Retrospective Analysis of Risk Factors for Periodic Limb Movements in a Large Cohort of Insomnia and Chronic Fatigue Patients
Discussion This retrospective study adds supportive evidence to the association of drug classes with PLMS and PLMD. These findings may impact on clinical management of patients with a combined anxiety or mood disorder in need for these drug classes on the one hand and a significant sleep architecture disturbance through PLMS, potentially contributing to daytime symptoms, on the other hand. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - August 26, 2019 Category: Psychiatry Authors: Tobback, Els Desmet, Olivier Hanoulle, Ignace Delesie, Liesbeth Pevernagie, Dirk Vogelaers, Dirk Mariman, An Tags: Original Paper Source Type: research
Ketamine in the Treatment of Depressive Episodes
Pharmacopsychiatry DOI: 10.1055/a-0991-0582The treatment of depressive episodes remains complicated by the long latency of antidepressant efficacy, insufficient response, and high risk of suicide. Ketamine and esketamine have been proposed as fast-acting substances able to overcome these impediments.Since the first randomized controlled trial in the year 2000, numerous studies have explored the antidepressant efficacy of ketamine and esketamine. Clear evidence has emerged that a single infusion exerts a significant antidepressant and antisuicidal effect in both unipolar and bipolar depression. A few studies suggest that an...
Source: Pharmacopsychiatry - August 20, 2019 Category: Psychiatry Authors: Ritter, Philipp Findeis, Hannelore Bauer, Michael Tags: Review Source Type: research
Psychiatry is Broadening the Biological Paradigm at Last – A Commentary on Hoffmann et al. “Dietary Supplements in Psychiatric Treatment – A Narrative Review”
Pharmacopsychiatry DOI: 10.1055/a-0987-0366 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - August 20, 2019 Category: Psychiatry Authors: Walach, Harald Tags: Commentary Source Type: research
Acute and Long-term Memantine Add-on Treatment to Risperidone Improves Cognitive Dysfunction in Patients with Acute and Chronic Schizophrenia
Discussions Our study gives further evidence that memantine add-on treatment to risperidone may have neuroprotective effects and improve cognitive function in patients with schizophrenia. ClinicalTrials.gov Number: NCT00148590 and NCT00148616. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - August 6, 2019 Category: Psychiatry Authors: Schaefer, Martin Sarkar, Susanne Theophil, Ines Leopold, Karolina Heinz, Andreas Gallinat, J ürgen Tags: Original Paper Source Type: research
Hippocampal Dysfunction in Schizophrenia and Aberrant Hippocampal Synaptic Plasticity in Rodent Model Psychosis: a Selective Review
Pharmacopsychiatry DOI: 10.1055/a-0960-9846Schizophrenia is a complex, heterogeneous psychiatric disorder that affects about 1% of the global population. Hippocampal dysfunction has been linked to both cognitive deficits and positive symptoms in schizophrenia. Here, we briefly review current findings on disrupted hippocampal processing from a clinical perspective before concentrating on preclinical studies of aberrant hippocampal synaptic plasticity using the N-methyl-D-aspartate receptor hypofunction model of psychosis and related findings from genetic models. Taken together, the results put the case for maladaptive hippo...
Source: Pharmacopsychiatry - July 31, 2019 Category: Psychiatry Authors: Bartsch, Julia C. Schott, Bj örn H. Behr, Joachim Tags: Review Source Type: research
The Role of Dietary Supplements in Depression and Anxiety – A Narrative Review
Discussion This review summarizes the current knowledge about supplements when used for some psychiatric conditions, but the data does not provide compelling evidence in any direction. There are only indications that there is an influence of supplements on psychiatric diseases. In support of this, there is further need for high-quality studies in this field. Reviews on other diagnoses, such as schizophrenia and dementia, will be part of further work. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 7, 2019 Category: Psychiatry Authors: Hoffmann, Knut Emons, Barbara Brunnhuber, Stefan Karaca, Sedya Juckel, Georg Tags: Review Source Type: research
Adjunctive Reboxetine for Schizophrenia: Meta-analysis of Randomized Double-blind, Placebo-controlled Trials
Conclusion Adjunctive reboxetine could be useful for attenuating antipsychotic-induced weight gain, but it was not effective in treating psychopathology including negative symptoms in schizophrenia. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 16, 2019 Category: Psychiatry Authors: Zheng, Wei Li, Xian-Bin Shi, Zhan-Ming Yang, Xin-Hu Cai, Dong-Bin Ng, Chee H. Ungvari, Gabor S. Liu, Wei-Jian Wu, Yu-Jie Wang, Yuan-Yuan Ning, Yu-Ping Xiang, Yu-Tao Tags: Original Paper Source Type: research
Roadmap for Routine Pharmacogenetic Testing in a Psychiatric University Hospital
This article describes a pilot study design aimed to combine clinical variables such as therapeutic drug monitoring, inflammatory and stress markers with static and variable genetic information of depressed patients to develop an algorithm that predicts treatment response, and tolerability using machine learning algorithms. Psychometric evaluation covers the Hamilton Depression Rating Scale, the Childhood Trauma Questionnaire, and adverse drug reactions. An in-depth (epi-)genetic assessment combines genome-wide gene association data with DNA methylation patterns of genes coding CYP enzymes along with a pharmacogenetic batt...
