Cognitive Deficits in Methamphetamine Users: How Strong is The Evidence?
Pharmacopsychiatry DOI: 10.1055/s-0043-123471Methamphetamine use has spread in many European countries and the United States. The current review provides a summary and critical analysis of research on cognitive deficits associated with methamphetamine, also known as “crystal meth.” The literature search performed for this review led us to the hypothesis that methamphetamine use is associated with persistent changes in brain metabolism that result in various impairments, such as deficits in memory, attention, and concentration. The dopaminergic system in particular seems to be affected. Some studies indicate that cognit...
Source: Pharmacopsychiatry - January 15, 2018 Category: Psychiatry Authors: Proebstl, Lisa Kamp, Felicia Koller, Gabi Soyka, Michael Tags: Review Source Type: research
Fat Mass and Obesity-Related Gene Variants rs9939609 and rs7185735 are Associated with Second-Generation Antipsychotic-Induced Weight Gain
Discussion Our findings confirm the role of the FTO gene as a high-potential risk factor for obesity and indicate a value for predicting a weight gain induced by second-generation antipsychotics. Further, we detected an additive effect of FTO rs7185735 and MC4R rs17782313. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 15, 2018 Category: Psychiatry Authors: Schr öder, Charlotte Czerwensky, Fabian Leucht, Stefan Steimer, Werner Tags: Original Paper Source Type: research
Sertindole: EEG Analysis, Tolerability, and Clinical Efficacy
Conclusions Patients treated with sertindole do not show side effects similar to those found during treatment with other antipsychotic drugs. Increased slow wave activity in EEG and sedation were absent in the majority of the investigated patients. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 11, 2018 Category: Psychiatry Authors: Kroc, Adam D ębicka, Marta Wierzbicka, Aleksandra Wo łkow, Lidia Jernajczyk, Wojciech Wichniak, Adam Tags: Original Paper Source Type: research
Clinical Perspectives of Lithium ’s Neuroprotective Effect
Pharmacopsychiatry DOI: 10.1055/s-0043-124436Evidence for a neuroprotective effect of lithium has accumulated over the last 2 decades, and this phenomenon has been regarded as an important mechanism of lithium action in mood disorders. It has been reflected by an increase in cerebral gray matter volume in lithium-treated subjects and by the favorable influence of lithium on cognitive functions. A neuroprotective effect of lithium also makes this ion a possible candidate for use as a therapeutic drug in neurology, especially in neurodegenerative disorders. In this paper, neurochemical mechanisms of neuroprotective action of...
Source: Pharmacopsychiatry - December 21, 2017 Category: Psychiatry Authors: Rybakowski, Janusz K. Suwalska, Aleksandra Hajek, Tomas Tags: Review Source Type: research
Lithium: An American Perspective
Pharmacopsychiatry DOI: 10.1055/s-0043-124086 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - December 19, 2017 Category: Psychiatry Authors: Gitlin, Michael J. Tags: Commentary Source Type: research
Can We Rely on AGNP Therapeutic Targets Also For LAI Antipsychotics?
Pharmacopsychiatry DOI: 10.1055/s-0043-122603The updated AGNP Consensus Guidelines for Therapeutic Drug Monitoring (TDM) in Neuropsychopharmacology recently published in the journal have reinforced the key role of TDM to individualize psychoparmacological therapies in clinical practice. However, we believe, that these guidelines have missed the important opportunity to face with, and to provide useful information on, the emerging issue of long-acting injectable formulations of atypical antipsychotics. Specific therapeutic ranges also for these formulations should be included in the next AGNP guidelines. [...] © Georg Thie...
Source: Pharmacopsychiatry - November 27, 2017 Category: Psychiatry Authors: Baldelli, Sara Clementi, Emilio Cattaneo, Dario Tags: Letter to the Editor Source Type: research
Is Venlafaxine More Effective than Escitalopram and Nortriptyline in the Management of Painful Symptoms in Patients with Major Depression?
