Life-time Actionable Pharmacogenetic Drug Use: A Population-based
Cohort Study in 86 040 Young People With and Without Mental Disorders in
Denmark
Conclusion PGx drugs are commonly used by younger people, more often by
individuals with mental disorders and by females. Panel-based PGx testing could
contribute to treatment decisions at a very young age. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 9, 2021 Category: Psychiatry Authors: Lunenburg, Carin A.T.C. Ishtiak-Ahmed, Kazi Werge, Thomas Gasse, Christiane Tags: Original Paper Source Type: research
Comparison of Sodium Lactate Infusion and Carbon Dioxide Inhalation
Panic Provocation Tests: A Meta-analysis
Conclusion The evidence for the efficacy of the two panic provocation
tests is very strong. Yet, the results support the superiority of NaL infusion
over CO2 inhalation challenge as a panic provocation test. Thus,
lactate seems a much stronger stimulus than CO2 for the brain
suffocation detector. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - October 19, 2021 Category: Psychiatry Authors: Tural, Umit Iosifescu, Dan V. Tags: Original Paper Source Type: research
Anti-SARS-CoV-2 Action of Fluvoxamine may be Mediated by Endothelial
Nitric Oxide Synthase
Pharmacopsychiatry DOI: 10.1055/a-1641-0357 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 23, 2021 Category: Psychiatry Authors: Papadopoulos, Konstantinos I. Sutheesophon, Warachaya Aw, Tar-Choon Tags: Letter to the Editor Source Type: research
Baseline Working Memory Predicted Response to Low-Dose Ketamine
Infusion in Patients with Treatment-Resistant Depression
Discussion An inverse relationship between pretreatment working memory
function and treatment response to ketamine infusion may confirm that low-dose
ketamine infusion is beneficial and should be reserved for patients with
TRD. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 16, 2021 Category: Psychiatry Authors: Chen, Mu-Hong Lin, Wei-Chen Li, Cheng-Ta Tsai, Shih-Jen Wu, Hui-Ju Bai, Ya-Mei Hong, Chen-Jee Tu, Pei-Chi Su, Tung-Ping Tags: Original Paper Source Type: research
Impact of Psychiatric and Related Somatic Medications on the Duration
and Severity of COVID-19: A Retrospective Explorative Multi-center Study from
the German Metropolitan Ruhr-area
Discussion None of the tested medications was significantly associated
with the COVID-19-duration and -severity up to the end of post-diagnosing week
3. However, there were a few biologically plausible and promising relationships
with antidepressants, anticoagulants, and RAAS-inhibitors before p-value
adjustment. These should encourage larger and prospective studies to re-evaluate
the influence of somatic and psychiatric routine medications on COVID-19-related
health outcomes. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thie...
Source: Pharmacopsychiatry - September 16, 2021 Category: Psychiatry Authors: Bonnet, Udo Claus, BenediktBernd Schaefer, Martin Kuhn, Jens Nyhuis, Peter Scherbaum, Norbert Br üne, Martin Wakili, Velat Juckel, Georg Tags: Original Paper Source Type: research
COVID-19: Risks, Complications, and Monitoring in Patients on Clozapine
We present an overview of relevant editorials, observational studies, and case studies, in which COVID-19 was reported in patients on clozapine. Patients using clozapine may have a higher risk of infection than patients with schizophrenia spectrum disorders (SSD) using other antipsychotics. SARS-CoV-2 infection can result in a dangerous increase of clozapine plasma levels, and granulocytopenia and lymphocytopenia (generally mild and short-term) may also occur, usually not as a result of clozapine treatment. Clozapine intoxication, pneumonia and delirium are the main complications of COVID-19 in patients on clozapine. In or...
Source: Pharmacopsychiatry - September 1, 2021 Category: Psychiatry Authors: Veerman, Selene R. T. Bogers, Jan P. A. M. Cohen, Dan Schulte, Peter F. J. Tags: Review Source Type: research
Expression Biomarkers of Pharmacological Treatment Outcomes in Women with Unipolar and Bipolar Depression
Conclusion Based on transcriptomic profiling, we identified potential expression biomarkers of treatment outcomes for UD and BD. We also proved that the Ras-GEF pathway associated with long-term memory, female stress response, and treatment response modulation in animal studies impacts treatment efficacy in patients with BD. Further studies focused on the outlined genes may help provide predictive markers of treatment outcomes in UD and BD. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 1, 2021 Category: Psychiatry Authors: Dmitrzak-Weglarz, Monika Szczepankiewicz, Aleksandra Rybakowski, Janusz Kapelski, Pawe ł Bilska, Karolina Skibinska, Maria Reszka, Edyta Lesicka, Monika Jablonska, Ewa Wieczorek, Edyta Pawlak, Joanna Tags: Original Paper Source Type: research
Digital Phenotyping and Mobile Sensing in Addiction Psychiatry
Pharmacopsychiatry DOI: 10.1055/a-1559-4003 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - August 18, 2021 Category: Psychiatry Authors: Liu, Shuyan Heinzel, Stephan Dolan, Raymond J. Tags: Letter to the Editor Source Type: research
Candidate Psychotropics against SARS – CoV – 2: A Narrative Review
Pharmacopsychiatry DOI: 10.1055/a-1551-3756Since few therapeutic options are clinically accessible for coronavirus disease 2019 (COVID-19), effective, safe, and globally available pharmaceuticals need to be urgently developed to prevent severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and alleviate the severity of COVID-19. In this regard, the present paper is intended to provide an extensive review of the clinical and preclinical evidence on the psychotropics’ anti-SARS-CoV-2 effects, giving an insight into their potential applications for patients with a proven or high likelihood of COVID-19 pneumon...
