Multiscale Structure and Function of the Aortic Valve Apparatus
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00038.2022. Online ahead of print.ABSTRACTWhile studying the aortic valve in isolation has facilitated the development of life-saving procedures and technologies, the dynamic interplay of the aortic valve and its surrounding structures is vital to preserving their function across the wide range of conditions encountered in an active lifestyle. Our view is that these structures should be viewed as an integrated functional unit, herein referred to as the aortic valve apparatus (AVA). The coupling of the aortic valve and root, left ventricular outflow tract, and blood circulation...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Hussam El-Nashar Malak Sabry Yuan-Tsan Tseng Nadine Francis Najma Latif Kim H Parker James E Moore Magdi H Yacoub Source Type: research
< em > Glucocorticoids, Their Uses, Sexual Dimorphisms, and Diseases: New Concepts, Mechanisms, and Discoveries < /em >
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00021.2023. Online ahead of print.ABSTRACTThe normal stress response in humans is governed by the hypothalamic-pituitary-adrenal (HPA) axis through heightened mechanisms during stress, raising blood levels of the glucocorticoid hormone cortisol. Glucocorticoids are quintessential compounds that balance the proper functioning of numerous systems in the mammalian body. They are also generated synthetically and are the preeminent therapy for inflammatory diseases. They act by binding to the nuclear receptor transcription factor, the glucocorticoid receptor (GR), which has two mai...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Genesee J Martinez Malik Appleton Zachary A Kipp Analia S Loria Booki Min Terry D Hinds Source Type: research
Multiscale Structure and Function of the Aortic Valve Apparatus
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00038.2022. Online ahead of print.ABSTRACTWhile studying the aortic valve in isolation has facilitated the development of life-saving procedures and technologies, the dynamic interplay of the aortic valve and its surrounding structures is vital to preserving their function across the wide range of conditions encountered in an active lifestyle. Our view is that these structures should be viewed as an integrated functional unit, herein referred to as the aortic valve apparatus (AVA). The coupling of the aortic valve and root, left ventricular outflow tract, and blood circulation...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Hussam El-Nashar Malak Sabry Yuan-Tsan Tseng Nadine Francis Najma Latif Kim H Parker James E Moore Magdi H Yacoub Source Type: research
< em > Glucocorticoids, Their Uses, Sexual Dimorphisms, and Diseases: New Concepts, Mechanisms, and Discoveries < /em >
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00021.2023. Online ahead of print.ABSTRACTThe normal stress response in humans is governed by the hypothalamic-pituitary-adrenal (HPA) axis through heightened mechanisms during stress, raising blood levels of the glucocorticoid hormone cortisol. Glucocorticoids are quintessential compounds that balance the proper functioning of numerous systems in the mammalian body. They are also generated synthetically and are the preeminent therapy for inflammatory diseases. They act by binding to the nuclear receptor transcription factor, the glucocorticoid receptor (GR), which has two mai...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Genesee J Martinez Malik Appleton Zachary A Kipp Analia S Loria Booki Min Terry D Hinds Source Type: research
Multiscale Structure and Function of the Aortic Valve Apparatus
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00038.2022. Online ahead of print.ABSTRACTWhile studying the aortic valve in isolation has facilitated the development of life-saving procedures and technologies, the dynamic interplay of the aortic valve and its surrounding structures is vital to preserving their function across the wide range of conditions encountered in an active lifestyle. Our view is that these structures should be viewed as an integrated functional unit, herein referred to as the aortic valve apparatus (AVA). The coupling of the aortic valve and root, left ventricular outflow tract, and blood circulation...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Hussam El-Nashar Malak Sabry Yuan-Tsan Tseng Nadine Francis Najma Latif Kim H Parker James E Moore Magdi H Yacoub Source Type: research
< em > Glucocorticoids, Their Uses, Sexual Dimorphisms, and Diseases: New Concepts, Mechanisms, and Discoveries < /em >
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00021.2023. Online ahead of print.ABSTRACTThe normal stress response in humans is governed by the hypothalamic-pituitary-adrenal (HPA) axis through heightened mechanisms during stress, raising blood levels of the glucocorticoid hormone cortisol. Glucocorticoids are quintessential compounds that balance the proper functioning of numerous systems in the mammalian body. They are also generated synthetically and are the preeminent therapy for inflammatory diseases. They act by binding to the nuclear receptor transcription factor, the glucocorticoid receptor (GR), which has two mai...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Genesee J Martinez Malik Appleton Zachary A Kipp Analia S Loria Booki Min Terry D Hinds Source Type: research
Multiscale Structure and Function of the Aortic Valve Apparatus
