Inflammation o'clock: interactions of circadian rhythms with inflammation-induced skeletal muscle atrophy
J Physiol. 2023 Aug 10. doi: 10.1113/JP284808. Online ahead of print.ABSTRACTCircadian rhythms are ∼24 h cycles evident in behaviour, physiology and metabolism. The molecular mechanism directing circadian rhythms is the circadian clock, which is composed of an interactive network of transcription-translation feedback loops. The core clock genes include Bmal1, Clock, Rev-erbα/β, Per and Cry. In addition to keeping time, the core clock regulates a daily programme of gene expression that is important for overall cell homeostasis. The circadian clock mechanism is present in all cells, including skeletal muscle fibres, and ...
Source: Physiological Reviews - August 11, 2023 Category: Physiology Authors: Francielly Morena da Silva Karyn A Esser Kevin A Murach Nicholas P Greene Source Type: research
Inflammation o'clock: interactions of circadian rhythms with inflammation-induced skeletal muscle atrophy
J Physiol. 2023 Aug 10. doi: 10.1113/JP284808. Online ahead of print.ABSTRACTCircadian rhythms are ∼24 h cycles evident in behaviour, physiology and metabolism. The molecular mechanism directing circadian rhythms is the circadian clock, which is composed of an interactive network of transcription-translation feedback loops. The core clock genes include Bmal1, Clock, Rev-erbα/β, Per and Cry. In addition to keeping time, the core clock regulates a daily programme of gene expression that is important for overall cell homeostasis. The circadian clock mechanism is present in all cells, including skeletal muscle fibres, and ...
Source: Physiological Reviews - August 11, 2023 Category: Physiology Authors: Francielly Morena da Silva Karyn A Esser Kevin A Murach Nicholas P Greene Source Type: research
Inflammation o'clock: interactions of circadian rhythms with inflammation-induced skeletal muscle atrophy
J Physiol. 2023 Aug 10. doi: 10.1113/JP284808. Online ahead of print.ABSTRACTCircadian rhythms are ∼24 h cycles evident in behaviour, physiology and metabolism. The molecular mechanism directing circadian rhythms is the circadian clock, which is composed of an interactive network of transcription-translation feedback loops. The core clock genes include Bmal1, Clock, Rev-erbα/β, Per and Cry. In addition to keeping time, the core clock regulates a daily programme of gene expression that is important for overall cell homeostasis. The circadian clock mechanism is present in all cells, including skeletal muscle fibres, and ...
Source: Physiological Reviews - August 11, 2023 Category: Physiology Authors: Francielly Morena da Silva Karyn A Esser Kevin A Murach Nicholas P Greene Source Type: research
Recent Insights into Channelopathies
Physiol Rev. 2023 Aug 10. doi: 10.1152/physrev.00022.2023. Online ahead of print.NO ABSTRACTPMID:37561136 | DOI:10.1152/physrev.00022.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - August 10, 2023 Category: Physiology Authors: Osama F Harraz Eric Delpire Source Type: research
Lung Endothelium, Tau, and Amyloids in Health and Disease
Physiol Rev. 2023 Aug 10. doi: 10.1152/physrev.00006.2023. Online ahead of print.ABSTRACTLung endothelium in the arteries, capillaries, and veins are heterogeneous in structure and function. Lung capillaries in particular represent a unique vascular niche, with a thin yet highly restrictive alveolar-capillary barrier that optimizes gas exchange. Capillary endothelium surveys the blood while simultaneously interpreting cues initiated within the alveolus and communicated via immediately adjacent type I and type II epithelial cells, fibroblasts, and pericytes. This cell-cell communication is necessary to coordinate the immune...
Source: Physiological Reviews - August 10, 2023 Category: Physiology Authors: Ron Balczon Mike T Lin Sarah Voth Amy R Nelson Jonas C Schupp Brant M Wagener Jean-Francois Pittet Troy Stevens Source Type: research
Ca < sup > 2+ < /sup > dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract
Physiol Rev. 2023 Aug 10. doi: 10.1152/physrev.00036.2022. Online ahead of print.ABSTRACTThe gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI motility, but interstitial cells, electrically coupled to SMCs, tune SMC excitability, transduce inputs from enteric motor neurons and generate pacemaker activity that underlies major motor patterns, such as peristalsis and segmentation. The interstitial cells regulating SMCs are interstitial cells of Cajal (ICC) and PDGFRa+ cells. Together these cells form the ...
Source: Physiological Reviews - August 10, 2023 Category: Physiology Authors: Kenton M Sanders Bernard T Drumm Caroline A Cobine Salah A Baker Source Type: research
The Role of Quality Metrics in the Evolution of AI in Healthcare and Implications for Generative AI
Physiol Rev. 2023 Aug 10. doi: 10.1152/physrev.00029.2023. Online ahead of print.NO ABSTRACTPMID:37561139 | DOI:10.1152/physrev.00029.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - August 10, 2023 Category: Physiology Authors: Ryan C Godwin Ryan L Melvin Source Type: research
Recent Insights into Channelopathies
Physiol Rev. 2023 Aug 10. doi: 10.1152/physrev.00022.2023. Online ahead of print.NO ABSTRACTPMID:37561136 | DOI:10.1152/physrev.00022.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - August 10, 2023 Category: Physiology Authors: Osama F Harraz Eric Delpire Source Type: research
Lung Endothelium, Tau, and Amyloids in Health and Disease
Physiol Rev. 2023 Aug 10. doi: 10.1152/physrev.00006.2023. Online ahead of print.ABSTRACTLung endothelium in the arteries, capillaries, and veins are heterogeneous in structure and function. Lung capillaries in particular represent a unique vascular niche, with a thin yet highly restrictive alveolar-capillary barrier that optimizes gas exchange. Capillary endothelium surveys the blood while simultaneously interpreting cues initiated within the alveolus and communicated via immediately adjacent type I and type II epithelial cells, fibroblasts, and pericytes. This cell-cell communication is necessary to coordinate the immune...