Source: Pharmacopsychiatry - June 10, 2019 Category: Psychiatry Authors: Menke, Andreas Weber, Heike Deckert, J ürgen Tags: Original Paper Source Type: research
8-Hydroxylation and Glucuronidation of Mirtazapine in Japanese Psychiatric Patients: Significance of the Glucuronidation Pathway of 8-Hydroxy-Mirtazapine
Discussion The plasma concentration of 8-OH-MIR was as low as 1.42 nmol/L, whereas 8-OH-MIR-G had an approximate 59.50 times higher concentration than 8-OH-MIR, suggesting a significant role for hydroxylation of MIR and its glucuronidation in the Japanese population. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 2, 2019 Category: Psychiatry Authors: Shinozaki, Masataka Pierce, Jason Hayashi, Yuki Watanabe, Takashi Sasaki, Taro Komahashi-Sasaki, Hazuki Akiyama, Kazufumi Kato, Kazuko Inoue, Yoshimasa Tsuchimine, Shoko Yasui-Furukori, Norio Ozeki, Yuji Shimoda, Kazutaka Tags: Original Paper Source Type: research
Very Low Frequency of Drug Therapy of Alcohol Dependence in Germany – Analysis of Data of A Statutory Health Insurance
Pharmacopsychiatry DOI: 10.1055/a-0896-2757Acamprosate and naltrexone are medications of proven efficacy in the treatment of alcohol dependence. In order to investigate the prescription of these drugs in outpatient routine treatment in Germany (frequency of prescription, duration, medical specialty of prescribing physician), data of a large statutory health insurance were analyzed. Persons were included who were discharged from inpatient treatment with an alcohol-related disorder among their diagnoses during a one year observation period and with no diagnosed additional substance-related disorder (apart from nicotine- and ...
Source: Pharmacopsychiatry - May 26, 2019 Category: Psychiatry Authors: Scherbaum, Norbert Holzbach, R üdiger Stammen, Gunnar Kirchof, Ute Bonnet, Udo Tags: Letter to the Editor Source Type: research
Can Kampo and Dietary Supplement Address Unmet Need? – A Commentary on Tatsumi et al. and Hoffmann et al.
Pharmacopsychiatry DOI: 10.1055/a-0902-5145 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 22, 2019 Category: Psychiatry Authors: Tsuboi, Takashi Tags: Commentary Source Type: research
Pathological Concentration of C-reactive Protein is Correlated to Increased Concentrations of Quetiapine, But Not of Risperidone, Olanzapine and Aripiprazole in a Naturalistic Setting
Conclusion During a period of inflammation in patients taking quetiapine, according to our results, attention in dosing strategies is required to prevent toxic plasma concentrations. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - March 25, 2019 Category: Psychiatry Authors: Scherf-Clavel, Maike Weidner, Anne Deckert, J ürgen Menke, Andreas Unterecker, Stefan Tags: Original Paper Source Type: research
Commercial Pharmacogenetic Tests in Psychiatry: Do they Facilitate the Implementation of Pharmacogenetic Dosing Guidelines?
Discussion Most commercial pharmacogenetic tests we examined are well-equipped to facilitate implementation of the majority of dosing guidelines relevant to psychiatry but are limited in their ability to facilitate implementation of the full spectrum of dosing guidelines currently available. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - March 20, 2019 Category: Psychiatry Authors: Fan, Mikayla Bousman, Chad A. Tags: Original Paper Source Type: research
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Pharmacopsychiatry 2019; 02 Article in Thieme eJournals: Table of contents | Congress (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 21, 2019 Category: Psychiatry Source Type: research
No Connection between Long-Term Lithium Treatment and Antithyroid Antibodies
Conclusion The results obtained showed no significant connection between long-term lithium treatment and antithyroid antibodies. In bipolar patients receiving lithium longitudinally, antithyroid antibodies can be associated with some indexes of thyroid function. However, they behave differently in male and female patients. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 7, 2019 Category: Psychiatry Authors: Kraszewska, Agnieszka Ziemnicka, Katarzyna Sowi ński, Jerzy Ferensztajn-Rochowiak, Ewa Rybakowski, Janusz K. Tags: Original Paper Source Type: research
