SIRT7: the seventh key to unlocking the mystery of aging

Physiol Rev. 2023 Sep 7. doi: 10.1152/physrev.00044.2022. Online ahead of print.ABSTRACTAging is a chronic yet natural physiological decline of the body. Throughout the life, humans are continuously exposed to a variety of exogenous and endogenous stresses, to which they engender various counteractive responses at the cellular, tissue, organ, as well as organismal levels. The compromised cellular and tissue functions, which occur due to genetic factors or prolonged stress (or even the stress response), may accelerate aging. Over the last two decades, the sirtuin (SIRT) family of lysine deacylases has emerged as a key regulator of longevity in a variety of organisms. SIRT7, the most recently identified member of SIRTs, maintains physiological homeostasis and provides protection against aging by functioning as a watchdog of genomic integrity, a dynamic sensor and modulator of stresses. SIRT7 decline disrupts metabolic homeostasis, accelerates aging and increases the risk of age-related pathologies including cardiovascular and neurodegenerative diseases, pulmonary and renal disorders, inflammatory diseases, and cancer etc. Here, we present SIRT7 as the seventh key to unlock the mystery of aging and its specific manipulation holds great potential to ensure healthiness and longevity.PMID:37676263 | DOI:10.1152/physrev.00044.2022
Source: Physiological Reviews - Category: Physiology Authors: Source Type: research