Phosphodiesterases in heart and vessels- From Physiology to Diseases
Physiol Rev. 2023 Nov 16. doi: 10.1152/physrev.00015.2023. Online ahead of print.ABSTRACTPhosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), critical secondary messengers in the neurohormonal regulation in the cardiovascular system. PDEs precisely control spatiotemporal subcellular distribution of cyclic nucleotides in a cell and tissue-specific manner, playing critical roles in physiological responses to hormone stimulation in the heart and vessels. Dysregulation of PDEs has been linked to the d...
Source: Physiological Reviews - November 16, 2023 Category: Physiology Authors: Qin Fu Ying Wang Chen Yan Yang K Xiang Source Type: research
Phosphodiesterases in heart and vessels- From Physiology to Diseases
Physiol Rev. 2023 Nov 16. doi: 10.1152/physrev.00015.2023. Online ahead of print.ABSTRACTPhosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), critical secondary messengers in the neurohormonal regulation in the cardiovascular system. PDEs precisely control spatiotemporal subcellular distribution of cyclic nucleotides in a cell and tissue-specific manner, playing critical roles in physiological responses to hormone stimulation in the heart and vessels. Dysregulation of PDEs has been linked to the d...
Source: Physiological Reviews - November 16, 2023 Category: Physiology Authors: Qin Fu Ying Wang Chen Yan Yang K Xiang Source Type: research
Phosphodiesterases in heart and vessels- From Physiology to Diseases
Physiol Rev. 2023 Nov 16. doi: 10.1152/physrev.00015.2023. Online ahead of print.ABSTRACTPhosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), critical secondary messengers in the neurohormonal regulation in the cardiovascular system. PDEs precisely control spatiotemporal subcellular distribution of cyclic nucleotides in a cell and tissue-specific manner, playing critical roles in physiological responses to hormone stimulation in the heart and vessels. Dysregulation of PDEs has been linked to the d...
Source: Physiological Reviews - November 16, 2023 Category: Physiology Authors: Qin Fu Ying Wang Chen Yan Yang K Xiang Source Type: research
Phosphodiesterases in heart and vessels- From Physiology to Diseases
Physiol Rev. 2023 Nov 16. doi: 10.1152/physrev.00015.2023. Online ahead of print.ABSTRACTPhosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), critical secondary messengers in the neurohormonal regulation in the cardiovascular system. PDEs precisely control spatiotemporal subcellular distribution of cyclic nucleotides in a cell and tissue-specific manner, playing critical roles in physiological responses to hormone stimulation in the heart and vessels. Dysregulation of PDEs has been linked to the d...
Source: Physiological Reviews - November 16, 2023 Category: Physiology Authors: Qin Fu Ying Wang Chen Yan Yang K Xiang Source Type: research
Editorial on Davis et al
Physiol Rev. 2023 Nov 9. doi: 10.1152/physrev.00033.2023. Online ahead of print.NO ABSTRACTPMID:37943247 | DOI:10.1152/physrev.00033.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - November 9, 2023 Category: Physiology Authors: Brooke R Shepley Anthony R Bain Source Type: research
Editorial on Davis et al
Physiol Rev. 2023 Nov 9. doi: 10.1152/physrev.00033.2023. Online ahead of print.NO ABSTRACTPMID:37943247 | DOI:10.1152/physrev.00033.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - November 9, 2023 Category: Physiology Authors: Brooke R Shepley Anthony R Bain Source Type: research
Editorial on Davis et al
Physiol Rev. 2023 Nov 9. doi: 10.1152/physrev.00033.2023. Online ahead of print.NO ABSTRACTPMID:37943247 | DOI:10.1152/physrev.00033.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - November 9, 2023 Category: Physiology Authors: Brooke R Shepley Anthony R Bain Source Type: research
Editorial on Davis et al
Physiol Rev. 2023 Nov 9. doi: 10.1152/physrev.00033.2023. Online ahead of print.NO ABSTRACTPMID:37943247 | DOI:10.1152/physrev.00033.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - November 9, 2023 Category: Physiology Authors: Brooke R Shepley Anthony R Bain Source Type: research
Editorial on Davis et al