Source: Pharmacopsychiatry - August 16, 2021 Category: Psychiatry Authors: Khosravi, Mohsen Tags: Review Source Type: research
Effect of Quetiapine, from Low to High Dose, on Weight and Metabolic Traits: Results from a Prospective Cohort Study
In this study, we evaluated the influence of quetiapine dose for 474 patients included in PsyMetab and PsyClin studies on weight and metabolic parameter evolution. Weight, blood pressure, lipid, and glucose profiles were evaluated during a follow-up period of 3 months after treatment initiation.
Results Significant dose-dependent metabolic alterations were observed. The daily dose was found to influence weight gain and increase the risk of undergoing clinically relevant weight gain (≥7% from baseline). It was also associated with a change in plasma levels of cholesterol (total cholesterol, LDL cholesterol, and HDL choles...
Source: Pharmacopsychiatry - August 13, 2021 Category: Psychiatry Authors: Dubath, C éline Piras, Marianna Gholam, Mehdi Laaboub, Nermine Grosu, Claire Sentissi, Othman Gamma, Franziska Solida, Alessandra von Gunten, Armin Conus, Philippe Eap, Chin B. Tags: Original Paper Source Type: research
Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports
This study analyzed reports of classic psychedelics administered with mood stabilizers from 3 websites (Erowid.org, Shroomery.org, and Reddit.com).
Results Strikingly, 47% of 62 lithium plus psychedelic reports involved seizures, and an additional 18% resulted in bad trips while none of 34 lamotrigine reports did. Further, 39% of lithium reports involved medical attention. Most of the lamotrigine reports (65%) but few (8%) of the lithium reports were judged to not affect the psychedelic experience.
Discussion Although further research is needed, we provisionally conclude that psychedelic use may pose a significant seizure ...
Source: Pharmacopsychiatry - August 4, 2021 Category: Psychiatry Authors: Nayak, Sandeep M. Gukasyan, Natalie Barrett, Frederick S. Erowid, Earth Erowid, Fire Griffiths, Roland R. Tags: Original Paper Source Type: research
An Oppositional Tolerance Account for Potential Cognitive Deficits Caused by the Discontinuation of Antidepressant Drugs
We present a novel framework based on the idea of allostatic adaptation, which allows to predict how different antidepressants likely impair different cognitive processes as a result of withdrawal and rebound effects. This framework relies on the assumptions that the type of cognitive impairments evoked by an antidepressant is determined by the targeted neurotransmitter systems, while the severity of deficits depends on its half-life. Our model predicts that the severity of detrimental cognitive withdrawal and rebound effects increases with a shorter half-life of the discontinued antidepressant drug. It further proposes dr...
Source: Pharmacopsychiatry - July 22, 2021 Category: Psychiatry Authors: Colzato, Lorenza Zhang, Wenxin Walter, Henrik Beste, Christian Stock, Ann-Kathrin Tags: Review Source Type: research
Drug-drug Interactions between COVID-19 Treatments and Antidepressants, Mood Stabilizers/Anticonvulsants, and Benzodiazepines: Integrated Evidence from 3 Databases
Conclusions Clinicians prescribing antidepressants, mood stabilizers/anticonvulsants, and benzodiazepines, should be aware of the probable risk of drug-drug interaction with COVID-19 medications and may benefit from heeding these recommendations for use to ensure patient safety. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 25, 2021 Category: Psychiatry Authors: Plasencia-Garc ía, Beatriz Oda Rico-Rangel, Mar ía Isabel Rodr íguez-Menéndez, Gonzalo Rubio-Garc ía, Ana Torell ó-Iserte, Jaime Crespo-Facorro, Benedicto Tags: Review Source Type: research
Psychedelics: A New Treatment Paradigm in Psychiatry?
Pharmacopsychiatry DOI: 10.1055/a-1520-5020The renaissance of psychedelics has accelerated further over the past year. At least
that’s true if you follow the public press. The New York Times
recently titled “The Psychedelic Revolution Is Coming. Psychiatry May Never
Be the Same.” on its front page 1. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 24, 2021 Category: Psychiatry Authors: Gr ünder, Gerhard Tags: Editorial Source Type: research
The Potential Role of Psychedelic Drugs in Mental Health Care of the Future
Pharmacopsychiatry DOI: 10.1055/a-1486-7386Serotonergic psychedelics such as psilocybin, lysergic acid diethylamide (LSD), or dimethyltryptamine (DMT), as well as psychoactive drugs that trigger phenomenologically- related experiences like 3,4-methylenedioxymethamphetamine (MDMA) and ketamine, belong to the most promising treatment approaches in contemporary psychiatry. Psychedelic-assisted psychotherapy is not only a new treatment paradigm in psychopharmacology, but it also requires a redefinition of psychotherapeutic processes and the contextualization of psychopharmacological interventions within a new treatment infrast...
Source: Pharmacopsychiatry - May 12, 2021 Category: Psychiatry Authors: Gr ünder, Gerhard Jungaberle, Henrik Tags: Review Source Type: research