Conclusion Our results do not support the hypothesis suggesting the superiority of VEN over ESC and NOR in the management of UPPS in major depression. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 15, 2017 Category: Psychiatry Authors: Jaracz, Jan Gattner, Karolina Jaracz, Krystyna G órna, Krystyna Moczko, Jerzy Hauser, Joanna Tags: Original Paper Source Type: research
Role of Glutamatergic System in Obsessive-Compulsive Disorder with Possible Therapeutic Implications
Pharmacopsychiatry DOI: 10.1055/s-0043-121511 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 15, 2017 Category: Psychiatry Authors: Vl ček, Přemysl Pol ák, Jakub Brunovsk ý, Martin Hor áček, Jiří Tags: Erratum Source Type: research
Memantine Augmentation Improves Symptoms in Serotonin Reuptake Inhibitor-Refractory Obsessive-Compulsive Disorder: A Randomized Controlled Trial
Discussion Memantine is an effective and well-tolerated augmentation in severe OCD patients refractory to SRI monotherapy. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 3, 2017 Category: Psychiatry Authors: Modarresi, Atieh Sayyah, Mehdi Razooghi, Setareh Eslami, Kaveh Javadi, Mohammadreza Kouti, Leila Tags: Original Paper Source Type: research
Drink and Think: Impact of Alcohol on Cognitive Functions and Dementia – Evidence of Dose-Related Effects
Pharmacopsychiatry DOI: 10.1055/s-0037-1600939 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - October 19, 2017 Category: Psychiatry Authors: Gutwinski, Stefan Schreiter, Stefanie Priller, Josef Henssler, Jonathan Wiers, Corinde E. Heinz, Andreas Tags: Erratum Source Type: research
Role of Glutamatergic System in Obsessive-Compulsive Disorder with Possible Therapeutic Implications
Pharmacopsychiatry DOI: 10.1055/s-0043-118665Obsessive-compulsive disorder (OCD) is a chronic psychiatric illness and 1 of the most common anxiety disorders with the prevalence of 3%. Although its pathogenesis remains unclear, the traditional model focused on alternations in the serotonin system. Selective serotonin reuptake inhibitors provide the most effective treatment; however, as much as 40–60% of patients do not respond to antidepressants therapy. Thus, attention has shifted towards other neurotransmitter systems and related neuroanatomical structures. Recently, there is extensive evidence showing a key role of glu...
Source: Pharmacopsychiatry - September 26, 2017 Category: Psychiatry Authors: Vl ček, Přemysl Pol ák, Jakub Brunovsk ý, Martin Hor áček, Jiří Tags: Review Source Type: research
Drink and Think: Impact of Alcohol on Cognitive Functions and Dementia – Evidence of Dose-Related Effects
Pharmacopsychiatry DOI: 10.1055/s-0043-118664Regular alcohol consumption affects cognitive performance and the development of dementia. So far, findings are contradicting, which might be explained in part by dose-related effects. For this narrative review, we undertook a literature search for surveys investigating the impact of alcohol consumption on cognitive performance and the development of dementia. The majority of studies observed a U-shaped relationship between regular alcohol consumption and cognitive function: frequent heavy consumption of alcohol alters brain functions and decreases cognitive performance; regular...
Source: Pharmacopsychiatry - September 26, 2017 Category: Psychiatry Authors: Gutwinski, Stefan Schreiter, Stefanie Priller, Josef Henssler, Jonathan Wiers, Corinde E. Heinz, Andreas Tags: Review Source Type: research
What Characterizes Depression in Old Age? Results from the Bruneck Study
Discussion Depressive symptoms are frequent in the elderly population. Our results confirm the negative influence of depressive symptoms on cognition and quality of life. Patients with somatic comorbidities are likely to receive more antidepressant medication. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 26, 2017 Category: Psychiatry Authors: Defrancesco, Michaela Pechlaner, Raimund Kiechl, Stefan Willeit, Johann Deisenhammer, Eberhard A. Hinterhuber, Hartmann Rungger, Gregor Gasperi, Arno Marksteiner, Josef Tags: Original Paper Source Type: research
Editorial to Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology
Pharmacopsychiatry DOI: 10.1055/s-0043-118103 [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 19, 2017 Category: Psychiatry Authors: Gr ünder, Gerhard Tags: Editorial Source Type: research
A Critical Commentary on the 2017 AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology
Pharmacopsychiatry DOI: 10.1055/s-0043-117891In 2004, 2011, and 2017, the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP), a group of German-speaking psychiatric researchers and psychiatrists, published successive versions of therapeutic drug monitoring (TDM) expert group consensus guidelines. The 2017 version has as a major strength its encyclopedic nature, including 1358 references. The guideline has 3 major sections: 1) theoretical aspects of TDM, 2) drug concentration levels in blood to guide neuropsychopharmacotherapy, and 3) practical aspects of TDM in psychiatry and neurology. The wr...
Source: Pharmacopsychiatry - September 18, 2017 Category: Psychiatry Authors: de Leon, Jose Tags: Commentary Source Type: research
