A Balancing Act: Learning from the Past to Build a Future-Focused Opioid Strategy
Annu Rev Physiol. 2023 Nov 29. doi: 10.1146/annurev-physiol-042022-015914. Online ahead of print.ABSTRACTThe harmful side effects of opioid drugs such as respiratory depression, tolerance, dependence, and abuse potential have limited the therapeutic utility of opioids for their entire clinical history. However, no previous attempt to develop effective pain drugs that substantially ameliorate these effects has succeeded, and the current opioid epidemic affirms that they are a greater hindrance to the field of pain management than ever. Recent attempts at new opioid development have sought to reduce these side effects by min...
Source: Physiological Reviews - November 29, 2023 Category: Physiology Authors: Sarah Warren Gooding Jennifer L Whistler Source Type: research
A Balancing Act: Learning from the Past to Build a Future-Focused Opioid Strategy
Annu Rev Physiol. 2023 Nov 29. doi: 10.1146/annurev-physiol-042022-015914. Online ahead of print.ABSTRACTThe harmful side effects of opioid drugs such as respiratory depression, tolerance, dependence, and abuse potential have limited the therapeutic utility of opioids for their entire clinical history. However, no previous attempt to develop effective pain drugs that substantially ameliorate these effects has succeeded, and the current opioid epidemic affirms that they are a greater hindrance to the field of pain management than ever. Recent attempts at new opioid development have sought to reduce these side effects by min...
Source: Physiological Reviews - November 29, 2023 Category: Physiology Authors: Sarah Warren Gooding Jennifer L Whistler Source Type: research
A Balancing Act: Learning from the Past to Build a Future-Focused Opioid Strategy
Annu Rev Physiol. 2023 Nov 29. doi: 10.1146/annurev-physiol-042022-015914. Online ahead of print.ABSTRACTThe harmful side effects of opioid drugs such as respiratory depression, tolerance, dependence, and abuse potential have limited the therapeutic utility of opioids for their entire clinical history. However, no previous attempt to develop effective pain drugs that substantially ameliorate these effects has succeeded, and the current opioid epidemic affirms that they are a greater hindrance to the field of pain management than ever. Recent attempts at new opioid development have sought to reduce these side effects by min...
Source: Physiological Reviews - November 29, 2023 Category: Physiology Authors: Sarah Warren Gooding Jennifer L Whistler Source Type: research
Mitochondrial Dysfunction in Kidney Tubulopathies
Annu Rev Physiol. 2023 Nov 27. doi: 10.1146/annurev-physiol-042222-025000. Online ahead of print.ABSTRACTMitochondria play a key role in kidney physiology and pathology. They produce ATP to fuel energy-demanding water and solute reabsorption processes along the nephron. Moreover, mitochondria contribute to cellular health by the regulation of autophagy, (oxidative) stress responses, and apoptosis. Mitochondrial abundance is particularly high in cortical segments, including proximal and distal convoluted tubules. Dysfunction of the mitochondria has been described for tubulopathies such as Fanconi, Gitelman, and Bartter-like...
Source: Physiological Reviews - November 27, 2023 Category: Physiology Authors: Charlotte A Hoogstraten Joost G Hoenderop Jeroen H F de Baaij Source Type: research
Metabolic Rewiring and Communication: An Integrative View of Kidney Proximal Tubule Function
Annu Rev Physiol. 2023 Nov 27. doi: 10.1146/annurev-physiol-042222-024724. Online ahead of print.ABSTRACTThe kidney proximal tubule is a key organ for human metabolism. The kidney responds to stress with altered metabolite transformation and perturbed metabolic pathways, an ultimate cause for kidney disease. Here, we review the proximal tubule's metabolic function through an integrative view of transport, metabolism, and function, and embed it in the context of metabolome-wide data-driven research. Function (filtration, transport, secretion, and reabsorption), metabolite transformation, and metabolite signaling determine k...
Source: Physiological Reviews - November 27, 2023 Category: Physiology Authors: Maria Chrysopoulou Markus M Rinschen Source Type: research
Mitochondrial Dysfunction in Kidney Tubulopathies
Annu Rev Physiol. 2023 Nov 27. doi: 10.1146/annurev-physiol-042222-025000. Online ahead of print.ABSTRACTMitochondria play a key role in kidney physiology and pathology. They produce ATP to fuel energy-demanding water and solute reabsorption processes along the nephron. Moreover, mitochondria contribute to cellular health by the regulation of autophagy, (oxidative) stress responses, and apoptosis. Mitochondrial abundance is particularly high in cortical segments, including proximal and distal convoluted tubules. Dysfunction of the mitochondria has been described for tubulopathies such as Fanconi, Gitelman, and Bartter-like...
Source: Physiological Reviews - November 27, 2023 Category: Physiology Authors: Charlotte A Hoogstraten Joost G Hoenderop Jeroen H F de Baaij Source Type: research
Metabolic Rewiring and Communication: An Integrative View of Kidney Proximal Tubule Function
Annu Rev Physiol. 2023 Nov 27. doi: 10.1146/annurev-physiol-042222-024724. Online ahead of print.ABSTRACTThe kidney proximal tubule is a key organ for human metabolism. The kidney responds to stress with altered metabolite transformation and perturbed metabolic pathways, an ultimate cause for kidney disease. Here, we review the proximal tubule's metabolic function through an integrative view of transport, metabolism, and function, and embed it in the context of metabolome-wide data-driven research. Function (filtration, transport, secretion, and reabsorption), metabolite transformation, and metabolite signaling determine k...