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00038.2022. Online ahead of print.ABSTRACTWhile studying the aortic valve in isolation has facilitated the development of life-saving procedures and technologies, the dynamic interplay of the aortic valve and its surrounding structures is vital to preserving their function across the wide range of conditions encountered in an active lifestyle. Our view is that these structures should be viewed as an integrated functional unit, herein referred to as the aortic valve apparatus (AVA). The coupling of the aortic valve and root, left ventricular outflow tract, and blood circulation...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Hussam El-Nashar Malak Sabry Yuan-Tsan Tseng Nadine Francis Najma Latif Kim H Parker James E Moore Magdi H Yacoub Source Type: research
< em > Glucocorticoids, Their Uses, Sexual Dimorphisms, and Diseases: New Concepts, Mechanisms, and Discoveries < /em >
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00021.2023. Online ahead of print.ABSTRACTThe normal stress response in humans is governed by the hypothalamic-pituitary-adrenal (HPA) axis through heightened mechanisms during stress, raising blood levels of the glucocorticoid hormone cortisol. Glucocorticoids are quintessential compounds that balance the proper functioning of numerous systems in the mammalian body. They are also generated synthetically and are the preeminent therapy for inflammatory diseases. They act by binding to the nuclear receptor transcription factor, the glucocorticoid receptor (GR), which has two mai...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Genesee J Martinez Malik Appleton Zachary A Kipp Analia S Loria Booki Min Terry D Hinds Source Type: research
Tissue Transglutaminase: A Multifunctional and Multisite Regulator in Health and Disease
In conclusion, TG2 provides a multifunctional and multisite response to physiological stress.PMID:37712623 | DOI:10.1152/physrev.00003.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - September 15, 2023 Category: Physiology Authors: Zhouzhou Yao Yuhua Fan Lizhen Lin Rodney E Kellems Yang Xia Source Type: research
Tissue Transglutaminase: A Multifunctional and Multisite Regulator in Health and Disease
In conclusion, TG2 provides a multifunctional and multisite response to physiological stress.PMID:37712623 | DOI:10.1152/physrev.00003.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - September 15, 2023 Category: Physiology Authors: Zhouzhou Yao Yuhua Fan Lizhen Lin Rodney E Kellems Yang Xia Source Type: research
Tissue Transglutaminase: A Multifunctional and Multisite Regulator in Health and Disease
In conclusion, TG2 provides a multifunctional and multisite response to physiological stress.PMID:37712623 | DOI:10.1152/physrev.00003.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - September 15, 2023 Category: Physiology Authors: Zhouzhou Yao Yuhua Fan Lizhen Lin Rodney E Kellems Yang Xia Source Type: research
Tissue Transglutaminase: A Multifunctional and Multisite Regulator in Health and Disease
In conclusion, TG2 provides a multifunctional and multisite response to physiological stress.PMID:37712623 | DOI:10.1152/physrev.00003.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - September 15, 2023 Category: Physiology Authors: Zhouzhou Yao Yuhua Fan Lizhen Lin Rodney E Kellems Yang Xia Source Type: research
Tissue Transglutaminase: A Multifunctional and Multisite Regulator in Health and Disease
In conclusion, TG2 provides a multifunctional and multisite response to physiological stress.PMID:37712623 | DOI:10.1152/physrev.00003.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - September 15, 2023 Category: Physiology Authors: Zhouzhou Yao Yuhua Fan Lizhen Lin Rodney E Kellems Yang Xia Source Type: research
SIRT7: the seventh key to unlocking the mystery of aging
Physiol Rev. 2023 Sep 7. doi: 10.1152/physrev.00044.2022. Online ahead of print.ABSTRACTAging is a chronic yet natural physiological decline of the body. Throughout the life, humans are continuously exposed to a variety of exogenous and endogenous stresses, to which they engender various counteractive responses at the cellular, tissue, organ, as well as organismal levels. The compromised cellular and tissue functions, which occur due to genetic factors or prolonged stress (or even the stress response), may accelerate aging. Over the last two decades, the sirtuin (SIRT) family of lysine deacylases has emerged as a key regul...
Source: Physiological Reviews - September 7, 2023 Category: Physiology Authors: Umar Raza Xiaolong Tang Zuojun Liu Baohua Liu Source Type: research
SIRT7: the seventh key to unlocking the mystery of aging
Physiol Rev. 2023 Sep 7. doi: 10.1152/physrev.00044.2022. Online ahead of print.ABSTRACTAging is a chronic yet natural physiological decline of the body. Throughout the life, humans are continuously exposed to a variety of exogenous and endogenous stresses, to which they engender various counteractive responses at the cellular, tissue, organ, as well as organismal levels. The compromised cellular and tissue functions, which occur due to genetic factors or prolonged stress (or even the stress response), may accelerate aging. Over the last two decades, the sirtuin (SIRT) family of lysine deacylases has emerged as a key regul...
Source: Physiological Reviews - September 7, 2023 Category: Physiology Authors: Umar Raza Xiaolong Tang Zuojun Liu Baohua Liu Source Type: research