Source: Physiological Reviews - August 10, 2023 Category: Physiology Authors: Ron Balczon Mike T Lin Sarah Voth Amy R Nelson Jonas C Schupp Brant M Wagener Jean-Francois Pittet Troy Stevens Source Type: research
Ca < sup > 2+ < /sup > dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract
Physiol Rev. 2023 Aug 10. doi: 10.1152/physrev.00036.2022. Online ahead of print.ABSTRACTThe gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI motility, but interstitial cells, electrically coupled to SMCs, tune SMC excitability, transduce inputs from enteric motor neurons and generate pacemaker activity that underlies major motor patterns, such as peristalsis and segmentation. The interstitial cells regulating SMCs are interstitial cells of Cajal (ICC) and PDGFRa+ cells. Together these cells form the ...
Source: Physiological Reviews - August 10, 2023 Category: Physiology Authors: Kenton M Sanders Bernard T Drumm Caroline A Cobine Salah A Baker Source Type: research
The Role of Quality Metrics in the Evolution of AI in Healthcare and Implications for Generative AI
Physiol Rev. 2023 Aug 10. doi: 10.1152/physrev.00029.2023. Online ahead of print.NO ABSTRACTPMID:37561139 | DOI:10.1152/physrev.00029.2023 (Source: Physiological Reviews)
Source: Physiological Reviews - August 10, 2023 Category: Physiology Authors: Ryan C Godwin Ryan L Melvin Source Type: research
CardIAP: calcium transients confocal image analysis tool
Front Bioinform. 2023 Jul 14;3:1137815. doi: 10.3389/fbinf.2023.1137815. eCollection 2023.ABSTRACTOne of the main topics of cardiovascular research is the study of calcium (Ca2+) handling, as even small changes in Ca2+ concentration can alter cell functionality (Bers, Annu Rev Physiol, 2014, 76, 107-127). Ionic calcium (Ca2+) plays the role of a second messenger in eukaryotic cells, associated with cellular functions such as cell cycle regulation, transport, motility, gene expression, and regulation. The use of fluorometric techniques in isolated cells loaded with Ca2+-sensitive fluorescent probes allows quantitative measu...
Source: Physiological Reviews - July 31, 2023 Category: Physiology Authors: Ana Julia Velez Rueda Luis Alberto Gonano Agust ín García Smith Gustavo Parisi Mar ía Silvina Fornasari Leandro Mat ías Sommese Source Type: research
CardIAP: calcium transients confocal image analysis tool
Front Bioinform. 2023 Jul 14;3:1137815. doi: 10.3389/fbinf.2023.1137815. eCollection 2023.ABSTRACTOne of the main topics of cardiovascular research is the study of calcium (Ca2+) handling, as even small changes in Ca2+ concentration can alter cell functionality (Bers, Annu Rev Physiol, 2014, 76, 107-127). Ionic calcium (Ca2+) plays the role of a second messenger in eukaryotic cells, associated with cellular functions such as cell cycle regulation, transport, motility, gene expression, and regulation. The use of fluorometric techniques in isolated cells loaded with Ca2+-sensitive fluorescent probes allows quantitative measu...
Source: Physiological Reviews - July 31, 2023 Category: Physiology Authors: Ana Julia Velez Rueda Luis Alberto Gonano Agust ín García Smith Gustavo Parisi Mar ía Silvina Fornasari Leandro Mat ías Sommese Source Type: research
CardIAP: calcium transients confocal image analysis tool
Front Bioinform. 2023 Jul 14;3:1137815. doi: 10.3389/fbinf.2023.1137815. eCollection 2023.ABSTRACTOne of the main topics of cardiovascular research is the study of calcium (Ca2+) handling, as even small changes in Ca2+ concentration can alter cell functionality (Bers, Annu Rev Physiol, 2014, 76, 107-127). Ionic calcium (Ca2+) plays the role of a second messenger in eukaryotic cells, associated with cellular functions such as cell cycle regulation, transport, motility, gene expression, and regulation. The use of fluorometric techniques in isolated cells loaded with Ca2+-sensitive fluorescent probes allows quantitative measu...
Source: Physiological Reviews - July 31, 2023 Category: Physiology Authors: Ana Julia Velez Rueda Luis Alberto Gonano Agust ín García Smith Gustavo Parisi Mar ía Silvina Fornasari Leandro Mat ías Sommese Source Type: research
CardIAP: calcium transients confocal image analysis tool
Front Bioinform. 2023 Jul 14;3:1137815. doi: 10.3389/fbinf.2023.1137815. eCollection 2023.ABSTRACTOne of the main topics of cardiovascular research is the study of calcium (Ca2+) handling, as even small changes in Ca2+ concentration can alter cell functionality (Bers, Annu Rev Physiol, 2014, 76, 107-127). Ionic calcium (Ca2+) plays the role of a second messenger in eukaryotic cells, associated with cellular functions such as cell cycle regulation, transport, motility, gene expression, and regulation. The use of fluorometric techniques in isolated cells loaded with Ca2+-sensitive fluorescent probes allows quantitative measu...
Source: Physiological Reviews - July 31, 2023 Category: Physiology Authors: Ana Julia Velez Rueda Luis Alberto Gonano Agust ín García Smith Gustavo Parisi Mar ía Silvina Fornasari Leandro Mat ías Sommese Source Type: research
