Comparative Efficacy and Safety of Antipsychotic Drugs for Tic Disorders: A Systematic Review and Bayesian Network Meta-Analysis
Conclusions Atypical antipsychotics (risperidone and aripiprazole) appear to be the most robust evidence-based options for the treatment of TDs. Quetiapine may be a promising therapy. Ziprasidone and olanzapine are also effective, but the evidence is lacking. Further high-quality directly comparing different pharmacological treatment studies are justified. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - March 5, 2018 Category: Psychiatry Authors: Yang, Chunsong Hao, Zilong Zhang, Ling-Li Zhu, Cai-Rong Zhu, Ping Guo, Qin Tags: Review Source Type: research
Impact of Chronic Cannabis Use on Auditory Mismatch Negativity Generation in Schizophrenia Patients
This study therefore examined the effects of CUD on MMN generation in SCZ patients.
Methods Twenty SCZ − CUD patients, 21 SCZ+CUD patients, and 20 healthy controls (HC) were included in this study. MMN to frequency and duration deviants was elicited within an auditory oddball paradigm and recorded by 32 channel EEG.
Results As expected, SCZ − CUD patients showed reduced frontocentral MMN amplitudes to duration deviants compared to HC. Interestingly, SCZ+CUD patients demonstrated greater MMN amplitudes to duration deviants compared to SCZ − CUD patients at central electrodes with no differences compared to HC.
Discuss...
Source: Pharmacopsychiatry - March 5, 2018 Category: Psychiatry Authors: Roser, Patrik Pichler, Eva-Maria Habermeyer, Benedikt Kawohl, Wolfram Juckel, Georg Tags: Original Paper Source Type: research
Lithium Treatment in Children and Adolescents
Discussion There is inadequate data about the full variety of benefit and tolerability of lithium treatment in pediatric patients. However, given the potential for protection against suicide and neurotoxic effects of illness, further studies should be a priority. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 28, 2018 Category: Psychiatry Authors: Duffy, Anne Grof, Paul Tags: Review Source Type: research
Combination of Metformin and Lifestyle Intervention for Antipsychotic-Related Weight Gain: A Meta-Analysis of Randomized Controlled Trials
Conclusion Combining metformin and lifestyle intervention shows significant effect in reducing AP-related weight gain. Higher quality and larger RCTs are needed to confirm these findings.Review registration: CRD42017059198 [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 27, 2018 Category: Psychiatry Authors: Zheng, Wei Zhang, Qing-E Cai, Dong-Bin Yang, Xin-Hu Ungvari, Gabor S. Ng, Chee H. Wu, Ren-Rong Xiang, Yu-Tao Tags: Original Paper Source Type: research
DNA Methylation Profiling in a Neuroblastoma Cell Line Exposed to the Antipsychotic Perospirone
Discussion Our comprehensive DNA methylation analyses will contribute to a better understanding of detailed pharmacological actions of perospirone. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 27, 2018 Category: Psychiatry Authors: Murata, Yui Bundo, Miki Sunaga, Fumiko Kasai, Kiyoto Iwamoto, Kazuya Tags: Original Paper Source Type: research
Response to Lithium in Patients with Bipolar Disorder: What are Psychiatrists ’ Experiences and Practices Compared to Literature Review?
This study aims at characterizing French psychiatrists’ opinions regarding definition criteria and factors associated with lithium prophylactic response in patients with bipolar disorders.
Methods After a literature review, an online survey targeted French psychiatrists in 2016.
Results Literature review showed inconsistencies in reported definition criteria and clinical predictors of lithium prophylactic response. A total of 104 psychiatrists, mostly working in hospitals, completed the survey. The inconsistencies regarding definition criteria and predictors of lithium response were confirmed. Five factors were commonly ...
Source: Pharmacopsychiatry - February 27, 2018 Category: Psychiatry Authors: Montlahuc, Claire Curis, Emmanuel Laroche, Diane Grillault Bagoe, G érald Etain, Bruno Bellivier, Frank Chevret, Sylvie Tags: Original Paper Source Type: research
QTc Time Correlates with Amitriptyline and Venlafaxine Serum Levels in Elderly Psychiatric Inpatients
Discussion Amitriptyline and venlafaxine induce QT prolongation depending on drug concentrations in blood. Its extent, however, is very low when drug serum levels are within the therapeutic range. Future pharmacokinetic studies that correlate drug serum level and QT time should classify the cardiac risk of drugs based on the grade of the regression line in relation to the therapeutic range. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 21, 2018 Category: Psychiatry Authors: Hefner, Gudrun Hahn, Martina Hohner, Matthias Roll, Sybille C. Klimke, Ansgar Hiemke, Christoph Tags: Original Paper Source Type: research
What Does Antidepressant Drug level Monitoring Reveal About Outpatient Treatment and Patient Adherence?