Physiol Rev. 2023 Nov 9. doi: 10.1152/physrev.00033.2023. Online ahead of print.NO ABSTRACTPMID:37943247 | DOI:10.1152/physrev.00033.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - November 9, 2023 Category: Physiology Authors: Brooke R Shepley Anthony R Bain Source Type: research
Editorial on Davis et al
Physiol Rev. 2023 Nov 9. doi: 10.1152/physrev.00033.2023. Online ahead of print.NO ABSTRACTPMID:37943247 | DOI:10.1152/physrev.00033.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - November 9, 2023 Category: Physiology Authors: Brooke R Shepley Anthony R Bain Source Type: research
Editorial on Davis et al
Physiol Rev. 2023 Nov 9. doi: 10.1152/physrev.00033.2023. Online ahead of print.NO ABSTRACTPMID:37943247 | DOI:10.1152/physrev.00033.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - November 9, 2023 Category: Physiology Authors: Brooke R Shepley Anthony R Bain Source Type: research
Transcendent Aspects of Proton Channels
Annu Rev Physiol. 2023 Nov 6. doi: 10.1146/annurev-physiol-042222-023242. Online ahead of print.ABSTRACTA handful of biological proton-selective ion channels exist. Some open at positive or negative membrane potentials, others open at low or high pH, and some are light activated. This review focuses on common features that result from the unique properties of protons. Proton conduction through water or proteins differs qualitatively from that of all other ions. Extraordinary proton selectivity is needed to ensure that protons permeate and other ions do not. Proton selectivity arises from a proton pathway comprising a hydro...
Source: Physiological Reviews - November 6, 2023 Category: Physiology Authors: Thomas E DeCoursey Source Type: research
Regulating Striated Muscle Contraction: Through Thick and Thin
Annu Rev Physiol. 2023 Nov 6. doi: 10.1146/annurev-physiol-042222-022728. Online ahead of print.ABSTRACTForce generation in striated muscle is primarily controlled by structural changes in the actin-containing thin filaments triggered by an increase in intracellular calcium concentration. However, recent studies have elucidated a new class of regulatory mechanisms, based on the myosin-containing thick filament, that control the strength and speed of contraction by modulating the availability of myosin motors for the interaction with actin. This review summarizes the mechanisms of thin and thick filament activation that reg...
Source: Physiological Reviews - November 6, 2023 Category: Physiology Authors: Elisabetta Brunello Luca Fusi Source Type: research
Structure, Function, and Regulation of the Junctophilin Family
Annu Rev Physiol. 2023 Nov 6. doi: 10.1146/annurev-physiol-042022-014926. Online ahead of print.ABSTRACTIn both excitable and nonexcitable cells, diverse physiological processes are linked to different calcium microdomains within nanoscale junctions that form between the plasma membrane and endo-sarcoplasmic reticula. It is now appreciated that the junctophilin protein family is responsible for establishing, maintaining, and modulating the structure and function of these junctions. We review foundational findings from more than two decades of research that have uncovered how junctophilin-organized ultrastructural domains r...
Source: Physiological Reviews - November 6, 2023 Category: Physiology Authors: Duane D Hall Hiroshi Takeshima Long-Sheng Song Source Type: research
Adipose Tissue in Cardiovascular Disease: From Basic Science to Clinical Translation
Annu Rev Physiol. 2023 Nov 6. doi: 10.1146/annurev-physiol-042222-021346. Online ahead of print.ABSTRACTThe perception of adipose tissue as a metabolically quiescent tissue, primarily responsible for lipid storage and energy balance (with some endocrine, thermogenic, and insulation functions), has changed. It is now accepted that adipose tissue is a crucial regulator of metabolic health, maintaining bidirectional communication with other organs including the cardiovascular system. Additionally, adipose tissue depots are functionally and morphologically heterogeneous, acting not only as sources of bioactive molecules that r...
Source: Physiological Reviews - November 6, 2023 Category: Physiology Authors: Murray D Polkinghorne Henry W West Charalambos Antoniades Source Type: research
