm, (mean ±SD)), not specifically trained in cycling, participated in this study. The subjects performed two cycling incremental tests at the pedalling rate of 60 rev x min-1. The first test, with the power output (PO) increases of 30 W every 3 min, was to determine the maximal oxygen uptake (V'O2max) and the power output (PO) at V'O2max, while the second test (series of 6 minutes bouts of increasing intensity) was to deter...
Source: Physiological Reviews - December 12, 2023 Category: Physiology Authors: J A Zoladz J Zapart-Bukowska M Grandys Z Szkutnik B Grassi J Majerczak Source Type: research