Conclusion The results show that antidepressant nonresponders are frequently under-dosed or nonadherent. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 19, 2018 Category: Psychiatry Authors: Silhan, Petr Urinovska, Romana Kacirova, Ivana Hyza, Martin Grundmann, Milan Ceskova, Eva Tags: Original Paper Source Type: research
Intramuscular Testosterone Supplementation Ameliorates Depression in Hypogonadal Men: A Retrospective Study in an Outpatient Department
Conclusions The depressed, hypogonadal men generally benefited from TS given that the BDI-II score reduction was almost twice as much as needed for a minimal clinically important difference. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 1, 2018 Category: Psychiatry Authors: Miclea, A. Miclea, M. Pistor, M. Stegmayer, K. Hoepner, R. Tags: Original Paper Source Type: research
A Big Thank You to Our Reviewers in the Past Year!
Pharmacopsychiatry 2018; 51: 7-8 DOI: 10.1055/s-0043-124712 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 1, 2018 Category: Psychiatry Tags: Acknowledgment to Reviewers Source Type: research
Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017
Pharmacopsychiatry 2018; 51: e1-e1 DOI: 10.1055/s-0037-1600991 [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 1, 2018 Category: Psychiatry Authors: Hiemke, C. Bergemann, N. Clement, H. W. Conca, A. Deckert, J. Domschke, K. Eckermann, G. Egberts, K. Gerlach, M. Greiner, C. Gr ünder, G. Haen, E. Havemann-Reinecke, U. Hefner, G. Helmer, R. Janssen, G. Jaquenoud, E. Laux, G. Messer, T. M össner, R. M à Tags: Erratum Source Type: research
Prescription of Benzodiazepines and Related Drugs in Patients with Mild Cognitive Deficits and Alzheimer ’s Disease
Discussion The inappropriate use of BZDR conflicts with national and international guidelines. We suggest evaluating indications and treatment duration and improving the knowledge of alternative therapies in healthcare institutions. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 31, 2018 Category: Psychiatry Authors: Hessmann, Philipp Dodel, Richard Baum, Erika M üller, Matthias J. Paschke, Greta Kis, Bernhard Zeidler, Jan Klora, Mike Reese, Jens-Peter Balzer-Geldsetzer, Monika Tags: Original Paper Source Type: research
Sexual Dysfunction in Unmedicated Patients with Schizophrenia and in Healthy Controls
This study implies that schizophrenia has an impact on the presence of sexual dysfunction and that sexual dysfunction is partly independent of antipsychotic treatment. Since the sample consisted mostly of first-episode males, conclusions might only be valid for this subgroup. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 29, 2018 Category: Psychiatry Authors: Dembler-Stamm, Theresa Fiebig, Jana Heinz, Andreas Gallinat, J ürgen Tags: Original Paper Source Type: research
Hypothalamic-Pituitary-Adrenocortical Axis Activity in Alcohol-Dependent Patients During Treatment with High-Dose Baclofen
Conclusions Our study underlines again the role of HPA axis alterations in AUD. Furthermore, a decrease in hormonal stress levels during treatment with high-dose baclofen might contribute to the relapse preventive effects of this compound. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 22, 2018 Category: Psychiatry Authors: Geisel, Olga Schlemm, Ludwig Hellweg, Rainer Wiedemann, Klaus M üller, Christian A. Tags: Original Paper Source Type: research
Lithium and Renal Impairment: A Review on a Still Hot Topic
This study reviewed 6 large observational studies addressing the risk of impaired renal function associated with lithium treatment and methodological issues impacting interpretation of results.
Results An increased risk of renal impairment associated with lithium treatment is suggested. This increased risk may, at least partly, be a result of surveillance bias. Additionally, the earliest studies pointed toward an increased risk of end-stage renal disease associated with lithium treatment, whereas the later and methodologically most sound studies do not.
Discussion The improved renal outcome found in the more recent lithium...
Source: Pharmacopsychiatry - January 18, 2018 Category: Psychiatry Authors: Nielsen, Ren é Ernst Kessing, Lars Vedel Nolen, Willem A. Licht, Rasmus W. Tags: Original Paper Source Type: research