Source: Physiological Reviews - November 27, 2023 Category: Physiology Authors: Maria Chrysopoulou Markus M Rinschen Source Type: research
Phosphodiesterases in heart and vessels- From Physiology to Diseases
Physiol Rev. 2023 Nov 16. doi: 10.1152/physrev.00015.2023. Online ahead of print.ABSTRACTPhosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), critical secondary messengers in the neurohormonal regulation in the cardiovascular system. PDEs precisely control spatiotemporal subcellular distribution of cyclic nucleotides in a cell and tissue-specific manner, playing critical roles in physiological responses to hormone stimulation in the heart and vessels. Dysregulation of PDEs has been linked to the d...
Source: Physiological Reviews - November 16, 2023 Category: Physiology Authors: Qin Fu Ying Wang Chen Yan Yang K Xiang Source Type: research
Phosphodiesterases in heart and vessels- From Physiology to Diseases
Physiol Rev. 2023 Nov 16. doi: 10.1152/physrev.00015.2023. Online ahead of print.ABSTRACTPhosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), critical secondary messengers in the neurohormonal regulation in the cardiovascular system. PDEs precisely control spatiotemporal subcellular distribution of cyclic nucleotides in a cell and tissue-specific manner, playing critical roles in physiological responses to hormone stimulation in the heart and vessels. Dysregulation of PDEs has been linked to the d...
Source: Physiological Reviews - November 16, 2023 Category: Physiology Authors: Qin Fu Ying Wang Chen Yan Yang K Xiang Source Type: research
Phosphodiesterases in heart and vessels- From Physiology to Diseases
Physiol Rev. 2023 Nov 16. doi: 10.1152/physrev.00015.2023. Online ahead of print.ABSTRACTPhosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), critical secondary messengers in the neurohormonal regulation in the cardiovascular system. PDEs precisely control spatiotemporal subcellular distribution of cyclic nucleotides in a cell and tissue-specific manner, playing critical roles in physiological responses to hormone stimulation in the heart and vessels. Dysregulation of PDEs has been linked to the d...
Source: Physiological Reviews - November 16, 2023 Category: Physiology Authors: Qin Fu Ying Wang Chen Yan Yang K Xiang Source Type: research
Phosphodiesterases in heart and vessels- From Physiology to Diseases
Physiol Rev. 2023 Nov 16. doi: 10.1152/physrev.00015.2023. Online ahead of print.ABSTRACTPhosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), critical secondary messengers in the neurohormonal regulation in the cardiovascular system. PDEs precisely control spatiotemporal subcellular distribution of cyclic nucleotides in a cell and tissue-specific manner, playing critical roles in physiological responses to hormone stimulation in the heart and vessels. Dysregulation of PDEs has been linked to the d...
Source: Physiological Reviews - November 16, 2023 Category: Physiology Authors: Qin Fu Ying Wang Chen Yan Yang K Xiang Source Type: research
Phosphodiesterases in heart and vessels- From Physiology to Diseases
Physiol Rev. 2023 Nov 16. doi: 10.1152/physrev.00015.2023. Online ahead of print.ABSTRACTPhosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), critical secondary messengers in the neurohormonal regulation in the cardiovascular system. PDEs precisely control spatiotemporal subcellular distribution of cyclic nucleotides in a cell and tissue-specific manner, playing critical roles in physiological responses to hormone stimulation in the heart and vessels. Dysregulation of PDEs has been linked to the d...
Source: Physiological Reviews - November 16, 2023 Category: Physiology Authors: Qin Fu Ying Wang Chen Yan Yang K Xiang Source Type: research
Phosphodiesterases in heart and vessels- From Physiology to Diseases
Physiol Rev. 2023 Nov 16. doi: 10.1152/physrev.00015.2023. Online ahead of print.ABSTRACTPhosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), critical secondary messengers in the neurohormonal regulation in the cardiovascular system. PDEs precisely control spatiotemporal subcellular distribution of cyclic nucleotides in a cell and tissue-specific manner, playing critical roles in physiological responses to hormone stimulation in the heart and vessels. Dysregulation of PDEs has been linked to the d...
Source: Physiological Reviews - November 16, 2023 Category: Physiology Authors: Qin Fu Ying Wang Chen Yan Yang K Xiang Source Type: research
Phosphodiesterases in heart and vessels- From Physiology to Diseases
Physiol Rev. 2023 Nov 16. doi: 10.1152/physrev.00015.2023. Online ahead of print.ABSTRACTPhosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), critical secondary messengers in the neurohormonal regulation in the cardiovascular system. PDEs precisely control spatiotemporal subcellular distribution of cyclic nucleotides in a cell and tissue-specific manner, playing critical roles in physiological responses to hormone stimulation in the heart and vessels. Dysregulation of PDEs has been linked to the d...
Source: Physiological Reviews - November 16, 2023 Category: Physiology Authors: Qin Fu Ying Wang Chen Yan Yang K Xiang Source Type: research
Editorial on Davis et al
Physiol Rev. 2023 Nov 9. doi: 10.1152/physrev.00033.2023. Online ahead of print.NO ABSTRACTPMID:37943247 | DOI:10.1152/physrev.00033.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - November 9, 2023 Category: Physiology Authors: Brooke R Shepley Anthony R Bain Source Type: research
